CN103565972A - Preparation method of traditional Chinese medicine (TCM) composition for treating allergic rhinitis - Google Patents
Preparation method of traditional Chinese medicine (TCM) composition for treating allergic rhinitis Download PDFInfo
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- CN103565972A CN103565972A CN201310507842.1A CN201310507842A CN103565972A CN 103565972 A CN103565972 A CN 103565972A CN 201310507842 A CN201310507842 A CN 201310507842A CN 103565972 A CN103565972 A CN 103565972A
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine (TCM) composition for treating allergic rhinitis. The preparation method comprises the steps of water extraction, alcohol extraction, grinding, mixing, soft material preparation and the like. The preparation process is scientific and controllable and the extraction process is reasonable in design, thus ensuring full extraction of active ingredients, ensuring definite curative effects of drugs, reducing waste and reducing the production cost. The TCM composition prepared by the preparation method is suitable for treatment of the symptoms, such as nasal obstruction, rhinocnesmus, sneezing, nasal discharge, cough, dizziness and poor concentration, caused by allergic rhinitis, is especially suitable for alleviating of the symptoms, such as dizziness and fullness in head, caused by allergic rhinitis and is taken by allergic rhinitis patients for a long time.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of preparation method of Chinese medicine composition for the treatment of of allergic rhinitis.
Background technology
Allergic rhinitis is allergic rhinitis, refers to that the medium (being mainly histamine) mainly being mediated by IgE after atopic individuals contact allergen discharges, and the non-infectious inflammatory diseases of nasal mucosa that has panimmunity competent cell and cytokine etc. to participate in.The essential condition of its generation has 3: 1. specific antigen causes the material of organism immune response.2. atopic individuals is so-called individual variation, allergic constitution.3. specific antigen and spy answer type individual the two meet.Allergic rhinitis are global health problems, can cause numerous disease and labour force to lose.
At present, Drug therapy for allergic rhinitis comprises chemotherapy and treatment by Chinese herbs, the former is mainly symptomatic treatment, substantially comprise that the medicine that shrinks nose bleeding pipe is if ephedrine, Loratadine are as cetirizine etc. and steroid hormone spray nasal preparation, these chemicalses all have side effect in various degree; The latter is because side effect is little, for etiological treatment thereby met preferably the medication demand of clinical patients.The herbal species that is used for the treatment of now allergic rhinitis in technology is various, but lacks the medicine that therapeutic effect is really supported by irrefutable evidence, and mostly treats in the Chinese medicine composition of sinusitis composition simple, and uncertain therapeutic efficacy is cut.
Summary of the invention
The object of this invention is to provide the preparation method that a kind of extraction process is reasonable, the Chinese medicine composition of few treatment of allergic rhinitis is lost in active ingredient.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
The preparation method of Chinese medicine composition, the formula of this Chinese medicine composition is:
5～10 parts of Flos Magnoliae, 5～10 parts of Fructus Xanthii, 5～10 parts of the Radixs Angelicae Dahuricae, 1～2 part of Herba Asari, 5～10 parts of Rhizoma Chuanxiongs, 5～10 parts, Radix Rubiae, 10～20 parts of Radix Salviae Miltiorrhizaes, 1～5 part of Herba Schizonepetae, 5～10 parts of Radix Saposhnikoviaes, 5～10 parts of Flos Chrysanthemis, 5～10 parts of Flos Loniceraes, 5～10 parts of Fructus Forsythiaes, 5～10 parts, Radix Glycyrrhizae, 5～10 parts of the Radix Paeoniae Albas, 5～10 parts of Ramulus Uncariae Cum Unciss, 2～5 parts of Fel Ursi powders, 1～3 part of Herba Menthae, 2～5 parts of Fructus Xanthii, 5～15 parts of Radix Platycodoniss, 2～5 parts of Radix Bupleuri;
Comprise the following steps:
(1), get Flos Magnoliae, Herba Asari, Herba Schizonepetae, Radix Rubiae, Flos Chrysanthemi, add 20 times of volume water gagings, soak after 4 hours and distill 3 hours, collect volatile oil, medicinal residues are deposited separately;
(2), get the Radix Paeoniae Alba, Flos Lonicerae, add 5～10 times of volume ethanol, decoct 1h after soaking 30min, filter and obtain extracting solution A, medicinal residues are deposited separately;
(3), get Fructus Xanthii, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Fructus Forsythiae, Radix Glycyrrhizae, decoct 1.5h after adding 10～20 times of volume water soaking 20min, filter and obtain extracting solution B, medicinal residues are deposited separately;
(4), the medicinal residues in step (1), (2), (3) are merged, after adding 0～20 times of volume water soaking 20min, decoct 1.5h, filtration obtains extracting solution C, and C and A, B merge and obtain mixed liquor, then concentrates to obtain the relative density thick extractum that is 1.1～1.5;
(5), get Fel Ursi powder, Herba Menthae, Fructus Xanthii, Radix Platycodonis and Radix Bupleuri crushed after being dried to 120 order fine powder;
(6), get the fine powder that the thick extractum of above-mentioned steps (4) adds step (5) to make, and 1～3 times of weight mixed with excipients becomes soft material, sieve granulate and in 60 ℃ dry, after granulate, obtain granule, then add volatile oil in step (1), encapsulated.
Preparation process science of the present invention is controlled, and extraction process is reasonable in design, has guaranteed the abundant extraction of active ingredient, has guaranteed that curative effect of medication is definite, has reduced waste, has reduced production cost.
Chinese medicine composition prepared by the present invention is applicable to nasal obstruction, rhinocnesmus, sneeze, snivel, cough, giddy, energy that allergic rhinitis causes and the symptom such as does not concentrate, and is specially adapted to alleviate dizzy due to allergic rhinitis, feeling of fullness in the head symptom and Allergic Rhinitis and takes for a long time.
The specific embodiment
For ease of understanding the present invention, it is as follows that the present invention enumerates embodiment.Those skilled in the art should understand, described embodiment only, for helping to understand the present invention, should not be considered as concrete restriction of the present invention.
Embodiment 1
The preparation method of Chinese medicine composition, the formula of this Chinese medicine composition is:
8 parts of Flos Magnoliae, 8 parts of Fructus Xanthii, 8 parts of the Radixs Angelicae Dahuricae, 1 part of Herba Asari, 8 parts of Rhizoma Chuanxiongs, 8 parts, Radix Rubiae, 15 parts of Radix Salviae Miltiorrhizaes, 3 parts of Herba Schizonepetae, 8 parts of Radix Saposhnikoviaes, 8 parts of Flos Chrysanthemis, 8 parts of Flos Loniceraes, 8 parts of Fructus Forsythiaes, 8 parts, Radix Glycyrrhizae, 8 parts of the Radix Paeoniae Albas, 8 parts of Ramulus Uncariae Cum Unciss, 3 parts of Fel Ursi powders, 2 parts of Herba Menthaes, 3 parts of Fructus Xanthii, 10 parts of Radix Platycodoniss, 3 parts of Radix Bupleuri;
Comprise the following steps:
(1), get Flos Magnoliae, Herba Asari, Herba Schizonepetae, Radix Rubiae, Flos Chrysanthemi, add 20 times of volume water gagings, soak after 4 hours and distill 3 hours, collect volatile oil, medicinal residues are deposited separately;
(2), get the Radix Paeoniae Alba, Flos Lonicerae, add 10 times of volume ethanol, decoct 1h after soaking 30min, filter and obtain extracting solution A, medicinal residues are deposited separately;
(3), get Fructus Xanthii, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Fructus Forsythiae, Radix Glycyrrhizae, decoct 1.5h after adding 15 times of volume water soaking 20min, filter and obtain extracting solution B, medicinal residues are deposited separately;
(4), medicinal residues in step (1), (2), (3) are merged, decoct 1.5h after adding 15 times of volume water soaking 20min, filter and obtain extracting solution C, C and A, B merging obtain mixed liquor, then concentrate to obtain the relative density thick extractum that is 1.1～1.5;
(5), get Fel Ursi powder, Herba Menthae, Fructus Xanthii, Radix Platycodonis and Radix Bupleuri crushed after being dried to 120 order fine powder;
(6), get the fine powder that the thick extractum of above-mentioned steps (4) adds step (5) to make, and 2 times of weight mixed with excipients become soft material, sieve granulate and in 60 ℃ dry, after granulate, obtain granule, then add volatile oil in step (1), encapsulated.
Embodiment 2
The preparation method of Chinese medicine composition, the formula of this Chinese medicine composition is:
5 parts of Flos Magnoliae, 5 parts of Fructus Xanthii, 5 parts of the Radixs Angelicae Dahuricae, 1 part of Herba Asari, 5 parts of Rhizoma Chuanxiongs, 5 parts, Radix Rubiae, 10 parts of Radix Salviae Miltiorrhizaes, 1 part of Herba Schizonepetae, 5 parts of Radix Saposhnikoviaes, 5 parts of Flos Chrysanthemis, 5 parts of Flos Loniceraes, 5 parts of Fructus Forsythiaes, 5 parts, Radix Glycyrrhizae, 5 parts of the Radix Paeoniae Albas, 5 parts of Ramulus Uncariae Cum Unciss, 2 parts of Fel Ursi powders, 1 part of Herba Menthae, 2 parts of Fructus Xanthii, 5 parts of Radix Platycodoniss, 2 parts of Radix Bupleuri;
Comprise the following steps:
(1), get Flos Magnoliae, Herba Asari, Herba Schizonepetae, Radix Rubiae, Flos Chrysanthemi, add 20 times of volume water gagings, soak after 4 hours and distill 3 hours, collect volatile oil, medicinal residues are deposited separately;
(2), get the Radix Paeoniae Alba, Flos Lonicerae, add 10 times of volume ethanol, decoct 1h after soaking 30min, filter and obtain extracting solution A, medicinal residues are deposited separately;
(3), get Fructus Xanthii, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Fructus Forsythiae, Radix Glycyrrhizae, decoct 1.5h after adding 15 times of volume water soaking 20min, filter and obtain extracting solution B, medicinal residues are deposited separately;
(4), medicinal residues in step (1), (2), (3) are merged, decoct 1.5h after adding 15 times of volume water soaking 20min, filter and obtain extracting solution C, C and A, B merging obtain mixed liquor, then concentrate to obtain the relative density thick extractum that is 1.1～1.5;
(5), get Fel Ursi powder, Herba Menthae, Fructus Xanthii, Radix Platycodonis and Radix Bupleuri crushed after being dried to 120 order fine powder;
(6), get the fine powder that the thick extractum of above-mentioned steps (4) adds step (5) to make, and 2 times of weight mixed with excipients become soft material, sieve granulate and in 60 ℃ dry, after granulate, obtain granule, then add volatile oil in step (1), encapsulated.
Embodiment 3
The preparation method of Chinese medicine composition, the formula of this Chinese medicine composition is:
5 parts of 10 parts of Flos Magnoliae, 10 parts of Fructus Xanthii, 10 parts of the Radixs Angelicae Dahuricae, 2 parts of Herba Asaris, 10 parts of Rhizoma Chuanxiongs, 10 parts, Radix Rubiae, 20 parts of Radix Salviae Miltiorrhizaes, 5 parts of Herba Schizonepetae, 10 parts of Radix Saposhnikoviaes, 10 parts of Flos Chrysanthemis, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 10 parts, Radix Glycyrrhizae, 10 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Uncariae Cum Unciss, 5 parts of Fel Ursi powders, 3 parts of Herba Menthaes, 5 parts of Fructus Xanthii, Radix Platycodonis～15 part, Radix Bupleuri;
Comprise the following steps:
(1), get Flos Magnoliae, Herba Asari, Herba Schizonepetae, Radix Rubiae, Flos Chrysanthemi, add 20 times of volume water gagings, soak after 4 hours and distill 3 hours, collect volatile oil, medicinal residues are deposited separately;
(2), get the Radix Paeoniae Alba, Flos Lonicerae, add 10 times of volume ethanol, decoct 1h after soaking 30min, filter and obtain extracting solution A, medicinal residues are deposited separately;
(3), get Fructus Xanthii, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Fructus Forsythiae, Radix Glycyrrhizae, decoct 1.5h after adding 20 times of volume water soaking 20min, filter and obtain extracting solution B, medicinal residues are deposited separately;
(4), medicinal residues in step (1), (2), (3) are merged, decoct 1.5h after adding 20 times of volume water soaking 20min, filter and obtain extracting solution C, C and A, B merging obtain mixed liquor, then concentrate to obtain the relative density thick extractum that is 1.1～1.5;
(5), get Fel Ursi powder, Herba Menthae, Fructus Xanthii, Radix Platycodonis and Radix Bupleuri crushed after being dried to 120 order fine powder;
(6), get the fine powder that the thick extractum of above-mentioned steps (4) adds step (5) to make, and 3 times of weight mixed with excipients become soft material, sieve granulate and in 60 ℃ dry, after granulate, obtain granule, then add volatile oil in step (1), encapsulated.
Applicant's statement, person of ordinary skill in the field is on the basis of above-described embodiment, by the concrete content point value of above-described embodiment component, combined with the technical scheme of summary of the invention part, thereby the new numerical range producing, also be one of record scope of the present invention, the application, for making description simple and clear, is no longer enumerated these numerical rangies.
Claims (1)
1. a preparation method for the Chinese medicine composition for the treatment of of allergic rhinitis, the formula of this Chinese medicine composition is:
5～10 parts of Flos Magnoliae, 5～10 parts of Fructus Xanthii, 5～10 parts of the Radixs Angelicae Dahuricae, 1～2 part of Herba Asari, 5～10 parts of Rhizoma Chuanxiongs, 5～10 parts, Radix Rubiae, 10～20 parts of Radix Salviae Miltiorrhizaes, 1～5 part of Herba Schizonepetae, 5～10 parts of Radix Saposhnikoviaes, 5～10 parts of Flos Chrysanthemis, 5～10 parts of Flos Loniceraes, 5～10 parts of Fructus Forsythiaes, 5～10 parts, Radix Glycyrrhizae, 5～10 parts of the Radix Paeoniae Albas, 5～10 parts of Ramulus Uncariae Cum Unciss, 2～5 parts of Fel Ursi powders, 1～3 part of Herba Menthae, 2～5 parts of Fructus Xanthii, 5～15 parts of Radix Platycodoniss, 2～5 parts of Radix Bupleuri;
It is characterized in that, comprise the following steps:
(1), get Flos Magnoliae, Herba Asari, Herba Schizonepetae, Radix Rubiae, Flos Chrysanthemi, add 20 times of volume water gagings, soak after 4 hours and distill 3 hours, collect volatile oil, medicinal residues are deposited separately;
(2), get the Radix Paeoniae Alba, Flos Lonicerae, add 5～10 times of volume ethanol, decoct 1h after soaking 30min, filter and obtain extracting solution A, medicinal residues are deposited separately;
(3), get Fructus Xanthii, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Fructus Forsythiae, Radix Glycyrrhizae, decoct 1.5h after adding 10～20 times of volume water soaking 20min, filter and obtain extracting solution B, medicinal residues are deposited separately;
(4), the medicinal residues in step (1), (2), (3) are merged, after adding 10～20 times of volume water soaking 20min, decoct 1.5h, filtration obtains extracting solution C, and C and A, B merge and obtain mixed liquor, then concentrates to obtain the relative density thick extractum that is 1.1～1.5;
(5), get Fel Ursi powder, Herba Menthae, Fructus Xanthii, Radix Platycodonis and Radix Bupleuri crushed after being dried to 120 order fine powder;
(6), get the fine powder that the thick extractum of above-mentioned steps (4) adds step (5) to make, and 1～3 times of weight mixed with excipients becomes soft material, sieve granulate and in 60 ℃ dry, after granulate, obtain granule, then add volatile oil in step (1), encapsulated.
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Cited By (6)
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| CN103933197A (en) * | 2014-03-29 | 2014-07-23 | 张勇飞 | Traditional Chinese medicine composition for treating rhinitis |
| CN105394502A (en) * | 2015-10-29 | 2016-03-16 | 丁亦芬 | Health beverage for treating allergic rhinitis |
| CN106491773A (en) * | 2016-10-27 | 2017-03-15 | 吴安相 | A kind of Chinese medicine formula for treating allergic rhinitises |
| CN107007692A (en) * | 2017-05-12 | 2017-08-04 | 大连大学 | A kind of Camellia nitidissima antiallergy oral liquid and preparation method thereof |
| CN107184737A (en) * | 2017-05-12 | 2017-09-22 | 大连大学 | It is a kind of to treat Camellia nitidissima bagged instant preparation of anaphylactia and preparation method thereof |
| TWI676479B (en) * | 2018-08-14 | 2019-11-11 | 長庚醫療財團法人嘉義長庚紀念醫院 | Use of glycyrrhiza extract in preparation of medicament for treatment of nasal inflammation and pharmaceutical composition including the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106491773A (en) * | 2016-10-27 | 2017-03-15 | 吴安相 | A kind of Chinese medicine formula for treating allergic rhinitises |
| CN107007692A (en) * | 2017-05-12 | 2017-08-04 | 大连大学 | A kind of Camellia nitidissima antiallergy oral liquid and preparation method thereof |
| CN107184737A (en) * | 2017-05-12 | 2017-09-22 | 大连大学 | It is a kind of to treat Camellia nitidissima bagged instant preparation of anaphylactia and preparation method thereof |
| TWI676479B (en) * | 2018-08-14 | 2019-11-11 | 長庚醫療財團法人嘉義長庚紀念醫院 | Use of glycyrrhiza extract in preparation of medicament for treatment of nasal inflammation and pharmaceutical composition including the same |
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Application publication date: 20140212 |