CN101239095B - Method for preparing embolism-extinguishing enteric-coated capsule - Google Patents
Method for preparing embolism-extinguishing enteric-coated capsule Download PDFInfo
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- CN101239095B CN101239095B CN200810049072XA CN200810049072A CN101239095B CN 101239095 B CN101239095 B CN 101239095B CN 200810049072X A CN200810049072X A CN 200810049072XA CN 200810049072 A CN200810049072 A CN 200810049072A CN 101239095 B CN101239095 B CN 101239095B
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Abstract
The invention discloses the preparation method of a medicine anti-plug enteric soluble capsule for curing anemic apoplexy, deficiency of vital energy and blood stasis. The Chinese medicines astragalus root, angelica and rhizoma ligustici wallichii are steeped into ethanol, the ethanol return flows twice, then is filtered; the filtrate is condensed at certain temperature; the dregs of a decoction are decocted in water with Chinese medicine rot of peony, semen persicae and safflower, then the liquid is filtered; the filtrate is condensed, and the concentrated solution is added by ethanol, stirred and standing; a supernatant fluid is given out and is carried on decompression condensation. Two condensates above are mixed and dried, then grinded so that an extractive is obtained; a fresh lumbricus is dried in shade and grinded, then steeped into water, an extract solution is obtained, decentered, condensed, a condensate is obtained, dried in vacuum at a certain temperature then grinded so that a lumbricus extract is obtained; the extract above is mixed with the lumbricus extract, then packed into the enteric soluble capsule. The effective ingredient of the Chinese medicine of the invention is extracted entirely, and the biological activity of the lumbrokinase of the lumbricus is kept so that the curing effect of the medicine is improved.
Description
Technical field
The present invention relates to a kind of preparation method for the treatment of cerebral infarction blood stasis due to qi deficiency disease drug, specifically a kind of preparation method of embolism-extinguishing enteric-coated capsule belongs to medical technical field.
Background technology
At present, the medicine of treatment cerebral infarction blood stasis due to qi deficiency disease is more, and dosage form commonly used has embolism extinguishing oral liquid, XIAOSHUAN KELI agent.The production method of embolism extinguishing oral liquid generally is with Chinese medicine astragalus, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Pheretima, decocts with water three times, merges decoction liquor, filter, filtrate decompression adds ethanol after concentrating, leave standstill, get and ask liquid, reclaim ethanol, concentrated medicament, thin up adds sweeting agent, antiseptic, mixing, embedding, sterilization makes.The production method of XIAOSHUAN KELI agent is to change dosage form on the basis of above-mentioned embolism extinguishing oral liquid.Embolism extinguishing oral liquid, two kinds of dosage form Chinese medicines of XIAOSHUAN KELI agent extract adopt the method for traditional water boiling and extraction, extracts active ingredients is incomplete, simultaneously, and the protein degeneration that the method that the Pheretima water decocts is extracted, its Lumbrukinase inanimate object activity influences the therapeutic effect of medicine.
Summary of the invention
Task of the present invention is to provide a kind of preparation method for the treatment of cerebral infarction blood stasis due to qi deficiency disease drug embolism-extinguishing enteric-coated capsule, it is more complete that this method can make Effective Components of Chinese Herb extract, and the biological activity of maintenance Chinese traditional medicine sleeper Lumbrukinase, the therapeutic effect of raising medicine.
For realizing above-mentioned task, technical solution of the present invention is: with Chinese medicine astragalus, Radix Angelicae Sinensis, behind the Rhizoma Chuanxiong mix homogeneously, add triplication 70% ethanol, flooded reheat backflow secondary, each 2 hours 1 hour, filter respectively, merging filtrate, earlier with filtrate under 50-70 ℃ of temperature, concentrating under reduced pressure, medicinal residues after will filtering again and Chinese medicine Radix Paeoniae Rubra, Semen Persicae, Flos Carthami decocts with water three times, each 2 hours, filters respectively, merging filtrate, filtrate decompression is concentrated, concentrated solution is added 4-6 doubly measure 95% ethanol, stir, leave standstill, after emitting supernatant, concentrating under reduced pressure again is with above-mentioned two kinds of concentrate mix homogeneously, crushed after being dried under 60-80 ℃ of temperature gets extract; Fresh Pheretima is dried in the shade, pulverizes, at 0-10 ℃, use flooding 2 times, each 6 hours, extracting solution was centrifugal, concentrating under reduced pressure under 20-35 ℃ of temperature, and concentrate is being pulverized behind the vacuum drying under the 20-35 ℃ of temperature, gets Pheretima extract; With said extracted thing and Pheretima extract mix homogeneously, the enteric coated capsule of packing into.
It is more complete that the present invention has the Effective Components of Chinese Herb extraction, and keep the biological activity of the Lumbrukinase of Chinese traditional medicine sleeper, improves the advantage of the therapeutic effect of medicine.
The specific embodiment
With preparation double centner embolism-extinguishing enteric-coated capsule is example.
Example 1, with 420 kilograms of Chinese medicine astragalus, 48 kilograms of Radix Angelicae Sinensis, behind 20 kilograms of mix homogeneously of Rhizoma Chuanxiong, add triplication 70% ethanol, flooded 1 hour, reheat backflow secondary each 2 hours, filters respectively, merging filtrate, under 50 ℃ of temperature, being evaporated to relative density is that 1.2g/ml is standby, 42 kilograms of medicinal residues after will filtering again and Chinese medicine Radix Paeoniae Rubra with filtrate in elder generation, 24 kilograms in Semen Persicae, Flos Carthami decocts with water three times for 24 kilograms, each 2 hours, filter respectively, merging filtrate, it is 1.1g/ml that filtrate decompression is concentrated into relative density, again concentrated solution is added 4 times of amount 95% ethanol, stir, leave standstill, emit supernatant after, being evaporated to relative density again is that 1.1g/ml is standby, with above-mentioned two kinds of concentrate mix homogeneously, crushed after being dried under 60 ℃ of temperature gets extract; Fresh Pheretima is dried in the shade, pulverizes for 24 kilograms, under 0 ℃ of temperature, use flooding 2 times, each 6 hours, extracting solution be not less than 15000 rev/mins centrifugal, being evaporated to relative density under 35 ℃ of temperature is 1.1g/ml, concentrate is pulverized behind 35 ℃ of vacuum dryings, gets Pheretima extract; With said extracted thing and Pheretima extract mix homogeneously, the enteric coated capsule of packing into is adorned 0.2 gram for every.
Example 2, with 430 kilograms of Chinese medicine astragalus, 47 kilograms of Radix Angelicae Sinensis, behind 22 kilograms of mix homogeneously of Rhizoma Chuanxiong, add triplication 70% ethanol, flooded 1 hour, reheat backflow secondary each 2 hours, filters respectively, merging filtrate, under 70 ℃ of temperature, being evaporated to relative density is that 1.1g/ml is standby, 43 kilograms of medicinal residues after will filtering again and Chinese medicine Radix Paeoniae Rubra with filtrate in elder generation, 25 kilograms in Semen Persicae, Flos Carthami decocts with water three times for 25 kilograms, each 2 hours, filter respectively, merging filtrate, it is 1.05g/ml that filtrate decompression is concentrated into relative density, again concentrated solution is added 6 times of amount 95% ethanol, stir, leave standstill, emit supernatant after, being evaporated to relative density again is that 1.05g/ml is standby, with above-mentioned two kinds of concentrate mix homogeneously, crushed after being dried under 80 ℃ of temperature gets extract; Fresh Pheretima 25 is dried in the shade, pulverizes, under 10 ℃ of temperature, use flooding 2 times, each 6 hours, extracting solution be not less than 15000 rev/mins centrifugal, being evaporated to relative density under 20 ℃ of temperature is 1.05g/ml, concentrate is pulverized behind 20 ℃ of vacuum dryings, gets Pheretima extract; With said extracted thing and Pheretima extract mix homogeneously, the enteric coated capsule of packing into is adorned 0.2 gram for every.
The instructions of taking of embolism-extinguishing enteric-coated capsule of the present invention, one time 2, three times on the one.
Claims (2)
1. the preparation method of an embolism-extinguishing enteric-coated capsule, its step is as follows: with 420 kilograms of Chinese medicine astragalus, 48 kilograms of Radix Angelicae Sinensis, behind 20 kilograms of mix homogeneously of Rhizoma Chuanxiong, add triplication 70% ethanol, flooded reheat backflow secondary 1 hour, each 2 hours, filter respectively, merging filtrate, earlier with filtrate under 50-70 ℃ of temperature, concentrating under reduced pressure, 42 kilograms of medicinal residues after will filtering again and Chinese medicine Radix Paeoniae Rubra, 24 kilograms in Semen Persicae, Flos Carthami decocts with water three times for 24 kilograms, each 2 hours, filters respectively, merging filtrate, filtrate decompression is concentrated, concentrated solution is added 4-6 doubly measure 95% ethanol, stir, leave standstill, after emitting supernatant, concentrating under reduced pressure again is with above-mentioned two kinds of concentrate mix homogeneously, crushed after being dried under 60-80 ℃ of temperature gets extract; Fresh Pheretima is dried in the shade, pulverizes for 24 kilograms, at 0-10 ℃, use flooding 2 times, each 6 hours, extracting solution was centrifugal, concentrating under reduced pressure under 20-35 ℃ of temperature, and concentrate is being pulverized behind the vacuum drying under the 20-35 ℃ of temperature, gets Pheretima extract; With said extracted thing and Pheretima extract mix homogeneously, the enteric coated capsule of packing into.
2. the preparation method of an embolism-extinguishing enteric-coated capsule, its step is as follows: with 430 kilograms of Chinese medicine astragalus, 47 kilograms of Radix Angelicae Sinensis, behind 22 kilograms of mix homogeneously of Rhizoma Chuanxiong, add triplication 70% ethanol, flooded reheat backflow secondary 1 hour, each 2 hours, filter respectively, merging filtrate, earlier with filtrate under 50-70 ℃ of temperature, concentrating under reduced pressure, 43 kilograms of medicinal residues after will filtering again and Chinese medicine Radix Paeoniae Rubra, 25 kilograms in Semen Persicae, Flos Carthami decocts with water three times for 25 kilograms, each 2 hours, filters respectively, merging filtrate, filtrate decompression is concentrated, concentrated solution is added 4-6 doubly measure 95% ethanol, stir, leave standstill, after emitting supernatant, concentrating under reduced pressure again is with above-mentioned two kinds of concentrate mix homogeneously, crushed after being dried under 60-80 ℃ of temperature gets extract; Fresh Pheretima is dried in the shade, pulverizes for 25 kilograms, at 0-10 ℃, use flooding 2 times, each 6 hours, extracting solution was centrifugal, concentrating under reduced pressure under 20-35 ℃ of temperature, and concentrate is being pulverized behind the vacuum drying under the 20-35 ℃ of temperature, gets Pheretima extract; With said extracted thing and Pheretima extract mix homogeneously, the enteric coated capsule of packing into.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810049072XA CN101239095B (en) | 2008-01-14 | 2008-01-14 | Method for preparing embolism-extinguishing enteric-coated capsule |
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| CN200810049072XA CN101239095B (en) | 2008-01-14 | 2008-01-14 | Method for preparing embolism-extinguishing enteric-coated capsule |
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| Publication Number | Publication Date |
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| CN101239095A CN101239095A (en) | 2008-08-13 |
| CN101239095B true CN101239095B (en) | 2011-04-13 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110368423B (en) * | 2019-08-20 | 2021-08-20 | 三门峡赛诺维制药有限公司 | Preparation process of thrombus-eliminating and collateral-dredging granules |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044907A (en) * | 1990-03-23 | 1990-08-29 | 地方国营哈尔滨中药二厂 | The manufacture method of fast-dissolved embolism-eliminating pulvis |
| CN1186686A (en) * | 1997-12-29 | 1998-07-08 | 中山医科大学 | New use of thrombus clearing oral liquor |
| CN1583103A (en) * | 2004-06-08 | 2005-02-23 | 江苏吴中中药研发有限公司 | Capsules for eliminating embolism and their preparation |
| CN1730037A (en) * | 2005-08-03 | 2006-02-08 | 包头市千年健药物研究开发有限公司 | Process for preparing thrombus eliminating dripping pills |
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2008
- 2008-01-14 CN CN200810049072XA patent/CN101239095B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044907A (en) * | 1990-03-23 | 1990-08-29 | 地方国营哈尔滨中药二厂 | The manufacture method of fast-dissolved embolism-eliminating pulvis |
| CN1186686A (en) * | 1997-12-29 | 1998-07-08 | 中山医科大学 | New use of thrombus clearing oral liquor |
| CN1583103A (en) * | 2004-06-08 | 2005-02-23 | 江苏吴中中药研发有限公司 | Capsules for eliminating embolism and their preparation |
| CN1730037A (en) * | 2005-08-03 | 2006-02-08 | 包头市千年健药物研究开发有限公司 | Process for preparing thrombus eliminating dripping pills |
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