CN1148220C - Antivirus defervescent - Google Patents

Antivirus defervescent Download PDF

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Publication number
CN1148220C
CN1148220C CNB021000646A CN02100064A CN1148220C CN 1148220 C CN1148220 C CN 1148220C CN B021000646 A CNB021000646 A CN B021000646A CN 02100064 A CN02100064 A CN 02100064A CN 1148220 C CN1148220 C CN 1148220C
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grams
antivirus
defervescent
select
herba
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CN1363366A (en
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马文汉
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Priority to AU2003203326A priority patent/AU2003203326A1/en
Priority to PCT/CN2003/000025 priority patent/WO2003057229A1/en
Priority to CNB03801243XA priority patent/CN1233400C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a medical composition, particularly to an antivirus febrifuge which is prepared by taking plant Chinese herbal medicine as raw materials. The present invention is mainly prepared from raw materials, such as dyers woad leaf, baikal skullcap root, honeysuckle flower, artificial bezoar, cyan warp, common lophatherum herb, arctium, mint, etc., and the raw materials are added with correctants, a proper amount of auxiliary materials and pH regulating agents. The present invention has the advantages that antivirus functions are strong; antivirus boards are wide; treating effects on upper respiratory tract infection and pulmonary infection caused by virus influenza and common cold are good and obvious; treating effects on herpes zoster, paratotis, virus eye conjunctivitis are good; the present invention has the functions of preventing bacterium, relieving inflammation, removing heat and enhancing immunizing power; safe functions are good.

Description

A kind of antivirus defervescent
Technical field
The present invention relates to a kind of pharmaceutical composition, be meant that especially a kind of is the antiviral antipyretic that raw material is made with the vegetable Chinese herbal medicine.
Background technology
In general, flu is divided into common cold and influenza, and it is a kind of respiratory infectious disease of serious harm health.Its sickness rate is higher, influences widely, often can cause diseases such as sinusitis, pharyngolaryngitis, bronchus and pneumonia, asthma, also is to cause one of old man, pediatric patient main causes of death.At present, treatment flu clinically adopts symptomatic therapy or antiviral therapies such as anti-inflammation, antiallergic, antipyretic analgesic usually.Injectable drugs such as anti-microbial type penicillin commonly used; Medicines such as antiallergic chlorphenamine commonly used; Analgesic relieving the pain, medicines such as aspirin commonly used, acetaminophen.The antiviral class is used medicines such as moroxydine, Radix Isatidis granules always.The traditional Chinese medical science adopts the method treatment of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature and relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, as decoction, Chinese patent medicine etc. usually according to the difference of flu type.Its curative effect of above Drug therapy was generally 3～4 days or longer, just can bring down a fever, and effect is slow, and treatment cycle is long.
Summary of the invention
The objective of the invention is to overcome the deficiency in the background technology and provide a kind of at viral respiratory system infection, can have in a short time significant curative effect, the antiviral antipyretic.
The present invention is achieved in that
The present invention is made by the raw material that following weight is formed: Folium Isatidis 10～60 grams, Radix Scutellariae 120～250 grams, Flos Lonicerae 120～250 grams, artificial Calculus Bovis's 1～3 gram, green grass or young crops stick up 60～150 grams, Herba Lophatheri 20～80 grams, Fructus Arctii 20～80 grams, Herba Menthae 20～80 grams; And adding correctives and appropriate amount of auxiliary materials; And the PH regulator, make pH value between 6.5～7.
Wherein, the also available Radix Isatidis of described Folium Isatidis; The also available Calculus Bovis of described artificial Calculus Bovis; Also available Folium Bambusae of described Herba Lophatheri or Herba Houttuyniae; The also available Radix Stemonae of described Fructus Arctii or Radix Sophorae Tonkinensis; The also available Oleum menthae of described Herba Menthae, described green grass or young crops sticks up also available Huang and sticks up or Herba Houttuyniae.Equally also can realize effect of the present invention.
Described correctives is to select glycyrrhizin or Radix Glycyrrhizae crude extract for use and is a kind of in the following raw material at least: stevioside, aspartame, cyclamate, protein sugar etc.
Described adjuvant is selected a kind of in the following raw material at least: starch, cellulose, lactose, dextrin, xylitol, carboxymethyl cellulose, microcrystalline Cellulose, micropowder silica gel, sucrose, glucose etc.
Described PH regulator can be selected a kind of in the following raw material: NaHCO 3, sodium citrate, sodium carbonate.
It is remarkable that popularity of the present invention is caught a cold, common cold belongs to the described anemopyretic person of traditional Chinese medical science effect, and sense and tonsillitis, pharyngitis patient take medicine and can make temperature recovery normal in 1 day on the majority, reach the purpose (promptly no longer take medicine, symptom fades away) of basic healing.After tracheitis and bronochitic took medicine 2 days, can make virus controlled, temperature recovery is normal, and other symptom disappears in 3 days substantially.To the patient of virus merging bacterial infection, can again with antibiotic therapy, can recover normal in most 3 days earlier with this medicine control virus.Than using antibiotic therapy to shorten the course of disease greatly separately.Herpes zoster and parotitis patient take medicine two days later, and promptly may command virus makes the recovery from illness of disease trend.
The part extracorporeal antivirus effect experiment of antivirus defervescent of the present invention is made June calendar year 2001 by China Academy Of Traditional Chinese Medicine Traditional Chinese Medicine Research Institute.Its conclusion is: " experimental result explanation; the agent of antiviral antipyretic granule has inhibitory action in various degree to Ard-3, Ard-7, parainfluenza-1, RSV, HSV-1, HSV-2 virus in the cell in vitro culture systems; valid density scope 0.19～1.56mg/ml, IC are between 0.252～0.282, and TI is between 5.0～6.3.Significant difference is relatively arranged, P＜0.01 with contrast (virazole).
The invention has the advantages that: antivirus action is strong, and antiviral spectrum is wide; Upper respiratory tract infection, pulmonary infection instant effect, good effect that viral influenza, common cold are caused; Herpes zoster, parotitis, viral conjunctivitis also there is better curative effect; Also have antibiotic, antiinflammatory, bring down a fever, the effect of enhancing immunity; And safety is good.
The specific embodiment
Embodiment 1:
The present invention is the pharmaceutical preparation of being made by following materials of weight proportions:
Folium Isatidis 10 grams, Radix Scutellariae 120 grams, Flos Lonicerae 120 grams, artificial Calculus Bovis's 1 gram, green grass or young crops stick up 60 grams, Herba Lophatheri 20 grams, Fructus Arctii 20 grams, Herba Menthae 20 grams; And adding correctives glycyrrhizin 2 restrains, stevioside's 2.1 grams; And appropriate amount of auxiliary materials: starch, lactose, microcrystalline Cellulose; With PH regulator: NaHCO 3, and make pH value between 6.5～7.
Its production technology is:
1, Folium Isatidis is measured lixiviate three times for 8 times with 70% ethanol, each 6 hours, merge lixiviating solution, filter then, obtain filtrate.
2, Herba Menthae is carried out distillating extracting oil, oil adds the beta-schardinger dextrin-parcel.
3, Radix Scutellariae is extracted acid precipitation method with decocting in water, extract baicalin.
4, Flos Lonicerae, green grass or young crops are stuck up, Fructus Arctii, Herba Lophatheri mix, and adds 10 times of water gagings, extract twice; 8 times of water gagings extract for the third time, and the time is 2 hours, 2 hours, 1 hour (can in multi-functional extractor);
5, again extract is merged the concentration that was evaporated to 1: 1; Then, adding second is liquor-saturated to 70%, staticly settles 48 hours;
6, leaching supernatant again; Being concentrated into appropriateness adds correctives and makes its dissolving; And then spray drying, dry powder;
7, add adjuvant, Oleum menthae wrappage, artificial Calculus Bovis, baicalin and PH regulator, and mix homogeneously;
8, make moist wood with 95% ethanol as binding agent; Granulate by granulator; Dry under 60 ℃, after 24～36 hours, collect dry product and granulate;
9, again through the packer packing, drug specifications is: every bag 10 grams of sugared granule (containing crude drug 9 grams approximately) are arranged, every bag 4 grams of sugar free granule (containing crude drug 9 grams approximately): dress box; Quality inspection; But finished product dispatches from the factory.
Embodiment 2:
The present invention is the pharmaceutical preparation of being made by following materials of weight proportions:
Folium Isatidis 60 grams, Radix Scutellariae 250 grams, Flos Lonicerae 250 grams, artificial Calculus Bovis's 3 grams, green grass or young crops stick up 150 grams, Herba Lophatheri 80 grams, Fructus Arctii 80 grams, Herba Menthae 80 grams; And adding correctives: glycyrrhizin 5～6 grams, stevioside's 5～7 grams: and appropriate amount of auxiliary materials: starch, carboxymethyl cellulose, microcrystalline Cellulose, lactose; And PH regulator: NaHCO 3, make pH value between 6.5～7.(its production technology is with embodiment 1.)
Most preferred embodiment:
The present invention is the pharmaceutical preparation of being made by following materials of weight proportions:
Folium Isatidis 10～30 grams, Radix Scutellariae 120～200 grams, Flos Lonicerae 120～200 grams, artificial Calculus Bovis's 1～1.5 gram, green grass or young crops stick up 60～120 grams, Herba Lophatheri 20～40 grams, Fructus Arctii 20～40 grams, Herba Menthae 20～40 grams; And adding correctives: glycyrrhizin 2～4 grams, stevioside's 2～4 grams; Appropriate amount of auxiliary materials: starch, lactose, xylitol, carboxymethyl cellulose, microcrystalline Cellulose; And PH regulator: NaHCO 3, make pH value between 6.5～7.(its production technology is with embodiment 1.)
The usage of this medicine is:
Each 2 bags of adult's (calculating) by 60 kg body weight, every day 3 times.Boiled water is taken after dissolving.
Points for attention:
1, this medicine should not be taken simultaneously with macrolides medicine (as: erythromycin ethylsuccinate, red enzyme element), in order to avoid reduce drug effect;
2, the patient should note warmingly after taking medicine, and has a rest, and avoiding suffers from cold gets involved:
3, the hyperpyrexia patient if took medicine 1～2 hour after, still the sense go cold all over, lossless, then can further take warming measure or add sweating medicine (as: aspirin).
The efficacy analysis of antivirus defervescent of the present invention (treatment group) is used efficacy analysis with " SHUANGHUANGLIAN KOUFUYE ", and both comparisons, shown in table 1～3.
Antiviral antipyretic granule agent efficacy analysis
(table 1)
The sick kind The produce effects of the curing the example number invalid healing obvious effective rate that takes a turn for the better
Last sense acute tonsillitis acute bronchitis sum 73 73 0 0 0 100％ 19 16 3 0 0 100％ 12 6 5 1 0 92％ 104 95 8 1 0 98％
SHUANGHUANGLIAN KOUFUYE is used efficacy analysis
(table 2)
The sick kind The produce effects of the curing the example number invalid healing obvious effective rate that takes a turn for the better
Last sense acute tonsillitis acute bronchitis sum 72 60 8 4 0 94％ 13 9 2 0 2 85％ 19 9 7 3 0 84％ 104 78 17 7 2 91％
Treatment group, matched group are relatively
(table 3)
Classification Total routine number is cured the produce effects number and is cured the average administration time of obvious effective rate
Treatment group matched group 104 103 99% 1.18 days 104 95 91% 3.57 days
Through the mathematical statistics analysis, there is the advantage of highly significant P=0.0075 P＜0.01.

Claims (10)

1, a kind of antivirus defervescent is characterized in that being made by the raw material that following weight is formed: Folium Isatidis 10～60 grams, Radix Scutellariae 120～250 grams, Flos Lonicerae 120～250 grams, artificial Calculus Bovis's 1～3 gram, green grass or young crops stick up 60～150 grams, Herba Lophatheri 20～80 grams, Fructus Arctii 20～80 grams, Herba Menthae 20～80 grams; And adding correctives; And appropriate amount of auxiliary materials; And the PH regulator, make pH value between 6.5～7.
2, antivirus defervescent according to claim 1 is characterized in that described artificial Calculus Bovis also can select Calculus Bovis for use.
3, antivirus defervescent according to claim 1 is characterized in that described Herba Lophatheri also can select Folium Bambusae or Herba Houttuyniae for use.
4, antivirus defervescent according to claim 1 is characterized in that described Fructus Arctii also can select the Radix Stemonae or Radix Sophorae Tonkinensis for use.
5, antivirus defervescent according to claim 1 is characterized in that described Herba Menthae also can select Oleum menthae for use.
6, antivirus defervescent according to claim 1 is characterized in that the also available Radix Isatidis of described Folium Isatidis.
7, antivirus defervescent according to claim 1 is characterized in that described green grass or young crops sticks up also can select for use Huang to stick up or Herba Houttuyniae.
8, antivirus defervescent according to claim 1 is characterized in that described correctives is with glycyrrhizin or Radix Glycyrrhizae crude extract and is a kind of in the following raw material at least: stevioside, aspartame, cyclamate, protein sugar; Described adjuvant can be selected a kind of in the following raw material at least: starch, cellulose, lactose, dextrin, xylitol, carboxymethyl cellulose, microcrystalline Cellulose, micropowder silica gel, sucrose, glucose.
9, antivirus defervescent according to claim 1 is characterized in that described PH regulator can select a kind of in the following raw material: NaHCO 3, sodium citrate, sodium carbonate.
10, antivirus defervescent according to claim 1 is characterized in that the weight proportion of each raw material is:
Folium Isatidis 10～30 grams, Radix Scutellariae 120～200 grams, Flos Lonicerae 120～200 grams, artificial Calculus Bovis's 1～1.5 gram, green grass or young crops stick up 60～120 grams, Herba Lophatheri 20～40 grams, Fructus Arctii 20～40 grams, Herba Menthae 20～40 grams; And adding correctives: glycyrrhizin 2～4 grams, stevioside's 2～4 grams; Appropriate amount of auxiliary materials: starch, lactose, xylitol, carboxymethyl cellulose, microcrystalline Cellulose; And PH regulator: NaHCO 3, make pH value between 6.5～7.
CNB021000646A 2002-01-14 2002-01-14 Antivirus defervescent Expired - Fee Related CN1148220C (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CNB021000646A CN1148220C (en) 2002-01-14 2002-01-14 Antivirus defervescent
AU2003203326A AU2003203326A1 (en) 2002-01-14 2003-01-14 Antiviral and antipyretic formulation and the preparation method thereof
PCT/CN2003/000025 WO2003057229A1 (en) 2002-01-14 2003-01-14 Antiviral and antipyretic formulation and the preparation method thereof
CNB03801243XA CN1233400C (en) 2002-01-14 2003-01-14 Fever bringing down formulating for preventing virus and its prepn. method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB021000646A CN1148220C (en) 2002-01-14 2002-01-14 Antivirus defervescent

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CN1148220C true CN1148220C (en) 2004-05-05

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Publication number Priority date Publication date Assignee Title
CN101313731B (en) * 2008-07-17 2012-02-22 北京中农博乐科技开发有限公司 Anti-stress feedstuff additive
CN104587317B (en) * 2015-01-08 2017-08-08 青岛农业大学 A kind of Chinese medicine composition for treating turbot reddish body
CN107789517A (en) * 2017-10-23 2018-03-13 上海凯宝药业股份有限公司 A kind of Chinese medicine compound prescription antivirus defervescent and preparation method thereof
CN111617196A (en) * 2020-06-17 2020-09-04 上海凯宝药业股份有限公司 Application of traditional Chinese medicine preparation for resisting viral cold in inhibiting pneumonia

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CN1129578A (en) * 1995-12-04 1996-08-28 周凌煜 Formulation of Ganmaosuyusan for curing common cold
CN1058894C (en) * 1998-03-10 2000-11-29 张锡明 Compound cold-preventing nose drops and their preparation
CN1290534A (en) * 2000-03-09 2001-04-11 丛繁滋 Quick-acting spray composition for proverting cold and its preparing method
CN1288734A (en) * 2000-03-09 2001-03-28 丛繁滋 Fast-acting composite spray for cold and its preparation
CN1273819A (en) * 2000-05-16 2000-11-22 刘安西 Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold

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CN1564692A (en) 2005-01-12
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CN1363366A (en) 2002-08-14
CN1233400C (en) 2005-12-28

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