CN1706446A

CN1706446A - Cold treating injection of mulberry leaf and ginger and its prepn process

Info

Publication number: CN1706446A
Application number: CN 200510020797
Authority: CN
Inventors: 耿福能
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-04-27
Filing date: 2005-04-27
Publication date: 2005-12-14

Abstract

The cold treating injection is prepared with mulberry leaf, chrysanthemum, perilla, forsythia, almond and dried ginger, and through decoction, alcohol extraction, filtering and other steps. It is deep brown clear liquid and packed in 2 ml ampoules. With the functions of dispelling wind, clearing away heat, eliminating phlegm and relieving cough, the cold treating injection is used in treating cold with cough, headache and pain throat. The injection acts through blood circulation without first pass effect, thus has high and fast effect, no toxic side effect, mild medicine property, and is especially suitable for the patient with delicate constitution and old patient.

Description

Mulberry leaf-ginger common cold injection and preparation method thereof

Technical field:

The invention belongs to injection of Chinese medicine preparation treatment flu and preparation method thereof.

Background technology:

Flu is a kind of commonly encountered diseases, frequently-occurring disease, its cardinal symptom is headache, fever, cough, nasal obstruction, laryngopharynx swelling and pain etc., allow the people not feel well, though flu is a kind of commonly encountered diseases, but it gives the influence of people's work and life is very big, and the patient who has causes life danger in case flu also can cause complication, therefore, the Chinese medicine and western medicine of treatment flu is all many, wherein the mulberry leaf-ginger common cold ball of Chinese medicine, sheet is exactly a kind of Chinese patent medicine of classics, a main diffusing wind heat clearing away, effects such as expelling phlegm for arresting cough, be used for the treatment of general flu, cough, headache, laryngopharynx swelling and pain, this traditional Chinese medicine is oral, because it will digest by the intestines and stomach, liver absorbs and just can take effect, so absorb inentirely, bioavailability is not high, and the curative effect performance is slowly so need to improve.

Summary of the invention:

The purpose of this invention is to provide a kind of blood circulation that passes through, avoid first pass effect, mulberry leaf-ginger common cold injection that curative effect is faster and better and preparation method thereof.

Medicine of the present invention is made up of the Chinese medicine (weight portion) of following proportioning:

Folium Mori 100～200 Flos Chrysanthemis 10～40 Folium Perillaes 50～100

Fructus Forsythiae 50～100 Semen Armeniacae Amarums 50～100 Rhizoma Zingiberiss 30～70

The best proportioning following (weight portion) of medicine of the present invention

Folium Mori 150 Flos Chrysanthemis 20 Folium Perillaes 80 Fructus Forsythiaes 80 Semen Armeniacae Amarums 80 Rhizoma Zingiberiss 50

Manufacture method of the present invention is as follows:

1, get the raw materials ready: 6 kinds of Chinese medicines by best proportioning are that unit prepares with the gram, clean standby;

2, decoct: decoct water extraordinarily for the first time, decocted mistake 2 hours by the 8-10 of drug weight

Filter, medicine juice is placed stand-by on one side;

Decoct for the second time, the medicinal residues that last time decocted are added 8 times decocting again boil 1 little

The time, the filter and remove residue medicine juice is placed stand-by on one side;

Decoct for the third time, decocting and concentrating again after the medicine juice of preceding twice decoction is merged,

Extractum 100ml;

3, purify: in extractum, add straight alcohol, make solution contain concentration of alcohol and reach 60% and leave standstill 12～24

Hour, filter and remove residue; Again solution is contained concentration of alcohol bring up to 70% leave standstill 12～

24 hours, behind the filter and remove residue, for the third time the ethanol content of solution is brought up to 80

% leaves standstill filtration in 12～24 hours, removes slag, and gets high-purity after the recovery Ethanol Treatment

Extractum;

4, preparation injection: high-purity extractum is added water 300～500ml dissolving boiled 10 minutes,

It is an amount of to add activated carbon, filters, and adds water again to 900ml, adds the benzene first

Alcohol 10ml adjusts PH=7.5, reuse with 4% sodium hydroxide solution

Sodium chloride transfers to etc. to ooze and left standstill 48 hours, filters, and adds the poly-mountain of 3ml

Pear ester 80 boils, filters to add the injection water to 1000ml, embedding,

Sterilize, be distributed into the glass ampule finished product of one of 2ml, this product is dark

Brown clear liquid.

The present invention is pure compound Chinese medicinal preparation, and acute toxicity test and long term toxicity test through to mice have no drug resistance and toxic and side effects.Clinical test results shows: this product has effects such as analgesic, analgesia, antiviral, antibacterial, cough-relieving.

The present invention is the intramuscular injection medication, by blood circulation, has avoided first pass effect, curative effect is faster and better, just can bring down a fever in average 2～3 hours, and can block the flu development course of disease fast, the property of medicine is gentle, has no side effect, and is the drug of first choice of crowd of having a delicate constitution and mid-aged population flu.

The specific embodiment:

The present invention is intramuscular injection, a 2～4ml, and every day 1～2 time is through 85 routine patients result's statistics of using of consumption routinely, cure 47 people, significant curative effect 23 people, effective 11 go into, invalid 4 people, total effective rate 95.3%, wherein fever time is average 2.01 ± 1.13 hours, and the fastest 1 hour takes effect.

The mulberry leaf-ginger common cold injection, inject convenient, evident in efficacy, have no side effect, timely releasing flu patient's misery has been played good action.

Claims

1, a kind of mulberry leaf-ginger common cold injection is characterized in that being made up of the Chinese medicine (weight portion) of following proportioning:

Folium Mori 100～200 Flos Chrysanthemis 10～40 Folium Perillaes 50～100

2, it is characterized in that forming according to the described mulberry leaf-ginger common cold injection of claim 1 by the Chinese medicine (weight portion) of following proportioning:

3, as follows according to claim 1,2 described mulberry leaf-ginger common cold injection manufacture methods:

One, gets the raw materials ready: prepare Chinese medicine by claim 2 proportioning, clean standby;

Two, decoct: by drug weight 8～10 water extraordinarily, decocted 2 hours for the first time, filter and add 8 times in water for the second time and decoct and filtered in 1 hour, the medicine juice of twice gained is merged decocting and concentrating get extractum;

Three, purify: adopt to add ethanol and make and contain the alcohol amount and be respectively 60%, 70%, 80% and leave standstill, filter, reclaim behind the ethanol high-purity extractum;

Four: the preparation injection: high-purity extractum is added entry 300～500ml dissolving boiled 10 minutes, it is an amount of to add activated carbon, filter, add water again, add benzyl alcohol 10ml to 900ml, make PH=7.5 with 4% sodium hydroxide solution adjustment, reuse sodium chloride transfers to etc. and to ooze, and leaves standstill 48 hours, filters, add the 3ml polyoxyethylene sorbitan monoleate, boil, filtration, filtrate add the injection water to 1000ml embedding, sterilization.