CN114224972A - Medicine atomized liquid formula for treating acute and chronic pharyngitis and preparation process thereof - Google Patents
Medicine atomized liquid formula for treating acute and chronic pharyngitis and preparation process thereof Download PDFInfo
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 17
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Abstract
The invention relates to a medicine atomized liquid formula for treating acute and chronic pharyngitis and a preparation process thereof, and the medicine atomized liquid formula is prepared from 25-40 parts of honeysuckle, 15-30 parts of tuber fleeceflower stem, 10-40 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange according to a certain proportion. According to the traditional Chinese medicine preparation method, a medicinal material formula with a high-efficiency treatment effect on acute and chronic pharyngitis is screened out through research on traditional Chinese herbal medicines, and the extraction of effective components of the medicinal materials is realized by utilizing a modern preparation process to prepare atomized liquid medicine convenient to absorb. The product has the characteristics of good treatment effect, no toxicity, easily obtained materials, low cost and the like.
Description
Technical Field
The invention relates to a formula of a medicine atomized liquid for treating acute and chronic pharyngitis and a preparation process thereof, belonging to the field of traditional Chinese medicines.
Technical Field
Pharyngitis is inflammation of pharyngeal mucosa, which is divided into acute inflammation and chronic inflammation, acute nasopharyngitis is acute inflammation of the pharyngeal mucosa, submucosa and lymphoid tissue, mainly occurs to pharynx and tonsil, and common symptoms are obvious pharyngeal foreign body sensation, dry itching and pain, and severe symptoms are obvious pharyngeal concave-convex particles, swelling, bleeding and the like. Chronic pharyngitis is the result of upper respiratory tract infection, and is caused by infection of the throat. Pharyngitis frequently occurs in adults, is particularly common in people with low immunity such as frequent smoking, alcoholism and the like, and has the characteristics of long course of disease, easy relapse, stubborn symptoms and difficult cure. The present research shows that pharyngitis is mostly caused by staphylococcus, beta hemolytic streptococcus and virus infection. At present, antibiotics are mainly used for treating pharyngitis, and long-term use of the antibiotics is easy to cause bacteria to generate drug resistance, the use dosage is larger and larger, so that the disease is repeatedly attacked, and the toxic and side effects are increasingly obvious.
Disclosure of Invention
The invention aims to provide a medicine atomized liquid formula for treating acute and chronic pharyngitis.
Yet another object of the present invention is to: provides a preparation process of the medicine atomized liquid formula for treating acute and chronic pharyngitis.
The purpose of the invention is realized by the following scheme: a medicine atomization liquid formula for treating acute and chronic pharyngitis is prepared from 25-40 parts of honeysuckle, 15-30 parts of tuber fleeceflower stem, 10-40 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange.
The invention also provides a preparation process of the medicine atomized liquid formula for treating acute and chronic pharyngitis, which comprises the following steps of extracting volatile oil from three herbs of grassleaf sweelflag rhizome, largehead atractylodes rhizome and immature bitter orange by a steam distillation method, and adding other herb extracts:
firstly, extracting volatile oil from 10-40 parts of grassleaf sweelflag rhizome, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the three medicinal materials are marked as medicine residue 1 and reserved for later use;
mixing and adding 25-40 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 15-30 parts of tuber fleeceflower stem into a container, adding 50% ethanol for soaking, shaking in a dark place under a closed condition of the container for 3 days, filtering, squeezing and squeezing the medicine residues to obtain medicine residues 2;
decocting the residue 1 and residue 2 in water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
The product of the invention has good effect on treating acute and chronic pharyngitis.
According to the invention, through the research on traditional Chinese herbal medicines, a medicinal material formula with a high-efficiency treatment effect on acute and chronic pharyngitis is screened, and the extraction of the effective components of the medicinal materials is realized by utilizing a modern preparation process, so that the atomized liquid medicine convenient to absorb is prepared. The product has the characteristics of good treatment effect, no toxicity, easily obtained materials, low cost and the like.
The product of the invention has the characteristics of good treatment effect, no toxicity, easily obtained materials, lower cost and the like.
Drawings
FIG. 1 is a schematic view of the process.
Detailed Description
Example one
A medicinal atomized liquid for treating acute and chronic pharyngitis is prepared by extracting volatile oil from 3 kinds of herbs including rhizoma Acori Graminei, Atractylodis rhizoma, and fructus Aurantii Immaturus by steam distillation, adding into other herbs extract, and making according to the process shown in figure 1:
taking materials according to the following mixture ratio: taking 25 parts of honeysuckle, 15 parts of tuber fleeceflower stem, 10 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange;
firstly, extracting volatile oil from three medicinal herbs of 10 parts of rhizoma acori graminei, 9 parts of rhizoma atractylodis macrocephalae and 10 parts of immature bitter orange by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the 3 medicinal herbs are marked as medicine residues 1 and reserved for later use;
mixing and adding 6 medicines of 25 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 15 parts of tuber fleeceflower stem into a container, adding 50% ethanol for infiltration, shaking in a dark place under a closed condition of the container for 3 days, then filtering, retaining ethanol extract, squeezing and squeezing dregs of a decoction to obtain dregs of a decoction 2;
decocting the residue 1 and residue 2 in water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
Wherein, the decoction dregs 1 and the decoction dregs 2 are respectively added with water and decocted twice according to the known technology.
Example two
A medicine atomized liquid for treating acute and chronic pharyngitis is prepared by the same steps as example 1 according to the flow shown in figure 1:
taking materials according to the following mixture ratio: taking 30 parts of honeysuckle, 20 parts of tuber fleeceflower stem, 30 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange;
firstly, extracting volatile oil from 30 parts of rhizoma acori graminei, 9 parts of rhizoma atractylodis macrocephalae and 10 parts of immature bitter orange 3 herbs by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the 3 herbs are marked as medicine residues 1 and reserved for later use;
mixing and adding 30 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 20 parts of tuber fleeceflower stem 6 medicines into a container, adding 50% ethanol for infiltration, shaking in a dark place under a closed condition of the container for 3 days, filtering, reserving ethanol extracting solution, squeezing and squeezing dregs to obtain dregs 2;
decocting the residue 1 and residue 2 in water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
EXAMPLE III
A medicine atomized liquid for treating acute and chronic pharyngitis is prepared by the same steps as example 1 according to the flow shown in figure 1:
taking materials according to the following mixture ratio: taking 40 parts of honeysuckle, 30 parts of tuber fleeceflower stem, 40 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange;
firstly, extracting volatile oil from 40 parts of rhizoma acori graminei, 9 parts of rhizoma atractylodis macrocephalae and 10 parts of immature bitter orange 3 herbs by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the 3 herbs are marked as medicine residues 1 and reserved for later use;
mixing 40 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 30 parts of tuber fleeceflower stem 6 medicines, adding the mixture into a container, adding 50% ethanol for infiltration, shaking the container in a dark place under a closed condition for 3 days, filtering, reserving ethanol extracting solution, squeezing and squeezing dregs to dry, and marking as dregs 2;
decocting the residue 1 and residue 2 with water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
Clinical examination
In order to verify the treatment effect of the medicine on pharyngitis, clinical experiments are carried out on the medicine.
Test object
In the clinical trial, 40 patients were outpatients aged 18-60 years, among which women 20 and men 20. The treatment group and the control group were divided by a randomized double-blind method. 10 acute pharyngitis treatment groups and 10 control groups; 10 cases of the chronic pharyngitis treatment group and 10 cases of the control group.
The diagnosis standard of acute pharyngitis is as follows: the oral liquid is suitable for patients with pharyngalgia, dysphagia, dry throat, ardor, general malaise, fever, aversion to cold, soreness of limbs, and anorexia; edema of pharyngeal membranes, congestion of pharyngeal membranes, swelling of cervical lymph nodes, etc., in varying degrees.
The diagnosis standard of chronic pharyngitis is as follows: the oral liquid is taken into patients with symptoms of throat pain and itching, irritable cough and dryness, burning sensation, foreign body sensation and the like with different degrees; there are different degrees of signs of mucosal congestion, water hypertrophy, etc. in the pharynx.
Excluding cases: pharyngeal symptoms or inflammation due to measles, scarlet fever, influenza, agranulocytosis, infectious mononucleosis, leukemia, and the like; pregnant and purposeful pregnant or lactating women; patients with serious primary diseases and mental diseases of heart, liver, kidney and hemopoietic system are combined.
The treatment scheme comprises the following steps:
treatment groups: the medicament is atomized and administered for 3 times a day, and each time is 1.5 mL;
control group: the normal saline is atomized and administered for 3 times every day, and each time is 1.5 mL;
criteria for evaluating therapeutic effects
The acute pharyngitis has the curative effect standard that the symptoms and physical signs are obviously improved within 3 days after the medicine is taken; the medicine has obvious effect, and symptoms and physical signs are obviously improved within 5 days after the medicine is taken; the medicine is effective, and symptoms and physical signs are partially improved within 5 days after the medicine is taken; no effect, no obvious improvement of symptoms and signs within 5 days of medication.
The curative effect standard of chronic pharyngitis is that the chronic pharyngitis is cured, and clinical symptoms and physical signs are obviously improved within 10 days after the chronic pharyngitis is taken; the effect is obvious, and the symptoms and physical signs are obviously improved within 1 month after the medicine is taken; has the advantages of effective treatment, reduced symptoms after administration,
partial improvement of symptoms and signs within 1 month; the medicine is ineffective, the symptoms are slightly reduced or not reduced after the medicine is taken, and the physical signs are not obviously improved.
The curative effect results are compared and shown in tables 1 and 2:
as shown in tables 1 and 2, the clinical effects of the atomized medicament on acute and chronic pharyngitis are observed by clinical observation of a random double-blind method and by taking physiological saline as a control, and the results show that: compared with a normal saline control group, the atomized liquid treatment group of the medicine for treating acute and chronic pharyngitis has obvious difference in curative effect. The cure rate and the significant efficiency of the treatment group are far higher than those of the control group, which shows that the product of the invention has obvious effect on treating acute and chronic pharyngitis.
Claims (5)
1. A medicine atomization liquid formula for treating acute and chronic pharyngitis is characterized in that: the traditional Chinese medicine composition is prepared from 25-40 parts of honeysuckle, 15-30 parts of tuber fleeceflower stem, 10-40 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange.
2. A process for preparing atomized liquid medicine for treating acute and chronic pharyngitis according to claim 1, which comprises the following steps: firstly extracting volatile oil from 3 kinds of herbs including grassleaf sweelflag rhizome, largehead atractylodes rhizome and immature bitter orange by a steam distillation method, and then adding other herb extracts, comprising the following steps:
firstly, extracting volatile oil from 10-40 parts of grassleaf sweelflag rhizome, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the three medicinal materials are marked as medicine residue 1 and reserved for later use;
mixing and adding 25-40 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 15-30 parts of tuber fleeceflower stem into a container, adding 50% ethanol for soaking, shaking in a dark place under a closed condition of the container for 3 days, filtering, squeezing and squeezing the medicine residues to obtain medicine residues 2;
decocting the residue 1 and residue 2 in water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
3. The process for preparing atomized liquid medicine for treating acute and chronic pharyngitis according to claim 2, wherein the atomized liquid medicine comprises the following components: the preparation method comprises the following steps:
taking materials according to the following mixture ratio: taking 25 parts of honeysuckle, 15 parts of tuber fleeceflower stem, 10 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange;
firstly, extracting volatile oil from three medicinal herbs of 10 parts of rhizoma acori graminei, 9 parts of rhizoma atractylodis macrocephalae and 10 parts of immature bitter orange by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the 3 medicinal herbs are marked as medicine residues 1 and reserved for later use;
mixing and adding 6 medicines of 25 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 15 parts of tuber fleeceflower stem into a container, adding 50% ethanol for infiltration, shaking in a dark place under a closed condition of the container for 3 days, then filtering, retaining ethanol extract, squeezing and squeezing dregs of a decoction to obtain dregs of a decoction 2;
decocting the residue 1 and residue 2 in water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
4. The process for preparing atomized liquid medicine for treating acute and chronic pharyngitis according to claim 2, wherein the atomized liquid medicine comprises the following components: the preparation method comprises the following steps:
taking materials according to the following mixture ratio: taking 30 parts of honeysuckle, 20 parts of tuber fleeceflower stem, 30 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange;
firstly, extracting volatile oil from 30 parts of rhizoma acori graminei, 9 parts of rhizoma atractylodis macrocephalae and 10 parts of immature bitter orange 3 herbs by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the 3 herbs are marked as medicine residues 1 and reserved for later use;
mixing and adding 30 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 20 parts of tuber fleeceflower stem 6 medicines into a container, adding 50% ethanol for infiltration, shaking in a dark place under a closed condition of the container for 3 days, filtering, reserving ethanol extracting solution, squeezing and squeezing dregs to obtain dregs 2;
decocting the residue 1 and residue 2 in water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
5. The process for preparing atomized liquid medicine for treating acute and chronic pharyngitis according to claim 2, wherein the atomized liquid medicine comprises the following components: the preparation method comprises the following steps:
taking materials according to the following mixture ratio: taking 40 parts of honeysuckle, 30 parts of tuber fleeceflower stem, 40 parts of grassleaf sweelflag rhizome, 30 parts of dwarf lilyturf tuber, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum, 9 parts of largehead atractylodes rhizome and 10 parts of immature bitter orange;
firstly, extracting volatile oil from 40 parts of rhizoma acori graminei, 9 parts of rhizoma atractylodis macrocephalae and 10 parts of immature bitter orange 3 herbs by a steam distillation method, wherein the obtained volatile oil is reserved, and residues of the 3 herbs are marked as medicine residues 1 and reserved for later use;
mixing 40 parts of honeysuckle, 30 parts of radix ophiopogonis, 25 parts of adenophora stricta, 15 parts of liquorice, 10 parts of chrysanthemum and 30 parts of tuber fleeceflower stem 6 medicines, adding the mixture into a container, adding 50% ethanol for infiltration, shaking the container in a dark place under a closed condition for 3 days, filtering, reserving ethanol extracting solution, squeezing and squeezing dregs to dry, and marking as dregs 2;
decocting the residue 1 and residue 2 with water twice for 15 min and 10 min respectively, mixing decoctions, standing, cooling, slowly adding ethanol extractive solution under stirring, filtering to remove residue, adding water and volatile oil into the filtrate, bottling, sealing, and sterilizing at 115 deg.C for 30 min to obtain atomized liquid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429578A (en) * | 2001-12-30 | 2003-07-16 | 济南市儿童医院 | Medicinal atomization liquid for treating pharyngitis and its manufacturing process |
| CN1813929A (en) * | 2002-11-22 | 2006-08-09 | 四川大学华西医院 | New use of tuber fleece flower stem |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429578A (en) * | 2001-12-30 | 2003-07-16 | 济南市儿童医院 | Medicinal atomization liquid for treating pharyngitis and its manufacturing process |
| CN1813929A (en) * | 2002-11-22 | 2006-08-09 | 四川大学华西医院 | New use of tuber fleece flower stem |
Non-Patent Citations (1)
| Title |
|---|
| 潘晓鸥等: "咽炎颗粒的提取工艺研究及对急性咽炎的临床观察", 《华西医学》 * |
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