CN1290534A - Quick-acting spray composition for proverting cold and its preparing method - Google Patents
Quick-acting spray composition for proverting cold and its preparing method Download PDFInfo
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- CN1290534A CN1290534A CN 00119169 CN00119169A CN1290534A CN 1290534 A CN1290534 A CN 1290534A CN 00119169 CN00119169 CN 00119169 CN 00119169 A CN00119169 A CN 00119169A CN 1290534 A CN1290534 A CN 1290534A
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Abstract
The present invention relates to a cold preventing medicine and its preparation. The present invention features that the quick-acting spray composition has pH regulating agent and Chinese medicinal materials capable of eliminating primary disease focus of cold and cutting off the inherent disease course of cold quickly and has antipyretic and analgesic capable of eliminating cold symptoms quickly. The application of clathrate technology makes the spray composition have no problems of stimulating nasal mucosa, bad smell, unstability and low solubility. In addition, it has rather long action period.
Description
The invention belongs to anti-cold medicine and preparation method thereof.
Flu is a kind of mondial commonly encountered diseases, frequently-occurring disease, it is the actute infection of the upper respiratory tract mucosa that causes by virus etc., its primary lesion is at nasal mucosa, therefore the author had applied for once that application number was 94108329.2 " Yinhuang " inhalation, spray, enema and preparation method thereof, application number is 96122296.4 the spray for cold that prevents, nose liniment and preparation method thereof, application number is the clear key SHUANGHUANLIAN spray of 97101390.X, nose liniment and preparation method thereof and application number are patent applications such as control spray for cold of 00102458.2 and preparation method thereof, it is making us very satisfied aspect primary lesion curative effect of removing flu, but it solves the heating of flu, speed is slower when General Symptoms such as feeling bad, and needs to wait for that body remove the required identical time with the toxin that antibacterial is produced with virus fully in body.
The objective of the invention is on the basis that above-mentioned four patent application curative effects are satisfied with very much, add antipyretic analgesic, thereby reach the primary lesion that not only can remove flu rapidly, cut off the intrinsic course of disease of flu, and can remove the heating of flu, the purpose of General Symptoms such as feel bad rapidly.
Fast-acting composite spray for cold of the present invention, mainly be to be raw material by PH regulator, Western medicine antipyretic analgesic, Chinese crude drug, with correctives, clathrate material of main part is that adjuvant and spray carrier prepare and form, it is characterized in that the PH regulator can select for use any or several acid that PH can be transferred to 1--6 that can tolerate on the physiology maybe PH can be transferred to the alkali of 9--13.5, its consumption accounts for 0～5% of spray content gross weight; The Western medicine antipyretic analgesic can be selected antipyretic analgesic commonly used for use, and its consumption accounts for 0～25% of spray content gross weight; Chinese crude drug can be selected Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Folium Isatidis for use, Herba Taraxaci, Radix Glycyrrhizae, cholic acid, Concha Margaritifera powder, Cornu Bubali, Fructus Gardeniae, Herba Houttuyniae, Radix Saposhnikoviae, Herba Corydalis Bungeanae, punching connect or the conventional Chinese medicine compound recipe that is made of these medical materials etc., and its raw medicinal herbs consumption accounts for 0～200% (accounting for 0～15% after the extraction) of spray content gross weight; Correctives can be selected Flos Chrysanthemi essence, glucose, protein sugar, Mentholum, Herba Menthae wet goods for use, and its consumption accounts for 0.005～5% of spray content gross weight; The clathrate material of main part can be selected cyclodextrin, substituted cyclodextrin etc. for use, and its consumption accounts for 0～5% of spray content gross weight; Solubilizing agent can be selected tween 80, lecithin etc. for use, and its consumption accounts for 0～5% of spray content gross weight; The optional water of solvent, ethanol etc.; Its consumption accounts for 75～99% of spray gross weight.Its preparation method by feed intake, extract, make with extra care, several procedures such as cyclodextrin clathrate enclose, ingredients, packing finish, wherein the enclose of cyclodextrin clathrate can be selected polishing, solwution method etc. for use, needs the component of enclose the Chinese crude drug effective ingredient that is difficult to accept on pair correctives that the nasal mucosa stimulation is bigger, the sense of taste to be arranged and be insoluble in unsettled Western medicine antipyretic analgesic in water or the water.Wherein PH regulator, Western medicine antipyretic analgesic, the Chinese crude drug three kinds of components in a prescription as the core component of fast-acting composite spray for cold can occur simultaneously, one or both components wherein also can only appear in a prescription, as: for the common cold initial stage patient, three kinds of components only add the PH regulator in the prescription, Chinese crude drug gets final product; Occurred the patient of General Symptoms for catching a cold, three kinds of component Western medicine antipyretic analgesic must occur in the prescription, and PH regulator, Chinese crude drug can be got respectively, give up or use entirely.
The invention has the advantages that: the selected PH regulator of fast-acting composite spray for cold of the present invention, primary lesion that Chinese crude drug can be removed flu rapidly, cut off the intrinsic course of disease of flu; The antipyretic analgesic of selecting for use can be removed the heating of flu, General Symptoms such as feel bad rapidly, thereby makes the present invention reach quick-acting; And the application of inclusion technique stimulates problem, abnormal flavour problem, the effective ingredient of nasal mucosa to be insoluble in problem of unstable in water or the water can solve spray nasal-cavity administration in the past the time, but the curative effect of proper extension medicine also simultaneously.
Embodiments of the invention:
Embodiment 1:PH adjustable type control spray for cold
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Glacial acetic acid 10ml (or sodium hydroxide 0.3g)
Tween 80 .3g, the smart 4.5g of Flos Chrysanthemi
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Get 15g β--cyclodextrin, 0.6g Mentholum place the container that the 1200ml distilled water is housed airtight, stirring under 45 ℃ of conditions cooled to such an extent that Mentholum enclose liquid is standby in 90 minutes, after other gets the smart 4.5g of glacial acetic acid 10ml (or sodium hydroxide 0.3g), tween 80 .3g, Flos Chrysanthemi and makes it be dissolved in the 200ml distilled water, add in the above-mentioned standby Mentholum enclose liquid, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, gets final product in 100 aerosol containers of mix homogeneously packing what.
Embodiment 2: available P H adjustable type control spray for cold
Prescription:
Beta-schardinger dextrin-20g, Mentholum 0.6g
Glacial acetic acid 10ml acetaminophen 15g
Tween 80 .3g, the smart 4.5g of Flos Chrysanthemi
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Getting 0.6g Mentholum, 15g acetaminophen adds 20ml ethanol and makes it dissolving, and its adding is ground 20 minutes in the 20g beta-schardinger dextrin-of twice distilled water moistening standby, after other gets the smart 4.5g of glacial acetic acid 10ml, tween 80 .3g, Flos Chrysanthemi and makes it be dissolved in the 1200ml distilled water, fully stir down and add in above-mentioned standby Mentholum, the acetaminophen enclose liquid, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, gets final product in 100 aerosol containers of mix homogeneously packing what.
Embodiment 3: available P H adjustable type control spray for cold
Prescription:
Beta-schardinger dextrin-20g, Mentholum 0.6g
Sodium hydroxide 0.3g naproxen 15g
Tween 80 .3g, the smart 4.5g of Flos Chrysanthemi
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Getting 0.6g Mentholum, 15g naproxen adds 20ml ethanol and makes it dissolving, and its adding is ground 20 minutes in the 20g beta-schardinger dextrin-of twice distilled water moistening standby, after other gets the smart 4.5g of sodium hydroxide 0.3g, tween 80 .3g, Flos Chrysanthemi and makes it be dissolved in the 1200ml distilled water, fully stir down and add in above-mentioned standby Mentholum, the naproxen enclose liquid, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, gets final product in 100 aerosol containers of mix homogeneously packing what.
Embodiment 4: clear key SHUANGHUANLIAN spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Flos Lonicerae 375g Radix Scutellariae 375g Fructus Forsythiae 750g
Tween 80 .3g, cyclamate 4.5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Getting the 0.6g Mentholum is dissolved in 2ml ethanol and its adding is ground 10 minutes in the 15g beta-schardinger dextrin-of twice distilled water moistening standby, other gets 10.5g baicalin (Radix Scutellariae extract) stirring and adds in the 1300ml distilled water down, transfer PH to 7.0 to make it dissolving with 40% sodium hydroxide solution, continue to stir and slowly add the refining dry powder of 67.5g Flos Lonicerae and Fructus Forsythiae extraction, above-mentioned standby cyclodextrin clathrate, 5g Flos Chrysanthemi essence, the 5g tween--80 abundant stirrings make it dissolving, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 5: quick-acting clear key SHUANGHUANLIAN sprays
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Flos Lonicerae 375g Radix Scutellariae 375g
Fructus Forsythiae 750g dipyrone 15g
Tween 80 .3g, cyclamate 4.5g glucose 20g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method:
Getting the 0.6g Mentholum is dissolved in 2ml ethanol and its adding is ground 10 minutes in the 15g beta-schardinger dextrin-of twice distilled water moistening standby, other gets 10.5g baicalin (Radix Scutellariae extract) stirring and adds in the 1300ml distilled water down, transfer PH to 7.0 to make it dissolving with 40% sodium hydroxide solution, continue to stir and slowly add the refining dry powder of 67.5g Flos Lonicerae and Fructus Forsythiae extraction, above-mentioned standby cyclodextrin clathrate, the 15g dipyrone, 5g Flos Chrysanthemi essence, the 20g glucose, the 5g tween--80 abundant stirrings make it dissolving, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 6: compound recipe Flos Lonicerae spray
Prescription:
Beta-schardinger dextrin-20g, Mentholum 0.6g
Flos Lonicerae 250g Fructus Forsythiae 250g
Punching connects 250g Radix Isatidis 250g
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method
Getting punching connects 250g water and carries, precipitate with ethanol, standby behind the recovery ethanol, after 0.6g Mentholum and 20g cyclodextrin are made clathrate according to the method for embodiment 2, connect the refined liquid mixed grinding with standby punching and become Herba Menthae, the a chain of cyclodextrin inclusion compound of punching is standby, other gets the 250g Radix Isatidis, the 250g Fructus Forsythiae, 250g Flos Lonicerae water is carried, precipitate with ethanol, reclaim ethanol and after having the alcohol flavor, do not add water to 1300ml, stir and slowly add above-mentioned standby cyclodextrin clathrate down, 5g Flos Chrysanthemi essence, the 5g tween--80 abundant stirrings make it dissolving, filter, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 7: quick effect compounded Flos Lonicerae spray
Prescription:
Beta-schardinger dextrin-20g, Mentholum 0.6g
Flos Lonicerae 250g Fructus Forsythiae 250g
Punching connects 250g Radix Isatidis 250g
Magnesium salicylate 15g tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Preparation method
Getting punching connects 250g water and carries, precipitate with ethanol, standby behind the recovery ethanol, after 0.6g Mentholum and 20g cyclodextrin are made clathrate according to the method for embodiment 2, connect the refined liquid mixed grinding with standby punching and become Herba Menthae, the a chain of cyclodextrin inclusion compound of punching is standby, other gets the 250g Radix Isatidis, the 250g Fructus Forsythiae, 250g Flos Lonicerae water is carried, precipitate with ethanol, reclaim ethanol and after having the alcohol flavor, do not add water to 1300ml, stir and slowly add above-mentioned standby cyclodextrin clathrate down, the 15g magnesium salicylate, 5g Flos Chrysanthemi essence, the 5g tween--80 abundant stirrings make it dissolving, filter, it is 1500ml that adding distil water makes the medicinal liquid cumulative volume in right amount, and mix homogeneously is sub-packed in 100 aerosol containers and gets final product.
Embodiment 8: the silver yellow spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6g
Flos Lonicerae extract is in chlorogenic acid 12g
Radix Scutellariae extract is in baicalin 20g
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Embodiment 9: the QINGKAILING spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
Cholic acid 6.5g Hyodeoxycholic Acid 7.5g
Concha Margaritifera powder 100g Cornu Bubali 50g
Baicalin 10g Fructus Gardeniae 50g
Flos Lonicerae 135g Radix Isatidis 400g
Tween 80 .5g, cyclamate 5g
It is 300ml that distilled water makes cumulative volume in right amount
Embodiment 10: the compound houttuynin spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
Herba Houttuyniae 490g Radix Scutellariae 126g
Radix Isatidis 126g Fructus Forsythiae 49g Flos Lonicerae 49g
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Embodiment 11: the eliminating inflammation and expelling toxin spray
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
Herba Taraxaci 800g Radix Saposhnikoviae 10g Radix Glycyrrhizae 20g
Fructus Forsythiae 20g Flos Lonicerae 20g
Tween 80 .5g, cyclamate 5g
It is 1500ml that distilled water makes cumulative volume in right amount
Embodiment 12: the blue antiinflammatory spray in ground, Pu
Prescription:
Beta-schardinger dextrin-15g, Mentholum 0.6
Herba Taraxaci 600g Herba Corydalis Bungeanae 150g
Radix Scutellariae 225g Radix Isatidis 225g
Tween 80 .5g, cyclamate 5g
It is that 1500ml annotates that distilled water makes cumulative volume in right amount:
Embodiment 8,9,10,11,12 and embodiment 1,2,3,4,5,6,7 preparation technologies are identical, and also can resemble 1 → 2,3 after adding antipyretic analgesic; 4 → 5; 6 → 7 like that the time its become quick-acting because the restriction of length is so be omitted.
The PH regulator that the present invention uses always has hydrochloric acid, acetic acid, citric acid, lactic acid, fruit acid, anti-bosom hematic acid, sodium hydroxide, sodium carbonate, sodium bicarbonate; Antipyretic analgesic commonly used has dipyrone, antondin, aminophenazone, phenazone, carbasalate calcium, magnesium salicylate, diclofenac, aspirin, acetaminophen, Diflonid, Tolmetin, indomethacin, naproxen, ibuprofen.
Claims (6)
1. fast-acting composite spray for cold, mainly be to be raw material by PH regulator, Western medicine antipyretic analgesic, Chinese crude drug, with correctives, clathrate material of main part is that adjuvant and spray carrier prepare and form, it is characterized in that the PH regulator can select for use any or several acid that PH can be transferred to 1--6 that can tolerate on the physiology maybe PH can be transferred to the alkali of 9--13.5, its consumption accounts for 0～5% of spray content gross weight; Antipyretic analgesic can be selected antipyretic analgesic commonly used for use, and its consumption accounts for 0～25% of spray content gross weight; Chinese crude drug can be selected Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Isatidis, Folium Isatidis for use, Herba Taraxaci, Radix Glycyrrhizae, cholic acid, Concha Margaritifera powder, Cornu Bubali, Fructus Gardeniae, Herba Houttuyniae, Radix Saposhnikoviae, Herba Corydalis Bungeanae, punching company or the conventional Chinese medicine compound recipe that constitutes by these medical materials, its raw medicinal herbs consumption accounts for 0～200% (accounting for 0～15% after the extraction) of spray content gross weight; Correctives can be selected Flos Chrysanthemi essence, glucose, protein sugar, Mentholum, Herba Menthae wet goods for use, and its consumption accounts for 0.005～5% of spray content gross weight; The clathrate material of main part can be selected cyclodextrin, substituted cyclodextrin for use, and its consumption accounts for 0～5% of spray content gross weight; Solubilizing agent can be selected tween 80, lecithin etc. for use, and its consumption accounts for 0～5% of spray content gross weight; The optional water of solvent, ethanol etc.; Its consumption accounts for 75～99% of spray gross weight, wherein core component PH regulator, Western medicine antipyretic analgesic, the Chinese crude drug three kinds of components in a prescription as fast-acting composite spray for cold can occur simultaneously, also can only occur one or both components wherein in a prescription.
2, by the described fast-acting composite spray for cold of claim 1, wherein, for the common cold initial stage patient, PH regulator, Western medicine antipyretic analgesic, three kinds of core components of Chinese crude drug only select for use PH regulator, Chinese crude drug to get final product in the prescription, and PH regulator, Chinese crude drug get final product independent prescription, also can unite prescription.
3, by the described fast-acting composite spray for cold of claim 1, wherein, the patient who has occurred General Symptoms for flu, PH regulator, Western medicine antipyretic analgesic, three kinds of core components of Chinese crude drug in the prescription, its Chinese medicine and western medicine antipyretic analgesic must occur, it can distinguish independent prescription with PH regulator, Chinese crude drug, also can unite prescription with PH regulator, Chinese crude drug.
4, by the described fast-acting composite spray for cold of claim 1, wherein, PH regulator commonly used has hydrochloric acid, acetic acid, citric acid, lactic acid, fruit acid, anti-bosom hematic acid, sodium hydroxide, sodium carbonate, sodium bicarbonate.
5, by the described fast-acting composite spray for cold of claim 1, wherein, Chang Yong antipyretic analgesic has dipyrone, antondin, aminophenazone, phenazone, carbasalate calcium, magnesium salicylate, diclofenac, aspirin, acetaminophen, Diflonid, Tolmetin, indomethacin, naproxen, ibuprofen.
6, a kind of preparation method of fast-acting composite spray for cold: it is described by the PH regulator by claim 1, the Western medicine antipyretic analgesic, Chinese crude drug is a raw material, with correctives, the clathrate material of main part is adjuvant and spray carrier--solubilizing agent, solvent cooperates in its ratio, by feeding intake, extract, refining, the cyclodextrin clathrate enclose, ingredients, the PH adjustable type control spray for cold that several procedures such as packing are finished, clear key SHUANGHUANLIAN spray, compound recipe Flos Lonicerae spray, the silver yellow spray, the QINGKAILING spray, the compound houttuynin spray, the eliminating inflammation and expelling toxin spray, the blue antiinflammatory spray in ground, Pu, available P H adjustable type control spray for cold, quick-acting clear key SHUANGHUANLIAN sprays, quick effect compounded Flos Lonicerae spray, quick-acting silver yellow sprays, quick-acting QINGKAILING sprays, quick effect compounded Herba Houttuyniae spray, fast-acting antiphlogistic detoxifcation spray, the blue antiinflammatory spray in ground, quick-acting Pu, wherein the enclose of cyclodextrin clathrate can be selected polishing for use, solwution methods etc. need the component of enclose to have pair nasal mucosa to stimulate bigger correctives, be difficult to the Chinese crude drug effective ingredient of accepting on the sense of taste and be insoluble in unsettled Western medicine antipyretic analgesic in water or the water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00119169 CN1290534A (en) | 2000-03-09 | 2000-07-03 | Quick-acting spray composition for proverting cold and its preparing method |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00102458.2 | 2000-03-09 | ||
| CN00102458 | 2000-03-09 | ||
| CN 00119169 CN1290534A (en) | 2000-03-09 | 2000-07-03 | Quick-acting spray composition for proverting cold and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1290534A true CN1290534A (en) | 2001-04-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00119169 Pending CN1290534A (en) | 2000-03-09 | 2000-07-03 | Quick-acting spray composition for proverting cold and its preparing method |
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| CN (1) | CN1290534A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057229A1 (en) * | 2002-01-14 | 2003-07-17 | Wenhan Ma | Antiviral and antipyretic formulation and the preparation method thereof |
| CN1883566B (en) * | 2006-06-02 | 2010-06-23 | 江苏济川制药有限公司 | Anti-inflammation medicine and method for preparing same |
| CN102908428A (en) * | 2012-09-27 | 2013-02-06 | 安徽金太阳生化药业有限公司 | Chinese herbal medicine for curing influenza |
| CN103520276A (en) * | 2013-10-23 | 2014-01-22 | 成都乾坤动物药业有限公司 | Veterinary medicinal composition as well as preparation method and application thereof |
| CN105168370A (en) * | 2015-07-29 | 2015-12-23 | 洛阳瑞华动物保健品有限公司 | Chinese herba preparation, medicament box and application thereof |
| CN108066613A (en) * | 2018-01-23 | 2018-05-25 | 孟庆霞 | A kind of pharmaceutical composition for treating post gynecologic operation low fever |
| CN109260329A (en) * | 2018-11-02 | 2019-01-25 | 云南康创生物医药科技孵化有限公司 | A kind of anti-cold pharmaceutical composition and preparation method thereof |
| CN114306429A (en) * | 2021-12-29 | 2022-04-12 | 北京康益药业有限公司 | Preparation method and application of compound honeysuckle preparation |
| CN115054627A (en) * | 2022-07-11 | 2022-09-16 | 陕西康惠制药股份有限公司 | Compound honeysuckle flower traditional Chinese medicine composition and preparation method thereof |
-
2000
- 2000-07-03 CN CN 00119169 patent/CN1290534A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057229A1 (en) * | 2002-01-14 | 2003-07-17 | Wenhan Ma | Antiviral and antipyretic formulation and the preparation method thereof |
| CN1883566B (en) * | 2006-06-02 | 2010-06-23 | 江苏济川制药有限公司 | Anti-inflammation medicine and method for preparing same |
| CN102908428A (en) * | 2012-09-27 | 2013-02-06 | 安徽金太阳生化药业有限公司 | Chinese herbal medicine for curing influenza |
| CN103520276A (en) * | 2013-10-23 | 2014-01-22 | 成都乾坤动物药业有限公司 | Veterinary medicinal composition as well as preparation method and application thereof |
| CN103520276B (en) * | 2013-10-23 | 2015-12-09 | 成都乾坤动物药业有限公司 | A kind of veterinary medical composition and its production and use |
| CN105168370B (en) * | 2015-07-29 | 2019-02-22 | 洛阳瑞华动物保健品有限公司 | A kind of Chinese materia medica preparation, kit and its application |
| CN105168370A (en) * | 2015-07-29 | 2015-12-23 | 洛阳瑞华动物保健品有限公司 | Chinese herba preparation, medicament box and application thereof |
| CN108066613A (en) * | 2018-01-23 | 2018-05-25 | 孟庆霞 | A kind of pharmaceutical composition for treating post gynecologic operation low fever |
| CN108066613B (en) * | 2018-01-23 | 2021-01-05 | 孟庆霞 | Pharmaceutical composition for treating gynecological postoperative low fever |
| CN109260329A (en) * | 2018-11-02 | 2019-01-25 | 云南康创生物医药科技孵化有限公司 | A kind of anti-cold pharmaceutical composition and preparation method thereof |
| CN114306429A (en) * | 2021-12-29 | 2022-04-12 | 北京康益药业有限公司 | Preparation method and application of compound honeysuckle preparation |
| CN115054627A (en) * | 2022-07-11 | 2022-09-16 | 陕西康惠制药股份有限公司 | Compound honeysuckle flower traditional Chinese medicine composition and preparation method thereof |
| CN115054627B (en) * | 2022-07-11 | 2023-05-26 | 陕西康惠制药股份有限公司 | Preparation method of compound honeysuckle traditional Chinese medicine composition |
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