JP2023514491A - ビタミンｋ２の合成 - Google Patents

ビタミンｋ２の合成 Download PDF

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Publication number
JP2023514491A
JP2023514491A JP2022543714A JP2022543714A JP2023514491A JP 2023514491 A JP2023514491 A JP 2023514491A JP 2022543714 A JP2022543714 A JP 2022543714A JP 2022543714 A JP2022543714 A JP 2022543714A JP 2023514491 A JP2023514491 A JP 2023514491A
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JP
Japan
Prior art keywords
formula
compound
vitamin
catalyst
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2022543714A
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English (en)
Japanese (ja)
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JP2023514491A5 (https=
Inventor
ワーナー ボンラス，
ロルフ クエンジ，
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DSM IP Assets BV
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DSM IP Assets BV
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Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of JP2023514491A publication Critical patent/JP2023514491A/ja
Publication of JP2023514491A5 publication Critical patent/JP2023514491A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2022543714A 2020-02-25 2021-02-16 ビタミンｋ２の合成 Pending JP2023514491A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20159175.7 2020-02-25
EP20159175 2020-02-25
PCT/EP2021/053706 WO2021170449A1 (en) 2020-02-25 2021-02-16 Vitamin k2 synthesis

Publications (2)

Publication Number Publication Date
JP2023514491A true JP2023514491A (ja) 2023-04-06
JP2023514491A5 JP2023514491A5 (https=) 2023-09-08

Family

ID=69740132

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022543714A Pending JP2023514491A (ja) 2020-02-25 2021-02-16 ビタミンｋ２の合成

Country Status (6)

Country Link
US (1) US12139456B2 (https=)
EP (1) EP4110753A1 (https=)
JP (1) JP2023514491A (https=)
CN (1) CN115151524B (https=)
BR (1) BR112022016774A2 (https=)
WO (1) WO2021170449A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768650A (en) * 1954-01-12 1957-02-20 Merck & Co Inc Vitamin k intermediates
WO2007032378A1 (ja) * 2005-09-15 2007-03-22 Eisai R & D Management Co., Ltd. キノン化合物の製造方法
CN102351677A (zh) * 2011-09-16 2012-02-15 重庆大学 一种化学合成维生素k2的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3801743A1 (de) 1987-07-03 1989-01-19 Bayer Ag Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone
US6790463B2 (en) 2001-03-30 2004-09-14 Robert F. Hofmann Uses of targeted oxidative therapeutic formulation in arteriosclerosis
CN100344621C (zh) 2003-01-13 2007-10-24 帝斯曼知识产权资产管理有限公司 α－生育酚乙酸酯的生产方法
WO2005005407A1 (en) 2003-07-08 2005-01-20 Dsm Ip Assets B.V. Manufacture of tocopherols using a bismuth catalyst
US7439402B2 (en) * 2005-09-15 2008-10-21 Eisai R&D Management Co., Ltd. Method for producing quinone compound
WO2008099858A1 (ja) * 2007-02-13 2008-08-21 Kaneka Corporation 硬化性組成物
JP6064264B2 (ja) 2011-12-27 2017-01-25 ディーエスエム アイピー アセッツ ビー．ブイ． ビタミンａ中間体の触媒合成
CN104513149A (zh) 2013-09-29 2015-04-15 天津瑞安医药科技发展有限公司 四烯甲萘醌的合成方法
CN104744230A (zh) 2015-02-13 2015-07-01 安徽万和制药有限公司 一种合成维生素k1的方法
CN105399615A (zh) 2015-10-23 2016-03-16 山东广通宝医药有限公司 一种合成维生素k1的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768650A (en) * 1954-01-12 1957-02-20 Merck & Co Inc Vitamin k intermediates
WO2007032378A1 (ja) * 2005-09-15 2007-03-22 Eisai R & D Management Co., Ltd. キノン化合物の製造方法
CN102351677A (zh) * 2011-09-16 2012-02-15 重庆大学 一种化学合成维生素k2的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YOSHITOMO SUHARA ET AL.: "Method for the Determination of Vitamin K Homologues in Human PlasmaUsing High-Performance Liquid Ch", ANALYTICALCHEMISTRY, vol. 77, no. 3, JPN6024028215, 23 December 2004 (2004-12-23), pages 757 - 763, XP055441579, ISSN: 0005577371, DOI: 10.1021/ac0489667 *

Also Published As

Publication number Publication date
US12139456B2 (en) 2024-11-12
CN115151524A (zh) 2022-10-04
US20230159429A1 (en) 2023-05-25
CN115151524B (zh) 2024-01-19
WO2021170449A1 (en) 2021-09-02
BR112022016774A2 (pt) 2022-10-11
EP4110753A1 (en) 2023-01-04

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