CN110038089A - A kind of Chinese herbal granules and preparation method thereof for treating hypertension - Google Patents
A kind of Chinese herbal granules and preparation method thereof for treating hypertension Download PDFInfo
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- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract
The present invention relates to a kind of Chinese herbal granules and preparation method thereof for treating hypertension, the Chinese herbal granules include following ingredient by percentage to the quality: drop smells good 10-20 parts, 2-8 parts of rhizoma cyperi, 5-15 parts of rhizoma anemarrhenae, 5-15 parts of Cortex Phellodendri, 5-15 parts of HERBA EPIMEDII, 20-40 parts of Huai wheat, 20-40 parts of uncaria and 20-40 parts of mother-of-pearl.The Chinese herbal granules and preparation method thereof for the treatment of hypertension provided by the invention, significant in efficacy, Small side effects and treatment cycle is short.
Description
Technical field
The present invention relates to the Chinese patent drug technique fields for the treatment of hypertension, and in particular to a kind of Chinese medicinal granule for treating hypertension
Agent and preparation method thereof.
Background technique
It with arterial pressure raising is the cardiovascular disease mainly showed that hypertension (Hypertension), which is a kind of, either
It is all a kind of common disease in developed country or developing country.The treatment of hypertension at present is high about treatment based on Western medicine
The drug report of blood pressure is growing day by day in recent years.
Often mechanism of action is single for previous antihypertensive drugs, like great fish is harnessed the river using the method crammed and cut is buried, although blood pressure
Be controlled, but bring many adverse reactions, as angiotensin converting enzyme inhibitor (ACEI) class drug it is significant not
Good reaction is cough.And traditional Chinese medicine is more to the treatment method and means of hypertension, like Yu Zhishui takes the side built canals and dredged
Formula not only can effectively be depressured and have certain protective effect to each related internal organs.The fact that given counterevidence and participate in blood pressure control
Mechanism is various.People gradually recognize this point in recent years, start the medication combined control using different role mechanism
Blood pressure.And Chinese medicine action temperature and, meet the principle being steadily depressured, adverse reaction is small, can obviously improve symptom, cheap,
Patient acceptability is good.Concern and investment recently as country to tcm field, the antihypertensive research of Chinese medicine and application
There is sustainable development.
Oblique leaf yellow wingceltis Dalbergia pinnata (Lour.) Prain is pulse family yellow wingceltis platymiscium, also known as tiltedly leaf wingceltis, main product
In the areas such as China Hainan, Guangxi, Yunnan, Tibet and Burma, Indonesia.It is recorded in " Chinese Plants will ", and " complete stool can
It is medicinal, control rheumatism, bruise, bruise, there is the benefits of swelling and pain relieving ", because its xylem is rich in anime, ancient times, imperial palace high ranking official was expensive
The fragrant material that race once will be enriched in anime is used as stacte raw material, and is referred to as fragrant product drop and smells good, while fragrant material is also used in ancient battlefield
Make hemostatic.Recognize that China Hainan, Yunnan etc. are civil by civil visit and investigate oblique leaf yellow wingceltis perfume (or spice) material is considered as treasure, commonly uses
In steeping in wine or folk prescription application, adjuvant therapy of cardiovascular disease, diabetes, respiratory disease, rheumatalgia, acute gastroenteritis and bruise
Damage, empyrosis, snakeworm such as bite at the wounds, have long Medicinal history.
Drop smell good volatile oil main component be elemicin, methyl eugenol, 4- allyl -2,6- syringol,
Whiskey lactone etc..Elemi is known as the effects of stronger hypnosis, mosquito repellent desinsection, antimycotic, anti-pneumonia;Methyl eugenol has drop
The effects of pressing, be anti-oxidant, antibacterial;4- allyl -2,6- syringol has anti-lipid peroxidation effect, and has clear
Except antioxidations such as free radicals;Whiskey lactone has the effects that stronger antibacterial, anti-inflammatory and anti-oxidant.Due to oblique leaf yellow wingceltis
Main component has functional activity in essential oil, thus can be used as it is a kind of calm the nerves, the raw material of the drugs such as anti-oxidant, antibacterial, anti-inflammatory.
Summary of the invention
A kind of mechanism of action is sound and the depressor of Small side effects to provide, and the present invention provides a kind of hypertension for the treatment of
Chinese herbal granules, including following ingredient by percentage to the quality: dropping smell good 10-20 parts, 2-8 parts of rhizoma cyperi, 5-15 parts of rhizoma anemarrhenae, Huang
5-15 parts of cypress, 5-15 parts of HERBA EPIMEDII, 20-40 parts of Huai wheat, 20-40 parts of uncaria and 20-40 parts of mother-of-pearl.
Wherein, the content of each ingredient is as follows by percentage to the quality: dropping smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, Cortex Phellodendri
10 parts, 10 parts of HERBA EPIMEDII, 30 parts of Huai wheat, 30 parts of uncaria and 30 parts of mother-of-pearl.
Wherein, further include following ingredient by percentage to the quality: 15-25 parts of mulberry fruit, 4-10 parts of Rhizoma Chuanxiong, radix achyranthis bidentatae 6-10
Part, 5-8 parts of motherwort, 8-12 parts of semen ziziphi spinosae, 9-15 parts of fructus gardeniae, 2-6 parts of the shell of seaear, 10-20 parts of pueraria lobata and rhizoma alismatis 10-20
Part.
Wherein, further include following ingredient by percentage to the quality: 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, motherwort 7
Part, 10 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, 4 parts of the shell of seaear, 15 parts of pueraria lobata and 15 parts of rhizoma alismatis.
Wherein, further include following ingredient by percentage to the quality: 2-4 parts of Prunella vulgaris, 2-4 parts of leech, 2-4 parts of scorpio,
8-15 parts of Radix Astragali, 3-5 parts of the larva of a silkworm with batrytis, 3-5 parts of pheretima and longspur epimedium 3-5 parts raw.
Wherein, 3 parts of Prunella vulgaris, 3 parts of leech, 3 parts of scorpio, 12 parts of Radix Astragali, 4 parts of the larva of a silkworm with batrytis, 4 parts of pheretima and raw longspur epimedium
4 parts.
Invention additionally provides a kind of preparation methods of Chinese herbal granules for treating hypertension, include the following steps:
Step S1: it weighs each ingredient of following mass percent: dropping smell good 10-20 parts, 2-8 parts of rhizoma cyperi, rhizoma anemarrhenae 5-15
Part, 5-15 parts of Cortex Phellodendri, 5-15 parts of HERBA EPIMEDII, 20-40 parts of Huai wheat, 20-40 parts of uncaria and 20-40 parts of mother-of-pearl;
Step S2: it by component materials each in step S1 cleaning, dries, is ground into particle;
Step S3: with laminated aluminum film to get finished product after sterilizing.
Wherein, in the step S1, weighed raw material further include following ingredient by percentage to the quality: mulberry fruit 15-
25 parts, 4-10 parts of Rhizoma Chuanxiong, 6-10 parts of radix achyranthis bidentatae, 5-8 parts of motherwort, 8-12 parts of semen ziziphi spinosae, 9-15 parts of fructus gardeniae, shell of seaear 2-6
Part, 10-20 parts of pueraria lobata and 10-20 parts of rhizoma alismatis.
Wherein, in the step S1, weighed raw material further include following ingredient by percentage to the quality: Prunella vulgaris 2-
4 parts, 2-4 parts of leech, 2-4 parts of scorpio, 8-15 parts of Radix Astragali, 3-5 parts of the larva of a silkworm with batrytis, 3-5 parts of pheretima and longspur epimedium 3-5 parts raw.
The Chinese herbal granules and preparation method thereof for the treatment of hypertension provided by the invention, significant in efficacy, Small side effects and are controlled
It is short to treat the period.
Specific embodiment
In order to have further understanding to technical solution of the present invention and beneficial effect, the following detailed description of of the invention
Technical solution and its beneficial effect of generation.
The Chinese herbal granules for the treatment of hypertension provided by the invention, are smelt good with drop as main ingredient, first group of drug formulation packet
It includes following ingredient by percentage to the quality: dropping smell good 10-20 parts, 2-8 parts of rhizoma cyperi, 5-15 parts of rhizoma anemarrhenae, 5-15 parts of Cortex Phellodendri, celestial being
Clever spleen 5-15 parts, 20-40 parts of Huai wheat, 20-40 parts of uncaria and 20-40 parts of mother-of-pearl, preferably, each ingredient in above-mentioned formula
Content it is as follows by percentage to the quality: drop smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, Huaihe River it is small
30 parts of wheat, 30 parts of uncaria and 30 parts of mother-of-pearl.
The Chinese herbal granules for the treatment of hypertension provided by the invention, second group of drug formulation include by percentage to the quality
Following ingredient: 15-25 parts of mulberry fruit, 4-10 parts of Rhizoma Chuanxiong, 6-10 parts of radix achyranthis bidentatae, 5-8 parts of motherwort, 8-12 parts of semen ziziphi spinosae, fructus gardeniae
9-15 parts, 2-6 parts of the shell of seaear, 10-20 parts of pueraria lobata and 10-20 parts of rhizoma alismatis, preferably, in above-mentioned formula each ingredient content with
Mass percent meter is as follows: 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, 7 parts of motherwort, 10 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, stone
4 parts of Cassia, 15 parts of pueraria lobata and 15 parts of rhizoma alismatis.
The Chinese herbal granules for the treatment of hypertension provided by the invention, the drug formulation of third group include by percentage to the quality
Following ingredient: 2-4 parts of Prunella vulgaris, 2-4 parts of leech, 2-4 parts of scorpio, 8-15 parts of Radix Astragali, 3-5 parts of the larva of a silkworm with batrytis, 3-5 parts of pheretima
And raw longspur epimedium 3-5 parts, preferably, the content of each ingredient is as follows by percentage to the quality in above-mentioned formula: 3 parts of Prunella vulgaris,
3 parts of leech, 3 parts of scorpio, 12 parts of Radix Astragali, 4 parts of the larva of a silkworm with batrytis, 4 parts of pheretima and 4 parts of raw longspur epimedium.
In specific medication treatment, first group of drug formulation is essential drug, compared to existing Western medicine or it is other in
Medicine, Chinese patent drug have a more obvious therapeutic effect in terms of decompression, the drug formulation of second group and third group reduce it is bad anti-
In terms of answering or shortening treatment cycle, play the role of adjuvant treatment to the first group of formula medication, it, can basis in specific treatment
The practical constitution status of patient, Symptomatic medicine, by first group of independent medication, alternatively, by first group and second group and third group
One of or both mixed reagent.It should be noted that since Chinese medicine is particular about dialectical formula, equilibrium between yin and yang, it is provided by the invention
Three groups of drug formulation is all to have done a large amount of theory analysis and clinical trial on the basis of in view of practical medication mechanism
It obtains, therefore, in practical medication, is such as intended to select wherein a certain group of formula drug, should select to be covered in the formula
Whole drugs, without that should randomly choose.
The drug of three groups of different formulations provided by the invention, the effect played in terms of blood pressure lowering will be by following
Embodiment and clinical laboratory data proved.
One, the-the first group of basic recipe drug
Embodiment 1:
Drop is weighed to smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part and 30 parts of mother-of-pearl, by each component materials cleaning, dry, be ground into particle.
Embodiment 2:
Drop is weighed to smell good 12 parts, 6 parts of rhizoma cyperi, 7 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 7 parts of HERBA EPIMEDII, 25 parts of Huai wheat, 25 parts of uncaria
And 25 parts of mother-of-pearl, it by the cleaning of each component materials, dries, is ground into particle.
Embodiment 3:
Drop is weighed to smell good 15 parts, 8 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 35 parts of Huai wheat, uncaria 35
Part and 35 parts of mother-of-pearl, by each component materials cleaning, dry, be ground into particle.
Embodiment 4:
Drop is weighed to smell good 18 parts, 6 parts of rhizoma cyperi, 12 parts of rhizoma anemarrhenae, 12 parts of Cortex Phellodendri, 12 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part and 30 parts of mother-of-pearl, by each component materials cleaning, dry, be ground into particle.
Take Chinese patent drug prepared by above-described embodiment of phase homogenous quantities and commercially available Chinese patent drug (Bezoar pill for lowering blood pressure, calming heart
Piece, NAOLIQING etc., respectively with the reference such as comparative example 1, comparative example 2), it is respectively acting on six groups of other patients of difference group, every group of trouble
20 people of person, diastolic pressure is between 100-109mmHg, and systolic pressure is between 160-170mmHg, also, the average of each group patient is relaxed
Difference numerical value is no more than 5mmHg between pressure and average systolic, and the basis to guarantee experiment sample was consistent, by 6 weeks control
After treatment, mean blood pressure decline situation is as follows:
Table 1: basic recipe therapeutic effect-average systolic fall (mmHg)
Group | 1st week | 2nd week | 4th week | 6th week |
Embodiment 1 | 12.33 | 20.15 | 25.78 | 37.33 |
Embodiment 2 | 10.13 | 18.44 | 22.19 | 35.44 |
Embodiment 3 | 11.57 | 19.15 | 21.08 | 33.72 |
Embodiment 4 | 10.94 | 19.73 | 22.39 | 35.47 |
Comparative example 1 | 8.31 | 12.15 | 15.69 | 25.03 |
Comparative example 2 | 6.45 | 10.17 | 14.75 | 20.48 |
Table 2: basic recipe therapeutic effect-AvDP fall (mmHg)
Corresponding 80 patients of embodiment 1- embodiment 4 occur adverse reaction 4 (5%), mainly over the course for the treatment of
Symptom is out of strength, dizzy.
1 corresponding 20 patient of comparative example occurs adverse reaction 2 (10%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, edema, dizziness, insomnia.
2 corresponding 20 patients of comparative example occur adverse reaction 3 (15%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, has a stuffy nose, is dizzy, out of strength, flushing.
As seen from the above comparison, drug provided by the invention, on antihypertensive effect, hence it is evident that better than existing city's mid-sales at
Medicine, also, the occurrence rate of adverse reaction is lower, and symptoms are mild.
Two, the-the first group of mixing formula drug the+the second group drug
Embodiment 5:
Drop is weighed to smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part, 30 parts of mother-of-pearl, 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, 7 parts of motherwort, 10 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, the shell of seaear
4 parts, 15 parts of pueraria lobata and 15 parts of rhizoma alismatis by the cleaning of each component materials, dry, are ground into particle.
Embodiment 6:
Weigh drop smell good 12 parts, 6 parts of rhizoma cyperi, 7 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 7 parts of HERBA EPIMEDII, 25 parts of Huai wheat, 25 parts of uncaria,
25 parts of mother-of-pearl, 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, 7 parts of motherwort, 9 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, 3 parts of the shell of seaear,
16 parts of pueraria lobata and 10 parts of rhizoma alismatis by the cleaning of each component materials, dry, are ground into particle.
Embodiment 7:
Drop is weighed to smell good 15 parts, 8 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 35 parts of Huai wheat, uncaria 35
Part, 35 parts of mother-of-pearl, 15 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 6 parts of radix achyranthis bidentatae, 8 parts of motherwort, 10 parts of semen ziziphi spinosae, 9 parts of fructus gardeniae, the shell of seaear 2
Part, 20 parts of pueraria lobata and 20 parts of rhizoma alismatis by the cleaning of each component materials, dry, are ground into particle.
Embodiment 8:
Drop is weighed to smell good 18 parts, 6 parts of rhizoma cyperi, 12 parts of rhizoma anemarrhenae, 12 parts of Cortex Phellodendri, 12 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part, 30 parts of mother-of-pearl, 25 parts of mulberry fruit, 4 parts of Rhizoma Chuanxiong, 10 parts of radix achyranthis bidentatae, 8 parts of motherwort, 12 parts of semen ziziphi spinosae, 9 parts of fructus gardeniae, Shi Jue
Bright 6 parts, 10 parts of pueraria lobata and 20 parts of rhizoma alismatis by the cleaning of each component materials, dry, are ground into particle.
It is same as described above, takes Chinese patent drug prepared by above-described embodiment of phase homogenous quantities and commercially available Chinese patent drug (ox
Yellow chiang ya wan, calming heart piece, NAOLIQING etc., respectively with the reference such as comparative example 1, comparative example 2), it is respectively acting on six groups of difference groups
Patient, every group of 20 people of patient, for diastolic pressure between 100-109mmHg, systolic pressure is also, each between 160-170mmHg
Difference numerical value is no more than 5mmHg between the AvDP and average systolic of group patient, to guarantee the basis one of experiment sample
It causes, after the treatment in 6 week, mean blood pressure decline situation is as follows:
Table 3: mixing formula therapeutic effect-average systolic fall (mmHg)
Table 4: mixing formula therapeutic effect-AvDP fall (mmHg)
Group | 1st week | 2nd week | 4th week | 6th week |
Embodiment 5 | 6.01 | 9.12 | 14.55 | 19.53 |
Embodiment 6 | 5.64 | 7.35 | 10.98 | 16.17 |
Embodiment 7 | 5.15 | 7.94 | 11.19 | 15.77 |
Embodiment 8 | 5.97 | 8.15 | 12.84 | 16.95 |
Comparative example 1 | 3.21 | 4.78 | 6.69 | 10.03 |
Comparative example 2 | 3.45 | 5.17 | 6.33 | 9.96 |
Corresponding 80 patients of embodiment 5- embodiment 8 occur adverse reaction 1 (1.25%) over the course for the treatment of,
Cardinal symptom is slight out of strength, dizzy, and with going deep into for treatment, symptom gradually mitigates and disappears.
1 corresponding 20 patient of comparative example occurs adverse reaction 2 (10%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, edema, dizziness, insomnia.
2 corresponding 20 patients of comparative example occur adverse reaction 3 (15%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, has a stuffy nose, is dizzy, out of strength, flushing.
As seen from the above comparison, second group of drug provided by the invention, in addition to first group of auxiliary of drug is realized more
Except good therapeutic effect, additionally it is possible to further decrease the adverse reaction occurred in therapeutic process.
Three, the-the first group of mixing formula drug+third group drug
Embodiment 9:
Drop is weighed to smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part, 30 parts of mother-of-pearl, 3 parts of Prunella vulgaris, 3 parts of leech, 3 parts of scorpio, 12 parts of Radix Astragali, 4 parts of the larva of a silkworm with batrytis, 4 parts of pheretima and raw excessive sheep
It 4 parts suddenly, by the cleaning of each component materials, dries, is ground into particle.
Embodiment 10:
Weigh drop smell good 12 parts, 6 parts of rhizoma cyperi, 7 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 7 parts of HERBA EPIMEDII, 25 parts of Huai wheat, 25 parts of uncaria,
25 parts of mother-of-pearl, 2 parts of Prunella vulgaris, 2 parts of leech, 2 parts of scorpio, 8 parts of Radix Astragali, 5 parts of the larva of a silkworm with batrytis, 5 parts of pheretima and raw longspur epimedium 5
Part, it by the cleaning of each component materials, dries, is ground into particle.
Embodiment 11:
Drop is weighed to smell good 15 parts, 8 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 35 parts of Huai wheat, uncaria 35
Part, 35 parts of mother-of-pearl, 4 parts of Prunella vulgaris, 4 parts of leech, 4 parts of scorpio, 8 parts of Radix Astragali, 3 parts of the larva of a silkworm with batrytis, 3 parts of pheretima and raw excessive sheep
It 5 parts suddenly, by the cleaning of each component materials, dries, is ground into particle.
Embodiment 12:
Drop is weighed to smell good 18 parts, 6 parts of rhizoma cyperi, 12 parts of rhizoma anemarrhenae, 12 parts of Cortex Phellodendri, 12 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part, 30 parts of mother-of-pearl, 3 parts of Prunella vulgaris, 3 parts of leech, 3 parts of scorpio, 10 parts of Radix Astragali, 3 parts of the larva of a silkworm with batrytis, 5 parts of pheretima and raw excessive sheep
It 5 parts suddenly, by the cleaning of each component materials, dries, is ground into particle.
It is same as described above, takes Chinese patent drug prepared by above-described embodiment of phase homogenous quantities and commercially available Chinese patent drug (ox
Yellow chiang ya wan, calming heart piece, NAOLIQING etc., respectively with the reference such as comparative example 1, comparative example 2), it is respectively acting on six groups of difference groups
Patient, every group of 20 people of patient, for diastolic pressure between 100-109mmHg, systolic pressure is also, each between 160-170mmHg
Difference numerical value is no more than 5mmHg between the AvDP and average systolic of group patient, to guarantee the basis one of experiment sample
It causes, after the treatment in 6 week, mean blood pressure decline situation is as follows:
Table 5: mixing formula therapeutic effect-average systolic fall (mmHg)
Group | 1st week | 2nd week | 3rd week | 4th week |
Embodiment 9 | 15.71 | 25.13 | 30.44 | 36.18 |
Embodiment 10 | 14.91 | 23.45 | 28.57 | 35.55 |
Embodiment 11 | 15.07 | 24.91 | 29.99 | 35.81 |
Embodiment 12 | 14.88 | 23.95 | 28.13 | 34.97 |
Comparative example 1 | 8.31 | 12.15 | 13.11 | 15.69 |
Comparative example 2 | 6.45 | 10.17 | 12.77 | 14.75 |
Table 6: mixing formula therapeutic effect-AvDP fall (mmHg)
Group | 1st week | 2nd week | 3rd week | 4th week |
Embodiment 9 | 8.14 | 11.33 | 15.17 | 18.73 |
Embodiment 10 | 7.15 | 10.78 | 14.18 | 16.63 |
Embodiment 11 | 7.72 | 10.31 | 14.89 | 15.98 |
Embodiment 12 | 8.01 | 9.97 | 15.01 | 16.71 |
Comparative example 1 | 3.21 | 4.78 | 5.18 | 6.69 |
Comparative example 2 | 3.45 | 5.17 | 5.03 | 6.33 |
Corresponding 80 patients of embodiment 9- embodiment 12 occur adverse reaction 12 (15%), master over the course for the treatment of
Wanting symptom is out of strength, dizzy, palpitaition, uncomfortable in chest, flushing.
1 corresponding 20 patient of comparative example occurs adverse reaction 2 (10%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, edema, dizziness, insomnia.
2 corresponding 20 patients of comparative example occur adverse reaction 3 (15%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, has a stuffy nose, is dizzy, out of strength, flushing.
As seen from the above comparison, third group drug can significantly shorten the treatment cycle of basic depressor, imitate decompression
Fruit is significantly improved, however, side effect is also more apparent since pharmacological property is stronger, therefore, and in practice, optimal therapeutic modality
It is the drug mixing treatment of three kinds of groups.
Four, the+the second group of the-the first group of mixing formula drug drug+third group drug
Embodiment 13:
Drop is weighed to smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part, 30 parts of mother-of-pearl, 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, 7 parts of motherwort, 10 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, the shell of seaear
4 parts, 15 parts of pueraria lobata, 15 parts of rhizoma alismatis, 3 parts of Prunella vulgaris, 3 parts of leech, 3 parts of scorpio, 12 parts of Radix Astragali, 4 parts of the larva of a silkworm with batrytis, 4 parts of pheretima
And raw 4 parts of longspur epimedium, it by the cleaning of each component materials, dries, is ground into particle.
Embodiment 14:
Weigh drop smell good 12 parts, 6 parts of rhizoma cyperi, 7 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 7 parts of HERBA EPIMEDII, 25 parts of Huai wheat, 25 parts of uncaria,
25 parts of mother-of-pearl, 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, 7 parts of motherwort, 9 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, 3 parts of the shell of seaear,
16 parts of pueraria lobata, 10 parts of rhizoma alismatis, 2 parts of Prunella vulgaris, 2 parts of leech, 2 parts of scorpio, 8 parts of Radix Astragali, 5 parts of the larva of a silkworm with batrytis, 5 parts of pheretima and life
It 5 parts of longspur epimedium, by the cleaning of each component materials, dries, is ground into particle.
Embodiment 15:
Drop is weighed to smell good 15 parts, 8 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 35 parts of Huai wheat, uncaria 35
Part, 35 parts of mother-of-pearl, 15 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 6 parts of radix achyranthis bidentatae, 8 parts of motherwort, 10 parts of semen ziziphi spinosae, 9 parts of fructus gardeniae, the shell of seaear 2
Part, 20 parts of pueraria lobata, 20 parts of rhizoma alismatis, 4 parts of Prunella vulgaris, 4 parts of leech, 4 parts of scorpio, 8 parts of Radix Astragali, 3 parts of the larva of a silkworm with batrytis, 3 parts of pheretima and
5 parts of raw longspur epimedium by the cleaning of each component materials, dries, is ground into particle.
Embodiment 16:
Drop is weighed to smell good 18 parts, 6 parts of rhizoma cyperi, 12 parts of rhizoma anemarrhenae, 12 parts of Cortex Phellodendri, 12 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part, 30 parts of mother-of-pearl, 25 parts of mulberry fruit, 4 parts of Rhizoma Chuanxiong, 10 parts of radix achyranthis bidentatae, 8 parts of motherwort, 12 parts of semen ziziphi spinosae, 9 parts of fructus gardeniae, Shi Jue
Bright 6 parts, 10 parts of pueraria lobata, 20 parts of rhizoma alismatis, 3 parts of Prunella vulgaris, 3 parts of leech, 3 parts of scorpio, 10 parts of Radix Astragali, 3 parts of the larva of a silkworm with batrytis, 5 parts of pheretima
And raw 5 parts of longspur epimedium, it by the cleaning of each component materials, dries, is ground into particle.
It is same as described above, takes Chinese patent drug prepared by above-described embodiment of phase homogenous quantities and commercially available Chinese patent drug (ox
Yellow chiang ya wan, calming heart piece, NAOLIQING etc., respectively with the reference such as comparative example 1, comparative example 2), it is respectively acting on six groups of difference groups
Patient, every group of 20 people of patient, for diastolic pressure between 100-109mmHg, systolic pressure is also, each between 160-170mmHg
Difference numerical value is no more than 5mmHg between the AvDP and average systolic of group patient, to guarantee the basis one of experiment sample
It causes, after the treatment in 6 weeks, mean blood pressure decline situation is as follows:
Table 7: mixing formula therapeutic effect-average systolic fall (mmHg)
Table 8: mixing formula therapeutic effect-AvDP fall (mmHg)
Group | 1st week | 2nd week | 3rd week | 4th week |
Embodiment 13 | 7.16 | 10.13 | 14.73 | 16.77 |
Embodiment 14 | 6.85 | 9.99 | 13.11 | 16.13 |
Embodiment 15 | 6.72 | 8.91 | 14.09 | 15.08 |
Embodiment 16 | 6.01 | 9.17 | 13.17 | 15.71 |
Comparative example 1 | 3.21 | 4.78 | 5.18 | 6.69 |
Comparative example 2 | 3.45 | 5.17 | 5.03 | 6.33 |
Corresponding 80 patients of embodiment 13- embodiment 16 occur adverse reaction 6 (7.5%) over the course for the treatment of,
Wherein 5 cardinal symptoms are out of strength, dizzy, flushing, and in addition 1 cardinal symptom is palpitaition, uncomfortable in chest, flushing.
1 corresponding 20 patient of comparative example occurs adverse reaction 2 (10%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, edema, dizziness, insomnia.
2 corresponding 20 patients of comparative example occur adverse reaction 3 (15%) over the course for the treatment of, and cardinal symptom is the heart
Throb with fear, is uncomfortable in chest, has a stuffy nose, is dizzy, out of strength, flushing.
As seen from the above comparison, it after three groups of pharmaceutical composition, during treating hypertension, is controlled compared to more existing
The Chinese medicine or Chinese patent drug of hypertension are treated, antihypertensive effect is obvious, and treatment cycle is short, and adverse reaction is also small, in addition, passing through above-mentioned several groups
Comparative experiments will also realize that the therapeutic agent of third group, drug effect is more violent, also, the drug cost of third group is also higher, therefore,
In clinical treatment, generally directed to the patient for needing to treat as early as possible that is in a bad way.
The present invention over the course for the treatment of, furthermore with embodiment 1 provide drug, the patient more serious to a symptom into
Go detailed tracking follow-up, follow-up situation is as follows:
Mrs Liu, discovery blood pressure increases when physical examination before 57 years old, patient 10 years, is never interrupted over 10 years and takes depressor, blood
Pressure is not controlled effectively, and fluctuation of blood pressure is in 170-210/95-120mmHg.Dizziness headache is felt when patient, the whole body is out of strength, loses
Dormancy amnesia, receives few, and drinking-water is few, and sleep still, is defecated partially dry, and urine is fine, has a blood test and presses 220/110mmHg, and heart rate 76 times/
Point.Patient is also at 10 milligrams, ethyldopa 0.25mg of oral nifepine, 3 times a day.
X piece shows: left ventricular hypertrophy.Electrocardio diagram: left axis deviation, left ventricular hypertrophy.Look into creatinine, urea nitrogen is in just
Ordinary water is flat.The dark red tongue fur of patient's tongue is yellowish, veins string.Doctor trained in Western medicine diagnosis are as follows: II phase of hypertension.Chinese medical discrimination are as follows: deficiency of qi and blood.
This granule is taken orally, is taken after mixing it with water with appropriate hot water, respectively takes 1 time sooner or later, one after each meal.After taking 5 doses, patient's dizziness,
Symptom nauseous, out of strength has been clearly better, and measuring blood pressure is reduced to 145/85mmHg.Even served a course for the treatment of, clinical symptoms disappear substantially,
Measuring blood pressure fluctuates between 130-150/95-90mmHg.Patient's recovery from illness.Follow-up 2 months, stable disease.
Beneficial effects of the present invention are as follows:
1, by drop smell good, rhizoma cyperi, rhizoma anemarrhenae, Cortex Phellodendri, HERBA EPIMEDII, Huai wheat, uncaria and mother-of-pearl addition and its match
The adjustment of side, improves antihypertensive effect.
2, by the addition of mulberry fruit, Rhizoma Chuanxiong, radix achyranthis bidentatae, motherwort, semen ziziphi spinosae, fructus gardeniae, the shell of seaear, pueraria lobata and rhizoma alismatis and
Its adjustment being formulated improves the adverse reaction during medication.
3, pass through the addition of Prunella vulgaris, leech, scorpio, Radix Astragali, the larva of a silkworm with batrytis, pheretima and raw longspur epimedium and its tune of formula
It is whole, shorten treatment cycle.
Although the present invention is illustrated using above-mentioned preferred embodiment, the protection model that however, it is not to limit the invention
It encloses, anyone skilled in the art are not departing within the spirit and scope of the present invention, and opposite above-described embodiment carries out various changes
It is dynamic still to belong to the range that the present invention is protected with modification, therefore protection scope of the present invention subjects to the definition of the claims.
Claims (9)
1. a kind of Chinese herbal granules for treating hypertension, it is characterised in that: including following ingredient by percentage to the quality: drop is true
10-20 parts fragrant, 2-8 parts of rhizoma cyperi, 5-15 parts of rhizoma anemarrhenae, 5-15 parts of Cortex Phellodendri, 5-15 parts of HERBA EPIMEDII, 20-40 parts of Huai wheat, uncaria 20-
40 parts and 20-40 parts of mother-of-pearl.
2. the Chinese herbal granules for the treatment of hypertension as described in claim 1, it is characterised in that: the content of each ingredient is with quality hundred
Divide as follows than counting: dropping smell good 15 parts, 5 parts of rhizoma cyperi, 10 parts of rhizoma anemarrhenae, 10 parts of Cortex Phellodendri, 10 parts of HERBA EPIMEDII, 30 parts of Huai wheat, uncaria 30
Part and 30 parts of mother-of-pearl.
3. the Chinese herbal granules for the treatment of hypertension as described in claim 1, it is characterised in that: further include by percentage to the quality
Following ingredient: 15-25 parts of mulberry fruit, 4-10 parts of Rhizoma Chuanxiong, 6-10 parts of radix achyranthis bidentatae, 5-8 parts of motherwort, 8-12 parts of semen ziziphi spinosae, fructus gardeniae
9-15 parts, 2-6 parts of the shell of seaear, 10-20 parts of pueraria lobata and 10-20 parts of rhizoma alismatis.
4. the Chinese herbal granules for the treatment of hypertension as claimed in claim 3, it is characterised in that: further include by percentage to the quality
Following ingredient: 20 parts of mulberry fruit, 6 parts of Rhizoma Chuanxiong, 8 parts of radix achyranthis bidentatae, 7 parts of motherwort, 10 parts of semen ziziphi spinosae, 12 parts of fructus gardeniae, the shell of seaear 4
Part, 15 parts of pueraria lobata and 15 parts of rhizoma alismatis.
5. the Chinese herbal granules for the treatment of hypertension as described in claim 1, it is characterised in that: further include by percentage to the quality
Following ingredient: 2-4 parts of Prunella vulgaris, 2-4 parts of leech, 2-4 parts of scorpio, 8-15 parts of Radix Astragali, 3-5 parts of the larva of a silkworm with batrytis, 3-5 parts of pheretima with
And raw longspur epimedium 3-5 parts.
6. the Chinese herbal granules for the treatment of hypertension as claimed in claim 5, it is characterised in that: further include by percentage to the quality
Following ingredient: 3 parts of Prunella vulgaris, 3 parts of leech, 3 parts of scorpio, 12 parts of Radix Astragali, 4 parts of the larva of a silkworm with batrytis, 4 parts of pheretima and raw longspur epimedium 4
Part.
7. a kind of preparation method for the Chinese herbal granules for treating hypertension, which comprises the steps of:
Step S1: it weighs each ingredient of following mass percent: dropping smell good 10-20 parts, 2-8 parts of rhizoma cyperi, 5-15 parts of rhizoma anemarrhenae, Cortex Phellodendri
5-15 parts, 5-15 parts of HERBA EPIMEDII, 20-40 parts of Huai wheat, 20-40 parts of uncaria and 20-40 parts of mother-of-pearl;
Step S2: it by component materials each in step S1 cleaning, dries, is ground into particle;
Step S3: with laminated aluminum film to get finished product after sterilizing.
8. the preparation method of the Chinese herbal granules for the treatment of hypertension as claimed in claim 7, it is characterised in that: the step S1
In, weighed raw material further include following ingredient by percentage to the quality: 15-25 parts of mulberry fruit, 4-10 parts of Rhizoma Chuanxiong, radix achyranthis bidentatae 6-10
Part, 5-8 parts of motherwort, 8-12 parts of semen ziziphi spinosae, 9-15 parts of fructus gardeniae, 2-6 parts of the shell of seaear, 10-20 parts of pueraria lobata and rhizoma alismatis 10-20
Part.
9. the preparation method of the Chinese herbal granules for the treatment of hypertension as claimed in claim 7 or 8, it is characterised in that: the step
In rapid S1, weighed raw material further include following ingredient by percentage to the quality: 2-4 parts of Prunella vulgaris, 2-4 parts of leech, scorpio
2-4 parts, 8-15 parts of Radix Astragali, 3-5 parts of the larva of a silkworm with batrytis, 3-5 parts of pheretima and longspur epimedium 3-5 parts raw.
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