CN105012426A - Chinese medicine composition for treating allergic rhinitis and preparation method thereof - Google Patents
Chinese medicine composition for treating allergic rhinitis and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a Chinese medicine composition for treating allergic rhinitis and a preparation method thereof. The Chinese medicine composition mainly comprises milkvetch roots, largehead atractylodes rhizomes, ligusticum wallichii, cocklebur fruits, magnolia flowers, cicada ecdysis, radix saposhnikoviae, ephedra herbs, radix scutellariae, Chinese dates, asarum and liquorice. The Chinese medicine composition is characterized in that through performing cleaning, soaking, reflux extraction, filtering, heating concentrating and others on the Chinese herbs, an extracting solution is obtained, then ethyl alcohol is added, and an external tincture is obtained. Compared with the prior art, the traditional Chinese herb components are matched reasonably, the allergic rhinitis is treated based on the concept of tonifying qi, strengthening body resistance, clearing and activating the channels and collaterals, achieving desensitization and orifice freeing and stopping itching and a running nose, and the ideal external tincture is formed at a low cost in a synthesis mode.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to Chinese medicine composition of a kind for the treatment of of allergic rhinitis and preparation method thereof.
Background technology
Allergic rhinitis is that a kind of allergic rhinitis (allergic rhinitis) is also known as allergic rhinitis, that the medium (mainly histamine) mediated by IgE after atopic individuals contact sensitinogen discharges and has the nasal mucosa chronic inflammatory reaction disease that panimmunity competent cell and cytokine etc. participate in, with rhinocnesmus, sneeze, nose hypersecretion, tunica mucosa nasi swelling etc. for main feature.
Primary disease is clinical is often divided into perennial allergic rhinitis and pollinosis, and the latter is also called " pollinosis ".Although allergic rhinitis are not a kind of serious diseases, but the daily life of patient, study and work efficiency can be affected, and cause heavy burden economically, bronchial asthma, sinusitis, nasal polyp, otitis media etc. can be brought out, or occur with allergic conjunctivitis simultaneously.
Therefore, a kind of Chinese medicine composition and preparation method thereof for the treatment of of allergic rhinitis is suggested.The present invention has efficacy consolidation, and curative effect is high, short treating period, and cost is low, and dredge the meridian passage, sensible, the dispel itch of desensitizing stop the features such as tears, and the present invention occupies critical role in the treatment of Drug therapy allergic rhinitis.
Summary of the invention
The object of this invention is to provide a kind of curative effect high, the Chinese crude drug compositions of the treatment of allergic rhinitis of short treating period, consolidate with QI invigorating, dredge the meridian passage, desensitization is sensible, dispel itch stops tears thinking treatment of allergic rhinitis, under the condition of low cost, synthesize desirable external-use tincture.
The present invention is Chinese medicine composition of a kind for the treatment of of allergic rhinitis and preparation method thereof, and the Chinese medicine composition of its treatment of allergic rhinitis is mainly through Chinese crude drug Huang Shi, white Intraoperative, Rhizoma Chuanxiong, Fructus Xanthii, Flos Magnoliae, Periostracum Cicadae, Radix Saposhnikoviae, Herba Ephedrae, Radix Scutellariae, Fructus Jujubae, Herba Asari, Radix Glycyrrhizae preparation.
Concrete preparation process is: get Chinese crude drug Huang Shi 2 ~ 4 parts, white Intraoperative 2 ~ 4 parts, Rhizoma Chuanxiong 1 ~ 3 part, Fructus Xanthii 3 ~ 8 parts, Flos Magnoliae 3 ~ 8 parts, Periostracum Cicadae 2 ~ 4 parts, Radix Saposhnikoviae 2 ~ 4 parts, 2 ~ 4 parts, Herba Ephedrae, Radix Scutellariae 2 ~ 4 parts, 3 ~ 5 parts, Fructus Jujubae, Herba Asari 1 ~ 3 part, 1 ~ 2 part, Radix Glycyrrhizae, by clean water 2 ~ 3 times.Soak Chinese crude drug 30 ~ 70 minutes with clear water again, the water yield is advisable to flood Chinese crude drug, generally adds water by 2 ~ 5 times amount of Chinese crude drug weight.
By soaked Chinese crude drug, with slow fire, reflux, extract, is controlled at 90 ~ 105 DEG C 30 ~ 120 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, filtering residue adds 2 ~ 5 times of water gagings again and carries out reflux, extract, at 90 ~ 105 DEG C, merge extractive liquid, heating is concentrated into medical material: extracting solution is 1:1.2 ~ 1.3, namely extracting solution weight is 1.2 ~ 1.3 times amount of medical material weight, when extracting solution temperature is 70 ~ 80 DEG C, add ethanol, the alcoholic strength of extracting solution (V/V) is made to reach 20 ~ 22%, namely the Chinese medicine composition external-use tincture for the treatment of of allergic rhinitis of the present invention is obtained.
Above-mentioned Chinese crude drug soaks after being preferably first ground into the granule of less than 350 μm or powder again.
Above-mentioned reflux, extract, preferably repeats 2 ~ 3 times, each 30 ~ 120 minutes, after each reflux, extract, preferably leaves standstill after 3 ~ 5 minutes, then with≤200 μm of filter screens or sievedly filter to obtain extracting solution.
Compared with prior art, the present invention has efficacy consolidation, and curative effect is high, short treating period, and cost is low, and dredge the meridian passage, sensible, the dispel itch of desensitizing stop the features such as tears.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine composition for the treatment of of allergic rhinitis, mainly through Chinese crude drug Huang Shi, white Intraoperative, Rhizoma Chuanxiong, Fructus Xanthii, Flos Magnoliae, Periostracum Cicadae, Radix Saposhnikoviae, Herba Ephedrae, Radix Scutellariae, Fructus Jujubae, Herba Asari, Radix Glycyrrhizae preparation, detailed process is: get Chinese crude drug Huang Shi 4 parts; white Intraoperative 4 parts, Rhizoma Chuanxiong 3 parts, Fructus Xanthii 6 parts, Flos Magnoliae 6 parts, Periostracum Cicadae 4 parts, Radix Saposhnikoviae 4 parts, 4 parts, Herba Ephedrae, Radix Scutellariae 4 parts, 5 parts, Fructus Jujubae, Herba Asari 3 parts, 1 part, Radix Glycyrrhizae, by clean water 2 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 70 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 2 times amount of Chinese crude drug weight.
Embodiment 2: a kind of Chinese medicine composition for the treatment of of allergic rhinitis, mainly through Chinese crude drug Huang Shi, white Intraoperative, Rhizoma Chuanxiong, Fructus Xanthii, Flos Magnoliae, Periostracum Cicadae, Radix Saposhnikoviae, Herba Ephedrae, Radix Scutellariae, Fructus Jujubae, Herba Asari, Radix Glycyrrhizae preparation, detailed process is: get Chinese crude drug Huang Shi 2 parts; white Intraoperative 2 parts, Rhizoma Chuanxiong 1 part, Fructus Xanthii 3 parts, Flos Magnoliae 3 parts, Periostracum Cicadae 2 parts, Radix Saposhnikoviae 2 parts, 2 parts, Herba Ephedrae, Radix Scutellariae 2 parts, 3 parts, Fructus Jujubae, Herba Asari 1 part, 1 part, Radix Glycyrrhizae, by clean water 3 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 55 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 4 times amount of Chinese crude drug weight.
Embodiment 3: a kind of Chinese medicine composition for the treatment of of allergic rhinitis, mainly through Chinese crude drug Huang Shi, white Intraoperative, Rhizoma Chuanxiong, Fructus Xanthii, Flos Magnoliae, Periostracum Cicadae, Radix Saposhnikoviae, Herba Ephedrae, Radix Scutellariae, Fructus Jujubae, Herba Asari, Radix Glycyrrhizae preparation, detailed process is: get Chinese crude drug Huang Shi 4 parts; white Intraoperative 4 parts, Rhizoma Chuanxiong 3 parts, Fructus Xanthii 8 parts, Flos Magnoliae 8 parts, Periostracum Cicadae 4 parts, Radix Saposhnikoviae 4 parts, 4 parts, Herba Ephedrae, Radix Scutellariae 4 parts, 5 parts, Fructus Jujubae, Herba Asari 3 parts, 2 parts, Radix Glycyrrhizae, by clean water 3 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 60 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 3 times amount of Chinese crude drug weight.
Embodiment 4: a kind of Chinese medicine composition for the treatment of of allergic rhinitis, mainly through Chinese crude drug Huang Shi, white Intraoperative, Rhizoma Chuanxiong, Fructus Xanthii, Flos Magnoliae, Periostracum Cicadae, Radix Saposhnikoviae, Herba Ephedrae, Radix Scutellariae, Fructus Jujubae, Herba Asari, Radix Glycyrrhizae preparation, detailed process is: get Chinese crude drug Huang Shi 3 parts; white Intraoperative 3 parts, Rhizoma Chuanxiong 2 parts, Fructus Xanthii 4 parts, Flos Magnoliae 4 parts, Periostracum Cicadae 3 parts, Radix Saposhnikoviae 3 parts, 3 parts, Herba Ephedrae, Radix Scutellariae 3 parts, 4 parts, Fructus Jujubae, Herba Asari 2 parts, 2 parts, Radix Glycyrrhizae, by clean water 2 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 50 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 5 times amount of Chinese crude drug weight.
Embodiment 5: a kind of preparation method of Chinese medicine composition for the treatment of of allergic rhinitis: mainly choose Chinese crude drug Huang Shi 4 parts, white Intraoperative 4 parts, Rhizoma Chuanxiong 3 parts, Fructus Xanthii 8 parts, Flos Magnoliae 8 parts, Periostracum Cicadae 4 parts, Radix Saposhnikoviae 4 parts, 4 parts, Herba Ephedrae, Radix Scutellariae 4 parts, 5 parts, Fructus Jujubae, Herba Asari 3 parts, 2 parts, Radix Glycyrrhizae, clean water 3 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 60 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 3 times amount of Chinese crude drug weight.By soaked Chinese crude drug, with slow fire, reflux, extract, is controlled at 95 DEG C 90 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, filtering residue adds 3 times of water gagings again, reflux, extract, preferably repeats 3 times, each 90 minutes, after each reflux, extract, preferably leave standstill after 5 minutes, again with≤200 μm of filter screens or sievedly filter to obtain extracting solution, merge extractive liquid, heating is concentrated into medical material: extracting solution is 1:1.25, namely extracting solution weight is 1.25 times amount of medical material weight, when extracting solution temperature is 73 DEG C, add ethanol, the alcoholic strength of extracting solution (V/V) is made to reach 22%, namely the Chinese medicine composition external-use tincture for the treatment of of allergic rhinitis of the present invention is obtained.
Embodiment 6: a kind of preparation method of Chinese medicine composition for the treatment of of allergic rhinitis: mainly choose and get Chinese crude drug Huang Shi 4 parts, white Intraoperative 4 parts, Rhizoma Chuanxiong 3 parts, Fructus Xanthii 6 parts, Flos Magnoliae 6 parts, Periostracum Cicadae 4 parts, Radix Saposhnikoviae 4 parts, 4 parts, Herba Ephedrae, Radix Scutellariae 4 parts, 5 parts, Fructus Jujubae, Herba Asari 3 parts, 1 part, Radix Glycyrrhizae, by clean water 2 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 70 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 4 times amount of Chinese crude drug weight.By soaked Chinese crude drug, with slow fire, reflux, extract, is controlled at 100 DEG C 60 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, filtering residue adds 4 times of water gagings again, reflux, extract, preferably repeats 2 times, each 60 minutes, after each reflux, extract, preferably leave standstill after 4 minutes, again with≤200 μm of filter screens or sievedly filter to obtain extracting solution, merge extractive liquid, heating is concentrated into medical material: extracting solution is 1:1.28, namely extracting solution weight is 1.28 times amount of medical material weight, when extracting solution temperature is 76 DEG C, add ethanol, the alcoholic strength of extracting solution (V/V) is made to reach 21%, namely the Chinese medicine composition external-use tincture for the treatment of of allergic rhinitis of the present invention is obtained.
Embodiment 7: a kind of preparation method of Chinese medicine composition for the treatment of of allergic rhinitis: mainly choose and get Chinese crude drug Huang Shi 3 parts, white Intraoperative 3 parts, Rhizoma Chuanxiong 2 parts, Fructus Xanthii 4 parts, Flos Magnoliae 4 parts, Periostracum Cicadae 3 parts, Radix Saposhnikoviae 3 parts, 3 parts, Herba Ephedrae, Radix Scutellariae 3 parts, 4 parts, Fructus Jujubae, Herba Asari 2 parts, 2 parts, Radix Glycyrrhizae, by clean water 2 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 50 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 5 times amount of Chinese crude drug weight.By soaked Chinese crude drug, with slow fire, reflux, extract, is controlled at 90 DEG C 120 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, filtering residue adds 5 times of water gagings again, reflux, extract, preferably repeats 3 times, each 120 minutes, after each reflux, extract, preferably leave standstill after 3 minutes, again with≤200 μm of filter screens or sievedly filter to obtain extracting solution, merge extractive liquid, heating is concentrated into medical material: extracting solution is 1:1.3, namely extracting solution weight is 1.3 times amount of medical material weight, when extracting solution temperature is 80 DEG C, add ethanol, the alcoholic strength of extracting solution (V/V) is made to reach 21.5%, namely the Chinese medicine composition external-use tincture for the treatment of of allergic rhinitis of the present invention is obtained.
Embodiment 8: a kind of preparation method of Chinese medicine composition for the treatment of of allergic rhinitis: mainly choose and get Chinese crude drug Huang Shi 2 parts, white Intraoperative 2 parts, Rhizoma Chuanxiong 1 part, Fructus Xanthii 3 parts, Flos Magnoliae 3 parts, Periostracum Cicadae 2 parts, Radix Saposhnikoviae 2 parts, 2 parts, Herba Ephedrae, Radix Scutellariae 2 parts, 3 parts, Fructus Jujubae, Herba Asari 1 part, 1 part, Radix Glycyrrhizae, by clean water 3 times.Selected Chinese crude drug to be preferably first ground into after the granule of less than 350 μm or powder again with clear water immersion Chinese crude drug 55 minutes, and the water yield is advisable to flood Chinese crude drug, generally adds water by 4 times amount of Chinese crude drug weight.By soaked Chinese crude drug, with slow fire, reflux, extract, is controlled at 105 DEG C 30 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, filtering residue adds 4 times of water gagings again, reflux, extract, preferably repeats 3 times, each 30 minutes, after each reflux, extract, preferably leave standstill after 3 minutes, again with≤200 μm of filter screens or sievedly filter to obtain extracting solution, merge extractive liquid, heating is concentrated into medical material: extracting solution is 1:1.2, namely extracting solution weight is 1.2 times amount of medical material weight, when extracting solution temperature is 70 DEG C, add ethanol, the alcoholic strength of extracting solution (V/V) is made to reach 20%, namely the Chinese medicine composition external-use tincture for the treatment of of allergic rhinitis of the present invention is obtained.
Claims (10)
1. a medicine for treatment of allergic rhinitis, is characterized in that: mainly through Chinese crude drug Huang Shi, Bai Intraoperative, Rhizoma Chuanxiong, Fructus Xanthii, Flos Magnoliae, Periostracum Cicadae, Radix Saposhnikoviae, Herba Ephedrae, Radix Scutellariae, Fructus Jujubae, Herba Asari, prepared by Radix Glycyrrhizae, detailed process is: get Chinese crude drug Huang Shi 2 ~ 4 parts, white Intraoperative 2 ~ 4 parts, Rhizoma Chuanxiong 1 ~ 3 part, Fructus Xanthii 3 ~ 8 parts, Flos Magnoliae 3 ~ 8 parts, Periostracum Cicadae 2 ~ 4 parts, Radix Saposhnikoviae 2 ~ 4 parts, 2 ~ 4 parts, Herba Ephedrae, Radix Scutellariae 2 ~ 4 parts, 3 ~ 5 parts, Fructus Jujubae, Herba Asari 1 ~ 3 part, 1 ~ 2 part, Radix Glycyrrhizae, reflux, extract, is carried out with clear water, the water yield is as the criterion at least to flood Chinese crude drug, to control at 90 ~ 105 DEG C reflux, extract, 30 ~ 120 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, being concentrated into medical material with the ratio of extracting solution is 1:1.2 ~ 1.3, namely extracting solution weight is 1.2 ~ 1.3 times amount of medical material weight, when extracting solution temperature is 70 ~ 80 DEG C, adds ethanol, make the alcoholic strength of extracting solution reach 20 ~ 22%, namely obtain the Chinese medicine external-use tincture for the treatment of of allergic rhinitis of the present invention.
2. the preparation method of the medicine of a treatment of allergic rhinitis, it is characterized in that comprising following steps: get Chinese crude drug Huang Shi 2 ~ 4 parts, Bai Intraoperative 2 ~ 4 parts, Rhizoma Chuanxiong 1 ~ 3 part, Fructus Xanthii 3 ~ 8 parts, Flos Magnoliae 3 ~ 8 parts, Periostracum Cicadae 2 ~ 4 parts, Radix Saposhnikoviae 2 ~ 4 parts, 2 ~ 4 parts, Herba Ephedrae, Radix Scutellariae 2 ~ 4 parts, 3 ~ 5 parts, Fructus Jujubae, Herba Asari 1 ~ 3 part, 1 ~ 2 part, Radix Glycyrrhizae, reflux, extract, is carried out with clear water, the water yield is as the criterion at least to flood Chinese crude drug, reflux, extract, is controlled at 90 ~ 105 DEG C 30 ~ 120 minutes in temperature, with≤200 μm of filter screens or sievedly filter to obtain extracting solution, being concentrated into medical material with the ratio of extracting solution is 1:1.2 ~ 1.3, namely extracting solution weight is 1.2 ~ 1.3 times amount of medical material weight, when extracting solution temperature is 70 ~ 80 DEG C, add ethanol, the alcoholic strength of extracting solution is made to reach 20 ~ 22%, namely the Chinese medicine external-use tincture for the treatment of of allergic rhinitis of the present invention is obtained.
3. the preparation method of the medicine for the treatment of of allergic rhinitis according to claim 2, is characterized in that: described traditional Chinese medicine powder is broken into granule or the powder of less than 350 μm.
4. the preparation method of the medicine of the treatment of allergic rhinitis according to Claims 2 or 3, is characterized in that: before carrying out reflux, extract, is soaked 30 ~ 70 minutes by described Chinese crude drug.
5. the medicine of a kind for the treatment of of allergic rhinitis according to Claims 2 or 3, it is characterized in that: described reflux, extract, repeats 2 ~ 3 times, each 30 ~ 120 minutes, after each reflux, extract, leave standstill after 3 ~ 5 minutes, then with≤200 μm of filter screens or sievedly filter to obtain extracting solution.
6. the medicine of a kind for the treatment of of allergic rhinitis according to claim 4, it is characterized in that: described reflux, extract, repeats 2 ~ 3 times, each 30 ~ 120 minutes, after each reflux, extract, leave standstill after 3 ~ 5 minutes, then with≤200 μm of filter screens or sievedly filter to obtain extracting solution.
7. the preparation method of the medicine of the treatment of allergic rhinitis according to Claims 2 or 3, is characterized in that: described clear water is 2 ~ 5 times of Chinese crude drug weight.
8. the preparation method of the medicine for the treatment of of allergic rhinitis according to claim 4, is characterized in that: described clear water is 2 ~ 5 times of Chinese crude drug weight.
9. the preparation method of the medicine for the treatment of of allergic rhinitis according to claim 6, is characterized in that: described clear water is 2 ~ 5 times of Chinese crude drug weight.
10. the preparation method of the medicine for the treatment of of allergic rhinitis according to claim 6, is characterized in that: described clear water is 2 ~ 5 times of Chinese crude drug weight.
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| CN201510508172.4A CN105012426A (en) | 2015-08-18 | 2015-08-18 | Chinese medicine composition for treating allergic rhinitis and preparation method thereof |
| CN201610571918.0A CN105943650A (en) | 2015-08-18 | 2016-07-19 | Chinese herbal composition for treating allergic rhinitis and preparing method of Chinese herbal composition |
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| CN201610571918.0A Pending CN105943650A (en) | 2015-08-18 | 2016-07-19 | Chinese herbal composition for treating allergic rhinitis and preparing method of Chinese herbal composition |
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| CN113384638A (en) * | 2021-07-09 | 2021-09-14 | 上海交通大学医学院附属上海儿童医学中心 | Traditional Chinese medicine composition for allergic rhinitis, patch and preparation method of patch |
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| CN110721219A (en) * | 2019-12-06 | 2020-01-24 | 上海市宝山区中西医结合医院(上海中医药大学附属曙光医院宝山分院) | Traditional Chinese medicine for treating allergic rhinitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102512502B (en) * | 2011-12-23 | 2013-09-11 | 慕常松 | Traditional Chinese medicinal composition for treating rhinitis |
| CN104436145B (en) * | 2014-12-25 | 2017-11-03 | 吉林一正药业集团有限公司 | It is a kind of to prevent and/or treatment allergic rhinitis and the pharmaceutical composition of allergic asthma |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113384638A (en) * | 2021-07-09 | 2021-09-14 | 上海交通大学医学院附属上海儿童医学中心 | Traditional Chinese medicine composition for allergic rhinitis, patch and preparation method of patch |
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Application publication date: 20151104 |