CN102935159B - Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN102935159B CN102935159B CN201210523489.1A CN201210523489A CN102935159B CN 102935159 B CN102935159 B CN 102935159B CN 201210523489 A CN201210523489 A CN 201210523489A CN 102935159 B CN102935159 B CN 102935159B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- treatment
- radix angelicae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention provides a traditional Chinese medicine composition for treating fracture. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of asplenium antiquum makino, 15 to 25 parts of ground beeltle, 15 to 25 parts of angelica sinensis, 8 to 12 parts of peach kernel, 8 to 12 parts of radix angelicae pubescentis, 6 to 10 parts of resina draconis, 10 to 14 parts of rhizoma drynariae, 10 to 14 parts of cuscuta chinensis, 18 to 22 parts of lindera strychnifolium vill, and 15 to 25 parts of murraya paniculata. The traditional Chinese medicine composition has the effects of strengthening tendons and bones, dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis, and eliminating stagnation stop pain, so that the purpose of treating fracture can be achieved. The invention also discloses a preparation method and application of the traditional Chinese medicine composition.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that is used for the treatment of fracture and its preparation method and application.
Background technology
Fracture refers to a kind of disease that causes sclerotin partially or completely to rupture due to reasons such as wound or pathology.Its main clinical manifestation is: fractures has limitation pain pain and tenderness, local swelling and occur ecchymosis, and limb function position or completely lose, still can there is cacomelia and abnormal movement in completeness sclerotin.
Western medicine adopts transfusion to add anti-inflammation class medicine (as penicillin) treatment more at present, and integrate and reset, mainly by self-recovery, conservative treatment, very person takes operative treatment to bring the hardship of broadsword play and burden economically to patient.Existing can invigorating blood circulation addiction, the treatment fracture herbal species of dredge the meridian passage, reducing swelling and alleviating pain is many, but the difference due to patient's the cause of disease, state of an illness weight, sick time length, and medicine is not equal to the effect of absorption of human body, performance, can't reach the effect of good dredging collateral, blood stasis dispelling, pain relieving in actual applications, thereby the slight illness that can not alleviate in time Most patients, can not obtain good therapeutic effect.For better treatment disease, pain and alleviation, make patient's body tissue early recovery, people in the urgent need to a kind of effective, oneself is by most people confirms to play that strengthening the tendons and bones, invigorating blood circulation are tired, the treatment of the good result of dredge the meridian passage, reducing swelling and alleviating pain is fractured Chinese medicine composition.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition that is used for the treatment of fracture and its preparation method and application.
Technical scheme: the object of the invention is to realize by following scheme:
A Chinese medicine composition that is used for the treatment of fracture, it is prepared by the raw material of following parts by weight: ferrum Hirudo 20-30 part, Eupolyphaga Seu Steleophaga 15-25 part, Radix Angelicae Sinensis 15-25 part, Semen Persicae 8-12 part, Radix Angelicae Pubescentis 8-12 part, Sanguis Draxonis 6-10 part, Rhizoma Drynariae 10-14 part, Semen Cuscutae 10-14 part, Radix Linderae 18-22 part, Folium Et Cacumen Murrayae 15-25 part.
The above-mentioned Chinese medicine composition that is used for the treatment of fracture, it is prepared by the raw material of following parts by weight: 25 parts of ferrum Hirudoes, 20 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Angelicae Sinensis, 10 parts, Semen Persicae, 10 parts of Radix Angelicae Pubescentiss, 8 parts of Sanguis Draxonis, 12 parts of Rhizoma Drynariae, 12 parts of Semen Cuscutae, 20 parts of the Radixs Linderae, 20 parts of Folium Et Cacumen Murrayae.
The above-mentioned Chinese medicine composition that is used for the treatment of fracture, described raw material adds adjuvant and makes oral liquid, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of fracture, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fracture, it comprises the steps: to get ferrum Hirudo, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Radix Angelicae Pubescentis, Sanguis Draxonis, Rhizoma Drynariae, Semen Cuscutae, the Radix Linderae and Folium Et Cacumen Murrayae medical material merge, decoct with water twice, collecting decoction, the extractum that while being evaporated to 65 ℃, relative density is 1.15-1.20, adding ethanol makes to reach 75-85% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with oral liquid, or concentrated solution spraying is dry, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fracture, in step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fracture, in step, spraying drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
Application in the medicine that the above-mentioned Chinese medicine composition that is used for the treatment of fracture is fractured in preparation treatment.
Beneficial effect:
1, from theory of Chinese medical science, ferrum Hirudo bone and muscle strengthening in we; Blood circulation promoting and blood stasis dispelling, with drug for invigorating blood circulation and eliminating stasis compatibilities such as Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Radix Angelicae Pubescentis, Sanguis Draxonis, strengthening the tendons and bones, invigorating blood circulation are tired, dredge the meridian passage, six is monarch drug, and Rhizoma Drynariae, Semen Cuscutae, the Radix Linderae are ministerial drug, the merit of principal drug assistance dredging collateral, reducing swelling and alleviating pain, Folium Et Cacumen Murrayae is adjuvant, all medicines are harmonious, and play altogether that strengthening the tendons and bones, invigorating blood circulation are tired, dredge the meridian passage, reducing swelling and alleviating pain effect, are used for the treatment of fracture.Theory of Chinese medical science is thought injury blood stasis swelling, blockage of main and collateral channels, and QI and blood retardance, treatment should be with blood circulation promoting and blood stasis dispelling, and circulation of qi promoting is dissipated as master.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, have no side effect, and low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
1,, in conjunction with the specific embodiment, the present invention is further described as follows:
According to the form below, listed weight proportion takes raw material required for the present invention, unit: part
| Ferrum Hirudo | Eupolyphaga Seu Steleophaga | Radix Angelicae Sinensis | Semen Persicae | Radix Angelicae Pubescentis | Sanguis Draxonis | Rhizoma Drynariae | Semen Cuscutae | The Radix Linderae | Folium Et Cacumen Murrayae | |
| 1 | 20 | 25 | 15 | 12 | 8 | 10 | 10 | 14 | 18 | 15 |
| 2 | 25 | 20 | 20 | 10 | 10 | 8 | 12 | 12 | 20 | 20 |
| 3 | 30 | 15 | 25 | 8 | 12 | 6 | 14 | 10 | 22 | 25 |
In the present invention, ferrum Hirudo is herb or the rhizome of Aspleniaceae plant Neottopteris nidus (L.) J. Smith.Latin plant animal mineral name: Neottopteris nidus(L.) J.Smith[Asplenium nidus L.] Folium Et Cacumen Murrayae is the herb of rutaceae Folium Et Cacumen Murrayae Murraya exotica L., all the other are pharmacopeia kind.
2. Preparation Example
More than showing Raw proportioning is example, comprises the following steps:
Embodiment 1: get ferrum Hirudo 20g, Eupolyphaga Seu Steleophaga 25g, Radix Angelicae Sinensis 15g, Semen Persicae 12g, Radix Angelicae Pubescentis 8g, Sanguis Draxonis 10g, Rhizoma Drynariae 10g, Semen Cuscutae 14g, Radix Linderae 18g, Folium Et Cacumen Murrayae 15g medical material merges, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 1h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1h, collecting decoction, 0.07MPa, while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.10, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, spraying is dry, and (condition is that inlet temperature is 120 ℃, leaving air temp is 100 ℃, temperature of charge is 90 ℃, atomizing pressure is 0.4 MPa, spray velocity is 10ml/s.), add starch, mix homogeneously, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, crosses 30 mesh sieves and granulates, in 70 ~ 80 ℃ dry, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains tablet.
Embodiment 2: get ferrum Hirudo 25g, Eupolyphaga Seu Steleophaga 20g, Radix Angelicae Sinensis 20g, Semen Persicae 10g, Radix Angelicae Pubescentis 10g, Sanguis Draxonis 8g, Rhizoma Drynariae 12g, Semen Cuscutae 12g, Radix Linderae 20g, Folium Et Cacumen Murrayae 20g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, spraying is dry, and (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), adding dextrin etc., dry granulation, crosses 60 mesh sieves, packs No. 1 capsule into and gets final product to obtain capsule.
Embodiment 3: get ferrum Hirudo 30g, Eupolyphaga Seu Steleophaga 15g, Radix Angelicae Sinensis 25g, Semen Persicae 8g, Radix Angelicae Pubescentis 12g, Sanguis Draxonis 6g, Rhizoma Drynariae 14g, Semen Cuscutae 10g, Radix Linderae 22g, Folium Et Cacumen Murrayae 25g medical material merges, decoct with water twice, adding for the first time water is 12 times of amounts of medical material weight, decoct 2h, adding for the second time water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, 0.07MPa, while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, spraying is dry, and (condition is that inlet temperature is 110 ℃, leaving air temp is 85 ℃, temperature of charge is 85 ℃, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s.), add above-mentioned Benexate Hydrochloride, pulverize, then add suitable lactose, with the moistening of appropriate 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 50-80 ℃ is dry, and 60 order granulate, obtain granule.
Embodiment 4: get ferrum Hirudo 25g, Eupolyphaga Seu Steleophaga 20g, Radix Angelicae Sinensis 20g, Semen Persicae 10g, Radix Angelicae Pubescentis 10g, Sanguis Draxonis 8g, Rhizoma Drynariae 12g, Semen Cuscutae 12g, Radix Linderae 20g, Folium Et Cacumen Murrayae 20g medical material merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, decompression filtrate recycling ethanol is also concentrated, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, add water and sucrose, be prepared into oral liquid.
3. the pharmacodynamic study on the impact of the bone density of laboratory animal
Sample preparation: press above-described embodiment 3 preparation clinical trial samples, specification is 10g/ bag, is 16.7g/ bag containing crude drug amount.Precious strong SHENGU JIAONANG, Shandong meeting elixir industry Group Co.,Ltd, lot number: 20100511.Tretinoin sheet, Shandong Liang Fu pharmaceutical Co. Ltd, lot number: 110120
Animal: Wistar rat, male, body weight 180-240g, Shanghai Slac Experimental Animal Co., Ltd. provides.
The foundation of experiment grouping and model rat with osteoporosis: get 30 of normal Wistar rats and be divided at random 5 groups, getting wherein 6 is NS group; Get wherein 6 as model group, press merely tretinoin 70mg/kg gavage two weeks; Get wherein 6 precious strong SHENGU JIAONANG matched groups of conduct; Remaining 12 rats are as the high low dose group of the present invention.When gavaging tretinoin as ZHENMUSHENGU JIAONANG matched group and high and low dose group of the present invention by the dosage of 70mg/kg, gavage corresponding medicine, withdraw tretinoin after gavaging two weeks and continue two weeks and measure indices.Rat sacrificed by decapitation, gets its femur and arranges by group, uses X-line mammary gland video camera production mating plate, the 5 positions bone density value of fixing a point to measure and record on the greater trochanter of femur, femoral head, neck of femur, intertrochanteric line and under intertrochanteric line with black and white densimeter.
Impact on rat bone density
With model group comparison, * 1P<0.01, * 2P<0.05
Experimental result shows, the present invention and model group comparison, have significant difference, illustrates that the present invention can improve bone density, treatment fracture, and also effect is better than precious strong SHENGU JIAONANG.
4. model case
Case 1: Lee, man, 40 years old.Injured be in hospital, clinical diagnosis is right lower extremity fracture, the therapeutic scheme of employing is as follows: take the above embodiment of the present invention 3 preparation clinical trial samples, each 10g, every day 2 times, is discharged from hospital after recovery after serveing on six weeks.
Case 2: Zhang, female, 48 years old.Patient is injured to be in hospital, and clinical diagnosis is that right chi is scratched bone fracture, takes the above embodiment of the present invention 3 preparation clinical trial samples, and each 10g is discharged from hospital after recovery after the bimester of serveing on.
Claims (6)
1. a Chinese medicine composition that is used for the treatment of fracture, it is characterized in that, it is prepared by the raw material of following parts by weight: ferrum Hirudo 20-30 part, Eupolyphaga Seu Steleophaga 15-25 part, Radix Angelicae Sinensis 15-25 part, Semen Persicae 8-12 part, Radix Angelicae Pubescentis 8-12 part, Sanguis Draxonis 6-10 part, Rhizoma Drynariae 10-14 part, Semen Cuscutae 10-14 part, Radix Linderae 18-22 part, Folium Et Cacumen Murrayae 15-25 part, preparation method comprises the steps: to get ferrum Hirudo, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Radix Angelicae Pubescentis, Sanguis Draxonis, Rhizoma Drynariae, Semen Cuscutae, the Radix Linderae and Folium Et Cacumen Murrayae medical material merge, decoct with water twice, collecting decoction, the extractum that while being evaporated to 65 ℃, relative density is 1.15-1.20, adding ethanol makes to reach 75-85% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30, and reclaim ethanol, obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with oral liquid, or concentrated solution spraying is dry, add adjuvant and make capsule, tablet, granule.
2. the Chinese medicine composition that is used for the treatment of fracture according to claim 1, it is characterized in that, it is prepared by the raw material of following parts by weight: 25 parts of ferrum Hirudoes, 20 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Angelicae Sinensis, 10 parts, Semen Persicae, 10 parts of Radix Angelicae Pubescentiss, 8 parts of Sanguis Draxonis, 12 parts of Rhizoma Drynariae, 12 parts of Semen Cuscutae, 20 parts of the Radixs Linderae, 20 parts of Folium Et Cacumen Murrayae.
3. the Chinese medicine composition that is used for the treatment of fracture according to claim 1, it is characterized in that, described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
4. the Chinese medicine composition that is used for the treatment of fracture according to claim 1, is characterized in that, in preparation method step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
5. the Chinese medicine composition that is used for the treatment of fracture according to claim 1, it is characterized in that, in preparation method step, spraying drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
6. the Chinese medicine composition that is used for the treatment of fracture described in claim 1 or 2 is treated the application in the medicine of fracturing in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210523489.1A CN102935159B (en) | 2012-12-08 | 2012-12-08 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210523489.1A CN102935159B (en) | 2012-12-08 | 2012-12-08 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102935159A CN102935159A (en) | 2013-02-20 |
| CN102935159B true CN102935159B (en) | 2014-09-10 |
Family
ID=47694106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210523489.1A Expired - Fee Related CN102935159B (en) | 2012-12-08 | 2012-12-08 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102935159B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274602A (en) * | 1999-12-13 | 2000-11-29 | 莫强林 | Externally applied medicated wine for treating traumatic injury and rheumatism |
| CN1339313A (en) * | 2001-09-30 | 2002-03-13 | 吴绍静 | Pure traditional Chinese medicine for relaxing muscles and tendons and promoting blood circulation |
| CN1457868A (en) * | 2003-05-19 | 2003-11-26 | 南明森 | Naturally curing fracture setting pill |
| CN1507892A (en) * | 2002-12-18 | 2004-06-30 | 潘荣秦 | Osteoproliferation medicine for external application |
| CN1824009A (en) * | 2005-02-22 | 2006-08-30 | 林立树 | Multipurpose medicinal composition capable of oral administration and external use |
| CN102793831A (en) * | 2012-08-27 | 2012-11-28 | 刘伟娟 | Preparation method for traditional Chinese medicine lotion for treatment of hypertension-type closed fracture |
-
2012
- 2012-12-08 CN CN201210523489.1A patent/CN102935159B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274602A (en) * | 1999-12-13 | 2000-11-29 | 莫强林 | Externally applied medicated wine for treating traumatic injury and rheumatism |
| CN1339313A (en) * | 2001-09-30 | 2002-03-13 | 吴绍静 | Pure traditional Chinese medicine for relaxing muscles and tendons and promoting blood circulation |
| CN1507892A (en) * | 2002-12-18 | 2004-06-30 | 潘荣秦 | Osteoproliferation medicine for external application |
| CN1457868A (en) * | 2003-05-19 | 2003-11-26 | 南明森 | Naturally curing fracture setting pill |
| CN1824009A (en) * | 2005-02-22 | 2006-08-30 | 林立树 | Multipurpose medicinal composition capable of oral administration and external use |
| CN102793831A (en) * | 2012-08-27 | 2012-11-28 | 刘伟娟 | Preparation method for traditional Chinese medicine lotion for treatment of hypertension-type closed fracture |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102935159A (en) | 2013-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101130030B (en) | Medicine composition for treating nephropathy and uses of the same | |
| CN102225138B (en) | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof | |
| CN101019975A (en) | Fracture treating Chinese medicine composition and its prepn | |
| CN104001004A (en) | Traditional Chinese medicine composition for curing fractures and osteoporosis and preparation method and application thereof | |
| CN105148019A (en) | Medicinal preparation used for treating fractures | |
| CN104013929A (en) | Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof | |
| CN102935159B (en) | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof | |
| CN107890528B (en) | Traditional Chinese medicine composition for treating hyperuricemia and preparation method thereof | |
| CN111358906B (en) | Traditional Chinese medicine composition suitable for exogenous diseases | |
| CN101658585A (en) | Application of Chinese medicinal composition in preparing medicament for treating nasosinusitis | |
| CN100579544C (en) | Chinese medicament preparation for treating cholecystitis and gall-stone as well as preparation method thereof | |
| CN101332268A (en) | Medicine for treating rhinitis, sinusitis and preparation method thereof | |
| CN102008635A (en) | Traditional Chinese medicine preparation for treating acute pancreatitis | |
| CN105641403A (en) | Traditional Chinese medicine heath care product for treating hyperglycemia and preparation method thereof | |
| CN101194959B (en) | Capsule for treating headache and method for preparing the same | |
| CN101194963B (en) | Process for preparing medicine for treating headache | |
| CN104800339A (en) | Traditional Chinese medicine composition for treating bone fracture | |
| CN104383263A (en) | Traditional Chinese medicine composition for treating bone fracture as well as preparation method and application thereof | |
| CN101745093A (en) | Medicine for quickly treating infantile chronic diarrhea | |
| CN101732469A (en) | Application of Chinese medicinal composition in preparation of medicament for treating aphonia | |
| CN104547246A (en) | Traditional Chinese medicine composition for treating haemorrhoids | |
| CN103784706A (en) | Medicine composition for treating intestinal tympany of equus animals | |
| CN100358556C (en) | Bone-recovering particles | |
| CN104435149A (en) | Traditional Chinese medicine composition containing kadsura pepper stem for treating gout | |
| CN102872234B (en) | Qingkailing and bupleurum orally disintegrating tablets for animals and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL Free format text: FORMER OWNER: NANJING ZHENGKUAN PHARMACEUTICAL SCIENCE AND TECHNOLOGY CO., LTD. Effective date: 20140815 |
|
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhao Jianhua Inventor after: Wang Chaowei Inventor after: Qin Xiuguang Inventor after: Li Qing Inventor after: Zhang Lijun Inventor before: The inventor has waived the right to be mentioned |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 211224 NANJING, JIANGSU PROVINCE TO: 453100 XINXIANG, HENAN PROVINCE Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: ZHAO JIANHUA WANG CHAOWEI QIN XIUGUANG LI QING ZHANG LIJUN |
|
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20140815 Address after: 453100 No. 88 health Road, Weihui, Henan, Xinxiang Applicant after: The First Affiliated Hospital of Xinxiang Medical University Address before: 211224 No. 1 Industrial Park, Jing Qiao Town, Lishui County, Jiangsu, Nanjing Applicant before: Nanjing Zhengkuan Pharmaceutical Science and Technology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140910 Termination date: 20151208 |
|
| EXPY | Termination of patent right or utility model |