CN115025079A - 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途 - Google Patents

结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途 Download PDF

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Publication number
CN115025079A
CN115025079A CN202210561490.7A CN202210561490A CN115025079A CN 115025079 A CN115025079 A CN 115025079A CN 202210561490 A CN202210561490 A CN 202210561490A CN 115025079 A CN115025079 A CN 115025079A
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ester
ethyl
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Chinese (zh)
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H·斯泰内格
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Pronova Biopharma Norge AS
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Pronova Biopharma Norge AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
CN202210561490.7A 2015-04-28 2016-04-21 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途 Pending CN115025079A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NO20150514 2015-04-28
NO20150514 2015-04-28
CN201680024704.XA CN107530306A (zh) 2015-04-28 2016-04-21 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途
PCT/EP2016/058909 WO2016173923A1 (en) 2015-04-28 2016-04-21 Use of structurally enhanced fatty acids containing sulphur for preventing and/or treating non-alcoholic steatohepatitis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680024704.XA Division CN107530306A (zh) 2015-04-28 2016-04-21 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途

Publications (1)

Publication Number Publication Date
CN115025079A true CN115025079A (zh) 2022-09-09

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680024704.XA Pending CN107530306A (zh) 2015-04-28 2016-04-21 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途
CN202210561490.7A Pending CN115025079A (zh) 2015-04-28 2016-04-21 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途

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CN201680024704.XA Pending CN107530306A (zh) 2015-04-28 2016-04-21 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途

Country Status (10)

Country Link
US (5) US20180104201A1 (enExample)
EP (1) EP3288550B1 (enExample)
JP (3) JP6784696B2 (enExample)
KR (2) KR102644400B1 (enExample)
CN (2) CN107530306A (enExample)
AU (2) AU2016256552B2 (enExample)
BR (1) BR112017023164A2 (enExample)
CA (1) CA2983377C (enExample)
ES (1) ES2980790T3 (enExample)
WO (1) WO2016173923A1 (enExample)

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* Cited by examiner, † Cited by third party
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KR102644400B1 (ko) 2015-04-28 2024-03-06 바스프 에이에스 비알코올성 지방간염의 예방 및/또는 치료를 위한 구조적으로 강화된 함황 지방산의 용도
ES2896686T3 (es) * 2017-06-16 2022-02-25 Avexxin As Composiciones y métodos para el tratamiento de una enfermedad fibrótica
US11925614B2 (en) * 2017-12-06 2024-03-12 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis
JP7508447B2 (ja) * 2018-05-23 2024-07-01 ノースシー セラピューティクス ベスローテン フェンノートシャップ 血糖制御を改善し、炎症性腸疾患を処置するための構造修飾脂肪酸
KR102186416B1 (ko) 2019-01-16 2020-12-07 서울대학교산학협력단 12-lox 발현 촉진제를 포함하는 간 질환 예방 또는 치료용 조성물
US20240325336A1 (en) 2020-12-22 2024-10-03 Northsea Therapeutics B.V. Combination therapies comprising oxygen-containing structurally enhanced fatty acids for treatment of non-alcoholic steatohepatitis

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