CN115151524B - 维生素k2合成 - Google Patents

维生素k2合成 Download PDF

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Publication number
CN115151524B
CN115151524B CN202180016011.7A CN202180016011A CN115151524B CN 115151524 B CN115151524 B CN 115151524B CN 202180016011 A CN202180016011 A CN 202180016011A CN 115151524 B CN115151524 B CN 115151524B
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China
Prior art keywords
formula
compound
vitamin
catalyst
heptane
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CN202180016011.7A
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English (en)
Chinese (zh)
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CN115151524A (zh
Inventor
维尔纳·邦拉蒂
沃夫·库恩滋
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DSM IP Assets BV
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN202180016011.7A 2020-02-25 2021-02-16 维生素k2合成 Active CN115151524B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20159175.7 2020-02-25
EP20159175 2020-02-25
PCT/EP2021/053706 WO2021170449A1 (en) 2020-02-25 2021-02-16 Vitamin k2 synthesis

Publications (2)

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CN115151524A CN115151524A (zh) 2022-10-04
CN115151524B true CN115151524B (zh) 2024-01-19

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CN202180016011.7A Active CN115151524B (zh) 2020-02-25 2021-02-16 维生素k2合成

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US (1) US12139456B2 (https=)
EP (1) EP4110753A1 (https=)
JP (1) JP2023514491A (https=)
CN (1) CN115151524B (https=)
BR (1) BR112022016774A2 (https=)
WO (1) WO2021170449A1 (https=)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1873188A (en) * 1987-07-03 1989-01-05 Bayer Aktiengesellschaft Substituted 1,4-naphthoquinones as pest combatting agents
CN1816539A (zh) * 2003-07-08 2006-08-09 帝斯曼知识产权资产管理有限公司 用铋催化剂制备生育酚
US20070060761A1 (en) * 2005-09-15 2007-03-15 Eisai Co., Ltd. Method for producing quinone compound
CN102351677A (zh) * 2011-09-16 2012-02-15 重庆大学 一种化学合成维生素k2的方法
CN104011016A (zh) * 2011-12-27 2014-08-27 帝斯曼知识产权资产管理有限公司 维生素a中间体的催化合成
CN104513149A (zh) * 2013-09-29 2015-04-15 天津瑞安医药科技发展有限公司 四烯甲萘醌的合成方法
CN104744230A (zh) * 2015-02-13 2015-07-01 安徽万和制药有限公司 一种合成维生素k1的方法
CN105399615A (zh) * 2015-10-23 2016-03-16 山东广通宝医药有限公司 一种合成维生素k1的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768650A (en) * 1954-01-12 1957-02-20 Merck & Co Inc Vitamin k intermediates
US6790463B2 (en) 2001-03-30 2004-09-14 Robert F. Hofmann Uses of targeted oxidative therapeutic formulation in arteriosclerosis
CN100344621C (zh) 2003-01-13 2007-10-24 帝斯曼知识产权资产管理有限公司 α－生育酚乙酸酯的生产方法
WO2007032378A1 (ja) * 2005-09-15 2007-03-22 Eisai R & D Management Co., Ltd. キノン化合物の製造方法
WO2008099858A1 (ja) * 2007-02-13 2008-08-21 Kaneka Corporation 硬化性組成物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1873188A (en) * 1987-07-03 1989-01-05 Bayer Aktiengesellschaft Substituted 1,4-naphthoquinones as pest combatting agents
CN1816539A (zh) * 2003-07-08 2006-08-09 帝斯曼知识产权资产管理有限公司 用铋催化剂制备生育酚
US20070060761A1 (en) * 2005-09-15 2007-03-15 Eisai Co., Ltd. Method for producing quinone compound
CN102351677A (zh) * 2011-09-16 2012-02-15 重庆大学 一种化学合成维生素k2的方法
CN104011016A (zh) * 2011-12-27 2014-08-27 帝斯曼知识产权资产管理有限公司 维生素a中间体的催化合成
CN104513149A (zh) * 2013-09-29 2015-04-15 天津瑞安医药科技发展有限公司 四烯甲萘醌的合成方法
CN104744230A (zh) * 2015-02-13 2015-07-01 安徽万和制药有限公司 一种合成维生素k1的方法
CN105399615A (zh) * 2015-10-23 2016-03-16 山东广通宝医药有限公司 一种合成维生素k1的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K系维生素中间体β-甲基萘醌合成的研究进展;刘兴泉, 唐毅, 林晓静, 李淑华, 何泽珍;化工科技(02);49-54 *
Method for the Determination of Vitamin K Homologues in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry;Yoshitomo Suhara et al.;《Anal. Chem》;第77卷;第757-763页 *
维生素K2的合成新工艺;剧锦亮等;《大连工业大学学报》;第27卷(第3期);第232-234页 *

Also Published As

Publication number Publication date
US12139456B2 (en) 2024-11-12
CN115151524A (zh) 2022-10-04
US20230159429A1 (en) 2023-05-25
WO2021170449A1 (en) 2021-09-02
JP2023514491A (ja) 2023-04-06
BR112022016774A2 (pt) 2022-10-11
EP4110753A1 (en) 2023-01-04

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