CN1274327C - Nose drops agent for treating common cold and its preparation method - Google Patents

Abstract

The present invention relates to a medicine composition for preventing and curing common cold, particularly to an external medicine composition which uses vegetal Chinese herbal medicines as raw materials and is used for preventing and curing common cold, and a preparation method of the external medicine composition. The nose drop of each 1000 ml comprises the following raw material medicines with the weight proportioning: 20 to 50g of giant knotweed, 20 to 40g of radix trichosanthis, 15 to 30g of rhizoma polystichi, and 30 to 80g of Chinese ephedra; the nose drop can also comprises 20 to 40g of tree peony bark, 10 to 30g of magnolia flowers, 15 to 30g of centipeda, 15 to 30g of herba houttuyniae, and 10 to 20g of radix scutellariae. The preparation method of the present invention comprises the following steps: the raw material medicines are taken and soaked in alcohol solution with the concentration of 40 to 70% for 24 to 72 hours (containing a percolation method) under the ordinary temperature; medicine dregs are filtered off, and the clear solution is taken to be statically placed for more than 12 hours; the clear solution is taken and filtered, the alcohol is recovered, and then, the medicine solution with lower than 20% of crude medicine is formed by preparation of the distilled water.

Description

The nasal drop and the preparation method of treatment flu

Technical field

The present invention relates to a kind of anti-pharmaceutical composition that cures cold, particularly relating to a kind of is anti-externally-applied medicinal composition that cures cold that raw material is made and preparation method thereof with the vegetable Chinese herbal medicine.

Background technology

Flu is to invade the disease that nasal cavity causes by multiple common cold virus, behind the poisoning intrusion nasal cavity, how on nasal mucosa, to grow, seldom down invade pharyngeal, clinical manifestation is diseases such as unexpected nose discomfort, nasal obstruction, snivel, sneeze or dry pharynx, headache, dry cough, is commonly called as cold.Endo-medicine decoction inconvenience, patent medicine often effect is not good enough, because of medicine by little intestinal absorption, behind liver, reenter blood circulation and be dissolved in about 6000 milliliters of blood, the drug level that arrives the nose mucosa after disperseing is too little, so DeGrain.From the direct administration of nasal cavity, medicine directly contacts with nasal mucosa, guarantees can to suppress and kill pathogenic bacteria, antibacterial on the mucosa rapidly by drug level, alleviates and eliminates cold symptoms, reaches prevention, treats the purpose of catching a cold.

Chinese patent CN1099644A (patent No. 941042332) discloses a kind of " Wenxianglu smell medicinal liquid for curing cold ", and its invention relates to a kind of middle medicament for flu patient nose news.Its constituent is that ethanol, Herba Menthae, the Radix Aucklandiae, Camphora, Folium eucalypti globueli (Eucalyptus globulus Labill.), TUCHENXIANG, winter daphne grass, Borneolum Syntheticum, this product form through refining refinement, but the patient that generally catches a cold hears mitigation symptoms through inhaling.Chinese patent CN1080545A (patent No. 931179653) discloses a kind of " nose liniment and preparation technology thereof ", and its prescription is made up of ten Six-element Chinese medicines such as Bulbus Allii, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Puerariaes.Preparation method is that medical material is cleaned, and sterilization through diafiltration, enzymolysis, mixing, adds Mel and forms through cryoconcentration in medicinal liquid.

Summary of the invention

It is the nasal drop and preparation method thereof of the treatment flu made of raw material by vegetable Chinese herbal medicine that purpose of the present invention is intended to provide a kind of.

Mainly contain following raw materials by weight proportions in the every 1000ml nasal drop of nasal drop of treatment flu of the present invention; Rhizoma Polygoni Cuspidati 20-50g, Radix Trichosanthis 20-40g, Rhizoma Osmundae 15-30g, Herba Ephedrae 30-80g.

Also can contain Cortex Moutan 20-40g, Flos Magnoliae 10-30g, Herba Centipedae 15-30g, Herba Houttuyniae 15-30g, Radix Scutellariae 10-20g in the above-mentioned nasal drop.

Medicament of the present invention is the external nasal drop, also can be nasal spray.Route of administration is for directly dripping (spray) nasal administration from nasal cavity.Usage and dosage is: directly drip (spray) and go into nasal cavity, face upward head or hands and pinch and rubbed the wing of nose (nose cheek) about 2-3 minute, 0.3-0.5 milliliter at every turn, every day several.

The preparation method of the nasal drop of treatment flu of the present invention is:

One, gets crude drug in room temperature following alcohol solution dipping 24-72 hour (containing percolation) with 40-70%;

Two, the elimination medicinal residues are got clear liquid, leave standstill more than 12 hours;

Three, get clear liquid, filter, reclaim ethanol, contain the medicinal liquid of crude drug below 20% with the distilled water furnishing.

In above-mentioned steps (three), also can add an amount of medicinal sodium chloride etc. and ooze, also can add a small amount of antiseptic etc.

Pharmaceutical composition of the present invention has no side effect through the toxicity test proof; Have dispelling wind to relieve the exterior syndrome, sensible antidotal function; Diseases such as the anti-ailment said due to cold or exposure invasion that cures cold, elimination nasal obstruction, snivel, sneeze, cough, headache, dry pharynx; Doublely control diseases such as acute nose membrane phlegmasia, allergic rhinitis, sinusitis.

Through pharmacodynamic study and clinical trial, have effects such as significant treatment nasal obstruction, sneeze, watery nasal discharge, headache, pharyngalgia, cough, prevention or treatment have some inkling of a cold, and the effect of treatment rhinitis is promptly arranged.

Pharmacodynamics test:

Suppress the virus test: rhinovirus, coronavirus, influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, Coxsackie virus, Echovirus are had inhibitory action.

Bacteriostatic test: mainly gold-coloured staphylococci, Hemolytic streptococcus are had bacteriostasis.

Suppress the test of nasal mucosa secretions; This product has the thin blood vessel function of the vibrissa of contraction, thereby secretion inhibitor and improvement nasal obstruction increase ventilation.

Clinical trial: to courses of disease such as nasal obstruction, watery nasal discharge, sneeze and dry pharynx, cough, headaches in 252 examples of the patient more than two days, drip (spray) nose with this product, each 0.3～0.5ml, four times a day, total effective rate is 94～98%, produce effects is more than 82～86.5%, and very fast controlling symptoms after the medication does not advance it.

The specific embodiment

Embodiment 1:

Get Rhizoma Polygoni Cuspidati 30g, Radix Trichosanthis 30g, Rhizoma Osmundae 30g, Herba Ephedrae 60g, it is ground into coarse powder, the alcohol solution dipping with 50% 72 hours, elimination medicinal residues, get clear liquid, leave standstill more than 12 hours, get clear liquid, filter, reclaim ethanol, contain the 1000ml medicinal liquid, filtration, packing, promptly with the distilled water furnishing.

Embodiment 2:

Get Rhizoma Polygoni Cuspidati 30g, Radix Trichosanthis 30g, Rhizoma Osmundae 20g, Herba Ephedrae 40g, Flos Magnoliae 20g, Herba Centipedae 20g, the alcoholic solution with 40% is made according to the method described above and is contained the 1000ml medicinal liquid, filtration, packing, promptly.

Embodiment 3:

Get Rhizoma Polygoni Cuspidati 50g, Radix Trichosanthis 20g, Rhizoma Osmundae 15g, Herba Ephedrae 70g, Cortex Moutan 20g, the alcoholic solution with 60% is made according to the method described above and is contained the 1000ml medicinal liquid, filtration, packing, promptly.

Claims (7)

1, a kind of nasal drop for the treatment of flu is characterized in that every 1000ml nasal drop made by following materials of weight proportions medicine: Rhizoma Polygoni Cuspidati 20-50g, Radix Trichosanthis 20-40g, Rhizoma Osmundae 15-30g, Herba Ephedrae 30-80g.

2, according to the nasal drop of the described treatment flu of claim 1, it is characterized in that also adding Flos Magnoliae 10-30g.

3, according to the nasal drop of the described treatment flu of claim 1, it is characterized in that also adding Herba Centipedae 15-30g.

4, according to the nasal drop of the described treatment flu of claim 1, it is characterized in that also adding Herba Houttuyniae 15-30g.

5, according to the nasal drop of the described treatment flu of claim 1, it is characterized in that also adding Radix Scutellariae 10-20g.

6, according to the nasal drop of the described treatment flu of claim 1, it is characterized in that also adding Cortex Moutan 20-40g.

7,, it is characterized in that preparation process is according to the preparation method of the described nasal drop of claim 1-6:

One, gets crude drug alcohol solution dipping 24-72 hour with 40-70% under room temperature;

Two, the elimination medicinal residues are got clear liquid, leave standstill more than 12 hours;

Three, get clear liquid, filter, reclaim ethanol, contain the medicinal liquid of crude drug below 20% with the distilled water furnishing.