CN103027992A - Preparation method of drug for nourishing blood, relaxing muscles and treating rheumatism - Google Patents
Preparation method of drug for nourishing blood, relaxing muscles and treating rheumatism Download PDFInfo
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Abstract
The invention relates to a preparation method of a drug for nourishing blood, relaxing muscles and treating rheumatism. Aiming at the defects of the prior art, the preparation method of the drug for nourishing the blood, relaxing the muscles and treating the rheumatism is provided based on research about steps of a production technology and technological parameters, production cost and crude drug bioavailability. With the adoption of the preparation method of the drug for nourishing the blood, relaxing the muscles and treating the rheumatism, the defects of tedious processing procedure, long production period, high manufacturing cost, low crude drug bioavailability and higher toxic or side effects in the prior art are overcome.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine composition, say that more specifically a kind of tonifying the blood and stretching the tendon treats the preparation method of rheumatismal medicine.Belong to medical technical field.
Background technology
Application number is the preparation method that 01100153.4 application for a patent for invention discloses a kind of nanometer DUHUO JISHENG HEJI.Goal of the invention is that bioavailability is high, solid is scattered, absorbs completely medicine and preparation method thereof.Its technology virtue case is
30～95 parts of 30～95 portions of nanometer Radix Gentianae Macrophyllae of 60～120 parts of nanometer Herba Taxillis of nanometer Radix Angelicae Pubescentis
30～95 parts of 30～95 parts of nano Chinese angelicas of 30～95 parts of nanometric Herbra Asarums of nanometer Radix Saposhnikoviae
30～95 parts of 30～95 parts of nanometer Radix Rehmanniae Preparata of 30～95 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
30～95 parts of 30～95 parts of nanometer Radix Codonopsis of 30～95 parts of nanometer Radix Cyathulaes of the nanometer Cortex Eucommiae
30～95 parts of 30～95 parts of nanometer Ramulus Cinnamomi of 30～95 parts of nanometer Radix Glycyrrhizaes of nano Poria
Its fineness of the particles is little, and particle diameter can be crossed 1200～1500 mesh sieves in 0.1～200 nanometer.Adopt the steps such as microwave extracting, the spraying of supersonic jet technology.
But complex process, equipment cost costliness.The preparation method of traditional DUHUO JISHENG HEJI then exist or extract not exclusively, problem that bioavailability is low, perhaps complex manufacturing, the production cycle is long, the defective that cost is high.
Radix Angelicae Pubescentis is a poisonous medical material, has certain toxic and side effects.
Summary of the invention
The present invention is directed to the defective of prior art, be studied aspect production craft step and the technological parameter, the bioavailability of taking into account production cost and medical material proposes.The invention provides and a kind ofly overcome that manufacturing procedure is loaded down with trivial details in the prior art, the production cycle is long, cost of manufacture is high, and the medical material bioavailability is low, the preparation method of the DUHUO JISHENG HEJI of the higher shortcoming of toxic and side effects.The preparation method of medicine of the present invention has been saved processing step, and production technology is simple, and has suitably reduced the dosage of Radix Angelicae Pubescentis, and the DUHUO JISHENG HEJI bioavailability that gets absorbs fully, and toxic and side effects is low.
The preparation method of a kind of DUHUO JISHENG HEJI of the present invention, technical scheme is:
(1) raw material is comprised of the medical material of following weight portion:
20～70 parts of 20～70 portions of Radix Gentianae Macrophyllae of 40～100 parts of Herba Taxillis of Radix Angelicae Pubescentis
20～70 parts of 20～70 parts of Radix Angelicae Sinensis of 20～70 parts of Herba Asaris of Radix Saposhnikoviae
20～70 parts of 20～70 parts of Radix Rehmanniae Preparata of 20～70 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
20～70 parts of 20～70 parts of Radix Codonopsis of 20～70 portions of Radix Cyathulaes of the Cortex Eucommiae
20～70 parts of 20～70 parts of Ramulus Cinnamomi of 20～70 portions of Radix Glycyrrhizaes of Poria
Its processing step is: Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 10～30 order powder, the percolator of packing into, add 5～9 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight with 65%～75% ethanol, carry out percolation with 1～3ml/kgmin, gained solution is in 70～90 ℃, negative 004～negative 0.06 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering;
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, be ground into 10～30 order powder when being attributed to, add 8～10 times of water gagings, distill with steam distillation in 90～100 ℃, distillation time 8～10 hours, obtain Aromatic water, weight is 0.9～1.1 times of Six-element medical material; Medicinal residues and all the other Six-elements add 7～9 times of decoctings and boil, and decoct secondary, and 90 ℃ of the temperature of decoction decocted 3～5 hours at every turn, collecting decoction filters, and it is 1.18～1.20(55 ℃～65 ℃ mensuration that filtrate is concentrated into the extractum relative density), then merge with the liquid of filtering, left standstill 23～25 hours, filter.Reconcentration is to relative density 1.10～1.15(60 ℃), adding volume is 95% ethanol of mentioned solution 1/3, adds the Aromatic water that obtains previously, adds water an amount of, stirs evenly, and obtains relative density 1.04～1.06(60 ℃) solution, and get final product.
The preferred version of technical scheme of the present invention:
(1), raw material is comprised of the medical material of following weight portion:
20～29 parts of 20～29 portions of Radix Gentianae Macrophyllae of 40～59 parts of Herba Taxillis of Radix Angelicae Pubescentis
20～29 parts of 20～29 parts of Radix Angelicae Sinensis of 20～29 parts of Herba Asaris of Radix Saposhnikoviae
20～29 parts of 20～29 parts of Radix Rehmanniae Preparata of 20～29 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
20～29 parts of 20～29 parts of Radix Codonopsis of 20～29 portions of Radix Cyathulaes of the Cortex Eucommiae
20～29 parts of 20～29 parts of Ramulus Cinnamomi of 20～29 portions of Radix Glycyrrhizaes of Poria
(2), its processing step is: its processing step is: Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 10 order powder, add percolator, 70% ethanol that adds 7 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight, carry out percolation with 2ml/kgmin, then gained solution is in 80 ℃, negative 005 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering.Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Angelicae Sinensis powder are broken into 20 order powder, add 9 times of water gagings, distill with steam distillation in 95 ℃, distill 9 hours, obtain Aromatic water, and weight is 1.0 times of Six-element medical material; Medicinal residues and all the other Six-elements add 8 times of decoctings and boil, and decoct secondary, and 90 ℃ of the temperature of decoction decocted 4 hours at every turn, and collecting decoction filters, and it is 1.19(55 ℃～65 ℃ mensuration that filtrate is concentrated into the extractum relative density), then merge with the liquid of filtering, left standstill 24 hours, filter.Reconcentration to relative density is 1.13(60 ℃), adding volume is 95% ethanol (percentage by weight) of mentioned solution 1/3, adds the Aromatic water that obtains previously, adds water an amount of, obtains relative density 1.05(60 ℃) solution, shake up, and get final product.
The concentration of ethanol refers to percentage by weight among the present invention.
Beneficial effect of the present invention:
The present invention has reduced the dosage of Radix Angelicae Pubescentis, has reduced toxicity.
The present invention is owing to having adopted preferably technological parameter, and the DUHUO JISHENG HEJI bioavailability that gets absorbs fully, and drug effect is remarkable.
The present invention is owing to having adopted good technological parameter and processing step, and production technology is simple, and is with short production cycle, and production cost is low.
The present invention directly substitutes volatile oil with Aromatic water, has saved processing step.
The clinical trial of medicine of the present invention
One, test objective
Further effectiveness and the safety of sick Liver and kidney two void of checking Drug therapy numbness of the present invention, syndrome of cold-dampness blocking collaterals.
Two, EXPERIMENTAL DESIGN
(1) design
This test is taked by random, the positive parallel group of design of test center.
(2) the contrast medicine is selected
Positive control drug is selected FENGSHI YE, and composition is the ten multi-flavor medicines such as Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Flos Carthami, Colla cornus cervi, Colla carapax Trionycis.Produced by Sichuan Baoguang Pharmaceutical Technology Co., Ltd., authentication code is: the accurate word Z51021692 of traditional Chinese medicines, it is identical with medicine of the present invention that its function cures mainly, and meets to generally acknowledge effectively similar comparable principle.
Three, result of the test
(1), the experimenter enters the group situation
Test enters group 160 examples, and 11 routine cases come off (outpatient service is lost and visited), and expulsion rate 6.88% is collected complete case 149 examples that meet scheme altogether, test group 113 examples wherein, matched group 36 examples.
(2) Clinical efficacy comparison
1, two groups of curative effect of disease relatively see Table 1
Table 1 curative effect of disease relatively
Analyze through Ridit, U=0.1691, P＞0.05 (P=0.8654), two groups of general curative effects compare there was no significant difference.
2, the tcm syndrome curative effect relatively sees Table 2
Table 2 tcm syndrome curative effect relatively
Analyze U=0.4917, P＞0.05 (P=0.6223), the comparison there was no significant difference of tcm syndrome curative effect between two groups through Ridit.
3, two groups of main tcm symptoms relatively
3.1 two groups the treatment before and after arthralgias relatively see Table 3
The comparison of table 3 arthralgia (
)
Arthralgias are through check before and after two groups of treatments, between P＞0.05, two group without significant difference.
3.2 two groups the treatment before and after arthroncuss relatively see Table 4
Table 4 arthroncus relatively
Arthroncuss are through check before and after two groups of treatments, between P＞0.05, two group without significant difference.
3.3 chills and pain of the waist and kness relatively sees Table 5 before and after two groups of treatments
Chills and pain of the waist and kness relatively before and after the table 5 liang group treatment
Chills and pain of the waist and kness are through check before and after two groups of treatments, between P＞0.05, two group without significant difference.
3.4 the joint joint stuffiness relatively sees Table 6 before and after two groups of treatments
Table 6 joint joint stuffiness relatively
The joint joint stuffiness is through check before and after two groups of treatments, between P＞0.05, two group without significant difference.
The specific embodiment:
Embodiment 1:
Get following raw material for standby:
Radix Angelicae Pubescentis 40kg, Herba Taxilli 20 kg, Radix Gentianae Macrophyllae 20 kg, Radix Saposhnikoviae 20 kg, Herba Asari 20 kg, Radix Angelicae Sinensis 20 kg, the Radix Paeoniae Alba 20 kg, Rhizoma Chuanxiong 20 kg, Radix Rehmanniae Preparata 20 kg, the Cortex Eucommiae 20 kg Radix Cyathulaes 20 kg, Radix Codonopsis 20 kg, Poria 20 kg, Radix Glycyrrhizae 20 kg, Ramulus Cinnamomi 20 kg;
Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 10 order powder, add percolator, add 65% ethanol of 5 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight, carry out percolation with 1 milliliter/kilogram minute, then gained solution is in 70 ℃, and negative 004 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering.
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, be ground into 10 order powder when being attributed to, add 8 times of water gagings, distill with steam distillation in 90 ℃, distilled 8 hours, obtain Aromatic water, weight is 0.9 times of Six-element medical material; Medicinal residues and all the other Six-elements add 7 times of decoctings and boil, and decoct secondary, and 85 ℃ of the temperature of decoction decocted 3 hours at every turn, and collecting decoction filters, and it is 1.18(55 ℃ of mensuration that filtrate is concentrated into the extractum relative density), then merge with the liquid of filtering, left standstill 23 hours, filter.Reconcentration to relative density is 1.10(60 ℃), adding volume is 95% ethanol of mentioned solution 1/3, adds the front and extracts the Aromatic water that obtains, and adds water an amount of, obtains relative density 1.04(60 ℃) solution, shake up, and get final product.
Embodiment 2:
Get following raw material for standby:
Radix Angelicae Pubescentis 100kg, Herba Taxilli 70kg, Radix Gentianae Macrophyllae 70kg, Radix Saposhnikoviae 70kg, Herba Asari 70kg, Radix Angelicae Sinensis 70kg, Radix Paeoniae Alba 70kg, Rhizoma Chuanxiong 70kg, Radix Rehmanniae Preparata 70kg, Cortex Eucommiae 70kg, Radix Cyathulae 70kg, Radix Codonopsis 70kg, Poria 70kg, Radix Glycyrrhizae 70kg, Ramulus Cinnamomi 70kg;
Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 30 order powder, add percolator, add 75% ethanol (percentage by weight) of 9 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight, to carry out percolation in 3 milliliters/kilogram minutes, then in 90 ℃, negative 006 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering.
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, be ground into 30 order powder when being attributed to, add 10 times of water gagings, in 100 ℃ with the steam distillation distillation, distilled 10 hours, obtain Aromatic water, weight is 1.1 times of Six-element medical material; Medicinal residues and all the other Six-elements add 9 times of decoctings and boil, and decoct secondary, and 95 ℃ of the temperature of decoction decocted 5 hours at every turn, and collecting decoction filters, and it is 1.20(65 ℃ of mensuration that filtrate is concentrated into the extractum relative density), then merge with the liquid of filtering, left standstill 25 hours, filter.Reconcentration to relative density is 1.15(60 ℃), adding volume is 95% ethanol of mentioned solution 1/3, adds the front and extracts the Aromatic water that obtains, and adds water an amount of, obtains relative density 1.06(60 ℃) solution, shake up, and get final product.
Embodiment 3
Get following raw material for standby:
Radix Angelicae Pubescentis 70kg, Herba Taxilli 45kg, Radix Gentianae Macrophyllae 45kg, Radix Saposhnikoviae 45kg, Herba Asari 45kg, Radix Angelicae Sinensis 45 kg, Radix Paeoniae Alba 45kg, Rhizoma Chuanxiong 45kg, Radix Rehmanniae Preparata 45kg, the Cortex Eucommiae 45 kg, Radix Cyathulae 45kg, Radix Codonopsis 45kg, Poria 45kg, Radix Glycyrrhizae 45kg, Ramulus Cinnamomi 45kg;
Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 20 order powder, add percolator, add 70% ethanol (percentage by weight) of 8 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight, to carry out percolation in 2 milliliters/kilogram minutes, then solution in 80 ℃, negative 005 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering.
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, be ground into 20 order powder when being attributed to, add 9 times of water gagings, distill with steam distillation in 95 ℃, distilled 9 hours, obtain Aromatic water, weight is 1.0 times of Six-element medical material; Medicinal residues and all the other Six-elements add 8 times of decoctings and boil, and decoct secondary, and 90 ℃ of the temperature of decoction decocted 4 hours at every turn, and collecting decoction filters, and it is 1.19(60 ℃ of mensuration that filtrate is concentrated into the extractum relative density), then merge with the liquid of filtering, left standstill 24 hours, filter.Reconcentration to relative density is 1.13(60 ℃), adding volume is 95% ethanol of mentioned solution 1/3, adds the front and extracts the Aromatic water that obtains, and adds water an amount of, obtains relative density 1.05(60 ℃) solution, shake up, and get final product.
Embodiment 4
Get following raw material for standby:
Radix Angelicae Pubescentis 59kg, Herba Taxilli 29kg, Radix Gentianae Macrophyllae 29kg, Radix Saposhnikoviae 29kg, Herba Asari 29 kg, Radix Angelicae Sinensis 29kg, Radix Paeoniae Alba 29kg, Rhizoma Chuanxiong 29kg, Radix Rehmanniae Preparata 29kg, Cortex Eucommiae 29kg, Radix Cyathulae 29kg, Radix Codonopsis 29kg, Poria 29kg, Radix Glycyrrhizae 29 kg, Ramulus Cinnamomi 29kg;
Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 20 order powder, add percolator, add 70% ethanol (percentage by weight) of 8 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight, to carry out percolation in 2 milliliters/kilogram minutes, then gained solution is in 80 ℃, and negative 005 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering.
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, be ground into 30 order powder when being attributed to, add 10 times of water gagings, distill with steam distillation in 100 ℃, distilled 10 hours, obtain Aromatic water, weight is 1.1 times of Six-element medical material; Medicinal residues and all the other Six-elements add 9 times of decoctings and boil, and decoct secondary, and 95 ℃ of the temperature of decoction decocted 5 hours at every turn, and collecting decoction filters, and it is 1.20(65 ℃ of mensuration that filtrate is concentrated into the extractum relative density), then merge with the liquid of filtering, stir evenly, left standstill 25 hours, filter.Reconcentration to relative density is 1.15(60 ℃), adding volume is 95% ethanol of mentioned solution 1/3, adds the front and extracts the Aromatic water that obtains, and adds water an amount of, obtains relative density 1.06(60 ℃) solution, shake up, and get final product.
Claims (3)
1. a tonifying the blood and stretching the tendon is treated the preparation method of rheumatismal medicine, it is characterized in that:
(1), raw material is comprised of the medical material of following weight portion:
20～70 parts of 20～70 portions of Radix Gentianae Macrophyllae of 40～100 parts of Herba Taxillis of Radix Angelicae Pubescentis
20～70 parts of 20～70 parts of Radix Angelicae Sinensis of 20～70 parts of Herba Asaris of Radix Saposhnikoviae
20～70 parts of 20～70 parts of Radix Rehmanniae Preparata of 20～70 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
20～70 parts of 20～70 parts of Radix Codonopsis of 20～70 portions of Radix Cyathulaes of the Cortex Eucommiae
20～70 parts of 20～70 parts of Ramulus Cinnamomi of 20～70 portions of Radix Glycyrrhizaes of Poria
(2), its processing step is:
Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 10～30 order powder, the percolator of packing into, add 5～9 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight with 65%～75% ethanol, carry out percolation with 1～3ml/kgmin, gained solution is in 70～90 ℃, and negative 004～negative 0.06 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering;
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Angelicae Sinensis powder are broken into 10～30 order powder, add the water of 8～10 times of weight, distill distillation time 8～10 hours with steam distillation in 90～100 ℃, obtain Aromatic water, weight is 0.9～1.1 times of Six-element medical material; The decocting that medicinal residues and all the other Six-elements add 7～9 times of weight boils, and decocts secondary, and 90 ℃ of the temperature of decoction decocted 3～5 hours at every turn, collecting decoction filters, and it is 1.18～1.20 that filtrate is concentrated into the extractum relative density, then merge with the liquid of filtering, left standstill 23～25 hours, filter; Reconcentration is to relative density 1.10～1.15, and adding volume is 95% ethanol of mentioned solution 1/3, adds the Aromatic water that obtains previously, adds water, stirs evenly, and obtains the solution of relative density 1.04～1.06.
2. according to claim 1 a kind of tonifying the blood and stretching the tendon is treated the preparation method of rheumatismal medicine, and it is characterized in that: raw material is comprised of the medical material of following weight portion:
Radix Angelicae Pubescentis 40--59 part Herba Taxilli 20---29 part Radix Gentianae Macrophyllae 20--29 part
Radix Saposhnikoviae 20---29 part Herba Asari 20---29 part Radix Angelicae Sinensis 20---29 part
Radix Paeoniae Alba 20---29 part Rhizoma Chuanxiong 20---29 part Radix Rehmanniae Preparata 20--29 part
Cortex Eucommiae 20---29 part Radix Cyathulae 20---29 part Radix Codonopsis 20---29 part
Poria 20---29 part Radix Glycyrrhizae 20---29 part Ramulus Cinnamomi 20---29 part.
3. according to claim 1 a kind of tonifying the blood and stretching the tendon is treated the preparation method of rheumatismal medicine, it is characterized in that:
Its processing step is: Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae powder are broken into 10 order powder, and the percolator of packing into adds 70% ethanol of 7 times of Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Cortex Eucommiae weight, carry out percolation with 2ml/kgmin, then in 80 ℃, negative 005 atmospheric pressure vacuum Recycled ethanol obtains the liquid of filtering;
Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, be ground into 20 order powder when being attributed to, add the water of 9 times of weight, distill with steam distillation in 95 ℃, distilled 9 hours, obtain Aromatic water, weight is 1.0 times of Six-element medical material; The decocting that medicinal residues and all the other Six-elements add 8 times of weight boils, and decocts secondary, 90 ℃ of the temperature of decoction, the each decoction 4 hours, collecting decoction filters, it is 1.19 that filtrate is concentrated into the extractum relative density, then merges with the liquid of filtering, and leaves standstill 24 hours, filter, reconcentration to relative density is 1.13, and adding volume is 95% ethanol of mentioned solution 1/3, adds the Aromatic water that obtains previously, add water, obtain the solution of relative density 1.05.
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| CN104173564A (en) * | 2014-08-25 | 2014-12-03 | 吕红权 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
| CN104288673A (en) * | 2014-09-23 | 2015-01-21 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine tablet for treating osteoarthritis and preparation method of traditional Chinese medicine tablet |
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| CN104689144A (en) * | 2013-12-09 | 2015-06-10 | 黄思齐 | Drug for treating rheumatoid arthritis |
| CN104173564A (en) * | 2014-08-25 | 2014-12-03 | 吕红权 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
| CN104173564B (en) * | 2014-08-25 | 2016-05-18 | 吕红权 | A kind of Chinese medicine composition for the treatment of rheumatoid arthritis |
| CN104288673A (en) * | 2014-09-23 | 2015-01-21 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine tablet for treating osteoarthritis and preparation method of traditional Chinese medicine tablet |
| CN105079250A (en) * | 2015-05-17 | 2015-11-25 | 柳晖 | Traditional Chinese medicine composition for treating numbness of limbs |
| CN105535090A (en) * | 2016-01-08 | 2016-05-04 | 周景波 | Traditional Chinese medicine composition for treating back pain, traditional Chinese preparation for treating back pain and preparation method thereof |
| CN105660687A (en) * | 2016-03-01 | 2016-06-15 | 江苏七洲绿色化工股份有限公司 | Refined glufosinate ammonium-dicamba compound |
| CN106474348A (en) * | 2016-12-12 | 2017-03-08 | 金乡县金醫堂保健食品有限公司 | A kind of Chinese medicine composition treating rheumatism bones and muscles pain |
| CN112791168A (en) * | 2021-02-02 | 2021-05-14 | 张玉坤 | Method for treating rheumatic osteoarthropathy |
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Application publication date: 20130410 |