CN100430087C - Chinese traditional medicine prescription for treating hepatitis B and preparation technics - Google Patents
Chinese traditional medicine prescription for treating hepatitis B and preparation technics Download PDFInfo
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Abstract
The present invention discloses a traditional Chinese medicine compound (Gandening tablets, capsules and granules) for treating hepatitis B, and a formula and a preparation technology thereof. The formula is composed of 680 to 900 shares of Chinese magnolivine fruit, 500 to 700 shares of glossy privet fruit, 300 to 450 shares of forsythia fruit, 190 to 300 shares of zedoray rhizome, 300 to 450 shares of north patrinia and 180 to 300 shares of ganoderma spore powder. The preparation technology comprises the following steps: the Chinese magnolivine fruit, the glossy privet fruit and the forsythia fruit are extracted by ethanol, and extract liquid is filtered and concentrated to obtain a concentrated liquid; next, the north patrinia is decocted in the water and is deposited in the ethanol; a supernatant liquid and the concentrated liquid are combined and concentrated to obtain an extract; the zedoray rhizome is ground into crude powder which is soaked and distilled; volatile oil is collected and is covered by beta-cyclodextrin; the extract is mixed with the ganoderma spore powder; hypromellose and calcium hydrophosphate are added to the extract; the extract is granulated by 65 to 70% of ethanol, and granules are dried; a volatile oil inclusion compound is added to the granules by an equivalent increasing method, and auxiliary materials are added to the granules to be prepared into the tablets, the capsules and the granules. The compound has the functions of enriching the kidney, nourishing the liver, removing toxins, clearing heat, quickening blood circulation and dispelling stasis, so that the compound is an effective Chinese patent medicine preparation aiming at the insufficiency of the liver, the spleen and the kidney of hepatitis B and the mutual aggregation of stasis heat and evil toxin. The total effective rate of the compound reaches 82.00%.
Description
Technical field
The present invention relates to Chinese medicine composition, particularly a kind of Chinese medicine preparation for the treatment of hepatitis B---liver gets three kinds of dosage forms and prescription and preparation technology rather.
Background technology
Chronic hepatitis B is common clinical, frequently-occurring disease, has now become one of principal disease of serious harm China people ' s health.Become the research focus in hepatopathy field with Chinese medicine preparation treatment viral hepatitis.Chronic hepatitis B is found in disease categories such as the traditional Chinese medical science " hypochondriac pain ", " jaundice " with regard to its clinical manifestation.The cause of disease is relevant with the damp and hot evil poison of impression.At the beginning of the morbidity, the invasion liver and gall of epidemic disease caused by damp-heat pathogen poison, unable the uncharming of healthy energy gone out, the epidemic disease caused by damp-heat pathogen poison is stopped in the body, damage liver and gall, latent blood system, be difficult to for the moment elimination, cause the impaired and QI and blood dysfunctional variation of internal organs, form the epidemic disease caused by damp-heat pathogen poison high Sheng of pathogen gradually and the pathological state of positive QI consumed wound.With the passing of time epidemic disease caused by damp-heat pathogen poison pathogen invasion human body consumes and hinders healthy energy." see the disease of liver, knowing the liver disease will be transmitted into the spleen ", with the passing of time hepatopathy adds up to cause the function of liver and spleen imbalance in spleen.The splenopathy is prolonged for a long time, fortuneization mistake department, and can not take a tonic or nourishing food to build up one's health congenital the day after tomorrow, and be easy to injuring YIN due to production of dryness damp and hot in addition accumulateing for a long time, and progressively the consumption wound is divided not enough for Liver and kidney is cloudy.With the passing of time, can consume again and hinder nutrient blood in the damp and hot body of stopping over, cause blood vessels unsmooth, the congestion knot stagnates not all right, so far in the stage, cloudy wound, pyretic toxicity, blood stasis progressively develop and are clinical main troops feature, become pyretic toxicity not to the greatest extent, and Liver and kidney is hindered heat, so feverish sensation in the palms and soles, the soreness of waist is unable, the few or no fur of tongue, and pulse condition is counted accurately; Heat is disturbed the mind, so irritated irritability has resembling of blood stasis such as ecchymosis and liver palm, spider angioma, tongue are dark red.
In sum, the chronic hepatitis b disease position is initially at liver, involves the spleen kidney then, and prolonged illness and hindering causes void, side of body heat folder becomes silted up for suffering from.Wherein the hepatic and renal YIN deficiency is main, and pyretic toxicity, blood stasis are the card of deficiency in origin and excess in superficiality for mark.According to theory of Chinese medical science, when with strengthening vital QI to eliminate pathogenic factors for controlling.The hepatic and renal YIN deficiency is this, so head is an elder generation with the YIN nourishing nourishing the liver, the liver body must be supported, and kidney yin is received benefits.
China recent years treatment by Chinese herbs viral hepatitis has obtained certain achievement, can be but lack at hepatitis B liver spleen kidney deficiency, and silt pathogenic heat poison is effective Chinese patent medicine preparation of knot syndrome mutually.
Summary of the invention
The purpose of this invention is to provide a kind of at hepatitis B deficiency of the liver and kindey, silt pathogenic heat poison mutually the knot syndrome compound recipe---liver gets peaceful tablet, capsule, granule and prescription thereof and preparation technology.
Liver of the present invention gets three kinds of dosage form nourishing the kidney and liver, detoxifcation heat clearing away, activating blood circulation to dissipate blood stasis rather, is used for the chronic hepatitis B hepatic and renal YIN deficiency, silt pathogenic heat poison and does not demonstrate,prove to the greatest extent.This Chinese medicine preparation cures mainly side of body rib dull pain or the discomfort that chronic hepatitis B causes, sore spot is fixing not to be moved, or sees side of body mass in the abdomen down, yellow skin and eye or do not have Huang, xerostomia is bitter and dry, feverish sensation in the palms and soles, and the soreness of waist is unable, agitation is easily dry, liver palm or spider angioma, yellowish or reddish urine, tongue is dark red or ecchymosis arranged, few or the no fur of tongue, pulse condition is counted accurately.
The present invention implements by the following technical programs:
Develop a kind of Chinese medicine compound, it is characterized in that having three kinds of dosage forms: tablet, capsule and granule.Prescription is made up of following materials based on weight:
Fructus Schisandrae Chinensis 680-900 part Fructus Ligustri Lucidi 500-700 part Fructus Forsythiae 300-450 part
Rhizoma Curcumae 190-300 part Sonchus brachyotus DC. 300-450 part Ganoderma spore powder 180-300 part
The card that liver rather gets to be controlled shows as the hepatic and renal YIN deficiency and is this, so head works as nourishing the kidney and liver, selecting Fructus Schisandrae Chinensis is monarch, to help Qi Yuan.
Fructus Schisandrae Chinensis is monarch in we, and sour in the mouth, temperature are gone into lung, kidney channel.At the chronic hepatitis hepatic and renal YIN deficiency, the resembling of healthy energy day consumption, with acid hold back promote the production of body fluid, nourishing the kidney and liver.
We are minister with the Fructus Ligustri Lucidi, and bitter but sweet flavor, flat is returned the Liver and kidney warp.The kind yin nourishing benefit of merit is smart, nourishing the liver and kidney.The principal drug assistance nourishing the kidney and liver that we use, the yin nourishing benefit is smart.
Fructus Forsythiae Sonchus brachyotus DC. Ganoderma spore powder is an adjuvant drug.The heart, liver, gallbladder meridian are gone in Fructus Forsythiae bitter in the mouth, cold.Merit is apt to heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.With liver heat removing through hot and suffocating, controlling the side of body poison of being detained.The Sonchus brachyotus DC. nature and flavor are bitter flat, go into liver, stomach large intestine channel.Merit is apt to heat-clearing and toxic substances removing, and evacuation of pus is broken becomes silted up.With heat clearing away poison, the broken knot that becomes silted up.The Fructus Forsythiae Sonchus brachyotus DC. helps the monarch-minister drug removing liver heat and toxic substances jointly.Ganoderma spore powder is an adjuvant drug, and the nature and flavor liver is flat.Help the monarch and his subjects to set upright beneficial smart tonify deficiency with it.
The described Rhizoma Curcumae bitter in the mouth suffering of we, temperature are gone into liver, spleen channel.Merit benefaction gas, removing blood stasis, removing food stagnancy, pain relieving, the hepatosplenomegaly that we cause at chronic hepatitis, the pathological state of stagnation of QI and blood, with the removing blood stasis circulation of qi promoting, for assistant helps; Rhizoma Curcumae is specially walked the property of Liver Channel simultaneously, draws all medicines and goes into liver, and be messenger drug.
Modern pharmacological research shows that the medical material of respectively distinguishing the flavor of in this prescription all has positive improvement effect to chronic hepatitis.Fructus Schisandrae Chinensis has function for protecting liver and reducing enzyme activity to the chronic hepatic injury rat; Contain effective ingredient such as oleanolic acid in Fructus Ligustri Lucidi, Fructus Forsythiae, the Sonchus brachyotus DC., protect the liver, effect such as diuresis; Fructus Forsythiae, Sonchus brachyotus DC. have inhibitory action to multiple pathogenic bacteria, virus; Ganoderma spore powder can enhancing human body immunity ability, alleviate the hepatic injury due to four carbonoxides, enzyme falls, alleviate the lobules of liver cellular infiltration, plain golden liver cell regeneration effect; Rhizoma Curcumae is one of best medicine of microcirculation improvement obstacle.
The preparation technology of above-mentioned prescriptions of Chinese medicine is:
1, the preparation of extractum
(1) Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Fructus Forsythiae are ground into coarse powder, add the 80-90% alcohol reflux, and solvent amount 5-8 times, time 2-4 hour, extracting solution filtered, and filtrate recycling ethanol to density is 1.00-1.20 (80 ℃), gets concentrated solution, and is standby.
(2) the Sonchus brachyotus DC. decocting boils 2 times, adds the water that 10-15 doubly measures for the first time, adds the water that 8-12 doubly measures for the second time, the each decoction 1-2 hour, it is 1.08-1.12 (80 ℃) that decocting liquid is evaporated to relative density, adds ethanol and is 70-80% to containing the alcohol amount, left standstill 12 hours, and drew supernatant.Supernatant and above-mentioned concentrated solution are merged, decompression recycling ethanol and to be concentrated into relative density be 1.25-1.30 (80 ℃), extractum.
2, the preparation of Rhizoma Curcumae volatile oil clathrate
Rhizoma Curcumae is ground into coarse powder, adds the water that 9-12 doubly measures, and soaks 10-12 hour, distills 6-8 hour, collects volatile oil, the beta-cyclodextrin inclusion compound that volatile oil is doubly measured with 6-10,40 ℃ of dryings.
3, tablet, capsule and granule are made in the mixing of extractum and Ganoderma spore powder
Ganoderma spore adopts superfine powder method breaking cellular wall, get Ganoderma spore powder with cellular wall broken, Ganoderma spore powder and extractum taste are closed, add the hypromellose of 2-4% and the calcium hydrogen phosphate of 2-4%, mix thoroughly, with the 65-70% alcohol granulation, granule is in 60 ℃ of dryings, with the equivalent incremental method volatile oil clathrate compound is added, add adjuvant again and make tablet, capsule and granule.
The invention has the beneficial effects as follows: nourishing the kidney and liver, detoxifcation heat clearing away, blood circulation promoting and blood stasis dispelling are effective Chinese patent medicine preparations of tying syndrome at hepatitis B liver spleen kidney deficiency, the evil poison of stagnant heat mutually.
Pharmacodynamics is to overall merit of the present invention: liver protection effect is preferably arranged, and enhancing human body immunity uses, antifatigue effect, anti-stress uses, to the rat experiment liver cirrhosis A/G ratio of growing tall, reduce the liver collagen content, the effect that obviously alleviates degree of hepatic fibrosis.Repeatedly practise through clinical ordering, cured and improved the state of an illness of hundreds of routine chronic hepatitis B patients, total effective rate reached for 82.00% (wherein dividing 93.75% and 80.77% to light-duty, the medium-sized effective percentage of chronic ashamed liver).This product treatment chronic hepatitis B has to face preferably orders safety.
The specific embodiment
Get 700 parts of Fructus Schisandrae Chinensis, 600 parts of Fructus Ligustri Lucidi, Fructus Forsythiae and be ground into coarse powder for 400 parts, add 90% alcohol reflux, 7 times of solvent amounts, 3 hours time, extracting solution filters, filtrate recycling ethanol to density is 1.10-1.20 (80 ℃), concentrated solution, standby.400 parts of decoctings of Sonchus brachyotus DC. boil 2 times, and the water of 2 times of amounts of processing factory adds the water of 10 times of amounts the second time for the first time, the each decoction 1 hour, decocting liquid is dense to subtract that to be compressed to relative density be 1.08-1.12 (80 ℃), and adding ethanol is 75% to containing the alcohol amount, what leave standstill pays no attention to 2 hours, draws supernatant.Supernatant and above-mentioned concentrated solution are merged, decompression recycling ethanol and to be concentrated into relative density be 1.25-1.30 (80 ℃), extractum.Rhizoma Curcumae is ground into coarse powder for 300 parts, adds the water of 11 times of amounts, soaks 10 hours, distills 8 hours, collects volatile oil, and volatile oil is with the beta-cyclodextrin inclusion compound of 9 times of amounts, and 40 ℃ of dryings get volatile oil clathrate compound.Ganoderma spore powder adopts the superfine grinding method breaking cellular wall for 250 parts, gets Ganoderma spore powder with cellular wall broken.Get extractum, add the Ganoderma spore powder mixing, add 3% hydroxypropyl first fiber and 2% calcium hydrogen phosphate again, mix thoroughly, with 70% alcohol granulation, granule was in 60 ℃ of dryings 2 hours.With the equivalent multiplication method volatile oil clathrate compound is added, add a spot of magnesium stearate again, tabletting, coating, promptly.
Claims (3)
1. a Chinese medicine preparation for the treatment of hepatitis B is characterized in that being made by the raw material of following weight parts: Fructus Schisandrae Chinensis 680-900 part, Fructus Ligustri Lucidi 500-700 part, Fructus Forsythiae 300-450 part, Rhizoma Curcumae 190-300 part, Sonchus brachyotus DC. 300-450 part, Ganoderma spore powder 180-300 part; Wherein said Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Fructus Forsythiae are through ethanol extraction, and extracting solution filters recovery ethanol and gets concentrated solution; Supernatant behind the Sonchus brachyotus DC. water decoction-alcohol sedimentation and concentrated solution merging are condensed into extractum, extractum and Ganoderma spore powder mix, add the hypromellose of 2-4% and the calcium hydrogen phosphate of 2-4%, mix granulation thoroughly, dry, to wait flow control to increase method the volatile oil inclusion is added, add adjuvant again and make corresponding preparation.
2. Chinese medicine preparation according to claim 1 is characterized in that tablet is arranged, capsule, three kinds of dosage forms of granule.
3. Chinese medicine preparation preparation technology according to claim 1 is characterized in that being:
(1) preparation of extractum
1. Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Fructus Forsythiae are ground into coarse powder, add the 80-90% alcohol reflux, and solvent amount 5-8 times, time 2-4 hour, extracting solution filtered, and filtrate recycling ethanol to density is at 80 ℃ of following 1.00-1.20, gets concentrated solution, and is standby;
2. the Sonchus brachyotus DC. decocting boils 2 times, add for the first time the water that 12-15 doubly measures, for the second time add the water that 8-12 doubly measures, decocted 1-2 hour at every turn, decocting liquid is dense to be subtracted and is compressed to relative density at 80 ℃ of following 1.08-1.12, add ethanol and be 70%-80% to containing the alcohol amount, left standstill 12 hours, and drew supernatant, supernatant and above-mentioned concentrated solution are merged, decompression recycling ethanol also is concentrated into relative density at 80 ℃ of following 1.25-1.30, gets extractum;
(2) preparation of Rhizoma Curcumae volatile oil clathrate
Rhizoma Curcumae is ground into coarse powder, adds the water that 9-12 doubly measures, and soaks 10-12 hour, distills 6-8 hour, collects volatile oil, the beta-cyclodextrin inclusion compound that volatile oil is doubly measured with 6-10,40 ℃ of dryings;
(3) tablet, capsule, granule are made in the mixing of extractum and Ganoderma spore powder
Ganoderma spore adopts superfine powder method breaking cellular wall, get Ganoderma spore powder with cellular wall broken, Ganoderma spore powder and extractum are mixed, add the hypromellose of 2-4% and the calcium hydrogen phosphate of 2-4%, mix thoroughly, with the 65-70% alcohol granulation, granule is in 60 ℃ of dryings, with the equivalent incremental method volatile oil clathrate compound is added, add adjuvant again and make respective tablets, capsule, granule.
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| CN103611087A (en) * | 2013-12-06 | 2014-03-05 | 山东世博金都药业有限公司 | Traditional Chinese medicine formula extract for treating hepatitis B and preparation method thereof |
| CN105758962A (en) * | 2016-03-03 | 2016-07-13 | 山东世博金都药业有限公司 | Quality control method of liuwei wuling tablets |
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| CN1107062A (en) * | 1994-12-09 | 1995-08-23 | 黄明和 | Medicine for hepatitis B |
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| CN1107062A (en) * | 1994-12-09 | 1995-08-23 | 黄明和 | Medicine for hepatitis B |
Non-Patent Citations (4)
| Title |
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| 肝得宁片中王味子，女贞妇提取工艺研究. 潘五九，肖小河，肖雪，袁海龙，赵艳玲.中国中药杂志，第29卷第8期. 2004 |
| 肝得宁片中王味子，女贞妇提取工艺研究. 潘五九，肖小河，肖雪，袁海龙，赵艳玲.中国中药杂志，第29卷第8期. 2004 * |
| 肝得宁片对小鼠免疫功能的影响. 赵艳玲，肖小河，袁海龙，张新全，贺承山.中草药，第33卷第2期. 2002 |
| 肝得宁片对小鼠免疫功能的影响. 赵艳玲，肖小河，袁海龙，张新全，贺承山.中草药，第33卷第2期. 2002 * |
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