CN1058894C - Compound cold-preventing nose drops and their preparation - Google Patents
Compound cold-preventing nose drops and their preparation Download PDFInfo
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- CN1058894C CN1058894C CN98100721A CN98100721A CN1058894C CN 1058894 C CN1058894 C CN 1058894C CN 98100721 A CN98100721 A CN 98100721A CN 98100721 A CN98100721 A CN 98100721A CN 1058894 C CN1058894 C CN 1058894C
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Abstract
The present invention relates to a medicine for treating colds, particularly to a nasal drop for preventing colds. The nasal drop which belongs to a compound preparation is prepared from cyrtomii rhizoma, baical skullcap root, radix isatidis, honeysuckle flower, weeping forsythia capsule, liquorice, dyers woad leaf, amantadine hydrochloride, menthol and vinegar, and is prepared by mixing the baical skullcap root, the radix isatidis, the honeysuckle flower, the weeping forsythia capsule, the liquorice and the dyers woad leaf according to a prescription, adding distilled water to the mixture to be distilled, filtrating the distilled solution, adding the amantadine hydrochloride, the menthol and the vinegar to the filtration according to the proportion of the prescription, sterilizing the mixture by an obturation method, bottling the sterilized mixture and microwave sterilizing the bottled mixture; thus, the nasal drop can be used.
Description
The present invention relates to a kind of Chinese medicine and western medicine compound nose drop of the medicine for the treatment of flu, particularly a kind of preventing cold.
Influenza and upper respiratory tract infection (referring to common cold) are the highest diseases of sickness rate among the crowd, and can cause complication such as sinusitis, otitis media, pneumonia, myocarditis, even cause death.China Agricultural University east 96 year winter of school district hospital and 97 year spring statistics show that community at less than 10,000 populations has 10,000 or more person-time because of the flu prescription on individual diagnosis.Investigate 3098 university students and 428 children below 12 years old 97 year winter, flu reaches 4557 person-times, 1.3 times per capita.According to World Health Organization's data, countries in the world are all carried out Prevention Research to influenza as focal disease at present.
The viral species that causes influenza and common cold is numerous, as influenza virus, rhinovirus, adenovirus, coronavirus, Ke Shaqi virus etc., virus also often morphs, therefore still there is not the very strong specific drug of specific aim at present both at home and abroad, existing Coritab can only mitigation symptoms, prevents complication.The effective measures of external flu-prevention at present and common cold are the injected current influenza vaccines, but due to illness the seed culture of viruses class is many, variation is fast, can only play the partial prophylaxis effect, and shortcoming such as side effect is many in addition, and price is expensive.The major measure of domestic preventing cold in recent years comprises Chinese herbal medicine and Western medicine such as moroxydine, amantadine such as pre-clothes Radix Isatidis; Stifling public place of vinegar and room; Also useful nasal cavity splashes into preventive measures such as vinegar, the plain collyrium of chlorine enzyme, injection of Radix Bupleuri, low concentration interferon-alpha, BCG vaccine polysaccharide nucleic acid, and also useful Chinese medicine sachet, essence are smelt methods such as news.
The object of the present invention is to provide and a kind ofly can play prevention and therapeutic purposes, side effect is little, route of administration is superior, effective, low-cost medicine.
Technical solution of the present invention is:
This preparation belongs to compound preparation, and its characteristics are: 5000 milliliters of medicinal liquid needed raw materials of every preparation medicine is: Rhizoma Osmundae 200～300g, Radix Scutellariae 200～280g, Radix Isatidis 200～300g, Flos Lonicerae 100～150g, Fructus Forsythiae 100～150g, Radix Glycyrrhizae 50～60g, Folium Isatidis 200～300g, amantadine hydrochloride 25g, Mentholum 5g, vinegar 100g.
The manufacture method of compound cold-preventing nasal drop, its characteristics are: Rhizoma Osmundae 200～300g, Radix Scutellariae 200～280g, Radix Isatidis 200～300g, Flos Lonicerae 100～150g, Fructus Forsythiae 100～150g, Radix Glycyrrhizae 50～60g, Folium Isatidis 200～300g are mixed, adding distil water distillation after-filtration, add amantadine hydrochloride 25g, vinegar 100g again, Mentholum 5g dissolves in earlier in 5 milliliters of 95% the ethanol and is dissolved in preparation again, through airtight sterilization, refill bottle and behind microwave sterilization, can use.
Beneficial effect of the present invention is:
(1) superiority of nasal-cavity administration:
1, nasal-cavity administration can be avoided the intestines and stomach-first pass effect of hepar, improves bioavailability of medicament;
2, the about 150cm of nasal cavity area
2, there is small fine hair in very abundant, the nose breathing road of blood vessel under the nasal membrane, further increases the effective area of drug absorption, makes medicine can enter the nasal cavity histiocyte rapidly.
(2) effectiveness of Chinese medicine of the present invention:
1, domestic a large amount of research data confirms, Chinese herb preventions such as Radix Isatidis, Folium Isatidis, Flos Lonicerae flu has certain effect.Also have and report that Chinese medicine nasal-cavity administrations such as confirming Radix Isatidis can suppress virus breeding.
2, the effect of vinegar
(1) vinegar can reduce the nasal cavity pH value, because of the lysozyme in the nasal secretion when the acid reaction, the biological function of just remaining valid;
(2) according to the study, influenza virus and rhinovirus are o'clock easily destroyed in pH value 3～5.This preparation add behind the vinegar pH value be 4～5 simultaneously vinegars certain inhibition virus function is also arranged.
3, the effectiveness of amantadine
Over nearly 10 years, there are a large amount of report amantadines that the effect that suppresses influenza virus is arranged abroad.
4, the application purpose of Mentholum
Mentholum is used nasal-cavity administration already, and the symptom curative effect that alleviates the acute nosal inflammation in flu back is affirmed.
This preparation comprises Rhizoma Osmundae, Radix Scutellariae, Radix Isatidis, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Folium Isatidis, amantadine hydrochloride, Mentholum, vinegar.
Describe technical solution of the present invention below in detail.
The prescription of this preparation is: in 5000 ml solns
Rhizoma Osmundae 200～300g, Radix Scutellariae 200～280g, Radix Isatidis 200～300g, Flos Lonicerae 100～150g, Fructus Forsythiae 100～150g, Radix Glycyrrhizae 50～60g, Folium Isatidis 200～300g, amantadine hydrochloride 25g, Mentholum 5g, vinegar 100g
The embodiment of this preparation is: in 5000 ml solns
Rhizoma Osmundae 240g, Radix Scutellariae 240g, Radix Isatidis 240g, Flos Lonicerae 120g, Fructus Forsythiae 120g, Radix Glycyrrhizae 60g, Folium Isatidis 240g, amantadine hydrochloride 25g, Mentholum 5g, vinegar 100g.
Manufacturing process of the present invention is:
Rhizoma Osmundae 200～300g, Radix Scutellariae 200～280g, Radix Isatidis 200～300g, Flos Lonicerae 100～150g, Fructus Forsythiae 100～150g, Radix Glycyrrhizae 50～60g, Folium Isatidis 200～300g are mixed, adding distil water distillation after-filtration, add amantadine hydrochloride 25g, vinegar 100g again, Mentholum 5g dissolves in earlier in 5 milliliters of 95% the ethanol and is dissolved in preparation again, through airtight sterilization, refill bottle and behind microwave sterilization, can use.
The effect analysis that large-scale crowd comes into operation:
In JIUYUE, (one) 97～October, do not find local powder irritant reaction through 2 routine animal experiments earlier, after 300 routine trial tests find that this medicine cures cold really effectively to anti-, does not also find untoward reaction.
In November, (two) 97～98 year January successively twice above to more than 4000 person-times of university students, 1000 person-times of pupils and kindergarten child and more than 1000 person-time are employed and retired veteran cadre and retired ex employee have been come into operation compound cold-preventing nasal drop.Most of medication person adopts the method for dripping the stifled nose of aseptic cotton balls of going up medicinal liquid, and directly the collunarium person is dripped 6 every day, and each 2～3, rub after dripping and turn round nose, it is contacted with na-sal cavity surfaces.
Provide the questionnaire statistics in mid-January, 98, reclaim 3526 parts of effective questionnaires.1442 of medication group university students, 428 of pupils, 651 of the plain matched groups of chlorine enzyme, the blank group of medication is 995.
Data shows according to statistics, and medication group flu obviously descended person-time last one year, and the prevention effective percentage: the university students organizes 80.3%, and the pupil organizes 87.1%, the plain collyrium group 50.2% of chlorine enzyme.The treatment effective percentage: the university students organizes 69.1%, and the pupil organizes 85.5%, the plain collyrium group 40.2% of chlorine enzyme.Above statistical test all has significant difference.
Claims (4)
1, compound cold-preventing nasal drop is characterized in that: 5000 milliliters of medicinal liquid needed raw materials of every preparation medicine is: Rhizoma Osmundae 200～300g, Radix Scutellariae 200～280g, Radix Isatidis 200～300g, Flos Lonicerae 100～150g, Fructus Forsythiae 100～150g, Radix Glycyrrhizae 50～60g, Folium Isatidis 200～300g, amantadine hydrochloride 25g, Mentholum 5g, vinegar 100g.
2, compound cold-preventing nasal drop as claimed in claim 1 is characterized in that: 5000 milliliters of medicinal liquid needed raw materials of every preparation medicine is: Rhizoma Osmundae 240g, Radix Scutellariae 240g, Radix Isatidis 240g, Flos Lonicerae 120g, Fructus Forsythiae 120g, Radix Glycyrrhizae 60g, Folium Isatidis 240g, amantadine hydrochloride 25g, Mentholum 5g, vinegar 100g.
3, compound cold-preventing nasal drop as claimed in claim 1 or 2 is characterized in that: the pH value of this preparation is 4～5.
4, the manufacture method of compound cold-preventing nasal drop, it is characterized in that: Rhizoma Osmundae 200～300g, Radix Scutellariae 200～280g, Radix Isatidis 200～300g, Flos Lonicerae 100～150g, Fructus Forsythiae 100～150g, Radix Glycyrrhizae 50～60g, Folium Isatidis 200～300g are mixed, adding distil water distillation after-filtration, add amantadine hydrochloride 25g, vinegar 100g again, Mentholum 5g dissolves in earlier in 5 milliliters of 95% the ethanol and is dissolved in preparation again, through airtight sterilization, refill bottle and behind microwave sterilization, can use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100721A CN1058894C (en) | 1998-03-10 | 1998-03-10 | Compound cold-preventing nose drops and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100721A CN1058894C (en) | 1998-03-10 | 1998-03-10 | Compound cold-preventing nose drops and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1190016A CN1190016A (en) | 1998-08-12 |
| CN1058894C true CN1058894C (en) | 2000-11-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98100721A Expired - Fee Related CN1058894C (en) | 1998-03-10 | 1998-03-10 | Compound cold-preventing nose drops and their preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN1058894C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1148220C (en) * | 2002-01-14 | 2004-05-05 | 马文汉 | Antivirus defervescent |
| CN100374104C (en) * | 2005-12-16 | 2008-03-12 | 贵州柏强制药有限公司 | Scutellaria alkyl amine granules and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099976A (en) * | 1993-09-09 | 1995-03-15 | 周孝正 | Compound xanthium fruit and ephedre nasal drops |
| CN1148494A (en) * | 1995-10-25 | 1997-04-30 | 河南省洛阳市秦岭制药厂 | Anti-cold nose drops and preparation method thereof |
-
1998
- 1998-03-10 CN CN98100721A patent/CN1058894C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099976A (en) * | 1993-09-09 | 1995-03-15 | 周孝正 | Compound xanthium fruit and ephedre nasal drops |
| CN1148494A (en) * | 1995-10-25 | 1997-04-30 | 河南省洛阳市秦岭制药厂 | Anti-cold nose drops and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1190016A (en) | 1998-08-12 |
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