CN1204903C - Gastropathy treating chinese medicine and its prepn. - Google Patents
Gastropathy treating chinese medicine and its prepn. Download PDFInfo
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- CN1204903C CN1204903C CN 01119486 CN01119486A CN1204903C CN 1204903 C CN1204903 C CN 1204903C CN 01119486 CN01119486 CN 01119486 CN 01119486 A CN01119486 A CN 01119486A CN 1204903 C CN1204903 C CN 1204903C
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Abstract
The present invention relates to gastropathy treating Chinese medicine and a preparing technology thereof, particularly to traditional Chinese medicine for bile reflux gastritis and non-ulcer dyspepsia and a preparing technology thereof, which is basically composed of the components of the following parts by weight: 500 to 600 parts of bupleurum root, 500 to 600 parts of immature orange fruit, 500 to 600 parts of common aucklandia root, 500 to 600 parts of dried tangerine peel, 520 to 580 parts of prepared rhizoma pinellize without adju-vant, 800 to 850 parts of dandelion, 500 to 600 parts of scorch-fry hawthorn, 300 to 360 parts of charred areca seed, 500 to 600 parts of paederia, 300 to 400 parts of dangshen, 300 to 400 parts of corydalis tuber and 500 to 600 parts of fry medicated leaven. Traditional Chinese medical materials adopted by the present invention are all varieties collected by China pharmacopoeia. According to clinical tests, when the gastropathy treating Chinese medicine is used for bile reflux gastritis (20 examples), 7 examples (35%) clinically recover, the gastropathy treating Chinese medicine has effect on 6 examples (30%), and the total effective rate of the gastropathy treating Chinese medicine is (18/20) 90%. When the gastropathy treating Chinese medicine is used for non-ulcer dyspepsia (16 examples), 7 examples (43.8%) recover, the gastropathy treating Chinese medicine has effect on 6 examples (37.5%), the total effective rate of the gastropathy treating Chinese medicine is (15/16) 93%, and the gastropathy treating Chinese medicine has no obviously adverse reaction in a treating period. According to animal tests, the present invention has no obviously toxic reaction, and the present invention is authorized as traditional Chinese medicine three type new medicine for the clinical tests.
Description
The present invention relates to a kind of Chinese medicine and preparation technology thereof who treats gastropathy, particularly a kind of Chinese medicine and preparation technology thereof who is adapted to bile reflux gastritis, non-ucler dyspepsia.
Liver controlling conveyance and dispersion, stomach receiving food and drink.The irritability catharsis is transferred and to be reached then gastric qi and fall, and the development of evil in febrile disease is normal, comes in and goes out in order, makes it to be received digesting food and the gas of the turbid descending the moon.Stomach happiness tonneau and dislike to stop up and stagnate, with logical be usefulness, suitable to reduce to.Do not fall then and to stagnate, not normal then heap soil or fertilizer over and around the roots of the development of evil in febrile disease stagnates disease.So Ye Tianshi says: " stomach should fall then with ".Have only the happy logical property of falling that keeps stomach, just can play it and be received the merit of becoming thoroughly decomposed.
If it is angry to be worried, feelings will is not smooth, depression of liver-QI, and perverse and unreasonable manner is violated stomach; Or the pathogenic factor visitor is obstructed the mechanism of qi of liver in Liver Channel, and venation is not smooth, involves taste; Or food and drink is excessive, injures the liver stomach; Cause the liver failing to maintain the normal flow of QI to transfer soothing the liver, stomach loses the merit that profit is fallen row, and syndrome of stagnation of QI is just given birth to thereupon.
Costa sternales is the dividing line of liver, stagnation of QI impairing the liver, and transverse invasion of hyperactive liver-QI connects and the stomach internal organs, and depression and stagnation of QI then occurs uncomfortable in chest, breast gastral cavity side of body rib distension, very then pain.Stomach-QI being unable to descend normally, the QI rising in reverse order upper punch is so see that dim hiccup due to disorder of QI is contrary, regurgitation is noisy, nausea and vomiting.The stomach failing to send downwards, conduction mistake department, reservoir of food and drink is stopped up long-pending not all right, then be difficult to be received, thus poor appetite, loss of appetite, very then the eating accumulation hollow heart is made acid, and seeing dim rotten acid regurgitation, heat-transformation person not as yet at the beginning of the stagnation of QI food stagnation sees that then tongue is white, strongly fragrant heat-transformation person of a specified duration, then see yellow fur, greasy fur is resembling of food stagnation, and stringy pulse is the disease of the stagnation of QI or pain.
Do not retrieve the Chinese medicine that above-mentioned pathogenesis is had good therapeutic effect and has no side effect in the prior art.
The object of the present invention is to provide a kind ofly has good therapeutic effect and Chinese medicine that has no side effect and preparation technology thereof to above-mentioned gastropathy.
For achieving the above object, the present invention adopts following technical scheme: it is made up of the component of following parts by weight basically:
Radix Bupleuri 500～600 Fructus Aurantii Immaturuss 500～600 Radix Aucklandiae 500～600
Pericarpium Citri Reticulatae 500～600 Rhizoma Pinelliae 520～580 Herba Taraxacis 800～850
Fructus Crataegi (parching to brown) 500～600 Semen Arecae Preparetas 300～360 fevervines 500～600
Radix Codonopsis 300～400 Rhizoma Corydalis, 300～400 Massa Medicata Fermentatas (stir-fry) 500～600.
The preparation technology of Chinese medicine of the present invention is: Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Aucklandiae, Pericarpium Citri Reticulatae extracts volatile oil, volatile oil is stuck with paste enclose with β one ring, aqueous solution after distillation device is in addition collected, all the other eight flavor components such as medicinal residues and Rhizoma Pinelliae merge, decoct with water secondary, each 2 hours, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, be evaporated to about 1.10 (50 ℃) of relative density, add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filter, filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add right amount of auxiliary materials, fully mixing, make granule with 65% alcoholic solution, drying with above-mentioned volatile oil beta one cyclodextrin clathrate mix homogeneously, promptly gets granule, adopt common process, it can advance to make tablet, capsule, oral liquid, syrup, dispersible tablet, buccal tablet, effervescent tablet, pill etc.
First-selected Radix Bupleuri and Fructus Aurantii Immaturus are monarch in the side.
Radix Bupleuri nature and flavor hardship, flat is gone into percardium, liver, three warmers, gallbladder meridian.Can gently rise clearly diffusing, again can catharsis, have the soothing liver-QI for relieving depression heat clearing away, the stagnate function of gas of regulating gastointestinal is the key medicine for the treatment of the liver stagnation of QI knot.
Fructus Aurantii Immaturus nature and flavor hardship is slightly cold, and goes into the taste warp, and the dispelling the stagnated QI removing food stagnancy is arranged, and rushes down the function that expectorant removes painful abdominal mass.Be used for diet and do not disappear, gastrointestinal retention, distension and fullness in the abdomen, the costa sternales feeling of fullness, the not smooth all diseases of dysentery are let out in the stomachache constipation.
Radix Bupleuri, Fructus Aurantii Immaturus are monarch drug altogether, and one liver, and one at stomach.One focuses on liver-smoothing, qi-regulating, and one focuses on that stomach function regulating is capable to stagnate, and two medicines and usefulness have the function of regulating qi-flowing for activating stagnancy, regulating the stomach and sending down the abnormal ascending QI, and abdominal distention due to the stagnation of liver-QI and stomach-QI is had effect greatly.
The Radix Aucklandiae, Rhizoma Pinelliae, Pericarpium Citri Reticulatae are ministerial drug altogether.
Radix Aucklandiae nature and flavor suffering, hardship, temperature are gone into spleen, large intestine channel, the pain relieving of merit benefaction gas.Be used for stagnation of QI in spleen and stomach, diseases such as abdominal distention, all pains of all stagnation of QIs all available it.Radix Aucklandiae fragrant odour, the promoting the circulation of QI to relieve pain effect is rather good, and the cooperation monarch drug of herein using is with controlling side of body rib distension and fullness in the abdomen pain.
Rhizoma Pinelliae suffering, temperature are gone into the taste warp.Merit is apt to dissolving lump and resolving mass, stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm.Be used for disorder of stomach-QI, breast gastral cavity painful abdominal mass is vexed, and vomiting and nausea etc. have better regulating the stomach and sending down the adverse rising QI to arrest nausea function.
Pericarpium Citri Reticulatae suffering, hardship, temperature are gone into spleen, lung meridian.Merit is apt to regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for stagnation of QI in spleen and stomach, distension and fullness in the abdomen, nausea and vomiting, dyspepsia etc.
More than three medicines work in coordination, have the circulation of qi promoting painful abdominal mass that disappears, the merit of normalizing the stomach by guiding QI downward, auxiliary monarch drug regulate the flow of vital energy smooth in and be ministerial drug altogether.
Herba Taraxaci, Massa Medicata Fermentata (stir-fry), Semen Arecae Prepareta, Fructus Crataegi (parching to brown), fevervine, Radix Codonopsis, the unit adjuvant drug of acting like a bully.
Herba Taraxaci, nature and flavor hardship, sweet, cold is gone into liver stomach warp.Merit is apt to heat-clearing and toxic substances removing, is the good medicine for the treatment of the liver peratodynia.Soothing liver-QI for relieving depression is arranged, the effect of heat clearing away spleen invigorating.
Massa Medicata Fermentata (stir-fry) nature and flavor are sweet, hot, temperature.Go into spleen, stomach warp.The stomach function regulating that helps digestion is used for accumulation of food in the stomach and intes tine due to indigestion, the vexed abdominal distention of gastral cavity, dyspepsia and disease such as have loose bowels.
Semen Arecae Prepareta nature and flavor suffering, hardship, temperature.Go into stomach, large intestine channel.Be good at the circulation of qi promoting removing food stagnancy, be used for the food stagnation flow of QI being obstructed, abdominal distention, the not well disease of waiting of defecating.
The acid of Fructus Crataegi (parching to brown) nature and flavor, sweet, tepor.Go into spleen, stomach, Liver Channel.Merit is apt to promoting digestion and removing stagnation, and dissipating blood stasis is capable general, helps spleen and is good for the stomach, and the merit of facilitating digestion is used for food stagnation and stagnates, and greasy meat is long-pending, diseases such as stomachache diarrhea.
The fevervine nature and flavor are sweet, sour, and are flat.Invigorate blood circulation, dissipating blood stasis, pain relieving, help digestion and lead the stasis of blood, dehumidifying detumescence, detoxifcation.Be used for epigastric pain, diseases such as lack of appetite diarrhoea dysentery.
More than five medicines help monarch-minister drug to help spleen to be good for the stomach altogether, help fortune smooth in.
Rhizoma Corydalis nature and flavor suffering, hardship, temperature.Go into spleen, Liver Channel.Merit is kind invigorates blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving, all pains of breast abdomen that all qi depressions to blood stasis cause all can be used.Especially the gastral cavilty hypochondriac pain is the most suitable.
The Radix Codonopsis nature and flavor are sweet, and are flat.Go into spleen, lung meridian, invigorating the spleen and replenishing QI.Be used for weakness of the spleen and stomach, deficiency of vital energy deficiency, insufficiency of the spleen lack of appetite, diseases such as fatigue and weakness.
The assertive evidence stagnation of liver-QI and stomach-QI, fullness in the epigastrium and abdomen does not disappear, and how the agent of right circulation of qi promoting food stagnation removing with probably hindering healthy energy, so protect QI of the spleen and stomach admittedly with a small amount of Radix Codonopsis, reaching the eliminating evil healthy energy of taking into account, do not hinder just purpose and get rid of evils.Above seven flavor medicine helps the monarch-minister drug relaxing liver and strengthening stomach altogether, and promoting the circulation of QI to relieve pain are held concurrently and set upright to invigorate blood circulation, and helps for assistant altogether.
Chinese crude drug of the present invention is the kind that Chinese Pharmacopoeia is collected.Through clinical trial, be used for bile reflux gastritis (20 example) clinical recovery 7 examples (35%), produce effects 6 examples (30%), total effective rate (18/20) 90%; Non-ucler dyspepsia (16 example) recovery from illness 7 examples (43.8%), produce effects 6 examples (37.5%), total effective rate (15/16) 93% is not seen obvious adverse reaction during the treatment.The present invention is through animal experiment, and no overt toxicity reaction has gone through to be used for clinical trial as Chinese medicine three kind new medicines.
With embodiment the present invention is done further auspicious stating below:
Embodiment 1, each amounts of components are: Radix Bupleuri 550g, Fructus Aurantii Immaturus 550g, Radix Aucklandiae 550g, Pericarpium Citri Reticulatae 550g, Rhizoma Pinelliae 550g, Herba Taraxaci 825g, Fructus Crataegi (parching to brown) 550g, Semen Arecae Prepareta 330g, fevervine 550g, Radix Codonopsis 330g, Rhizoma Corydalis 330g, Massa Medicata Fermentata (stir-fry) 550g.Above-mentioned Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Aucklandiae, Pericarpium Citri Reticulatae extracts volatile oil, volatile oil is stuck with paste enclose with β one ring, aqueous solution after distillation device is in addition collected, all the other eight flavors such as medicinal residues and Rhizoma Pinelliae decoct with water secondary, each 2 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and are evaporated to about 1.10 (50 ℃) of relative density, add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, and filtered filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add right amount of auxiliary materials such as steviosin and dextrin, fully mixing is made granule with 65% alcoholic solution, dry, with above-mentioned volatile oil beta one cyclodextrin clathrate mix homogeneously, make 1000g, promptly get granule.
Embodiment 2, each amounts of components are: Radix Bupleuri 500g, Fructus Aurantii Immaturus 500g, Radix Aucklandiae 500g, Pericarpium Citri Reticulatae 500g, Rhizoma Pinelliae 520g, Herba Taraxaci 850g, Fructus Crataegi (parching to brown) 600g, Semen Arecae Prepareta 360g, fevervine 600g, Radix Codonopsis 400g, Rhizoma Corydalis 400g, Massa Medicata Fermentata (stir-fry) 550g.Above-mentioned Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Aucklandiae, Pericarpium Citri Reticulatae extracts volatile oil, volatile oil is stuck with paste enclose with β one ring, and the aqueous solution after distillation device is in addition collected, all the other eight flavors such as medicinal residues and Rhizoma Pinelliae, decoct with water secondary, each 2 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, be evaporated to about 1.10 (50 ℃) of relative density, add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filter, filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add right amount of auxiliary materials such as steviosin and dextrin, abundant mixing, make granule with 65% alcoholic solution, drying is with above-mentioned volatile oil beta one cyclodextrin clathrate mix homogeneously, make 1000g, promptly get granule, adopt common process, above-mentioned granule can be made tablet.
Embodiment 3, each amounts of components are: Radix Bupleuri 600g, Fructus Aurantii Immaturus 600g, Radix Aucklandiae 600g, Pericarpium Citri Reticulatae 600g, Rhizoma Pinelliae 600g, Herba Taraxaci 800g, Fructus Crataegi (parching to brown) 500g, Semen Arecae Prepareta 300g, fevervine 500g, Radix Codonopsis 300g, Rhizoma Corydalis 300g, Massa Medicata Fermentata (stir-fry) 600g.Above-mentioned Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Aucklandiae, Pericarpium Citri Reticulatae extracts volatile oil, volatile oil is stuck with paste enclose with β one ring, and the aqueous solution after distillation device is in addition collected, all the other eight flavors such as medicinal residues and Rhizoma Pinelliae, decoct with water secondary, each 2 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, be evaporated to about 1.10 (50 ℃) of relative density, add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filter, filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add right amount of auxiliary materials such as steviosin and dextrin, abundant mixing, make granule with 65% alcoholic solution, drying is with above-mentioned volatile oil beta one cyclodextrin clathrate mix homogeneously, make 1000g, promptly get granule, adopt common process, above-mentioned granule can be made capsule.
Embodiment 4, each amounts of components are: Radix Bupleuri 580g, Fructus Aurantii Immaturus 530g, Radix Aucklandiae 570g, Pericarpium Citri Reticulatae 520g, Rhizoma Pinelliae 540g, Herba Taraxaci 825g, Fructus Crataegi (parching to brown) 545g, Semen Arecae Prepareta 315g, fevervine 590g, Radix Codonopsis 380g, Rhizoma Corydalis 360g, Massa Medicata Fermentata (stir-fry) 520g.Above-mentioned Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Aucklandiae, Pericarpium Citri Reticulatae extracts volatile oil, volatile oil is stuck with paste enclose with β one ring, and the aqueous solution after distillation device is in addition collected, all the other eight flavors such as medicinal residues and Rhizoma Pinelliae, decoct with water secondary, each 2 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, be evaporated to about 1.10 (50 ℃) of relative density, add ethanol and make that to contain alcohol amount be 65%, left standstill 24 hours, filter, filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add right amount of auxiliary materials such as steviosin and dextrin, abundant mixing, make granule with 65% alcoholic solution, drying is with above-mentioned volatile oil beta one cyclodextrin clathrate mix homogeneously, make 1000g, promptly get granule, adopt common process, above-mentioned granule can be made pill.
Claims (3)
1, a kind of Chinese medicine for the treatment of gastropathy is characterized in that it is made by following parts by weight proportion raw material:
Radix Bupleuri 500～600 Fructus Aurantii Immaturuss 500～600 Radix Aucklandiae 500～600
Pericarpium Citri Reticulatae 500～600 Rhizoma Pinelliae 520～580 Herba Taraxacis 800～850
Fructus Crataegi parching to brown 500～600 Semen Arecae Preparetas 300～360 fevervines 500～600
Radix Codonopsis 300～400 Rhizoma Corydalis 300～400 Massa Medicata Fermentatas fry 500～600.
2, the Chinese medicine of treatment gastropathy according to claim 1 is characterized in that: it is granule, tablet, capsule, oral liquid, syrup, dispersible tablet, buccal tablet, effervescent tablet, pill.
3, the preparation technology of the Chinese medicine of the described treatment gastropathy of a kind of claim 1, it is characterized in that: Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Aucklandiae, Pericarpium Citri Reticulatae extracts volatile oil, the volatile oil beta-cyclodextrin inclusion compound, aqueous solution after distillation device is in addition collected medicinal residues and Rhizoma Pinelliae, Herba Taraxaci, the Fructus Crataegi parching to brown, Semen Arecae Prepareta, fevervine, Radix Codonopsis, Rhizoma Corydalis, Massa Medicata Fermentata is fried and is merged, and decocts with water secondary, each 2 hours, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, be evaporated to about 1.10 (50 ℃) of relative density, adding ethanol, to make content be 65%, left standstill 24 hours, filters, filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add adjuvant, mixing, make granule with 65% alcoholic solution, drying is with above-mentioned volatile oil beta cyclodextrin inclusion complex mix homogeneously, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01119486 CN1204903C (en) | 2001-06-06 | 2001-06-06 | Gastropathy treating chinese medicine and its prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01119486 CN1204903C (en) | 2001-06-06 | 2001-06-06 | Gastropathy treating chinese medicine and its prepn. |
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| Publication Number | Publication Date |
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| CN1389230A CN1389230A (en) | 2003-01-08 |
| CN1204903C true CN1204903C (en) | 2005-06-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01119486 Expired - Lifetime CN1204903C (en) | 2001-06-06 | 2001-06-06 | Gastropathy treating chinese medicine and its prepn. |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224293B (en) * | 2007-11-28 | 2010-08-25 | 王科先 | Medicine for treating cholecystitis and superficial gastritis |
| CN103127339A (en) * | 2011-12-05 | 2013-06-05 | 姚树坤 | Drug composition for curing functional dyspepsia and bile reflux gastritis |
| CN103417786A (en) * | 2013-01-28 | 2013-12-04 | 成都中医药大学 | Semen arecae prepareta extractive capable of promoting gastrointestinal motility and preparing method thereof |
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2001
- 2001-06-06 CN CN 01119486 patent/CN1204903C/en not_active Expired - Lifetime
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Assignee: Nanchang Helioeast Pharmaceutical Co., Ltd. Assignor: Hongyi Science and Technology Co., Ltd., Nanchang Contract fulfillment period: 2009.1.20 to 2021.1.20 Contract record no.: 2009360000014 Denomination of invention: Gastropathy treating chinese medicine and its prepn. Granted publication date: 20050608 License type: Exclusive license Record date: 20090318 |
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