CN108066613A - A kind of pharmaceutical composition for treating post gynecologic operation low fever - Google Patents
A kind of pharmaceutical composition for treating post gynecologic operation low fever Download PDFInfo
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- CN108066613A CN108066613A CN201810063899.XA CN201810063899A CN108066613A CN 108066613 A CN108066613 A CN 108066613A CN 201810063899 A CN201810063899 A CN 201810063899A CN 108066613 A CN108066613 A CN 108066613A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of pharmaceutical composition for treating post gynecologic operation low fever, include the raw material of following parts by weight：0.1~0.3 part of Indomethacin, 5~10 parts of honeysuckle, 8~16 parts of dandelion, 10~20 parts of folium isatidis, 3~8 parts of radix bupleuri, 3~8 parts of radix scrophulariae, 10~15 parts of jujube, 10~15 parts of the fruit of Chinese wolfberry, 5~10 parts of lucid asparagus, 3~8 parts of the fruit of glossy privet, 2~6 parts of kuh-seng, 3~8 parts of dried human placenta, 5~10 parts of sealwort, 0.5~2.5 part of cordyceps sinensis.Pharmaceutical composition proposed by the present invention has anti-inflammatory analgetic, clearing heat and detoxicating, nourishing yin and lessening fire, moisturizes the effect of promoting the production of body fluid, is promoting blood circulation and removing blood stasis, blood-enrich, nourishing the body, improving immunity, the effect of to post gynecologic operation low fever, is notable, treatment time is short, and dependence is small, and treatment cost is low.
Description
Technical field
The present invention relates to medicament research and development technical field more particularly to a kind of pharmaceutical compositions for treating post gynecologic operation low fever
Object.
Background technology
Post gynecologic operation low fever is one of common illness after gynaecology and obstetrics operation, and clinical manifestation is dizziness, palpitaition, cough
It coughs, is weak, anorexia etc., mostly triggering because of the inflammation such as immunity degradation or rheumatism, tuberculosis after corrective surgery, ultimately result in
The illness that body temperature nerve center wadding is random or impaired and generates.Remedy measures clinically are usually that antibiotics is controlled at present
It treats, the cost such as penicillin, second generation cephalosporin, but antibiotics is higher, and long-term use can generate pharmacological dependence
Property.Therefore more and more researchers turn to Chinese and Western combination or pure Chinese medicinal preparation.
Chinese patent application publication No.：CN 104922426A and CN 105497439A, which are respectively disclosed, a kind of treats gynemetrics
The pharmaceutical composition of postoperative low fever, it is not unique, but has its counterpart, the pharmaceutical composition that they are proposed be it is compound by several kinds of Chinese medicinal materials and
Into, and tests prove that there is the effect of certain to post gynecologic operation low fever, the treatment cycle of the two usually requires 40 days
As long as, and basic cure rate only has 30%, and for traditional western medicine, treatment cycle is long.Based on this, this hair
A kind of bright pharmaceutical composition for treating post gynecologic operation low fever for proposing that therapeutic effect is good, therapeutic effect is fast.
The content of the invention
The purpose of the present invention is to solve shortcoming in the prior art, and a kind of of proposition treats post gynecologic operation
The pharmaceutical composition of low fever.
A kind of pharmaceutical composition for treating post gynecologic operation low fever includes the raw material of following parts by weight：Indomethacin 0.1
~0.3 part, 5~10 parts of honeysuckle, 8~16 parts of dandelion, 10~20 parts of folium isatidis, 3~8 parts of radix bupleuri, 3~8 parts of radix scrophulariae, jujube
10~15 parts, 10~15 parts of the fruit of Chinese wolfberry, 5~10 parts of lucid asparagus, 3~8 parts of the fruit of glossy privet, 2~6 parts of kuh-seng, 3~8 parts of dried human placenta, Huang
5~10 parts of essence, 0.5~2.5 part of cordyceps sinensis.
Preferably, described pharmaceutical composition includes the raw material of following parts by weight：0.2 part of Indomethacin, 8 parts of honeysuckle, Pu
Public 12 parts of English, 15 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae, 13 parts of jujube, 13 parts of the fruit of Chinese wolfberry, 8 parts of lucid asparagus, 5 parts of the fruit of glossy privet,
4 parts of kuh-seng, 5 parts of dried human placenta, 8 parts of sealwort, 1.5 parts of cordyceps sinensis.
Preferably, described pharmaceutical composition includes the raw material of following parts by weight：0.2 part of Indomethacin, Indomethacin 0.1~
0.3 portion of 6 parts of honeysuckle, 12 parts of dandelion, 14 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae, 12 parts of jujube, 14 parts of the fruit of Chinese wolfberry, Tianmen
8 parts of winter, 6 parts of the fruit of glossy privet, 4 parts of kuh-seng, 6 parts of dried human placenta, 8 parts of sealwort, 2 parts of cordyceps sinensis.
Preferably, described pharmaceutical composition includes the raw material of following parts by weight：0.2 part of Indomethacin, 7 parts of honeysuckle, Pu
Public 10 parts of English, 14 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae, 12 parts of jujube, 12 parts of the fruit of Chinese wolfberry, 6 parts of lucid asparagus, 5 parts of the fruit of glossy privet,
5 parts of kuh-seng, 4 parts of dried human placenta, 8 parts of sealwort, 1 part of cordyceps sinensis.
The invention also provides a kind of preparation method for the pharmaceutical composition for treating post gynecologic operation low fever, including following
Step：
S1, according to 0.2 part of Indomethacin, 5~10 parts of honeysuckle, 8~16 parts of dandelion, 10~20 parts of folium isatidis, radix bupleuri 3
~8 parts, 3~8 parts of radix scrophulariae, 10~15 parts of jujube, 10~15 parts of the fruit of Chinese wolfberry, 5~10 parts of lucid asparagus, 3~8 parts of the fruit of glossy privet, kuh-seng 2
~6 parts, 3~8 parts of dried human placenta, 5~10 parts of sealwort, 0.5~2.5 part of cordyceps sinensis weighs each raw material, spare；
S2, the honeysuckle that step S1 is weighed, dandelion, folium isatidis, radix bupleuri, lucid asparagus, the fruit of glossy privet, dried human placenta, sealwort
It is placed in pulverizer and crushes, cross 10~18 mesh sieves, sieving is collected respectively with oversize, sieving is measured mixed with 8~12 times
Bonding solvent extracts 1~3h, then is extracted 2 times with the water of 6~10 times of amounts, and 1~2h, filters, merging filtrate subtracts after extraction every time every time
Pressure is concentrated to give thick paste A, spare；
The oversize collected in S3, the radix scrophulariae that step S1 is weighed, jujube, the fruit of Chinese wolfberry and kuh-seng and step S2 merges,
And extracted 2 times with the ethyl alcohol of 8~10 times of amounts, 1~2h, then extract 1~2h with the water of 6~10 times of amounts every time is filtered after extraction every time
It crosses, merging filtrate, the recycling ethyl alcohol that is concentrated under reduced pressure obtains thick paste B, spare；
S4, the cordyceps sinensis crushed into powder for weighing step S1, mix with thick paste A, thick paste B, dry, crush again to obtain the final product
Chinese medicine composition；
S5, the Indomethacin that step S1 is weighed with not receiving the Chinese medicine composition of S4 preparations is mixed, adds pharmaceutic adjuvant,
It is dried, sieves again, whole grain, then pharmaceutical composition of the regular dosage form to get treatment post gynecologic operation low fever is made.
Preferably, the mixed solvent is that volume ratio is 4~5：1 ethyl alcohol and the mixture of ether, and the quality of ethyl alcohol
Concentration is 55%~65%.
Pharmaceutical composition proposed by the present invention, from honeysuckle, dandelion, folium isatidis, radix bupleuri, radix scrophulariae, jujube, the fruit of Chinese wolfberry,
In lucid asparagus, the fruit of glossy privet, kuh-seng, dried human placenta, sealwort and cordyceps sinensis extract medicinal ingredient composition Chinese medicine composition, then with indoles
U.S. pungent synergistic treatment post gynecologic operation low fever, is stopped by 13 taste Chinese medicines with the pharmaceutical composition that Indomethacin forms with anti-inflammatory
Bitterly, clearing heat and detoxicating, nourishing yin and lessening fire moisturizes the effect of promoting the production of body fluid, is promoting blood circulation and removing blood stasis, blood-enrich, nourishing the body, improving immunity, and
And the combination that Chinese and Western combines, it is treated compared to pure Chinese medicine, evident in efficacy, treatment time is short, and patient need not take for long periods of time,
Pain is small, convenient to take, and compared to pure western medicine, dependence is small, and toxic side effect is small, and treatment cost is low, and 13
In the extraction process of taste Chinese medicine, for the Chinese medicine of hardly possible extraction, crushed, sieved, and sieving is mixed with alcohol-ether
Bonding solvent and water extract respectively, and the same radix scrophulariae of oversize, jujube, the fruit of Chinese wolfberry and kuh-seng ethyl alcohol and moisture you can well imagine and take,
To improve the extraction of active ingredient in Chinese medicine material, and then the therapeutic effect of pharmaceutical composition is improved, shorten treatment cycle.
Specific embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment one
A kind of pharmaceutical composition for treating post gynecologic operation low fever proposed by the present invention includes the original of following parts by weight
Material：0.2 part of Indomethacin, 8 parts of honeysuckle, 12 parts of dandelion, 15 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae, 13 parts of jujube, Chinese holly
13 parts of matrimony vine, 8 parts of lucid asparagus, 5 parts of the fruit of glossy privet, 4 parts of kuh-seng, 5 parts of dried human placenta, 8 parts of sealwort, 1.5 parts of cordyceps sinensis.
Its preparation method comprises the following steps：
S1, according to 0.2 part of Indomethacin, 8 parts of honeysuckle, 12 parts of dandelion, 15 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae,
13 parts of jujube, 13 parts of the fruit of Chinese wolfberry, 8 parts of lucid asparagus, 5 parts of the fruit of glossy privet, 4 parts of kuh-seng, 5 parts of dried human placenta, 8 parts of sealwort, cordyceps sinensis 1.5
Part weighs each raw material, spare；
S2, the honeysuckle that step S1 is weighed, dandelion, folium isatidis, radix bupleuri, lucid asparagus, the fruit of glossy privet, dried human placenta, sealwort
It is placed in pulverizer and crushes, cross 14 mesh sieves, sieving is collected respectively with oversize, sieving is 4 with the volume ratio of 10 times of amounts：
1 ethyl alcohol and the mixture extraction 2h of ether, then extracted 2 times, each 1.5h with the water of 8 times of amounts, it filters, merges after extraction every time
Filtrate, be concentrated under reduced pressure to obtain thick paste A, spare；
The oversize collected in S3, the radix scrophulariae that step S1 is weighed, jujube, the fruit of Chinese wolfberry and kuh-seng and step S2 merges,
And extracted 2 times, each 2h with the ethyl alcohol of 8 times of amounts, then 1.5h is extracted with the water of 8 times of amounts, it is filtered every time after extraction, merging filtrate,
The recycling ethyl alcohol that is concentrated under reduced pressure obtains thick paste B, spare；
S4, the cordyceps sinensis crushed into powder for weighing step S1, mix with thick paste A, thick paste B, dry, crush again to obtain the final product
Chinese medicine composition；
S5, the Indomethacin that step S1 is weighed with not receiving the Chinese medicine composition of S4 preparations is mixed, adds pharmaceutic adjuvant,
It is dried, sieves again, whole grain, then pharmaceutical composition of the tablet of 200mg to get treatment post gynecologic operation low fever is made.
In the present invention, the mass concentration of ethyl alcohol is 60%.
Embodiment two
A kind of pharmaceutical composition for treating post gynecologic operation low fever proposed by the present invention includes the original of following parts by weight
Material：0.2 part of Indomethacin, 6 parts of honeysuckle, 12 parts of dandelion, 14 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae, 12 parts of jujube, Chinese holly
14 parts of matrimony vine, 8 parts of lucid asparagus, 6 parts of the fruit of glossy privet, 4 parts of kuh-seng, 6 parts of dried human placenta, 8 parts of sealwort, 2 parts of cordyceps sinensis.
Its preparation method comprises the following steps：
S1, according to 0.2 part of Indomethacin, 6 parts of honeysuckle, 12 parts of dandelion, 14 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae,
12 parts of jujube, 14 parts of the fruit of Chinese wolfberry, 8 parts of lucid asparagus, 6 parts of the fruit of glossy privet, 4 parts of kuh-seng, 6 parts of dried human placenta, 8 parts of sealwort, 2 parts of cordyceps sinensis
Each raw material is weighed, it is spare；
S2, the honeysuckle that step S1 is weighed, dandelion, folium isatidis, radix bupleuri, lucid asparagus, the fruit of glossy privet, dried human placenta, sealwort
It is placed in pulverizer and crushes, cross 18 mesh sieves, sieving is collected respectively with oversize, sieving is 5 with the volume ratio of 8 times of amounts：1
Ethyl alcohol and ether mixture extraction 2h, then with 10 times amount water extract 2 times, each 1h, every time extraction after filter, merge filter
Liquid, be concentrated under reduced pressure to obtain thick paste A, spare；
The oversize collected in S3, the radix scrophulariae that step S1 is weighed, jujube, the fruit of Chinese wolfberry and kuh-seng and step S2 merges,
And extracted 2 times, each 1h with the ethyl alcohol of 10 times of amounts, then 1h is extracted with the water of 10 times of amounts, it is filtered every time after extraction, merging filtrate,
The recycling ethyl alcohol that is concentrated under reduced pressure obtains thick paste B, spare；
S4, the cordyceps sinensis crushed into powder for weighing step S1, mix with thick paste A, thick paste B, dry, crush again to obtain the final product
Chinese medicine composition；
S5, the Indomethacin that step S1 is weighed with not receiving the Chinese medicine composition of S4 preparations is mixed, adds pharmaceutic adjuvant,
It is dried, sieves again, whole grain, then pharmaceutical composition of the granule of 200mg to get treatment post gynecologic operation low fever is made
Object.
In the present invention, the mass concentration of ethyl alcohol is 65%.
Embodiment three
A kind of pharmaceutical composition for treating post gynecologic operation low fever proposed by the present invention includes the original of following parts by weight
Material：0.2 part of Indomethacin, 7 parts of honeysuckle, 10 parts of dandelion, 14 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae, 12 parts of jujube, Chinese holly
12 parts of matrimony vine, 6 parts of lucid asparagus, 5 parts of the fruit of glossy privet, 5 parts of kuh-seng, 4 parts of dried human placenta, 8 parts of sealwort, 1 part of cordyceps sinensis.
Its preparation method comprises the following steps：
S1, according to 0.2 part of Indomethacin, 7 parts of honeysuckle, 10 parts of dandelion, 14 parts of folium isatidis, 5 parts of radix bupleuri, 5 parts of radix scrophulariae,
12 parts of jujube, 12 parts of the fruit of Chinese wolfberry, 6 parts of lucid asparagus, 5 parts of the fruit of glossy privet, 5 parts of kuh-seng, 4 parts of dried human placenta, 8 parts of sealwort, 1 part of cordyceps sinensis
Each raw material is weighed, it is spare；
S2, the honeysuckle that step S1 is weighed, dandelion, folium isatidis, radix bupleuri, lucid asparagus, the fruit of glossy privet, dried human placenta, sealwort
It is placed in pulverizer and crushes, cross 10 mesh sieves, sieving is collected respectively with oversize, sieving is 4 with the volume ratio of 12 times of amounts：
1 ethyl alcohol and the mixture extraction 1h of ether, then extracted 2 times, each 2h with the water of 6 times of amounts, it is filtered every time after extraction, merges filter
Liquid, be concentrated under reduced pressure to obtain thick paste A, spare；
The oversize collected in S3, the radix scrophulariae that step S1 is weighed, jujube, the fruit of Chinese wolfberry and kuh-seng and step S2 merges,
And extracted 2 times, each 1h with the ethyl alcohol of 10 times of amounts, then 2h is extracted with the water of 6 times of amounts, it is filtered every time after extraction, merging filtrate subtracts
Pressure concentration and recovery ethyl alcohol obtains thick paste B, spare；
S4, the cordyceps sinensis crushed into powder for weighing step S1, mix with thick paste A, thick paste B, dry, crush again to obtain the final product
Chinese medicine composition；
S5, the Indomethacin that step S1 is weighed with not receiving the Chinese medicine composition of S4 preparations is mixed, adds pharmaceutic adjuvant,
It is dried, sieves again, whole grain, then pharmaceutical composition of the capsule of 200mg to get treatment post gynecologic operation low fever is made.
In the present invention, the mass concentration of ethyl alcohol is 55%.
Comparative example one
Chinese medicine composition in embodiment one is substituted for 0.2 part of Indomethacin, and according to the preparation side of embodiment one
Pharmaceutical composition is made in method.
Comparative example two
Indomethacin in embodiment one is removed, and the amount of Chinese medicine composition is doubled, according still further to embodiment one
Preparation method pharmaceutical composition is made.
Pharmaceutical composition proposed by the present invention is as follows to the experiment of post gynecologic operation low fever therapeutic effect：
1st, the selection of case
Choose the patient 180 for being diagnosed as post gynecologic operation low fever, 26~54 years old age.
Case is divided into 3 groups, every group of 60 people, the 1st group of pharmaceutical composition for trying out the preparation of embodiment one is treated, the
2 groups of pharmaceutical compositions prepared using comparative example one are treated, and the 3rd group of pharmaceutical composition prepared using comparative example two is carried out
Treatment, and the 1st group, the 2nd group, the 3rd group is taken 2 times daily, each one, 10 days as a treatment course treat 2 courses for the treatment of.
2nd, efficacy assessment standard
Reference《Disease of tcm Standardization of diagnosis and curative effect》To formulate following efficacy assessment standard.
Recovery from illness：Body temperature is normal, and symptom disappears；It is effective：Temperature recovery is normal, and symptom disappears substantially；Effectively：Body temperature is substantially extensive
Multiple normal, symptom disappears substantially；It is invalid：Body temperature is unchanged or symptom does not disappear.
3. treat 2 courses for the treatment of after the effect of result it is as follows：
| Recovery from illness | It is effective | Effectively | It is invalid | |
| 1st group | 35 (58.3%) | 22 (36.7%) | 2 (3.3%) | 1 (1.7%) |
| 2nd group | 8 (13.3%) | 10 (16.7%) | 18 (30%) | 24 (40%) |
| 3rd group | 4 (6.7%) | 7 (11.7%) | 14 (23.3%) | 35 (58.3%) |
After 2 courses for the treatment of i.e. 20 days are treated, the 1st group of cure rate can reach 58.3%, and 13.3% compared to the 2nd group
It is significantly improved with the 6.7% of the 3rd group, and the 1st group of total effective rate can reach 98.3%, and the 2nd group of effective percentage only has
60%, the 3rd group of effective percentage only has 41.7%, shows the Chinese medicine composition in pharmaceutical composition proposed by the present invention and indoles U.S.
It is pungent that there is synergistic treatment post gynecologic operation low fever.
4th, typical case
Mr. Wang, female 43 years old, with fibroid, carry out fibroid operation, and postoperative pyrexia is not moved back, body temperature performance
37.8~38.5e, and, dry more with sweat, loss of appetite, tongue fur is yellowish, yellow and greasy fur, takes pharmaceutical composition prepared by the present invention
Object, further consultation after 2 courses for the treatment of, temperature recovery is normal, and symptom disappears.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of pharmaceutical composition for treating post gynecologic operation low fever, which is characterized in that include the raw material of following parts by weight：Yin
U.S. pungent 0.1~0.3 part of diindyl, 5~10 parts of honeysuckle, 8~16 parts of dandelion, 10~20 parts of folium isatidis, 3~8 parts of radix bupleuri, radix scrophulariae 3
~8 parts, 10~15 parts of jujube, 10~15 parts of the fruit of Chinese wolfberry, 5~10 parts of lucid asparagus, 3~8 parts of the fruit of glossy privet, 2~6 parts of kuh-seng, purple river
3~8 parts of vehicle, 5~10 parts of sealwort, 0.5~2.5 part of cordyceps sinensis.
2. a kind of pharmaceutical composition for treating post gynecologic operation low fever according to claim 1, which is characterized in that described
Pharmaceutical composition includes the raw material of following parts by weight：0.2 part of Indomethacin, 8 parts of honeysuckle, 12 parts of dandelion, 15 parts of folium isatidis,
5 parts of radix bupleuri, 5 parts of radix scrophulariae, 13 parts of jujube, 13 parts of the fruit of Chinese wolfberry, 8 parts of lucid asparagus, 5 parts of the fruit of glossy privet, 4 parts of kuh-seng, 5 parts of dried human placenta are yellow
8 parts of essence, 1.5 parts of cordyceps sinensis.
3. a kind of pharmaceutical composition for treating post gynecologic operation low fever according to claim 1, which is characterized in that described
Pharmaceutical composition includes the raw material of following parts by weight：0.2 part of Indomethacin, 6 parts of honeysuckle, 12 parts of dandelion, 14 parts of folium isatidis,
5 parts of radix bupleuri, 5 parts of radix scrophulariae, 12 parts of jujube, 14 parts of the fruit of Chinese wolfberry, 8 parts of lucid asparagus, 6 parts of the fruit of glossy privet, 4 parts of kuh-seng, 6 parts of dried human placenta are yellow
8 parts of essence, 2 parts of cordyceps sinensis.
4. a kind of pharmaceutical composition for treating post gynecologic operation low fever according to claim 1, which is characterized in that described
Pharmaceutical composition includes the raw material of following parts by weight：0.2 part of Indomethacin, 7 parts of honeysuckle, 10 parts of dandelion, 14 parts of folium isatidis,
5 parts of radix bupleuri, 5 parts of radix scrophulariae, 12 parts of jujube, 12 parts of the fruit of Chinese wolfberry, 6 parts of lucid asparagus, 5 parts of the fruit of glossy privet, 5 parts of kuh-seng, 4 parts of dried human placenta are yellow
8 parts of essence, 1 part of cordyceps sinensis.
5. a kind of pharmaceutical composition for treating post gynecologic operation low fever according to claim 1 or 2 or 3 or 4, feature
It is, its preparation method comprises the following steps：
S1, according to 0.2 part of Indomethacin, 5~10 parts of honeysuckle, 8~16 parts of dandelion, 10~20 parts of folium isatidis, radix bupleuri 3~8
Part, 3~8 parts of radix scrophulariae, 10~15 parts of jujube, 10~15 parts of the fruit of Chinese wolfberry, 5~10 parts of lucid asparagus, 3~8 parts of the fruit of glossy privet, kuh-seng 2~6
Part, 3~8 parts of dried human placenta, 5~10 parts of sealwort, 0.5~2.5 part of cordyceps sinensis weighs each raw material, spare；
S2, the honeysuckle that step S1 is weighed, dandelion, folium isatidis, radix bupleuri, lucid asparagus, the fruit of glossy privet, dried human placenta, sealwort are placed in
It is crushed in pulverizer, crosses 10~18 mesh sieves, sieving is collected respectively with oversize, sieving is molten with the mixing of 8~12 times of amounts
1~3h is extracted in agent, then is extracted 2 times with the water of 6~10 times of amounts, and 1~2h, filters, merging filtrate after extraction every time every time, and decompression is dense
Contract to obtain thick paste A, spare；
The oversize collected in S3, the radix scrophulariae that step S1 is weighed, jujube, the fruit of Chinese wolfberry and kuh-seng and step S2 merges, and with 8
The ethyl alcohol of~10 times of amounts extracts 2 times, and 1~2h, then extract 1~2h with the water of 6~10 times of amounts every time is filtered after extraction, closed every time
And filtrate, the recycling ethyl alcohol that is concentrated under reduced pressure obtains thick paste B, spare；
S4, the cordyceps sinensis crushed into powder for weighing step S1 are mixed with thick paste A, thick paste B, dried, being crushed again up to Chinese medicine
Composition；
S5, the Indomethacin that step S1 is weighed with not receiving the Chinese medicine composition of S4 preparations is mixed, adds pharmaceutic adjuvant, then into
Row is dry, sieves, whole grain, then pharmaceutical composition of the regular dosage form to get treatment post gynecologic operation low fever is made.
6. a kind of preparation method of pharmaceutical composition for treating post gynecologic operation low fever according to claim 5, special
Sign is that the mixed solvent is that volume ratio is 4~5：1 ethyl alcohol and the mixture of ether, and the mass concentration of ethyl alcohol is
55%~65%.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1290534A (en) * | 2000-03-09 | 2001-04-11 | 丛繁滋 | Quick-acting spray composition for proverting cold and its preparing method |
| EP2700431A1 (en) * | 2012-08-24 | 2014-02-26 | AnalytiCon Discovery GmbH | Plant extracts for modulating TRPV1 function |
| CN107496772A (en) * | 2017-10-09 | 2017-12-22 | 宿淑平 | A kind of pharmaceutical composition for treating post gynecologic operation low fever |
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2018
- 2018-01-23 CN CN201810063899.XA patent/CN108066613B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1290534A (en) * | 2000-03-09 | 2001-04-11 | 丛繁滋 | Quick-acting spray composition for proverting cold and its preparing method |
| EP2700431A1 (en) * | 2012-08-24 | 2014-02-26 | AnalytiCon Discovery GmbH | Plant extracts for modulating TRPV1 function |
| CN107496772A (en) * | 2017-10-09 | 2017-12-22 | 宿淑平 | A kind of pharmaceutical composition for treating post gynecologic operation low fever |
Non-Patent Citations (1)
| Title |
|---|
| 魏亚平等: "吲哚美辛治疗剖宫产术后发热50例疗效观察", 《苏州大学学报（医学版）》 * |
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