CN106581601A - Medicine for treating anaphylactic rhinitis and preparation method thereof - Google Patents
Medicine for treating anaphylactic rhinitis and preparation method thereof Download PDFInfo
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- CN106581601A CN106581601A CN201510670934.0A CN201510670934A CN106581601A CN 106581601 A CN106581601 A CN 106581601A CN 201510670934 A CN201510670934 A CN 201510670934A CN 106581601 A CN106581601 A CN 106581601A
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- 239000003814 drug Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 230000002052 anaphylactic effect Effects 0.000 title abstract 3
- 206010039083 rhinitis Diseases 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 7
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 7
- 235000008434 ginseng Nutrition 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 22
- 201000010105 allergic rhinitis Diseases 0.000 claims description 22
- 241000628997 Flos Species 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
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- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
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- 239000009670 cang er zi wan Substances 0.000 claims description 6
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- 238000005469 granulation Methods 0.000 claims description 5
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- 239000000843 powder Substances 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
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- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 claims description 3
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- 241001251949 Xanthium sibiricum Species 0.000 description 1
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- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
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- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a medicine for treating anaphylactic rhinitis and a preparation method thereof. The medicine is mainly prepared from magnolia flowers, cocklebur, radix angelicae, asarum, ligusticum wallichii, madder, salvia miltiorrhiza, schizonepeta, divaricate saposhnikovia roots, chrysanthemums, honeysuckles, fructus forsythia, radix paeoniae alba, rhynohophylla, ginseng, poria cocos, bighead atractylodes rhizomes, rhizoma zingiberis, notopterygium roots, meretrix and liquorice. The medicine can be used for treating anaphylactic rhinitis, is remarkable in curative effect, is short in treatment cycle and is safe and free from side effect.
Description
Technical field
The present invention relates to a kind of treat medicine of allergic rhinitises and preparation method thereof, belong to the field of medicine technology.
Technical background
Allergic rhinitises are allergic rhinitis, refer to that the main medium mediated by IgE is (mainly after atopic individuals contact allergen
It is histamine) release, and have the nasal mucosa non-infectious inflammatory disease of the participations such as panimmunity competent cell and cytokine.Its
The essential condition of generation has 3：1. specific antigen causes the material of organism immune response.2. atopic individuals are so-called
Body difference, allergic constitution.3. specific antigen answers both type individualities to meet with spy.Allergic rhinitis are that a global health is asked
Topic, can cause numerous disease and disability.
It is many currently used for the medicine for the treatment of allergic rhinitises for above-mentioned disease, but most drug drug effect is slow, treatment
Cycle is long, large side effects.
The content of the invention：
It is an object of the present invention to provide a kind of treat medicine of allergic rhinitises and preparation method thereof.The medicine can be used to control
Treat allergic rhinitises；Evident in efficacy, treatment cycle is short, has no side effect safely.
To solve above-mentioned technical problem, the present invention employs the following technical solutions realization：A kind of medicine for treating allergic rhinitises, presses
Listed as parts by weight, mainly by Flos Magnoliae 1-10 parts, Fructus Xanthii 5-15 parts, Radix Angelicae Dahuricae 15-25 parts, Herba Asari 1-5 parts, Rhizoma Chuanxiong 10-20
Part, Radix Rubiae 15-25 parts, Radix Salviae Miltiorrhizae 10-20 parts, Herba Schizonepetae 1-5 parts, Radix Saposhnikoviae 20-30 parts, Flos Chrysanthemi 15-25 parts, Flos Lonicerae 5-15
Part, Fructus Forsythiae 5-15 parts, Radix Paeoniae Alba 1-10 parts, Ramulus Uncariae Cum Unciss 1-10 parts, Radix Ginseng 25-35 parts, Poria 30-40 parts, Rhizoma Atractylodis Macrocephalae 25-35
Part, Rhizoma Zingiberiss 1-10 parts, Rhizoma Et Radix Notopterygii 15-25 parts, Concha Meretricis seu Cyclinae 30-40 parts and Radix Glycyrrhizae 15-25 parts are made.
In the medicine of aforesaid treatment allergic rhinitises, calculate by weight, mainly by 5 parts of Flos Magnoliae, 10 parts of Fructus Xanthii, white
20 parts of the root of Dahurian angelica, 2.5 parts of Herba Asari, 15 parts of Rhizoma Chuanxiong, 20 parts of Radix Rubiae, 15 parts of Radix Salviae Miltiorrhizae, 2.5 parts of Herba Schizonepetae, 25 parts of Radix Saposhnikoviae, chrysanthemum
Spend 20 parts, 10 parts of Flos Lonicerae, 10 parts of Fructus Forsythiae, 5 parts of the Radix Paeoniae Alba, 5 parts of Ramulus Uncariae Cum Unciss, 30 parts of Radix Ginseng, 35 parts of Poria, the Rhizoma Atractylodis Macrocephalae
20 parts of 30 parts, 5 parts of Rhizoma Zingiberiss, 20 parts of Rhizoma Et Radix Notopterygii, 35 parts of Concha Meretricis seu Cyclinae and Radix Glycyrrhizae are made.
A kind of manufacture method of the medicine of aforementioned therapies allergic rhinitises, takes said medicine, can add adjuvant, it is also possible to be not added with auxiliary
Material, makes oral formulations.
In the manufacture method of the medicine of aforementioned therapies allergic rhinitises, the oral formulations are granule, capsule, tablet, ball
Agent, powder or cream.
In the manufacture method of the medicine of aforementioned therapies allergic rhinitises, the granule so makes：Take said medicine, plus 10 times
Amount decocting is boiled 3 times, and each 1.5h is filtered, and merges decoction liquor, and relative density is 1.15-1.20's when being condensed into 50-60 DEG C
Extractum, extractum and the starch and 20% dextrine powder mixing granulation of extractum amount 20%, are dried, and obtain final product.
In the manufacture method of the medicine of aforementioned therapies allergic rhinitises, the manufacture method of the capsule is：Said medicine is taken, is used
The alcohol reflux 2 times of 6 times of amounts 70%, 1 hour every time, extracting solution was filtered, and filtrate recycling ethanol is simultaneously condensed into 50-60 DEG C
When relative density be the extractum of 1.20-1.25, separately take the starch and 0.7% magnesium stearate of extractum amount 30% and mix with extractum, use
60% alcohol granulation, dry, pulverize, and fill capsule, obtain final product.
In the manufacture method of the medicine of aforementioned therapies allergic rhinitises, the manufacture method of the tablet is：Said medicine is taken, plus 10
Again amount decocting is boiled 3 times, and each 1.5h is filtered, and merges decoction liquor, and relative density is 1.15-1.20 when being condensed into 50-60 DEG C
Extractum, the starch of extractum and above-mentioned mixed powder and extractum amount 20% mixes, and tabletting, film coating is obtained final product.
Compared with prior art, medicine of the present invention mainly by Flos Magnoliae, Fructus Xanthii, the Radix Angelicae Dahuricae, Herba Asari, Rhizoma Chuanxiong, Radix Rubiae,
Radix Salviae Miltiorrhizae, Herba Schizonepetae, Radix Saposhnikoviae, Flos Chrysanthemi, Flos Lonicerae, Fructus Forsythiae, the Radix Paeoniae Alba, Ramulus Uncariae Cum Unciss, Radix Ginseng, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberiss, Rhizoma Et Radix Notopterygii,
Concha Meretricis seu Cyclinae and Radix Glycyrrhizae are made.Each raw material has good synergism in prescription, and all medicine cooperations can be used to treat allergia nose
It is scorching；Evident in efficacy, treatment cycle is short, has no side effect safely.
Treatment example：
Liu, female, 33 years old, morning and evening sneeze takes place frequently, rhinocnesmus and with headache, insomnia, flu take place frequently.Take by embodiment 1
Medicine of the present invention, after 5 days, hence it is evident that alleviate, rehabilitation after 8 days.
Zhang, female, 45 years old, have mild and adenoids, nasal polyp, nasal vestibule edema and drying, nasal conchae hypertrophy,
Have a sleepless night, snore and with gastrointestinal upset, dysmenorrhea, constipation and watery stool.Medicine of the present invention is taken by embodiment 1, after 10 days,
It is relieved, rehabilitation after 15 days.
Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.
Specific embodiment：
Embodiment 1.
Formula：Flos Magnoliae 5g, Fructus Xanthii 10g, Radix Angelicae Dahuricae 20g, Herba Asari 2.5g, Rhizoma Chuanxiong 15g, Radix Rubiae 20g, Radix Salviae Miltiorrhizae 15g,
Herba Schizonepetae 2.5g, Radix Saposhnikoviae 25g, Flos Chrysanthemi 20g, Flos Lonicerae 10g, Fructus Forsythiae 10g, Radix Paeoniae Alba 5g, Ramulus Uncariae Cum Unciss 5g, Radix Ginseng 30g, Fu
Siberian cocklebur 35g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Zingiberiss 5g, Rhizoma Et Radix Notopterygii 20g, Concha Meretricis seu Cyclinae 35g and Radix Glycyrrhizae 20g.
Technique：Said medicine is taken, plus 10 times of amount decoctings are boiled 3 times, each 1.5h is filtered, and merges decoction liquor, is condensed into 50-60 DEG C
When relative density for 1.15-1.20 extractum, the starch and 20% dextrine powder mixing granulation of extractum and extractum amount 20% is dried,
Obtain final product granule.
Specification：0.5g/ grains.
Usage and dosage：Every time 2-3 grains, daily 2-3 time.
Claims (7)
1. a kind of medicine for treating allergic rhinitises, it is characterised in that：Calculate by weight, mainly by Flos Magnoliae 1-10 parts, Fructus Xanthii
5-15 parts, Radix Angelicae Dahuricae 15-25 parts, Herba Asari 1-5 parts, Rhizoma Chuanxiong 10-20 parts, Radix Rubiae 15-25 parts, Radix Salviae Miltiorrhizae 10-20 parts, Herba Schizonepetae
1-5 parts, Radix Saposhnikoviae 20-30 parts, Flos Chrysanthemi 15-25 parts, Flos Lonicerae 5-15 parts, Fructus Forsythiae 5-15 parts, Radix Paeoniae Alba 1-10 parts, Ramulus Uncariae Cum Unciss
1-10 parts, Radix Ginseng 25-35 parts, Poria 30-40 parts, Rhizoma Atractylodis Macrocephalae 25-35 parts, Rhizoma Zingiberiss 1-10 parts, Rhizoma Et Radix Notopterygii 15-25 parts, sea
Concha Meretricis Seu Cyclinae 30-40 parts and Radix Glycyrrhizae 15-25 parts are made.
2. the medicine of allergic rhinitises is treated as claimed in claim 1, it is characterised in that：Calculate by weight, mainly by Flos Magnoliae
5 parts, 10 parts of Fructus Xanthii, 20 parts of the Radix Angelicae Dahuricae, 2.5 parts of Herba Asari, 15 parts of Rhizoma Chuanxiong, 20 parts of Radix Rubiae, 15 parts of Radix Salviae Miltiorrhizae, Herba Schizonepetae
2.5 parts, 25 parts of Radix Saposhnikoviae, 20 parts of Flos Chrysanthemi, 10 parts of Flos Lonicerae, 10 parts of Fructus Forsythiae, 5 parts of the Radix Paeoniae Alba, 5 parts of Ramulus Uncariae Cum Unciss, Radix Ginseng 30
20 parts of part, 35 parts of Poria, 30 parts of the Rhizoma Atractylodis Macrocephalae, 5 parts of Rhizoma Zingiberiss, 20 parts of Rhizoma Et Radix Notopterygii, 35 parts of Concha Meretricis seu Cyclinae and Radix Glycyrrhizae are made.
3. it is a kind of it is as claimed in claim 1 or 2 treatment allergic rhinitises medicine manufacture method, it is characterised in that：Take said medicine,
Adjuvant can be added, it is also possible to be not added with adjuvant, make oral formulations.
4. the manufacture method for treating the medicine of allergic rhinitises as claimed in claim 3, it is characterised in that：The oral formulations for
Granule, capsule, tablet, pill, powder or cream.
5. the manufacture method for treating the medicine of allergic rhinitises as claimed in claim 4, it is characterised in that：The granule is so made
Make：Said medicine is taken, plus 10 times of amount decoctings are boiled 3 times, each 1.5h is filtered, and merges decoction liquor, when being condensed into 50-60 DEG C
Relative density is the extractum of 1.15-1.20, extractum and the starch and 20% dextrine powder mixing granulation of extractum amount 20%, is dried, i.e.,
.
6. the manufacture method for treating the medicine of allergic rhinitises as claimed in claim 4, it is characterised in that：The making of the capsule
Method is：Said medicine is taken, with the alcohol reflux 2 times of 6 times of amounts 70%, 1 hour every time, extracting solution was filtered, filtrate
Relative density is the extractum of 1.20-1.25 when reclaiming ethanol and being condensed into 50-60 DEG C, separately takes the starch and 0.7% of extractum amount 30%
Magnesium stearate and extractum mix, with 60% alcohol granulation, dry, pulverize, fill capsule, obtain final product.
7. the manufacture method for treating the medicine of allergic rhinitises as claimed in claim 4, it is characterised in that：The making side of the tablet
Method is：Said medicine is taken, plus 10 times of amount decoctings are boiled 3 times, each 1.5h is filtered, and merges decoction liquor, is condensed into 50-60 DEG C
When relative density for 1.15-1.20 extractum, the starch of extractum and above-mentioned mixed powder and extractum amount 20% mixes, and tabletting is wrapped thin
Film clothing, obtains final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510670934.0A CN106581601A (en) | 2015-10-16 | 2015-10-16 | Medicine for treating anaphylactic rhinitis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568415A (en) * | 2019-01-29 | 2019-04-05 | 成都中医药大学附属医院 | A kind of pharmaceutical composition and its preparation method and application for treating allergic rhinitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568415A (en) * | 2019-01-29 | 2019-04-05 | 成都中医药大学附属医院 | A kind of pharmaceutical composition and its preparation method and application for treating allergic rhinitis |
| CN109568415B (en) * | 2019-01-29 | 2021-07-02 | 成都中医药大学附属医院 | Pharmaceutical composition for treating allergic rhinitis and preparation method and application thereof |
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Application publication date: 20170426 |