CN1429578A - Medicinal atomization liquid for treating pharyngitis and its manufacturing process - Google Patents
Medicinal atomization liquid for treating pharyngitis and its manufacturing process Download PDFInfo
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- CN1429578A CN1429578A CN 01142853 CN01142853A CN1429578A CN 1429578 A CN1429578 A CN 1429578A CN 01142853 CN01142853 CN 01142853 CN 01142853 A CN01142853 A CN 01142853A CN 1429578 A CN1429578 A CN 1429578A
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Abstract
A Chinese medicine in the form of atomizing liquid for treating pharyngitis is prepared from 7 Chinese medicinal materials including honey suckle flower, ophiopogon root, scrophularia root, liquorice root, etc. through proportioning, then extracting volatile component by decocting separately, fininally mixing, filtering, split loading and sterilizing.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of pharyngitis, is the Chinese patent medicine atomized liquid of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the processing technology of this medicine.
Background technology
Acute/chronic pharyngitis is that children's appreciates and sees disease, frequently-occurring disease, outbreak repeatedly, and delay is difficult, and may become the complication that focus causes other system of whole body, has a strong impact on the physical and mental health and the growth promoter of infant, as one of four inflammation of otorhinolaryngology keypoint control.Acute pharyngitis is due to due to illness bacterium infects, and chronic pharyngitis is many to be caused because of acute pharyngitis shows effect repeatedly.Motherland's medical science thinks that throat is all communications centres through coming in and going out, and garget, inaccessible disadvantageous symptom are referred to as " sore throat ".The traditional Chinese medical science is divided into anemopyretic and YIN-deficiency type with pharyngitis, and the many heresies because of wind heat of acute pharyngitis (anemopyretic) are invaded by mouth, cause stagnation of QI-blood, give birth to the transconversion into heat poison, hold back through the stagnation of QI, pent up pharyngeal.Red swelling of the pharynx appears in clinical symptoms.Pharynx rear wall follicle hypertrophy also has thick secretions.The many children's because of the deficiency of YIN of chronic pharyngitis (YIN-deficiency type) are subjected to the ailment said due to cold or exposure visitor in pharyngeal because cold and hot inappropriate repeatly, cause a long delay; It is pharyngeal that the long-pending heat of stomach internal organs goes up steaming; Or occupy unclean border, it is inappropriate to rest; Damage cloudy liquid, knot is pharyngeal for a long time to cause pathogenic factor.Dry pharynx, itching throat appear in clinical symptoms, choke with sobs if any thing, dried choke etc.The medicine of existing various treatments mostly is buccal tablet such as tablet of cow-bezoar for throat trouble, and effect is relatively poor, even oral liquid medicine, effect is also undesirable, and medicine often also has stimulation to the intestines and stomach simultaneously.
Summary of the invention
The purpose of this invention is to provide a kind of medicine atomized liquid and processing technology thereof for the treatment of pharyngitis.
Solution of the present invention is based on understanding and the modern pharmacological research achievement of motherland's medical science to pharyngitis mechanism, filters out the Drug therapy acute/chronic pharyngitis of heat-clearing and toxic substances removing, YIN nourishing sore-throat relieving from motherland's medicine treasure-house.
Medicine of the present invention is made by following weight (gram) proportioning:
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 15～36 25～50 Radix Ophiopogonis 25～50
Radix Glycyrrhizae 6～18 Radix Scrophulariae 15～38 Fructus Canariis 15～36
Ethanol 250～500ml water 950～1900ml of Flos Chrysanthemi 10～30 50%
Better weight (gram) proportioning of medicine of the present invention is:
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 24 40 Radix Ophiopogonis 40
Radix Glycyrrhizae 12 Radix Scrophulariae 28 Fructus Canariis 24
The ethanol 400ml water 1520ml of Flos Chrysanthemi 20 50%
The processing technology of said components being made medicine of the present invention is:
Press said ratio with Flos Lonicerae, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Radix Glycyrrhizae, Radix Scrophulariae, Fructus Canarii, Flos Chrysanthemi 7 flavor medicines mix and add in the lidded container, adding concentration by proportioning again is that 50% ethanol makes it to soak into fully, add a cover, often placed 2～4 days the jolting dark place, filter, the medicinal residues squeezing is extracted, remaining medicinal residues add decocting respectively by known technology and boil 2 times, time was respectively 12～18 minutes for the first time, and 8～12 minutes for the second time, collecting decoction, leave standstill and cool, under fully stirring, slowly add ethanol extract, use filter paper filtering then, will add water in the filtrate at last, make the content of water in the filtrate reach the ratio requirement of medicine of the present invention, then be distributed into bottle, seal the back and sterilize under 105～125 ℃ of temperature, the time is 25～35 minutes.
Pharyngitis classification and pharmacological research according to the traditional Chinese medical science should adopt cleaning heat and expelling wind antidotal means when treating for acute pharyngitis (anemopyretic), for chronic pharyngitis (YIN-deficiency type), should adopt the means of nourishing YIN and clearing away heat during treatment.In the medicine of the present invention, to be that monarch, its property are sweet tremble with fear, go into lung heart stomach warp for Flos Lonicerae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, and clearing away heat with drugs sweet in flavor and cold in nature does not injure one's stomach, and fragrance is not held back heresy clearly thoroughly, can dispelling wind-heat, and kind again heat-clearing and toxic substances removing.All health preserving with drugs Yin and promoting production of body liquid sore-throat relievings such as Radix Adenophorae (Radix Glehniae), Radix Scrophulariae, Fructus Canarii are minister, all walk lung yin through, matter profit, are all sweet coldly or salty-cold, and the effect of nourishing YIN and clearing away heat is all arranged.Wherein unit participates in warp on the lung kidney, can the last clearly thorough nourishing YIN to lower pathogenic fire medicine that is down.Flos Chrysanthemi wind and heat dispersing, sweet cold tonifying YIN, clear light cool loosing, the order clearly that uncharms also has significant antibacterial and resistant effect.Concoct all medicines and have the effect of heat-clearing and toxic substances removing sore-throat relieving emergency concurrently.Radix Glycyrrhizae walks 12 through concocting all medicines, for making, has the effect of heat-clearing and toxic substances removing, emergency in medicine of the present invention.
According to the chlorogenic acid in its water soluble ingredient of modern pharmacological research Flos Lonicerae, isochlorogenic acid is the bacteriostatic main component.Liposoluble constituent luteolin and lonicerin have the bacteriostatic effect, and be more abundant through ethanol extraction, and antibacterial action is widely arranged.Bacteriostasis is in various degree all arranged Radix Adenophorae (Radix Glehniae), Radix Scrophulariae, Fructus Canarii, Radix Ophiopogonis.Contain volatile oil such as chrysanthemum glycoside, ketone in the Flos Chrysanthemi significant antibacterial action is arranged.Radix Glycyrrhizae has the hydrocortisone functions of hormones, has the antiviral effect of antiinflammatory.
For the therapeutic effect of checking medicine of the present invention to pharyngitis, medicine of the present invention is carried out Clinical Laboratory, acute pharyngitis 156 examples are established treatment group (with medicine treatment of the present invention) 86 examples, wherein male 46 examples, women 40 examples; If matched group (with other known approaches treatment) 70 examples, wherein male 38 examples, women 32 examples; Chronic pharyngitis patient's 78 examples are established 43 examples and are treatment group (with medicine treatment of the present invention), wherein male 25 examples, and women 18 examples are established matched group (with other known approaches treatment) 35 examples, male 19 examples, women 16 examples.
The Therapeutic Method of medicine of the present invention with medicine 40ml of the present invention, is put into the steam nebulizer, carries out the steam atomizing and sucks, and twice, one time 10 minutes on the one, it was 4-7 days that a course of treatment is organized in the acute pharyngitis treatment, and it is 7-14 days that a course of treatment is organized in the chronic pharyngitis treatment.
Therapeutic outcome, 86 examples are organized in the acute pharyngitis treatment, 46 examples of fully recovering (53.5%), produce effects 23 examples (26.7%), total effective rate is 96.5%; Matched group 24 examples (34.3%) produce effects 20 examples (28.6%) of fully recovering, total effective rate is 82.9%.Chronic treatment group 43 examples, 21 examples of fully recovering (48.8%), produce effects fruit 10 examples (23.3%), total effective rate 97.7%.Chronic matched group 35 examples, 10 examples of fully recovering (28.6%), produce effects 12 examples (34.2%), total effective rate 91.4%.In sum, application medicine of the present invention compares no significant difference for the therapeutic effect of acute pharyngitis and chronic pharyngitis.And treatment group and matched group comparative effectiveness obviously are dominant, and illustrate that the present invention has curative effect preferably to pharyngitis.
For the further antiinflammation of checking medicine of the present invention, the spy has carried out antiinflammatory, bacteriostatic experiment to the present invention, experimental results show that the present invention not only has antiinflammation preferably for non-special inflammation, all has certain inhibitory action to Gram-positive and gram negative bacteria simultaneously.
Description of drawings
Accompanying drawing is the processing technology flow chart of medicine of the present invention.
The specific embodiment
Take by weighing raw material by following weight (gram) proportioning
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 24 40 Radix Ophiopogonis 40
Radix Glycyrrhizae 12 Radix Scrophulariae 28 Fructus Canariis 24
Flos Chrysanthemi 20
Processing technology is as follows:
Said components is added in the lidded container, add 50% ethanol 400ml and make infiltration fully, add a cover, often put 3 days the jolting dark place, filters, and the medicinal residues squeezing is extracted.Remaining medicinal residues add 1500 respectively, and the 1200ml decocting boils 2 times, and the time was respectively 15 minutes, and 10 minutes, collecting decoction left standstill and cools.Slowly add ethanol extract under fully stirring, use filter paper filtering then, add water at last and make filtrate to 1920ml, be distributed into bottle, every bottle of 240ml (every 10ml is equivalent to crude drug in whole 0.98g) seals, and carries out sterilization in 30 minutes under 115 ℃.
Take by weighing raw material by following weight (gram) proportioning
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 26 25 Radix Ophiopogonis 30
Radix Glycyrrhizae 10 Radix Scrophulariae 19 Fructus Canariis 21
Flos Chrysanthemi 15
Processing technology is as follows: said components is added in the lidded container, add 50% ethanol 250ml and make infiltration fully, add a cover, often put 3 days the jolting dark place, filters, and the medicinal residues squeezing is extracted.Remaining medicinal residues add 940ml respectively, and the 750ml decocting boils 2 times, and the time was respectively 16 minutes, and 11 minutes, collecting decoction left standstill and cools.Under fully stirring, slowly add ethanol extract, use filter paper filtering then, add water at last and make filtrate, be distributed into bottle closure, under 110 ℃, carry out sterilization in 28 minutes to 1450ml.
Take by weighing raw material by following weight (gram) proportioning
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 27 50 Radix Ophiopogonis 30
Radix Glycyrrhizae 12 Radix Scrophulariae 29 Fructus Canariis 22
Flos Chrysanthemi 18
Processing technology is as follows: said components is added in the lidded container, add 50% ethanol 450ml and make infiltration fully, add a cover, often put 2 days the jolting dark place, filters, and the medicinal residues squeezing is extracted.Remaining medicinal residues add 1470ml respectively, and the 1350ml decocting boils 2 times, and the time was respectively 17 minutes, and 9 minutes, collecting decoction left standstill and cools.Under fully stirring, slowly add ethanol extract, use filter paper filtering then, add water at last and make filtrate, be distributed into bottle closure, under 125 ℃, carry out sterilization in 32 minutes to 2160ml.
Claims (6)
1, a kind of medicine atomized liquid for the treatment of pharyngitis is characterized in that it is the medicament of being made by following weight (gram) proportion raw material
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 15～36 25～50 Radix Ophiopogonis 25～50
Radix Glycyrrhizae 6～18 Radix Scrophulariae 15～38 Fructus Canariis 15～36
Ethanol 250～500ml water 950～1900ml of Flos Chrysanthemi 10～30 50%
2, the medicine atomized liquid of treatment pharyngitis according to claim 1 is characterized in that wherein the weight of each raw material (gram) proportioning is
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 24 40 Radix Ophiopogonis 40
Radix Glycyrrhizae 12 Radix Scrophulariae 28 Fructus Canariis 24
The ethanol 400ml water 1520ml of Flos Chrysanthemi 20 50%
3, the medicine atomized liquid of treatment pharyngitis according to claim 1 is characterized in that wherein the weight of each raw material (gram) proportioning is
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 26 25 Radix Ophiopogonis 30
Radix Glycyrrhizae 10 Radix Scrophulariae 19 Fructus Canariis 21
The ethanol 250ml water 950ml of Flos Chrysanthemi 15 50%
4, the medicine atomized liquid of treatment pharyngitis according to claim 1 is characterized in that wherein the weight of each raw material (gram) proportioning is
Flos Lonicerae Radix Adenophorae (Radix Glehniae) 27 50 Radix Ophiopogonis 30
Radix Glycyrrhizae 12 Radix Scrophulariae 29 Fructus Canariis 22
The ethanol 450ml water 1710ml of Flos Chrysanthemi 18 50%
5, a kind of processing technology for the treatment of the medicine atomized liquid of pharyngitis, it is characterized in that Flos Lonicerae, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Radix Glycyrrhizae, Radix Scrophulariae, Fructus Canarii, Flos Chrysanthemi 7 flavor medicines mix and add in the lidded container, adding 50% ethanol makes it to soak into fully, add a cover, often placed 2～4 days the jolting dark place, filter, the medicinal residues squeezing is extracted, remaining medicinal residues add decocting respectively by known technology and boil 2 times, and the time was respectively 12～18 minutes for the first time, 8～12 minutes for the second time, collecting decoction, leave standstill and cool, under fully stirring, slowly add ethanol extract, use filter paper filtering then, water will be added at last in the filtrate, be distributed into bottle, seal the back and sterilize under 105～125 ℃ of temperature, the time is 25～35 minutes.
6, processing technology according to the medicine atomized liquid of the said treatment pharyngitis of claim 5, it is characterized in that Flos Lonicerae, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Radix Glycyrrhizae, Radix Scrophulariae, Fructus Canarii, Flos Chrysanthemi 7 flavor medicines mix and add in the lidded container, adding 50% ethanol makes it to soak into fully, add a cover, often placed 3 days the jolting dark place, filter, the medicinal residues squeezing is extracted, remaining medicinal residues add decocting respectively by known technology and boil 2 times, and the time was respectively 15 minutes for the first time, 10 minutes for the second time, collecting decoction, leave standstill and cool, under fully stirring, slowly add ethanol extract, use filter paper filtering then, water will be added at last in the filtrate, be distributed into bottle, seal the back and sterilize under 115 ℃ of temperature, the time is 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01142853 CN1201756C (en) | 2001-12-30 | 2001-12-30 | Medicinal atomization liquid for treating pharyngitis and its manufacturing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01142853 CN1201756C (en) | 2001-12-30 | 2001-12-30 | Medicinal atomization liquid for treating pharyngitis and its manufacturing process |
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| Publication Number | Publication Date |
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| CN1429578A true CN1429578A (en) | 2003-07-16 |
| CN1201756C CN1201756C (en) | 2005-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01142853 Expired - Fee Related CN1201756C (en) | 2001-12-30 | 2001-12-30 | Medicinal atomization liquid for treating pharyngitis and its manufacturing process |
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| CN (1) | CN1201756C (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332269B (en) * | 2008-07-10 | 2011-09-07 | 江汉大学 | Traditional Chinese medicine propellant for treating pharyngitis and preparation method thereof |
| CN101658632B (en) * | 2009-08-27 | 2012-06-27 | 广州白云山和记黄埔中药有限公司 | Chinese herbal preparation for treating chronic pharyngitis and preparation method thereof |
| CN104548152A (en) * | 2014-12-23 | 2015-04-29 | 葵花药业集团（重庆）有限公司 | Sterilization method for traditional Chinese medicine preparation |
| CN105343503A (en) * | 2015-11-30 | 2016-02-24 | 中国人民解放军第二军医大学 | Medicine composition for treating sphagitis and application thereof |
| CN105902836A (en) * | 2016-06-17 | 2016-08-31 | 济南市儿童医院 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
| CN108066580A (en) * | 2016-11-11 | 2018-05-25 | 许颢瀚 | A kind of lung lavage formula and its device |
| CN114224972A (en) * | 2021-12-10 | 2022-03-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Medicine atomized liquid formula for treating acute and chronic pharyngitis and preparation process thereof |
-
2001
- 2001-12-30 CN CN 01142853 patent/CN1201756C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332269B (en) * | 2008-07-10 | 2011-09-07 | 江汉大学 | Traditional Chinese medicine propellant for treating pharyngitis and preparation method thereof |
| CN101658632B (en) * | 2009-08-27 | 2012-06-27 | 广州白云山和记黄埔中药有限公司 | Chinese herbal preparation for treating chronic pharyngitis and preparation method thereof |
| CN104548152A (en) * | 2014-12-23 | 2015-04-29 | 葵花药业集团（重庆）有限公司 | Sterilization method for traditional Chinese medicine preparation |
| CN104548152B (en) * | 2014-12-23 | 2018-08-31 | 葵花药业集团重庆小葵花儿童制药有限公司 | A kind of sterilizing methods of Chinese medicine preparation |
| CN105343503A (en) * | 2015-11-30 | 2016-02-24 | 中国人民解放军第二军医大学 | Medicine composition for treating sphagitis and application thereof |
| CN105343503B (en) * | 2015-11-30 | 2018-10-30 | 中国人民解放军第二军医大学 | A kind of pharmaceutical composition that treating sphagitis and its application |
| CN105902836A (en) * | 2016-06-17 | 2016-08-31 | 济南市儿童医院 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
| CN108066580A (en) * | 2016-11-11 | 2018-05-25 | 许颢瀚 | A kind of lung lavage formula and its device |
| CN114224972A (en) * | 2021-12-10 | 2022-03-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Medicine atomized liquid formula for treating acute and chronic pharyngitis and preparation process thereof |
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| Publication number | Publication date |
|---|---|
| CN1201756C (en) | 2005-05-18 |
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