CN102671005B - Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia - Google Patents
Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia Download PDFInfo
- Publication number
- CN102671005B CN102671005B CN201210183062.1A CN201210183062A CN102671005B CN 102671005 B CN102671005 B CN 102671005B CN 201210183062 A CN201210183062 A CN 201210183062A CN 102671005 B CN102671005 B CN 102671005B
- Authority
- CN
- China
- Prior art keywords
- grams
- radix
- root
- extracting
- chinese medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia. The Chinese medicinal particle is prepared by the following steps of: soaking paniculate swallowwort root and tree peony root-bark with 75 percent ethanol for 24 hours, extracting with a percolation method, and recovering ethanol under increased pressure for later use; (2) extracting alcohol-soluble active ingredients from a prescribed amount of dangshen and szechuan lovage rhizome in a refluxing way with 70 percent ethanol for three times, recovering ethanol under reduced pressure, standing, and extracting a supernatant for later use; (3) adding water into Chinese angelica for 3 hours, and extracting volatile oil by using a volatile oil extractor for later use; (4) adding water into prepared common monkshood daughter root for soaking, decocting for 2 hours, adding decoction dregs of paniculate swallowwort root, tree peony root-bark, dangshen, szechuan lovage rhizome and Chinese angelica, and astragalus, Chinese yam, spina date seed, tall gastrodia tuber, red-rooted salvia root, safflower, rehmannia root, prepared rehmannia root, barbary wolfberry fruit, platycodon root and roasted liquoric root which are soaked for 1 hour into a multifunctional extractor, heating and extracting twice, combining extracting solutions, standing, and extracting a supernatant for later use; and (5) concentrating supernatants extracted in the step (1) and the step (3) into thick paste, adding an inclusion compound prepared in the step (2) and an appropriate amount of starch for serving as adsorbents, sieving with a 14-mesh sieve to obtain particles, ventilating, drying, and performing split charging to obtain particles.
Description
Technical field:
The invention belongs to technical field of Chinese medicines, particularly a kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule for vertebro-basilar artery insufficiency.
Background technology:
Vertebro-basilar artery insufficiency is a kind of old people's common disease, when vertebro-basilar artery insufficiency, brain thrombosis, blood supply insufficiency, cause the symptoms such as dizziness, insomnia, poor memory, trick be cool, this interior syndrome medical science belongs to dizzy category, how by many factors such as wind, fire, expectorant, void, to be caused pathogenesis and insufficiency of vital energy and blood, congestion resistance network, this disease is often delayed difficult, and outbreak repeatedly also easily forms acute cerebrovascular disease.
Summary of the invention:
The invention provides a kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule for vertebro-basilar artery insufficiency, this Chinese medicinal granule is comprised of 12 grams of 15 grams of Radix Codonopsis, 15 grams of Radix Angelicae Sinensis, 12 grams of the Radixs Astragali, 12 grams of Rhizoma Dioscoreaes, 12 grams of Semen Ziziphi Spinosaes, 9 grams, Rhizoma Gastrodiae, 9 grams of Radix Salviae Miltiorrhizaes, 9 grams, Flos Carthami, 9 grams of Radix Rehmanniae Preparata, 9 grams of Rhizoma Chuanxiongs, 6 grams of Fructus Lyciis, 6 grams of Radix Aconiti Lateralis Preparatas, 6 grams of Radix Glycyrrhizae Preparatas, 12 grams of Radix Cynanchi Paniculatis, 12 grams, the Radix Rehmanniae, 9 grams of Cortex Moutans and Radix Platycodoniss.
Its processing technology is: 75% soak with ethanol 24 hours for (1) Radix Cynanchi Paniculati, Cortex Moutan, with percolation, extract, and collect percolate, pressurization is reclaimed after ethanol standby; (2) 70% alcohol reflux alcohol dissolubility effective ingredient 3 times for the Radix Codonopsis, Rhizoma Chuanxiong of getting recipe quantity, each 1.5 hours, merge alcohol extract, decompression recycling ethanol, standing 24 hours precipitations, get supernatant standby; (3) getting Radix Angelicae Sinensis and soak 3 hours, extract volatile oil, then obtain volatile oil with anhydrous sodium sulfate drying with volatile oil extractor, is weak yellow liquid, with beta-cyclodextrin inclusion compound, standby; (4) Radix Aconiti Lateralis Preparata is soaked, be decocted first 2 hours, the Radix Astragali, Rhizoma Dioscoreae, Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Radix Platycodonis, the Radix Glycyrrhizae Preparata that adds Radix Cynanchi Paniculati, Cortex Moutan, Radix Codonopsis, Rhizoma Chuanxiong, Radix Angelicae Sinensis medicinal residues again and soaked 1 hour put into multi-functional extractor heating extraction 2 times, each 1 hour, merge extractive liquid,, standing 24 hours precipitations, get supernatant standby; (4) get the supernatant extracting in (1) step and (3) step, be concentrated into thick paste and add the prepared clathrate of (2) step and appropriate amount of starch to make absorbent, cross 14 mesh sieve granule processed, 60 ℃ of aeration-dryings, subpackage, obtains granule.
Method for making explanation: the contained paeonol fusing point of Radix Cynanchi Paniculati and Cortex Moutan is lower, volatile, has the multiple effects such as analgesia, hemostasis, antiinflammatory, therefore extract with alcohol percolation method; Radix Angelicae Sinensis contains volatile oil, first with volatile oil extractor, extracts volatile oil, and with beta-cyclodextrin inclusion compound, has strengthened the stability of preparation; Beta-cyclodextrin inclusion compound: take beta-schardinger dextrin-appropriate, add 10 times of amount distilled water, 80 ℃ of heating in water bath dissolve, and are placed in magnetic stirring apparatus, slowly add volatile oil (volatile oil: beta-schardinger dextrin-=1: 8), mixing time 2 hours, enclose temperature is 30 ℃.Conclusion constant temperature stirs after certain hour, and standing, cold preservation 24 hours, filters, and precipitate is successively used distilled water and petroleum ether 3 times, 40 ℃ dry 4 hours, obtain the extraction that clathrate ethanol extraction is conducive to Radix Codonopsis, Rhizoma Chuanxiong effective ingredient.
Side separates: in side, Radix Codonopsis is that QI invigorating is enriched blood again, and Flos Carthami, Radix Salviae Miltiorrhizae have the effect of promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain, and Radix Rehmanniae Preparata has the effect that moist, the beneficial essence of enriching blood is filled out marrow; Chinese angelica blood supplementing is invigorated blood circulation, Semen Ziziphi Spinosae tranquilizing by nourishing the heart, Rhizoma Chuanxiong have invigorate blood circulation, the effect of activating QI to alleviate the depression, wind-expelling pain-stopping, Radix Aconiti Lateralis Preparata promoting flow of qi by warming channel, Radix Glycyrrhizae Preparata QI invigorating again can coordinating the actions of various ingredients in a prescription, above drug combination, play nourish blood, the effect of promoting blood circulation to remove obstruction in the collateral.Modern pharmacology shows: the effect that Radix Codonopsis has blood circulation promoting and blood stasis dispelling, removes free radical; Radix Cynanchi Paniculati dispels the wind, removing dampness, dredging collateral; The Radix Rehmanniae, Cortex Moutan heat clearing away YIN nourishing; Radix Platycodonis lung qi dispersing eliminates the phlegm.
The specific embodiment:
For a promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule for vertebro-basilar artery insufficiency, this Chinese medicinal granule is comprised of 12 grams of 15 grams of Radix Codonopsis, 15 grams of Radix Angelicae Sinensis, 12 grams of the Radixs Astragali, 12 grams of Rhizoma Dioscoreaes, 12 grams of Semen Ziziphi Spinosaes, 9 grams, Rhizoma Gastrodiae, 9 grams of Radix Salviae Miltiorrhizaes, 9 grams, Flos Carthami, 9 grams of Radix Rehmanniae Preparata, 9 grams of Rhizoma Chuanxiongs, 6 grams of Fructus Lyciis, 6 grams of Radix Aconiti Lateralis Preparatas, 6 grams of Radix Glycyrrhizae Preparatas, 12 grams of Radix Cynanchi Paniculatis, 12 grams, the Radix Rehmanniae, 9 grams of Cortex Moutans and Radix Platycodoniss.Its processing technology is: 75% soak with ethanol 24 hours for (1) Radix Cynanchi Paniculati, Cortex Moutan, with percolation, extract, and collect percolate, pressurization is reclaimed after ethanol standby; (2) 70% alcohol reflux alcohol dissolubility effective ingredient 3 times for the Radix Codonopsis, Rhizoma Chuanxiong of getting recipe quantity, each 1.5 hours, merge alcohol extract, decompression recycling ethanol, standing 24 hours precipitations, get supernatant standby; (3) getting Radix Angelicae Sinensis and soak 3 hours, extract volatile oil, then obtain volatile oil with anhydrous sodium sulfate drying with volatile oil extractor, is weak yellow liquid, with beta-cyclodextrin inclusion compound, standby; (4) Radix Aconiti Lateralis Preparata is soaked, be decocted first 2 hours, the Radix Astragali, Rhizoma Dioscoreae, Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Radix Platycodonis, the Radix Glycyrrhizae Preparata that adds Radix Cynanchi Paniculati, Cortex Moutan, Radix Codonopsis, Rhizoma Chuanxiong, Radix Angelicae Sinensis medicinal residues again and soaked 1 hour put into multi-functional extractor heating extraction 2 times, each 1 hour, merge extractive liquid,, standing 24 hours precipitations, get supernatant standby; (4) get the supernatant extracting in (1) step and (3) step, be concentrated into thick paste and add the prepared clathrate of (2) step and appropriate amount of starch to make absorbent, cross 14 mesh sieve granule processed, 60 ℃ of aeration-dryings, subpackage, obtains granule.
Through clinical verification:
By this side's treatment vertebro-basilar artery insufficiency person 82 examples, medication 10th is a course for the treatment of, medication cured person 70 examples on the 10th～30; Wherein, 1 the course for the treatment of healing person's 49 examples, 2 the course for the treatment of healing person's 28 examples, 3 the course for the treatment of healing person's 1 example; Effective 3 examples, nonresponder's 2 examples, total effective rate 97.5%.
1, Zhang, female, 48 years old, is not admitted to hospital because dizziness, headache, tinnitus, insomnia, dreaminess, brain are limpid, forgetful, patient's cold hand and foot, limbs weakness, likes lying up, cranium brain MR is without extremely, and cranium brain Doppler shows color ultrasound: slow blood flow, prompting cerebral blood supply insufficiency.Promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule is taken 3 days, and dizzy, tinnitus obviously alleviates, and continues medication 7 days, and sleep improvement, requires to leave hospital.
2, Wang, man, 56 years old, because of drowsiness, numb limbs and tense tendons, weak, dumb and be admitted to hospital, CT is without extremely, and it is that blood viscosity increases that blood flow becomes.Be diagnosed as cerebral blood supply insufficiency, expand blood vessel, this medicine for oral administration, treat symptom improvement in a week and leave hospital.
3, Lee, man, is admitted to hospital because of dizziness, headache, numbness of hand for 62 years old, and nuclear magnetic resonance, NMR shows cervical spondylosis, and brain color ultrasound is shown cerebral blood supply insufficiency, gives and improves microcirculation, coordinates this granule oral, and symptom alleviates, and within 10 days, leaves hospital in hospital.
Claims (1)
1. for a promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule for vertebro-basilar artery insufficiency, it is characterized in that: the raw material of described Chinese medicinal granule consists of 12 grams of 15 grams of Radix Codonopsis, 15 grams of Radix Angelicae Sinensis, 12 grams of the Radixs Astragali, 12 grams of Rhizoma Dioscoreaes, 12 grams of Semen Ziziphi Spinosaes, 9 grams, Rhizoma Gastrodiae, 9 grams of Radix Salviae Miltiorrhizaes, 9 grams, Flos Carthami, 9 grams of Radix Rehmanniae Preparata, 9 grams of Rhizoma Chuanxiongs, 6 grams of Fructus Lyciis, 6 grams of Radix Aconiti Lateralis Preparatas, 6 grams of Radix Glycyrrhizae Preparatas, 12 grams of Radix Cynanchi Paniculatis, 12 grams, the Radix Rehmanniae, 9 grams of Cortex Moutans and Radix Platycodoniss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210183062.1A CN102671005B (en) | 2012-05-31 | 2012-05-31 | Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210183062.1A CN102671005B (en) | 2012-05-31 | 2012-05-31 | Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102671005A CN102671005A (en) | 2012-09-19 |
| CN102671005B true CN102671005B (en) | 2014-08-20 |
Family
ID=46803990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210183062.1A Expired - Fee Related CN102671005B (en) | 2012-05-31 | 2012-05-31 | Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102671005B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853759B (en) * | 2015-01-20 | 2019-12-06 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition, extract thereof, preparation method thereof and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343785A (en) * | 2015-12-02 | 2016-02-24 | 匡素清 | Traditional Chinese medicine pills for treating vertebrobasilar insufficiency (VBI) and preparation method thereof |
-
2012
- 2012-05-31 CN CN201210183062.1A patent/CN102671005B/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853759B (en) * | 2015-01-20 | 2019-12-06 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition, extract thereof, preparation method thereof and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102671005A (en) | 2012-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103211892B (en) | Chinese medicinal composition for treating insomnia | |
| CN104337974A (en) | Drug for treating metrorrhagia and preparation method thereof | |
| CN104606470A (en) | Traditional Chinese medicine composition for treating endocrine dyscrasia | |
| CN103212021A (en) | Traditional Chinese medicine composition used for treating chloasma | |
| CN104888131A (en) | Traditional Chinese medicine composition for treatment of insomnia | |
| CN102671005B (en) | Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia | |
| CN104225426A (en) | Chinese medicine for treating cerebral arteriosclerosis and preparation method thereof | |
| CN104524159A (en) | Pharmaceutical composition for treating hyperplasia of mammary glands | |
| CN104000933A (en) | Traditional Chinese medicine oral liquid for treating osteoproliferation | |
| CN103211980A (en) | Traditional Chinese medicine composition for treatment of yin deficiency and yang excess | |
| CN103007064A (en) | Traditional Chinese medicine (TCM) composition for treating cerebral posterior circulation ischemia | |
| CN105250427A (en) | Pharmaceutical composition for treating heart diseases | |
| CN103550674A (en) | Blood stasis removing and blood circulation invigorating soup | |
| CN104606514A (en) | Traditional Chinese medicine composition for treating kidney deficiency type tinnitus | |
| CN104225507A (en) | Chinese medicine for treating limb paralysis and pain caused by cerebral hemorrhage | |
| CN103550688A (en) | Traditional Chinese medicine (TCM) composition for treating palpitation | |
| CN103550533B (en) | Chinese medicine composition for treating headache during menstruation | |
| CN103463427B (en) | Medicinal tea for treating arteriosclerosis | |
| CN106138772A (en) | Gastrodia tuber and fleece-flower root combined pharmaceutical composition and preparation technology thereof | |
| CN105079515A (en) | Traditional Chinese medicine composition for treating post-traumatic headache | |
| CN105381289A (en) | Pharmaceutical composition for treating abnormal menstruation | |
| CN105125658A (en) | Granules with effects of eliminating obstruction to activate collaterals and preparation method thereof | |
| CN103860914A (en) | Chinese medicine composition for treating epilepsy | |
| CN103816343A (en) | Traditional Chinese medicine composition for treating head ring of old people | |
| CN105381302A (en) | Drug for treating hemophilia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140820 Termination date: 20150531 |
|
| EXPY | Termination of patent right or utility model |