CN1288734A - Fast-acting composite spray for cold and its preparation - Google Patents
Fast-acting composite spray for cold and its preparation Download PDFInfo
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- CN1288734A CN1288734A CN 00108505 CN00108505A CN1288734A CN 1288734 A CN1288734 A CN 1288734A CN 00108505 CN00108505 CN 00108505 CN 00108505 A CN00108505 A CN 00108505A CN 1288734 A CN1288734 A CN 1288734A
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Abstract
The present invention relates to a spray composition for quickly-curing common cold and its preparation method. It processes the following advantages: it selects and utilizes pH regulating agent and Chinese medicinal material to quickly eliminate primary focus of cold and cut off course of cold, and utilizes the Chinese medicinal material with the functions of antigyretic analgesic to quickly eliminate fever due to cold, and adopts the clathration technique to solve the adverse reaction of irritating nasal mucosa due to nasal medication, at the same time it can properly prolong the therapeutic effect of the medicine.
Description
The invention belongs to anti-cold medicine and preparation method thereof.
Flu is a kind of mondial commonly encountered diseases, frequently-occurring disease, it is the actute infection of the upper respiratory tract mucosa that causes by virus etc., its primary lesion is at nasal mucosa, therefore the author had applied for once that application number was 94108329.2 " Yinhuang " inhalation, spray, enema and preparation method thereof, application number is 96122296.4 the spray for cold that prevents, nose liniment and preparation method thereof, application number is the clear key SHUANGHUANLIAN spray of 97101390.X, nose liniment and preparation method thereof and application number are patent applications such as control spray for cold of 00102458.2 and preparation method thereof, its primary lesion curative effect of removing flu makes us very satisfied, but it solves the heating of flu, speed is slower when General Symptoms such as feeling bad, and needs to wait for that body remove the required identical time with the toxin that antibacterial is produced with virus fully in body.
The objective of the invention is on the basis that above-mentioned four patent application curative effects are satisfied with very much, add antipyretic analgesic, thereby reach the primary lesion that not only can remove flu rapidly, cut off its intrinsic course of disease, and can remove the heating of flu, the purpose of General Symptoms such as feel bad rapidly.
Fast-acting composite spray for cold of the present invention, mainly be to be raw material by PH regulator, Western medicine antipyretic analgesic, Chinese crude drug, with correctives, clathrate material of main part is that adjuvant and spray carrier prepare and form, it is characterized in that the PH regulator can select for use any or several acid that PH can be transferred to 1--6 that can tolerate on the physiology maybe PH can be transferred to the alkali of 9--13.5, its consumption accounts for 0～5% of spray content gross weight; The Western medicine antipyretic analgesic can select water soluble for use and in water stable antipyretic analgesic commonly used, its consumption accounts for 0～25% of spray content gross weight; Chinese crude drug can be selected Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Folium Isatidis for use, Herba Taraxaci, Radix Glycyrrhizae, cholic acid, Concha Margaritifera powder, Cornu Bubali, Fructus Gardeniae, Herba Houttuyniae, Radix Saposhnikoviae, Herba Corydalis Bungeanae, punching connect or the conventional Chinese medicine compound recipe that is made of these medical materials etc., and its raw medicinal herbs consumption accounts for 0～200% (accounting for 0～15% after the extraction) of spray content gross weight; Correctives can be selected Flos Chrysanthemi essence, protein sugar, Mentholum, Herba Menthae wet goods for use, and its consumption accounts for 0.005～5% of spray content gross weight; The clathrate material of main part can be selected cyclodextrin, substituted cyclodextrin etc. for use, and its consumption accounts for 0.005～3% of spray content gross weight; Solubilizing agent can be selected tween 80, lecithin etc. for use, and its consumption accounts for 0～5% of spray content gross weight; The optional water of solvent, ethanol etc.; Its consumption accounts for 75～99% of spray gross weight.Its preparation method by feed intake, extract, make with extra care, several procedures such as cyclodextrin clathrate enclose, ingredients, packing finish, wherein the enclose of cyclodextrin clathrate can be selected polishing, solwution method etc. for use, but no matter takes the consumption of the sort of method cyclodextrin should be less than its saturated meltage in spray liquid.Wherein PH regulator, Western medicine antipyretic analgesic, the Chinese crude drug three kinds of components in a prescription as the core component of fast-acting composite spray for cold can occur simultaneously, one or both components wherein also can only appear in a prescription, as: for the common cold initial stage patient, three kinds of components only add the PH regulator in the prescription, Chinese crude drug gets final product; Occurred the patient of General Symptoms for catching a cold, three kinds of component Western medicine antipyretic analgesic must occur in the prescription, and PH regulator, Chinese crude drug can be got respectively or give up.
The invention has the advantages that: the selected PH regulator of fast-acting composite spray for cold of the present invention, primary lesion that Chinese crude drug can be removed flu rapidly, cut off the intrinsic course of disease of flu; The antipyretic analgesic of selecting for use can be removed the heating of flu, General Symptoms such as feel bad rapidly, thereby makes the present invention reach quick-acting; And the application of inclusion technique stimulates the untoward reaction of nasal mucosa that the patient is taken like a shot can solve spray nasal-cavity administration in the past the time, but the curative effect of proper extension medicine also simultaneously.
Embodiments of the invention:
Embodiment 1:PH adjustable type control spray for cold
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Glacial acetic acid 10ml (or sodium hydroxide 0.3g)
Tween 80 .3g, the smart 4.5g of Flos Chrysanthemi
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Get 15g β--cyclodextrin, 0.6g Mentholum place the container that the 1200ml distilled water is housed airtight, stirring under the 45C condition cooled to such an extent that Mentholum enclose liquid is standby in 90 minutes, after other gets the smart 4.5g of glacial acetic acid 10ml (or sodium hydroxide 0.3g), tween 80 .3g, Flos Chrysanthemi and makes it be dissolved in the 200ml distilled water, add in the above-mentioned standby Mentholum enclose liquid, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, gets final product in 100 aerosol containers of mix homogeneously packing what.
Embodiment 2: available P H adjustable type control spray for cold
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Glacial acetic acid 10ml (or sodium hydroxide 0.3g)
Dipyrone 15g tween 80 .3g, the smart 4.5g of Flos Chrysanthemi
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Get the 15g beta cyclodextrin, the 0.6g Mentholum places the container that the 1200ml distilled water is housed airtight, stirring under the 45C condition cooled to such an extent that Mentholum enclose liquid is standby in 90 minutes, after other gets the smart 4.5g of glacial acetic acid 10ml (or sodium hydroxide 0.3g), dipyrone 15g, tween 80 .3g, Flos Chrysanthemi and makes it be dissolved in the 200ml distilled water, add in the above-mentioned standby Mentholum enclose liquid, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, gets final product in 100 aerosol containers of mix homogeneously packing what.
Embodiment 3: clear key SHUANGHUANLIAN spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Flos Lonicerae 375g Radix Scutellariae 375g Fructus Forsythiae 750g
Tween 80 .3g, cyclamate 4.5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Getting the 0.6g Mentholum is dissolved in 2ml ethanol and its adding is ground 10 minutes in the 15g beta-schardinger dextrin-of twice distilled water moistening standby, other gets 10.5g baicalin (Radix Scutellariae extract) stirring and adds in the 1300ml distilled water down, transfer PH to 7.0 to make it dissolving with 40% sodium hydroxide solution, continue to stir and slowly add the refining dry powder of 67.5g Flos Lonicerae and Fructus Forsythiae extraction, above-mentioned standby cyclodextrin clathrate, 5g Flos Chrysanthemi essence, 5g tween--80 abundant stirrings make it dissolving, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 4: quick-acting clear key SHUANGHUANLIAN sprays
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Flos Lonicerae 375g Radix Scutellariae 375g
Fructus Forsythiae 750g dipyrone 10g
Tween 80 .3g, cyclamate 4.5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Getting the 0.6g Mentholum is dissolved in 2ml ethanol and its adding is ground 10 minutes in the 15g beta-schardinger dextrin-of twice distilled water moistening standby, other gets 10.5g baicalin (Radix Scutellariae extract) stirring and adds in the 1300ml distilled water down, transfer PH to 7.0 to make it dissolving with 40% sodium hydroxide solution, continue to stir and slowly add the refining dry powder of 67.5g Flos Lonicerae and Fructus Forsythiae extraction, above-mentioned standby cyclodextrin clathrate, the 10g dipyrone, 5g Flos Chrysanthemi essence, the 5g tween--80 abundant stirrings make it dissolving, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 5: compound recipe Flos Lonicerae spray
Prescription:
Beta-schardinger dextrin-20g, Mentholum 0.6g
Flos Lonicerae 250g Fructus Forsythiae 250g
Punching connects 250g Radix Isatidis 250g
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method
Getting punching connects 250g water and carries, precipitate with ethanol, standby behind the recovery ethanol, after 0.6g Mentholum and 20g cyclodextrin are made clathrate according to the method for embodiment 2, connect the refined liquid mixed grinding with standby punching and become Herba Menthae, the a chain of cyclodextrin inclusion compound of punching is standby, other gets the 250g Radix Isatidis, the 250g Fructus Forsythiae, 250g Flos Lonicerae water is carried, precipitate with ethanol, reclaim ethanol and after having the alcohol flavor, do not add water to 1300ml, stir and slowly add above-mentioned standby cyclodextrin clathrate down, 5g Flos Chrysanthemi essence, the 5g tween--80 abundant stirrings make it dissolving, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 6: quick effect compounded Flos Lonicerae spray
Prescription:
Beta-schardinger dextrin-20g, Mentholum 0.6g
Flos Lonicerae 250g Fructus Forsythiae 250g
Punching connects 250g Radix Isatidis 250g
Dipyrone 10g tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method
Getting punching connects 250g water and carries, precipitate with ethanol, standby behind the recovery ethanol, after 0.6g Mentholum and 20g cyclodextrin are made clathrate according to the method for embodiment 2, connect the refined liquid mixed grinding with standby punching and become Herba Menthae, the a chain of cyclodextrin inclusion compound of punching is standby, other gets the 250g Radix Isatidis, the 250g Fructus Forsythiae, 250g Flos Lonicerae water is carried, precipitate with ethanol, reclaim ethanol and after having the alcohol flavor, do not add water to 1300ml, stir and slowly add above-mentioned standby cyclodextrin clathrate down, the 10g dipyrone, 5g Flos Chrysanthemi essence, the 5g tween--80 abundant stirrings make it dissolving, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 7: the silver yellow spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Flos Lonicerae extract is in chlorogenic acid 12g
Radix Scutellariae extract is in baicalin 20g
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Embodiment 8: the QINGKAILING spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
The cholic acid Hyodeoxycholic Acid
The Concha Margaritifera powder Cornu Bubali
The baicalin Fructus Gardeniae
The Flos Lonicerae Radix Isatidis
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Embodiment 9 compound houttuynin sprays
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
The Herba Houttuyniae Radix Scutellariae
Radix Isatidis Fructus Forsythiae Flos Lonicerae
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Embodiment 10 eliminating inflammation and expelling toxin sprays
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
Herba Taraxaci Radix Saposhnikoviae Radix Glycyrrhizae
The Fructus Forsythiae Flos Lonicerae
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
The blue antiinflammatory spray in ground, embodiment 11 Pus
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
The Herba Taraxaci Herba Corydalis Bungeanae
The Radix Scutellariae Radix Isatidis
Tween 80 .5g, cyclamate 5g
It is that 1500ml annotates that distilled water makes cumulative volume in right amount:
Embodiment 7,8,9,10,11 and embodiment 1,2,3,4,5,6 preparation technologies are identical, and add also can resemble 1 → 2,3 → 4,5 → 6 behind the antipyretic analgesic the time its become quick-acting, owing to the restriction of length so be omitted.
The PH regulator that the present invention uses always has hydrochloric acid, acetic acid, citric acid, lactic acid, fruit acid, anti-bosom hematic acid, sodium hydroxide, sodium carbonate, sodium bicarbonate; Antipyretic analgesic has dipyrone, antondin, aminophenazone, phenazone, carbasalate calcium, magnesium salicylate.
Claims (6)
1. fast-acting composite spray for cold, mainly be to be raw material by PH regulator, antipyretic analgesic, Chinese crude drug, with correctives, clathrate material of main part is that adjuvant and spray carrier prepare and form, it is characterized in that the PH regulator can select for use any or several acid that PH can be transferred to 1-6 that can tolerate on the physiology maybe PH can be transferred to the alkali of 9-13.5, its consumption accounts for 0～5% of spray content gross weight; Antipyretic analgesic can be selected water soluble for use, and in water stable antipyretic analgesic commonly used, its consumption accounts for 0～25% of spray content gross weight; Chinese crude drug can be selected Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Folium Isatidis for use, Herba Taraxaci, Radix Glycyrrhizae, cholic acid, Concha Margaritifera powder, Cornu Bubali, Fructus Gardeniae, Herba Houttuyniae, Radix Saposhnikoviae, Herba Corydalis Bungeanae, punching connect or the conventional Chinese medicine compound recipe that is made of these medical materials etc., and its raw medicinal herbs consumption accounts for 0～200% (accounting for 0～15% after the extraction) of spray content gross weight; Correctives can be selected Flos Chrysanthemi essence, protein sugar, Mentholum, Herba Menthae wet goods for use, and its consumption accounts for 0.005～5% of spray content gross weight; The clathrate material of main part can be selected cyclodextrin, substituted cyclodextrin etc. for use, and its consumption accounts for 0.005～3% of spray content gross weight; Solubilizing agent can be selected tween 80, lecithin etc. for use, and its consumption accounts for 0～5% of spray content gross weight; The optional water of solvent, ethanol etc.; Its consumption accounts for 75～99% of spray gross weight, wherein core component PH regulator, antipyretic analgesic, the Chinese crude drug three kinds of components in a prescription as fast-acting composite spray for cold can occur simultaneously, also can only occur one or both components wherein in a prescription.
2, by the described fast-acting composite spray for cold of claim 1, wherein, for the common cold initial stage patient, PH regulator, Western medicine antipyretic analgesic, three kinds of core components of Chinese crude drug only select for use PH regulator, Chinese crude drug to get final product in the prescription, and PH regulator, Chinese crude drug get final product independent prescription, also can unite prescription.
3, by the described fast-acting composite spray for cold of claim 1, wherein, the patient who has occurred General Symptoms for flu, in the prescription PH regulator, Western medicine antipyretic analgesic, three kinds of core components of Chinese crude drug wherein antipyretic analgesic must occur, it can distinguish independent prescription with PH regulator, Chinese crude drug, also can unite prescription with PH regulator, Chinese crude drug.
4, by the described fast-acting composite spray for cold of claim 1, wherein, PH regulator commonly used has hydrochloric acid, acetic acid, citric acid, lactic acid, fruit acid, anti-bosom hematic acid, sodium hydroxide, sodium carbonate, sodium bicarbonate.
5, by the described fast-acting composite spray for cold of claim 1, wherein, antipyretic analgesic commonly used has dipyrone, antondin, aminophenazone, phenazone, carbasalate calcium, magnesium salicylate.
6, a kind of preparation method of fast-acting composite spray for cold: it is described by the PH regulator by claim 1, the Western medicine antipyretic analgesic, Chinese crude drug is a raw material, with correctives, the clathrate material of main part is adjuvant and spray carrier--solubilizing agent, solvent cooperates in its ratio, by feeding intake, extract, refining, the cyclodextrin clathrate enclose, ingredients, the PH adjustable type control spray for cold that several procedures such as packing are finished, clear key SHUANGHUANLIAN spray, compound recipe Flos Lonicerae spray, the silver yellow spray, the QINGKAILING spray, the compound houttuynin spray, the eliminating inflammation and expelling toxin spray, the blue antiinflammatory spray in ground, Pu, available P H adjustable type control spray for cold, quick-acting clear key SHUANGHUANLIAN sprays, quick effect compounded Flos Lonicerae spray, quick-acting silver yellow sprays, quick-acting QINGKAILING sprays, quick effect compounded Herba Houttuyniae spray, fast-acting antiphlogistic detoxifcation spray, the blue antiinflammatory spray in ground, quick-acting Pu, wherein the enclose of cyclodextrin clathrate can be selected polishing for use, solwution method etc., but no matter take the consumption of the sort of method cyclodextrin should be less than its saturated meltage in spray liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00108505 CN1288734A (en) | 2000-03-09 | 2000-04-27 | Fast-acting composite spray for cold and its preparation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00102458.2 | 2000-03-09 | ||
| CN00102458 | 2000-03-09 | ||
| CN 00108505 CN1288734A (en) | 2000-03-09 | 2000-04-27 | Fast-acting composite spray for cold and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1288734A true CN1288734A (en) | 2001-03-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00108505 Pending CN1288734A (en) | 2000-03-09 | 2000-04-27 | Fast-acting composite spray for cold and its preparation |
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| CN (1) | CN1288734A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057229A1 (en) * | 2002-01-14 | 2003-07-17 | Wenhan Ma | Antiviral and antipyretic formulation and the preparation method thereof |
| CN1298372C (en) * | 2005-04-26 | 2007-02-07 | 上海千兆商务咨询有限公司 | Chinese traditional medicine for treating common cold |
| CN103919851A (en) * | 2014-04-29 | 2014-07-16 | 南京海思创新生物科技有限公司 | Preparation method of spica schizonepetae volatile oil clathrate compound, application thereof in preparation of children cold spray and preparation method of spray |
| CN109260329A (en) * | 2018-11-02 | 2019-01-25 | 云南康创生物医药科技孵化有限公司 | A kind of anti-cold pharmaceutical composition and preparation method thereof |
| CN113440563A (en) * | 2020-03-26 | 2021-09-28 | 浙江康恩贝制药股份有限公司 | Compound houttuynia cordata spray and preparation method and application thereof |
-
2000
- 2000-04-27 CN CN 00108505 patent/CN1288734A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057229A1 (en) * | 2002-01-14 | 2003-07-17 | Wenhan Ma | Antiviral and antipyretic formulation and the preparation method thereof |
| CN1298372C (en) * | 2005-04-26 | 2007-02-07 | 上海千兆商务咨询有限公司 | Chinese traditional medicine for treating common cold |
| CN103919851A (en) * | 2014-04-29 | 2014-07-16 | 南京海思创新生物科技有限公司 | Preparation method of spica schizonepetae volatile oil clathrate compound, application thereof in preparation of children cold spray and preparation method of spray |
| CN109260329A (en) * | 2018-11-02 | 2019-01-25 | 云南康创生物医药科技孵化有限公司 | A kind of anti-cold pharmaceutical composition and preparation method thereof |
| CN113440563A (en) * | 2020-03-26 | 2021-09-28 | 浙江康恩贝制药股份有限公司 | Compound houttuynia cordata spray and preparation method and application thereof |
| CN113440563B (en) * | 2020-03-26 | 2022-09-06 | 浙江康恩贝制药股份有限公司 | Compound houttuynia cordata spray and preparation method and application thereof |
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