CN115327121A - 凝血酶-抗凝血酶复合体的测定试剂及测定方法 - Google Patents

凝血酶-抗凝血酶复合体的测定试剂及测定方法 Download PDF

Info

Publication number
CN115327121A
CN115327121A CN202210943256.0A CN202210943256A CN115327121A CN 115327121 A CN115327121 A CN 115327121A CN 202210943256 A CN202210943256 A CN 202210943256A CN 115327121 A CN115327121 A CN 115327121A
Authority
CN
China
Prior art keywords
tat
antibody
reagent
antithrombin
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210943256.0A
Other languages
English (en)
Chinese (zh)
Inventor
吉田竜也
杨宇航
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pu Heji
Original Assignee
LSI Medience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2015074173A external-priority patent/JP6615474B2/ja
Priority claimed from JP2015074168A external-priority patent/JP6594641B2/ja
Application filed by LSI Medience Corp filed Critical LSI Medience Corp
Publication of CN115327121A publication Critical patent/CN115327121A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202210943256.0A 2015-03-31 2016-03-29 凝血酶-抗凝血酶复合体的测定试剂及测定方法 Pending CN115327121A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2015074173A JP6615474B2 (ja) 2015-03-31 2015-03-31 トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
JP2015-074168 2015-03-31
JP2015-074173 2015-03-31
JP2015074168A JP6594641B2 (ja) 2015-03-31 2015-03-31 トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
PCT/JP2016/060261 WO2016159015A1 (ja) 2015-03-31 2016-03-29 トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
CN201680017680.5A CN107533050A (zh) 2015-03-31 2016-03-29 凝血酶‑抗凝血酶复合体的测定试剂及测定方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680017680.5A Division CN107533050A (zh) 2015-03-31 2016-03-29 凝血酶‑抗凝血酶复合体的测定试剂及测定方法

Publications (1)

Publication Number Publication Date
CN115327121A true CN115327121A (zh) 2022-11-11

Family

ID=57005837

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680017680.5A Pending CN107533050A (zh) 2015-03-31 2016-03-29 凝血酶‑抗凝血酶复合体的测定试剂及测定方法
CN202210943256.0A Pending CN115327121A (zh) 2015-03-31 2016-03-29 凝血酶-抗凝血酶复合体的测定试剂及测定方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201680017680.5A Pending CN107533050A (zh) 2015-03-31 2016-03-29 凝血酶‑抗凝血酶复合体的测定试剂及测定方法

Country Status (7)

Country Link
US (2) US20180106793A1 (ja)
EP (1) EP3279659B1 (ja)
KR (1) KR102520342B1 (ja)
CN (2) CN107533050A (ja)
ES (1) ES2908437T3 (ja)
HK (1) HK1244537A1 (ja)
WO (1) WO2016159015A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116162165A (zh) * 2022-11-22 2023-05-26 杭州博茵生物技术有限公司 抗人凝血酶-抗凝血酶复合物抗体、制备方法、检测试剂及应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6927472B2 (ja) 2015-10-30 2021-09-01 株式会社Ｌｓｉメディエンス トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
CN108709988A (zh) * 2018-04-10 2018-10-26 波音特生物科技（南京）有限公司 一种新型抗原抗体反应增敏剂
CN111239403B (zh) * 2019-02-13 2020-12-08 武汉生之源生物科技股份有限公司 一种β2微球蛋白胶乳增强免疫比浊试剂盒及应用
CN111190003A (zh) * 2020-03-30 2020-05-22 吉林省富生医疗器械有限公司 一种视黄醇结合蛋白检测试剂盒及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0348158A (ja) * 1989-04-07 1991-03-01 Teijin Ltd ヒト・トロンビン・アンチトロンビン３複合体の免疫学的測定方法、そのための測定試薬およびキット
AU628960B2 (en) 1989-04-07 1992-09-24 Teijin Limited Method of immunologically assaying human thrombin- antithrombin III complex, assay reagent and kit therefor
JPH07238099A (ja) * 1994-02-25 1995-09-12 Dai Ichi Pure Chem Co Ltd モノクローナル抗体及びこれを用いる免疫学的測定法
JP3328053B2 (ja) * 1994-03-16 2002-09-24 積水化学工業株式会社 免疫凝集反応による抗体又は抗原の濃度定量法
JP3618797B2 (ja) * 1994-10-11 2005-02-09 積水化学工業株式会社 免疫測定法
JPH1026621A (ja) 1996-07-12 1998-01-27 Dai Ichi Pure Chem Co Ltd イムノアッセイ法
JP2001228153A (ja) 2000-02-15 2001-08-24 Dai Ichi Pure Chem Co Ltd 免疫学的測定方法
JP4390963B2 (ja) 2000-04-05 2009-12-24 シスメックス株式会社 免疫測定方法及び試薬キット
JP2002316999A (ja) 2001-04-17 2002-10-31 Dai Ichi Pure Chem Co Ltd モノクローナル抗体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116162165A (zh) * 2022-11-22 2023-05-26 杭州博茵生物技术有限公司 抗人凝血酶-抗凝血酶复合物抗体、制备方法、检测试剂及应用

Also Published As

Publication number Publication date
EP3279659A4 (en) 2018-11-14
EP3279659B1 (en) 2022-02-16
US20180106793A1 (en) 2018-04-19
KR102520342B1 (ko) 2023-04-10
US11237157B2 (en) 2022-02-01
EP3279659A1 (en) 2018-02-07
US20200256864A1 (en) 2020-08-13
WO2016159015A1 (ja) 2016-10-06
ES2908437T3 (es) 2022-04-29
HK1244537A1 (zh) 2018-08-10
KR20170132310A (ko) 2017-12-01
CN107533050A (zh) 2018-01-02

Similar Documents

Publication Publication Date Title
JP5807300B2 (ja) 試料中のｃ反応性蛋白質の測定方法及び測定試薬
JP4625879B2 (ja) モノクローナル抗体及びこれを用いた免疫学的測定方法
US11237157B2 (en) Reagent and method for assaying thrombin-antithrombin complex
JP6927472B2 (ja) トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
JP5199067B2 (ja) 免疫凝集反応試薬キット及び抗原の測定方法
US11768209B2 (en) Method and reagent for measuring thyroglobulin
JP3652029B2 (ja) 高感度免疫測定法
JP6594641B2 (ja) トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
JP7315968B2 (ja) 生物学的試料中の遊離ａｉｍの免疫学的分析方法及び対象におけるｎａｓｈの検出方法
CN112888946B (zh) 富含亮氨酸的α2糖蛋白的免疫测定法和测定试剂
JP6615474B2 (ja) トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
US20240302366A1 (en) Immunological assay method
JP6687183B2 (ja) トロンビン・アンチトロンビン複合体の測定試薬及び測定方法
WO2023163176A1 (ja) セリンプロテアーゼの検出用または測定用試薬
JP7315966B2 (ja) 生物学的試料中の遊離ａｉｍの免疫学的分析方法
JP2000266748A (ja) 抗マウスＩｇＥ抗体を用いたマウスＩｇＥの測定キット及び測定方法
JPH10132818A (ja) 免疫学的分析方法
JP2000266747A (ja) 抗ラットＩｇＥ抗体を用いたラットＩｇＥの測定キット及び測定方法
JPH0552845A (ja) 免疫測定用試薬

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40082358

Country of ref document: HK

TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20240415

Address after: Ehime Prefecture, Japan

Applicant after: Pu Heji

Country or region after: Japan

Address before: Tokyo

Applicant before: LSI MEDIENCE Corp.

Country or region before: Japan