CN1368257A - Nano compound pear medicine and its preparing process - Google Patents
Nano compound pear medicine and its preparing process Download PDFInfo
- Publication number
- CN1368257A CN1368257A CN 01102594 CN01102594A CN1368257A CN 1368257 A CN1368257 A CN 1368257A CN 01102594 CN01102594 CN 01102594 CN 01102594 A CN01102594 A CN 01102594A CN 1368257 A CN1368257 A CN 1368257A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- parts
- part nanometer
- radix
- nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nmanometre (0.1-200 nm) medicine "Compound pear" is prepared from the nanometre powders of 31 Chinese medicinal materials including pear clear extract, adenophora tetraphylla, aster root, ephedra, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of nourishing YIN and moistening the lung, increase that liquid promotes the production of body fluid, the nano compound pear medicine of preventing phlegm from forming and stopping coughing, the invention still further relates to the method for this medication preparation.
The compound recipe pear paste is a kind of classical Chinese patent medicine, mainly contains nourishing YIN and moistening the lung, increases effects such as liquid promotes the production of body fluid, preventing phlegm from forming and stopping coughing, be used for deficiency of YIN chronic cough, xeropulmonary cough, after being ill void cough, stagnation of phlegm asthma, sputum mixed with blood, one's lips are dry and one's mouth parched etc.But traditional compound recipe pear paste absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano compound pear medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano compound pear medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Pyri thin paste 1000-2200 part nanometer Radix Adenophorae 30-65 part nanometer Radix Asteris 20-45 part
Nanometer Herba Ephedrae 12-30 part nanometer Flos Farfarae 12-30 part nanometer Fructus Perillae 20-45 part
Nanometer Radix Platycodonis 30-55 part nanometer Folium Perillae 12-30 part nanometer Radix Peucedani 30-65 part
Nanometer Folium Mori 20-45 part nanometer Fructus Aurantii 12-30 part nanometer Radix Glycyrrhizae 20-45 part
Nano Poria 20-45 part nanometer Rhizoma Imperatae 20-45 part nanometer Radix Stemonae 20-45 part
Nanometer Pseudobulbus Bletillae (Rhizoma Bletillae) 20-45 part nanometer Rhizoma Pinelliae Preparatum 20-45 part nanometer Semen Sinapis Albae 20-45 part
Nanometer Bulbus Fritillariae Thunbergii 20-45 part nano-lotus leaf charcoal 20-45 part nanometer Rhizoma Polygonati Odorati 20-45 part
Nanometer Semen Trichosanthis 12-30 part nanometer Pericarpium Citri Reticulatae 12-35 part nanometer Radix Asparagi 12-30 part
Nanometer Radix Paeoniae Alba 12-35 part nanometer Nodus Nelumbinis Rhizomatis 12-35 part nanometer Semen Armeniacae Amarum 12-35 part
Nanometer charred Petiolus Trachycarpi 30-55 part nano ass hide glue 30-55 part nanometer Folium Eriobotryae 100-250 part
Nanometer Fructus Gardeniae 6-12 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Pyri thin paste 1200-2000 part nanometer Radix Adenophorae 35-55 part nanometer Radix Asteris 25-35 part
Nanometer Herba Ephedrae 15-25 part nanometer Flos Farfarae 15-25 part nanometer Fructus Perillae 25-35 part
Nanometer Radix Platycodonis 35-45 part nanometer Folium Perillae 15-25 part nanometer Radix Peucedani 35-55 part
Nanometer Folium Mori 25-35 part nanometer Fructus Aurantii 15-25 part nanometer Radix Glycyrrhizae 25-35 part
Nano Poria 25-35 part nanometer Rhizoma Imperatae 25-35 part nanometer Radix Stemonae 25-35 part
Nanometer Pseudobulbus Bletillae (Rhizoma Bletillae) 25-35 part nanometer Rhizoma Pinelliae Preparatum 25-35 part nanometer Semen Sinapis Albae 25-35 part
Nanometer Bulbus Fritillariae Thunbergii 25-35 part nano-lotus leaf charcoal 25-35 part nanometer Rhizoma Polygonati Odorati 25-35 part
Nanometer Semen Trichosanthis 15-25 part nanometer Pericarpium Citri Reticulatae 15-25 part nanometer Radix Asparagi 15-25 part
Nanometer Radix Paeoniae Alba 15-25 part nanometer Nodus Nelumbinis Rhizomatis 15-25 part nanometer Semen Armeniacae Amarum 15-25 part
Nanometer charred Petiolus Trachycarpi 35-45 part nano ass hide glue 35-45 part nanometer Folium Eriobotryae 120-200 part
Nanometer Fructus Gardeniae 8-15 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 40 parts of nanometer Radix Asteriss of 1600 parts of nanometer Radix Adenophoraes of nanometer Fructus Pyri thin paste
30 parts of 20 parts of nanometer Fructus Perillaes of 20 parts of nanometer Flos Farfaraees of nanometer Herba Ephedrae
40 parts of 20 parts of nanometer Radix Peucedanis of 40 parts of nanometer Folium Perillaes of nanometer Radix Platycodonis
30 parts in 20 parts of nanometer Radix Glycyrrhizaes of 30 parts of nanometer Fructus Aurantiis of nanometer Folium Mori
30 parts of 30 parts of nanometer Radixs Stemonae of 30 parts of nanometer Rhizoma Imperataes of nano Poria
30 parts of 30 parts of nanometer Semen Sinapis Albaes of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nanometer Pseudobulbus Bletillae (Rhizoma Bletillae)
30 parts of 30 parts of nanometer Rhizoma Polygonati Odorati of 30 parts of nano-lotus leaf charcoals of nanometer Bulbus Fritillariae Thunbergii
20 parts of 20 parts of nanometer Radix Asparagis of 20 parts of nanometer Pericarpium Citri Reticulataes of nanometer Semen Trichosanthis
20 parts of 20 portions of nanometer Semen Armeniacae Amarums of 20 parts of nanometer Nodus Nelumbinis Rhizomatis of the nanometer Radix Paeoniae Alba
160 parts of 40 parts of nanometer Folium Eriobotryaes of 40 parts of nano ass hide glues of nanometer charred Petiolus Trachycarpi
10 parts of nanometer Fructus Gardeniaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get compound recipe pears preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano compound pear medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common compound recipe pear paste preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano compound pear medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for deficiency of YIN chronic cough, xeropulmonary cough, after being ill void cough, stagnation of phlegm asthma, sputum mixed with blood, treatment of conditions such as one's lips are dry and one's mouth parched, clinical efficacy significantly is better than traditional compound recipe pear paste.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 40 parts of nanometer Radix Asteriss of 1600 parts of nanometer Radix Adenophoraes of nanometer Fructus Pyri thin paste
30 parts of 20 parts of nanometer Fructus Perillaes of 20 parts of nanometer Flos Farfaraees of nanometer Herba Ephedrae
40 parts of 20 parts of nanometer Radix Peucedanis of 40 parts of nanometer Folium Perillaes of nanometer Radix Platycodonis
30 parts in 20 parts of nanometer Radix Glycyrrhizaes of 30 parts of nanometer Fructus Aurantiis of nanometer Folium Mori
30 parts of 30 parts of nanometer Radixs Stemonae of 30 parts of nanometer Rhizoma Imperataes of nano Poria
30 parts of 30 parts of nanometer Semen Sinapis Albaes of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nanometer Pseudobulbus Bletillae (Rhizoma Bletillae)
30 parts of 30 parts of nanometer Rhizoma Polygonati Odorati of 30 parts of nano-lotus leaf charcoals of nanometer Bulbus Fritillariae Thunbergii
20 parts of 20 parts of nanometer Radix Asparagis of 20 parts of nanometer Pericarpium Citri Reticulataes of nanometer Semen Trichosanthis
20 parts of 20 portions of nanometer Semen Armeniacae Amarums of 20 parts of nanometer Nodus Nelumbinis Rhizomatis of the nanometer Radix Paeoniae Alba
160 parts of 40 parts of nanometer Folium Eriobotryaes of 40 parts of nano ass hide glues of nanometer charred Petiolus Trachycarpi
10 parts of nanometer Fructus Gardeniaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 40 parts of nanometer Radix Asteriss of 1600 parts of nanometer Radix Adenophoraes of nanometer Fructus Pyri thin paste
30 parts of 20 parts of nanometer Fructus Perillaes of 20 parts of nanometer Flos Farfaraees of nanometer Herba Ephedrae
40 parts of 20 parts of nanometer Radix Peucedanis of 40 parts of nanometer Folium Perillaes of nanometer Radix Platycodonis
30 parts in 20 parts of nanometer Radix Glycyrrhizaes of 30 parts of nanometer Fructus Aurantiis of nanometer Folium Mori
30 parts of 30 parts of nanometer Radixs Stemonae of 30 parts of nanometer Rhizoma Imperataes of nano Poria
30 parts of 30 parts of nanometer Semen Sinapis Albaes of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nanometer Pseudobulbus Bletillae (Rhizoma Bletillae)
30 parts of 30 parts of nanometer Rhizoma Polygonati Odorati of 30 parts of nano-lotus leaf charcoals of nanometer Bulbus Fritillariae Thunbergii
20 parts of 20 parts of nanometer Radix Asparagis of 20 parts of nanometer Pericarpium Citri Reticulataes of nanometer Semen Trichosanthis
20 parts of 20 portions of nanometer Semen Armeniacae Amarums of 20 parts of nanometer Nodus Nelumbinis Rhizomatis of the nanometer Radix Paeoniae Alba
160 parts of 40 parts of nanometer Folium Eriobotryaes of 40 parts of nano ass hide glues of nanometer charred Petiolus Trachycarpi
10 parts of nanometer Fructus Gardeniaes
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano compound pear powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 40 parts of nanometer Radix Asteriss of 1600 parts of nanometer Radix Adenophoraes of nanometer Fructus Pyri thin paste
30 parts of 20 parts of nanometer Fructus Perillaes of 20 parts of nanometer Flos Farfaraees of nanometer Herba Ephedrae
40 parts of 20 parts of nanometer Radix Peucedanis of 40 parts of nanometer Folium Perillaes of nanometer Radix Platycodonis
30 parts in 20 parts of nanometer Radix Glycyrrhizaes of 30 parts of nanometer Fructus Aurantiis of nanometer Folium Mori
30 parts of 30 parts of nanometer Radixs Stemonae of 30 parts of nanometer Rhizoma Imperataes of nano Poria
30 parts of 30 parts of nanometer Semen Sinapis Albaes of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nanometer Pseudobulbus Bletillae (Rhizoma Bletillae)
30 parts of 30 parts of nanometer Rhizoma Polygonati Odorati of 30 parts of nano-lotus leaf charcoals of nanometer Bulbus Fritillariae Thunbergii
20 parts of 20 parts of nanometer Radix Asparagis of 20 parts of nanometer Pericarpium Citri Reticulataes of nanometer Semen Trichosanthis
20 parts of 20 portions of nanometer Semen Armeniacae Amarums of 20 parts of nanometer Nodus Nelumbinis Rhizomatis of the nanometer Radix Paeoniae Alba
160 parts of 40 parts of nanometer Folium Eriobotryaes of 40 parts of nano ass hide glues of nanometer charred Petiolus Trachycarpi
10 parts of nanometer Fructus Gardeniaes
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano compound pear membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano compound pear medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Pyri thin paste 1000-2200 part nanometer Radix Adenophorae 30-65 part nanometer Radix Asteris 20-45 part
Nanometer Herba Ephedrae 12-30 part nanometer Flos Farfarae 12-30 part nanometer Fructus Perillae 20-45 part
Nanometer Radix Platycodonis 30-55 part nanometer Folium Perillae 12-30 part nanometer Radix Peucedani 30-65 part
Nanometer Folium Mori 20-45 part nanometer Fructus Aurantii 12-30 part nanometer Radix Glycyrrhizae 20-45 part
Nano Poria 20-45 part nanometer Rhizoma Imperatae 20-45 part nanometer Radix Stemonae 20-45 part
Nanometer Pseudobulbus Bletillae (Rhizoma Bletillae) 20-45 part nanometer Rhizoma Pinelliae Preparatum 20-45 part nanometer Semen Sinapis Albae 20-45 part
Nanometer Bulbus Fritillariae Thunbergii 20-45 part nano-lotus leaf charcoal 20-45 part nanometer Rhizoma Polygonati Odorati 20-45 part
Nanometer Semen Trichosanthis 12-30 part nanometer Pericarpium Citri Reticulatae 12-35 part nanometer Radix Asparagi 12-30 part
Nanometer Radix Paeoniae Alba 12-35 part nanometer Nodus Nelumbinis Rhizomatis 12-35 part nanometer Semen Armeniacae Amarum 12-35 part
Nanometer charred Petiolus Trachycarpi 30-55 part nano ass hide glue 30-55 part nanometer Folium Eriobotryae 100-250 part
Nanometer Fructus Gardeniae 6-12 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano compound pear medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Pyri thin paste 1200-2000 part nanometer Radix Adenophorae 35-55 part nanometer Radix Asteris 25-35 part
Nanometer Herba Ephedrae 15-25 part nanometer Flos Farfarae 15-25 part nanometer Fructus Perillae 25-35 part
Nanometer Radix Platycodonis 35-45 part nanometer Folium Perillae 15-25 part nanometer Radix Peucedani 35-55 part
Nanometer Folium Mori 25-35 part nanometer Fructus Aurantii 15-25 part nanometer Radix Glycyrrhizae 25-35 part
Nano Poria 25-35 part nanometer Rhizoma Imperatae 25-35 part nanometer Radix Stemonae 25-35 part
Nanometer Pseudobulbus Bletillae (Rhizoma Bletillae) 25-35 part nanometer Rhizoma Pinelliae Preparatum 25-35 part nanometer Semen Sinapis Albae 25-35 part
Nanometer Bulbus Fritillariae Thunbergii 25-35 part nano-lotus leaf charcoal 25-35 part nanometer Rhizoma Polygonati Odorati 25-35 part
Nanometer Semen Trichosanthis 15-25 part nanometer Pericarpium Citri Reticulatae 15-25 part nanometer Radix Asparagi 15-25 part
Nanometer Radix Paeoniae Alba 15-25 part nanometer Nodus Nelumbinis Rhizomatis 15-25 part nanometer Semen Armeniacae Amarum 15-25 part
Nanometer charred Petiolus Trachycarpi 35-45 part nano ass hide glue 35-45 part nanometer Folium Eriobotryae 120-200 part
Nanometer Fructus Gardeniae 8-15 part
3, nano compound pear medicine according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 40 parts of nanometer Radix Asteriss of 1600 parts of nanometer Radix Adenophoraes of nanometer Fructus Pyri thin paste
30 parts of 20 parts of nanometer Fructus Perillaes of 20 parts of nanometer Flos Farfaraees of nanometer Herba Ephedrae
40 parts of 20 parts of nanometer Radix Peucedanis of 40 parts of nanometer Folium Perillaes of nanometer Radix Platycodonis
30 parts in 20 parts of nanometer Radix Glycyrrhizaes of 30 parts of nanometer Fructus Aurantiis of nanometer Folium Mori
30 parts of 30 parts of nanometer Radixs Stemonae of 30 parts of nanometer Rhizoma Imperataes of nano Poria
30 parts of 30 parts of nanometer Semen Sinapis Albaes of 30 parts of nanometer Rhizoma Pinelliae Preparatum of nanometer Pseudobulbus Bletillae (Rhizoma Bletillae)
30 parts of 30 parts of nanometer Rhizoma Polygonati Odorati of 30 parts of nano-lotus leaf charcoals of nanometer Bulbus Fritillariae Thunbergii
20 parts of 20 parts of nanometer Radix Asparagis of 20 parts of nanometer Pericarpium Citri Reticulataes of nanometer Semen Trichosanthis
20 parts of 20 portions of nanometer Semen Armeniacae Amarums of 20 parts of nanometer Nodus Nelumbinis Rhizomatis of the nanometer Radix Paeoniae Alba
160 parts of 40 parts of nanometer Folium Eriobotryaes of 40 parts of nano ass hide glues of nanometer charred Petiolus Trachycarpi
10 parts of nanometer Fructus Gardeniaes
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano compound pear medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano compound pear medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102594 CN1368257A (en) | 2001-02-01 | 2001-02-01 | Nano compound pear medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102594 CN1368257A (en) | 2001-02-01 | 2001-02-01 | Nano compound pear medicine and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368257A true CN1368257A (en) | 2002-09-11 |
Family
ID=4652852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102594 Pending CN1368257A (en) | 2001-02-01 | 2001-02-01 | Nano compound pear medicine and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368257A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874626A (en) * | 2010-06-30 | 2010-11-03 | 福建农林大学 | Compound loquat leaf extract and preparation method thereof |
| CN103623203A (en) * | 2013-12-09 | 2014-03-12 | 百花医药集团股份有限公司 | Method for preparing cough-suppressing oral preparation |
| CN103638300A (en) * | 2013-12-05 | 2014-03-19 | 青岛中科菲力工程技术研发有限公司 | Sauropus spatulifolius beille lung-clearing syrup and preparation method thereof |
| CN103920078A (en) * | 2014-04-25 | 2014-07-16 | 刘子令 | Drug for treating cough and asthma and preparation method thereof |
| CN104256586A (en) * | 2014-09-09 | 2015-01-07 | 董春年 | Pear syrup candy and preparation method thereof |
| CN105981887A (en) * | 2015-12-03 | 2016-10-05 | 山东建筑大学 | Preparation method of fermentation pear syrup candies capable of relieving cough and product obtained by preparation method |
| CN106578261A (en) * | 2016-12-22 | 2017-04-26 | 佛山泓乾生物科技有限公司 | Tea beverage with effects of clearing away lung heat and relieving cough and making method thereof |
-
2001
- 2001-02-01 CN CN 01102594 patent/CN1368257A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874626A (en) * | 2010-06-30 | 2010-11-03 | 福建农林大学 | Compound loquat leaf extract and preparation method thereof |
| CN101874626B (en) * | 2010-06-30 | 2012-05-23 | 福建农林大学 | Compound loquat leaf extract and preparation method thereof |
| CN103638300A (en) * | 2013-12-05 | 2014-03-19 | 青岛中科菲力工程技术研发有限公司 | Sauropus spatulifolius beille lung-clearing syrup and preparation method thereof |
| CN103623203A (en) * | 2013-12-09 | 2014-03-12 | 百花医药集团股份有限公司 | Method for preparing cough-suppressing oral preparation |
| CN103623203B (en) * | 2013-12-09 | 2015-08-26 | 百花医药集团股份有限公司 | A kind of preparation method of dimethoxanate oral formulations |
| CN103920078A (en) * | 2014-04-25 | 2014-07-16 | 刘子令 | Drug for treating cough and asthma and preparation method thereof |
| CN103920078B (en) * | 2014-04-25 | 2016-04-27 | 刘子令 | A kind of medicine for the treatment of cough with asthma and preparation method thereof |
| CN104256586A (en) * | 2014-09-09 | 2015-01-07 | 董春年 | Pear syrup candy and preparation method thereof |
| CN105981887A (en) * | 2015-12-03 | 2016-10-05 | 山东建筑大学 | Preparation method of fermentation pear syrup candies capable of relieving cough and product obtained by preparation method |
| CN106578261A (en) * | 2016-12-22 | 2017-04-26 | 佛山泓乾生物科技有限公司 | Tea beverage with effects of clearing away lung heat and relieving cough and making method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368257A (en) | Nano compound pear medicine and its preparing process | |
| CN1363290A (en) | Nano medicine 'Shenshu' for invigorating function of baby spleen and its preparing process | |
| CN1368292A (en) | Nano medicing 'Wenzhong Zhixie' and its preparing process | |
| CN1366936A (en) | Nano antelope lung-clearing preparation medicine and preparation method | |
| CN1368086A (en) | Nano medicine 'Niuhuang Ninggong' and its preparing process | |
| CN1368151A (en) | Nano medicine 'Hailong Gejie' and its preparing process | |
| CN1365688A (en) | Nano medicine 'Ertong Qingfei' and its preparing process | |
| CN1368318A (en) | Nano medicine 'Shugantiaoqi' and its preparing process | |
| CN1366953A (en) | Nano midday tea preparation medicine and preparation method | |
| CN1365746A (en) | Nano medicine 'Sizheng' and its preparing process | |
| CN1362124A (en) | Nano eyesight-improving noble dendrobium medicine and its preparation | |
| CN1365758A (en) | Nano antitussive phlegm-resolving medicine and its preparing process | |
| CN1365695A (en) | Nano medicine 'Xiaoer Jindan' and its preparing process | |
| CN1368155A (en) | Nano medicine 'Huanshao' and its preparing process | |
| CN1368161A (en) | Nano medicine 'Jieyuhegan' and its preparing process | |
| CN1364550A (en) | Nano Rugi asthma-relieving medicine and its preparing method | |
| CN1365787A (en) | Nano medicine 'Baokening' and its preparing process | |
| CN1368265A (en) | Nano medicine 'Xingsu' and its preparing process | |
| CN1366925A (en) | Nano stomach-clearing coptis preparation medicine and preparation method | |
| CN1368251A (en) | Nano medicine 'Changchunbao' and its preparing process | |
| CN1368085A (en) | Nano medicine 'Niuhuang Xiling' and its preparing process | |
| CN1365774A (en) | Nano medicine 'Niuhuang Shangqing' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1364580A (en) | Nano children cough arresting medicine and its preparing method | |
| CN1368182A (en) | Nano medicine 'Shuganghewei' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |