CN1742799A - Copmound effervescent preparation for treating upper respiratang tract inflammation and producing method - Google Patents
Copmound effervescent preparation for treating upper respiratang tract inflammation and producing method Download PDFInfo
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- CN1742799A CN1742799A CN 200410060480 CN200410060480A CN1742799A CN 1742799 A CN1742799 A CN 1742799A CN 200410060480 CN200410060480 CN 200410060480 CN 200410060480 A CN200410060480 A CN 200410060480A CN 1742799 A CN1742799 A CN 1742799A
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Abstract
The present invention relates to a compound effervescent preparation for curing upper respiratory tract infection and its production method. Said preparation is made up by using Chinese medicinal material lonicera flower, scutellaria root and forsythia fruit, etc. Said invention also provides the concrete steps of its production method.
Description
Technical field
The invention belongs to composite effervescent formulation and the production method thereof that to treat upper respiratory tract infection from a kind of, it is by Chinese herbal medicine such as Flos Lonicerae, Radix Scutellariae, Fructus Forsythiaes by a certain percentage, after certain solvent and technology extraction, being condensed into extractum, purified, add adjuvant or add a certain proportion of other physiologically active ingredient, as: vitamin, aminoacid, mineral element, mix, drying, the effervescent tablet or the effervescent granule that process through special process.It is disintegrate rapidly in water, and effective ingredient is discharged rapidly, the physiologically active of the composition of fully remaining valid, improve the stability of bioactive substance, promote the rapid absorption of human body to effective ingredient, it has special fruity, is particularly suitable for old man and child and uses.Cure mainly diseases such as heating that affection due to external wind and heat causes, pharyngalgia, cough.Be applicable to the treatment of the upper respiratory tract infection that causes by virus or bacterial infection, acute bronchitis, pneumonia, pharyngitis, tonsillitis etc.
Background technology
The preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae is the most frequently used Chinese medicine that is used for the treatment of upper respiratory tract infection.Flos Lonicerae, Fructus Forsythiae are heat and toxic materials clearing away medicine, and Radix Scutellariae is a heat clearing and dampness removing medicine, three and with the effect with relieving exterior-interior syndrome, clearing away heat in both QI and blood.This preparation has broad-spectrum antibacterial action and stronger anti respiratory syncytial virus and resisiting influenza virus effect.Compositions such as the chlorogenic acid in this preparation, baicalin, flavone, polysaccharide have the anti-peroxidation effect of good removing free radical, also have the enhance immunity effect.
The modal preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae has: oral liquid, lyophilized injectable powder, granule, suppository etc.
The pharmacodynamic experiment of the preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae shows: have tangible antivirus action, respiratory syncytial virus, adenovirus, parainfluenza virus I type, influenza first, B virus, herpes simplex virus etc. are had its effect in time multiplexed cell system, growth of obvious inhibition; Have tangible antibacterial action, streptococcus pneumoniae, gold-coloured staphylococci, streptococcus, diphtheria corynebacterium, Bacillus typhi, dysentery bacterium etc. are had certain inhibitory action; Have tangible antiinflammatory and antipyretic effect etc.Because treatment influenza, upper respiratory tract infection, tonsil are right, pharyngitis, viral pneumonia and multiple infection disease.
The preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae not only has the effect of the growth of obvious suppression influenza A virus, especially Du Te broad-spectrum antiseptic, antiviral dual-use function.By once reporting the acute epidemic febrile disease in birds, the domestic animal (as diseases such as fowl plague, domestic animal asthma, infectious bronchitis, canine distemper) there was specially good effect, therefore the preparation preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae is the choice drug of the prevention and the treatment human and bird fluenza because unique curative effect is arranged aspect the prevention of people and bird flu and the treatment.
In the various preparations of making by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, oral liquid transportation difficulty, poor, the poor stability of mouthfeel, anaphylaxis very easily takes place in lyophilized injectable powder, suppository uses inconvenient, traditional granule disintegrating property is relatively poor and a lot of precipitations are arranged, have only effervescent formulation can overcome above deficiency, it can make effective ingredient discharge rapidly simultaneously, fully the remain valid physiologically active of composition, improve the stability of bioactive substance, promote the rapid absorption of human body to effective ingredient, it has special fruity, is particularly suitable for old man and child and uses.
Summary of the invention
Purpose of the present invention utilizes China's traditional Chinese medicine theory to combine with modern pharmacology exactly, from Chinese herbal medicine, filter out Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae etc., and adding other biological active substanceies and adjuvant is made compound formulation, said preparation has the effect of relieving exterior-interior syndrome, clearing away heat in both QI and blood.Modern pharmacology studies show that the preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae has broad-spectrum antibacterial action and stronger anti respiratory syncytial virus and resisiting influenza virus effect.Compositions such as the chlorogenic acid in the preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, baicalin, flavone, polysaccharide have the anti-peroxidation effect of good removing free radical, also have the enhance immunity effect.
It is high-quality Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae that the preparation of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae that the present invention adopts is selected Chinese herbal medicine for use, and its ratio in Chinese medicine comprises: Flos Lonicerae: 5～65%%, be preferably 10～40%; Radix Scutellariae: 5～65%, be preferably 10～40%; Fructus Forsythiae: 25～75%, be preferably 40～70%.The ratio of Chinese medicine extract in total preparation is 40%～70%, is preferably 45%～60%.
Other physiologically active ingredient that the present invention adopts comprises vitamin, trace element, aminoacid etc.The vitamin of selecting for use comprises vitamin C, vitamin E, vitamin B
1, B
2, B
6, vitamin D, folic acid etc.Preferably vitamin C, vitamin E and folic acid, vitamin D, content range is respectively 0.5～30%, and preferably 5～15%.
The trace element that the present invention selects for use has calcium salt, zinc salt, iron salt etc., is generally calcium lactate, calcium gluconate, calcium ascorbate, zinc lactate, ferrous lactate etc., and content range is respectively 0.01～10%, and preferably 0.1～5%.
The freshly prepd effervescent formulation of the present invention comprises effervescent tablet and effervescent granule, be after the preparation extract of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae behind the purification and other effective ingredient are mixed by a certain percentage, add effervescent adjuvants such as citric acid, malic acid, sodium carbonate, sodium bicarbonate, and add corresponding adhesive, behind mixing, granulation, drying, granulate, pack, promptly get the preparation effervescent granule of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, the every packed 4～9g of granule is preferably 4～5g.Add lubricant through abundant mixing, tabletting as the effervescent granule with gained behind the granulate, promptly get the preparation composite effervescent sheet of being made by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, sheet is 2～5g heavily, is preferably 3.0～4.0g.
The specific embodiment
Embodiment one
A kind of composite effervescent sheet that can treat upper respiratory tract infection
Prescriptions of Chinese medicine:
Flos Lonicerae: 750g Radix Scutellariae: 750g Fructus Forsythiae: 1500g
Take by weighing the Chinese medicine of respectively distinguishing the flavor of by above-mentioned recipe quantity, the Radix Scutellariae section, water decocts three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate is concentrated into relative density 1.05～1.10 (80 ℃ of surveys), adds 2mol/l acid hydrochloride salt solution and regulate pH value to 1.0～2.0 in the time of 80 ℃, be incubated 1 hour, left standstill 24 hours, filter, precipitation washes with water to pH value 5.0, continuing and being washed till pH value with 70% ethanol is 7.0, and cold drying is standby; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct each 1.5 hours 2 times, gradation filters, merging filtrate, and being concentrated into relative density is the extractum of 1.20～1.30 (70～80 ℃ of surveys), in the time of cold 40 ℃, slowly adding ethanol under stirring, is to contain the alcohol amount to reach 75%, and stir the Spring Equinox, left standstill 24 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, left standstill 12 hours, filter, merge ethanol liquid, reclaim ethanol to nothing alcohol flavor, and be condensed into the extractum that relative density is 1.30～1.40 (60～70 ℃ of surveys), drying under reduced pressure, be ground into fine powder with Radix Scutellariae extract, mix, standby.
Prescription: every contains:
Chinese medicine extract 2500mg
Citric acid 750mg
Vitamin C 100mg
Sodium bicarbonate 500mg
Polyvinylpyrrolidone (PVP) 50mg
Sweeting agent 100mg
Above-mentioned raw materials is pulverized, crossed 80～120 mesh sieves, weigh, mix, granulate, total mixed, the tabletting in dry back, sheet heavily is 4g.Three of every days.When taking effervescent tablet being taken out from packaging bag, put into one glass of drinking water, was solubilized in 3 minutes, drank to get final product.
Embodiment two
A kind of composite effervescent sheet that can treat upper respiratory tract infection
Make Chinese medicine extract according to embodiment one.
Prescription: every contains:
Chinese medicine extract 3000mg
Calcium lactate 50mg
Citric acid 480mg
Sodium bicarbonate 320mg
Polyvinylpyrrolidone (PVP) 50mg
Sweeting agent 100mg
Become effervescent tablet by embodiment one processes, sheet heavily is 4.0g, takes 2～3 every day.
Embodiment three
A kind of composite effervescent granule that can treat upper respiratory tract infection
Prescription: every bag of effervescent granule contains:
Chinese medicine extract 3000mg
Vitamin C 50mg
Vitamin B
650mg
L-arginine 50mg
Citric acid 840mg
Malic acid 50mg
Sodium bicarbonate 560mg
Sweeting agent 400mg
Adhesive is an amount of
Above-mentioned raw materials is pulverized, crossed 80 mesh sieves, weigh, fully mix, granulate, in dry below 70 ℃, reduce to the granulate of back below 2% to moisture, choose the granule packaging between 12～14 orders, every bag of 5g took 2～3 bags on 1st.
Embodiment four
A kind of clinical efficacy that can treat the composite effervescent formulation of upper respiratory tract infection
Through 257 routine patient's clinical observation result are shown: this product is 91.4% to the upper respiratory tract infection portion effective percentage due to antibacterial or the viral infection; To the acute bronchitis aggregate efficiency is 87.1%; To the acute time scorching aggregate efficiency of peach body is 82.4%; To light-duty pneumonia total effective rate is 84.4%.
This product can obviously be improved clinical symptoms and sign, to the rate of bringing down a fever always of upper respiratory tract infection, acute bronchitis, acute tonsillitis and light-duty pneumonia be respectively 91.4%, 83.9%, 79.4%, and 81.3%; Total effective rate to cough, cough up phlegm, swallow red and swollen pain, antiadoncus, the total sign of lung, picture of the tongue, pulse condition, hemogram is respectively 81.8%, 76.3%, 87.55,70.6%, 68.3%, 81.7%, 87.9% and 86.8%.
Claims (9)
1, a kind of composite effervescent formulation and the production method thereof that can treat upper respiratory tract infection is characterized in that: described composite effervescent formulation is made up of one group of Chinese herbal medicine extract and other biological active substanceies and adjuvant.
2, composite effervescent formulation according to claim 1 is characterized in that: described one group of Chinese herbal medicine comprises that Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae etc. mix the back respectively or by a certain percentage and adopt the solvent extraction effective ingredient.Described solvent is an ethanol/water mixed solvent, and alcoholic acid ratio is 0～85%.
3, composite effervescent formulation according to claim 1 is characterized in that: the ratio of described one group of Chinese herbal medicine is: Flos Lonicerae: 5～65%, and Radix Scutellariae 5～65%, Fructus Forsythiae 5～75%.
4, composite effervescent formulation according to claim 1 is characterized in that: described one group of Chinese herbal medicine can extract separately also can mixed extraction, and extracting method is: take by weighing the Chinese medicine of respectively distinguishing the flavor of by recipe quantity, the Radix Scutellariae section, water decocts three times, collecting decoction, filter, concentrate pickling, leave standstill, filter, washing, ethanol is washed, cold drying, standby; Flos Lonicerae, Fructus Forsythiae decoct with water 2 times, and collecting decoction concentrates, and precipitate with ethanol reclaims ethanol, concentrates, and drying under reduced pressure is ground into fine powder with Radix Scutellariae extract, mixes, promptly.Perhaps ethanol in the Radix Scutellariae leaching process is washed the back spray drying, spray drying behind the recovery ethanol in Flos Lonicerae, the Fructus Forsythiae leaching process, drying is mixed, promptly.
5, composite effervescent formulation according to claim 1 is characterized in that: add other biological active substances, adjuvant in proportion in Chinese medicine extract, fully mix after effervescent tablet that special process processes or effervescent granule are packed promptly.Ratio between Chinese medicine extract and other biological active substanceies, the adjuvant is 1: 1～1: 2, is preferably 1: 1～1: 1.5.
6, composite effervescent formulation according to claim 1 is characterized in that: described other biological active substances comprises vitamin, aminoacid, mineral element etc., can be one or more, and its ratio is 0.01～10%.
7, composite effervescent formulation according to claim 1 is characterized in that: described adjuvant is sweeting agent, citric acid, malic acid, sodium carbonate, sodium bicarbonate etc.
8, composite effervescent formulation according to claim 1 is characterized in that: described effervescent formulation is effervescent tablet or effervescent granule.
9, composite effervescent formulation according to claim 1 is characterized in that: described effervescent formulation cures mainly diseases such as heating that affection due to external wind and heat causes, pharyngalgia, cough.Be applicable to the treatment of the upper respiratory tract infection that causes by virus or bacterial infection, acute bronchitis, pneumonia, pharyngitis, tonsillitis etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410060480 CN1742799A (en) | 2004-08-30 | 2004-08-30 | Copmound effervescent preparation for treating upper respiratang tract inflammation and producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410060480 CN1742799A (en) | 2004-08-30 | 2004-08-30 | Copmound effervescent preparation for treating upper respiratang tract inflammation and producing method |
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| CN1742799A true CN1742799A (en) | 2006-03-08 |
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|---|---|---|---|
| CN 200410060480 Pending CN1742799A (en) | 2004-08-30 | 2004-08-30 | Copmound effervescent preparation for treating upper respiratang tract inflammation and producing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239518A (en) * | 2013-05-22 | 2013-08-14 | 烟台海研制药有限公司 | Traditional Chinese medicine composition for treating avian influenza |
| CN103705581A (en) * | 2013-12-30 | 2014-04-09 | 长沙理工大学 | Compound Huodan dispersible tablet and preparation method and application thereof |
| CN111617196A (en) * | 2020-06-17 | 2020-09-04 | 上海凯宝药业股份有限公司 | Application of traditional Chinese medicine preparation for resisting viral cold in inhibiting pneumonia |
-
2004
- 2004-08-30 CN CN 200410060480 patent/CN1742799A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239518A (en) * | 2013-05-22 | 2013-08-14 | 烟台海研制药有限公司 | Traditional Chinese medicine composition for treating avian influenza |
| CN103239518B (en) * | 2013-05-22 | 2014-08-06 | 烟台海研制药有限公司 | Traditional Chinese medicine composition for treating avian influenza |
| CN103705581A (en) * | 2013-12-30 | 2014-04-09 | 长沙理工大学 | Compound Huodan dispersible tablet and preparation method and application thereof |
| CN103705581B (en) * | 2013-12-30 | 2016-01-13 | 长沙理工大学 | Compound Huodan dispersible tablet and its preparation method and application |
| CN111617196A (en) * | 2020-06-17 | 2020-09-04 | 上海凯宝药业股份有限公司 | Application of traditional Chinese medicine preparation for resisting viral cold in inhibiting pneumonia |
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Addressee: Xu Pinghui Document name: Notification before expiration of term |
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