CN102671005A

CN102671005A - Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia

Info

Publication number: CN102671005A
Application number: CN2012101830621A
Authority: CN
Inventors: 郑文婧; 李留芝
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-05-31
Filing date: 2012-05-31
Publication date: 2012-09-19
Anticipated expiration: 2032-05-31
Also published as: CN102671005B

Abstract

The invention discloses a Chinese medicinal particle with effects of promoting blood circulation and removing obstruction in channels for treating vertebrobasilar ischemia. The Chinese medicinal particle is prepared by the following steps of: soaking paniculate swallowwort root and tree peony root-bark with 75 percent ethanol for 24 hours, extracting with a percolation method, and recovering ethanol under increased pressure for later use; (2) extracting alcohol-soluble active ingredients from a prescribed amount of dangshen and szechuan lovage rhizome in a refluxing way with 70 percent ethanol for three times, recovering ethanol under reduced pressure, standing, and extracting a supernatant for later use; (3) adding water into Chinese angelica for 3 hours, and extracting volatile oil by using a volatile oil extractor for later use; (4) adding water into prepared common monkshood daughter root for soaking, decocting for 2 hours, adding decoction dregs of paniculate swallowwort root, tree peony root-bark, dangshen, szechuan lovage rhizome and Chinese angelica, and astragalus, Chinese yam, spina date seed, tall gastrodia tuber, red-rooted salvia root, safflower, rehmannia root, prepared rehmannia root, barbary wolfberry fruit, platycodon root and roasted liquoric root which are soaked for 1 hour into a multifunctional extractor, heating and extracting twice, combining extracting solutions, standing, and extracting a supernatant for later use; and (5) concentrating supernatants extracted in the step (1) and the step (3) into thick paste, adding an inclusion compound prepared in the step (2) and an appropriate amount of starch for serving as adsorbents, sieving with a 14-mesh sieve to obtain particles, ventilating, drying, and performing split charging to obtain particles.

Description

A kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule that is used for vertebro-basilar artery insufficiency

Technical field:

The invention belongs to technical field of Chinese medicines, particularly a kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule that is used for vertebro-basilar artery insufficiency.

Background technology:

Vertebro-basilar artery insufficiency is a kind of common in older people disease, when vertebro-basilar artery insufficiency, and the brain thrombosis; Blood supply insufficiency causes symptoms such as dizziness, insomnia, poor memory, trick cold, and this interior syndrome medical science belongs to dizzy category; How to cause pathogenesis and insufficiency of vital energy and blood, congestion resistance network by multiple factors such as wind, fire, expectorant, void; This disease is often delayed difficult, and outbreak repeatedly also forms ACVD easily.

Summary of the invention:

The present invention provides a kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule that is used for vertebro-basilar artery insufficiency, and the prescription of this Chinese medicinal granule is: 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 12 parts of the Radixs Astragali, 12 parts of Rhizoma Dioscoreaes, 12 parts of Semen Ziziphi Spinosaes, 9 parts in Rhizoma Gastrodiae, 9 parts of Radix Salviae Miltiorrhizaes, 9 parts on Flos Carthami, 9 parts of Radix Rehmanniae Preparata, 9 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Lyciis, 6 parts of Radix Aconiti Lateralis Preparatas, 6 parts of Radix Glycyrrhizae Preparatas, Radix Cynanchi Paniculati 12 grams, the Radix Rehmanniae 12 grams, Cortex Moutan 9 grams and Radix Platycodonis 12 grams.

Its processing technology is: (1) Radix Cynanchi Paniculati, Cortex Moutan extract with percolation with 75% soak with ethanol 24 hours, collect percolate, and pressurization is reclaimed behind the ethanol subsequent use; (2) Radix Codonopsis, Rhizoma Chuanxiong of getting recipe quantity be with 70% alcohol reflux alcohol dissolubility effective ingredient 3 times, and each 1.5 hours, merge alcohol extract, decompression recycling ethanol leaves standstill 24 hours depositions, and it is subsequent use to get supernatant; (3) get Radix Angelicae Sinensis and soaked 3 hours, extract volatile oil with volatile oil extractor, the reuse anhydrous sodium sulfate drying is obtained volatile oil, is weak yellow liquid, uses beta-cyclodextrin inclusion compound, and is subsequent use; (4) Radix Aconiti Lateralis Preparata is soaked; Be decocted first 2 hours; The Radix Astragali, Rhizoma Dioscoreae, Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Radix Platycodonis, the Radix Glycyrrhizae Preparata that adds Radix Cynanchi Paniculati, Cortex Moutan, Radix Codonopsis, Rhizoma Chuanxiong, Radix Angelicae Sinensis medicinal residues again and soaked 1 hour put into the multi-functional extractor heating extraction 2 times, and each 1 hour, merge extractive liquid; Leave standstill 24 hours depositions, it is subsequent use to get supernatant; (4) get the supernatant that extracts in (1) step and (3) step, be concentrated into thick paste adding prepared clathrate of (2) step and appropriate amount of starch and make absorbent, cross 14 mesh sieve system granules, 60 ℃ of aeration-dryings, packing promptly gets granule.

Method for making explanation: the contained paeonol fusing point of Radix Cynanchi Paniculati and Cortex Moutan is lower, volatile, has multiple effects such as analgesia, hemostasis, antiinflammatory, so extract with alcohol percolation method; Radix Angelicae Sinensis contains volatile oil, extracts volatile oil with volatile oil extractor earlier, and has strengthened stability of formulation with beta-cyclodextrin inclusion compound; Beta-cyclodextrin inclusion compound: it is an amount of to take by weighing beta-schardinger dextrin-, adds 10 times of amount distilled water, and 80 ℃ of heating in water bath dissolvings place magnetic stirring apparatus, and (volatile oil: beta-schardinger dextrin-=1: 8), mixing time 2 hours, enclose temperature are 30 ℃ slowly to add volatile oil.After conclusion constant temperature stirs certain hour, leave standstill, cold preservation 24 hours, filter, precipitate is successively with distilled water and petroleum ether 3 times, 40 ℃ of dryings 4 hours promptly get the extraction that the clathrate ethanol extraction helps Radix Codonopsis, Rhizoma Chuanxiong effective ingredient.

The side separates: Radix Codonopsis is that QI invigorating is enriched blood again in the side, and Flos Carthami, Radix Salviae Miltiorrhizae have the effect of promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain, and Radix Rehmanniae Preparata has the effect that moist, the beneficial essence of enriching blood is filled out marrow; Chinese angelica blood supplementing is invigorated blood circulation, Semen Ziziphi Spinosae tranquilizing by nourishing the heart, Rhizoma Chuanxiong have invigorate blood circulation, the effect of activating QI to alleviate the depression, wind-expelling pain-stopping, the Radix Aconiti Lateralis Preparata promoting flow of qi by warming channel, the Radix Glycyrrhizae Preparata QI invigorating again can coordinating the actions of various ingredients in a prescription, above drug combination, play nourish blood, the effect of promoting blood circulation to remove obstruction in the collateral.Modern pharmacology shows: the effect that Radix Codonopsis has blood circulation promoting and blood stasis dispelling, removes free radical; Radix Cynanchi Paniculati dispels the wind, removing dampness, collateral dredging; The Radix Rehmanniae, Cortex Moutan heat clearing away YIN nourishing; The Radix Platycodonis lung qi dispersing eliminates the phlegm.

The specific embodiment:

A kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule that is used for vertebro-basilar artery insufficiency, the prescription of this Chinese medicinal granule is: 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 12 parts of the Radixs Astragali, 12 parts of Rhizoma Dioscoreaes, 12 parts of Semen Ziziphi Spinosaes, 9 parts in Rhizoma Gastrodiae, 9 parts of Radix Salviae Miltiorrhizaes, 9 parts on Flos Carthami, 9 parts of Radix Rehmanniae Preparata, 9 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Lyciis, 6 parts of Radix Aconiti Lateralis Preparatas, 6 parts of Radix Glycyrrhizae Preparatas, Radix Cynanchi Paniculati 12 grams, the Radix Rehmanniae 12 grams, Cortex Moutan 9 grams and Radix Platycodonis 12 grams.Its processing technology is: (1) Radix Cynanchi Paniculati, Cortex Moutan extract with percolation with 75% soak with ethanol 24 hours, collect percolate, and pressurization is reclaimed behind the ethanol subsequent use; (2) Radix Codonopsis, Rhizoma Chuanxiong of getting recipe quantity be with 70% alcohol reflux alcohol dissolubility effective ingredient 3 times, and each 1.5 hours, merge alcohol extract, decompression recycling ethanol leaves standstill 24 hours depositions, and it is subsequent use to get supernatant; (3) get Radix Angelicae Sinensis and soaked 3 hours, extract volatile oil with volatile oil extractor, the reuse anhydrous sodium sulfate drying is obtained volatile oil, is weak yellow liquid, uses beta-cyclodextrin inclusion compound, and is subsequent use; (4) Radix Aconiti Lateralis Preparata is soaked; Be decocted first 2 hours; The Radix Astragali, Rhizoma Dioscoreae, Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Radix Platycodonis, the Radix Glycyrrhizae Preparata that adds Radix Cynanchi Paniculati, Cortex Moutan, Radix Codonopsis, Rhizoma Chuanxiong, Radix Angelicae Sinensis medicinal residues again and soaked 1 hour put into the multi-functional extractor heating extraction 2 times, and each 1 hour, merge extractive liquid; Leave standstill 24 hours depositions, it is subsequent use to get supernatant; (4) get the supernatant that extracts in (1) step and (3) step, be concentrated into thick paste adding prepared clathrate of (2) step and appropriate amount of starch and make absorbent, cross 14 mesh sieve system granules, 60 ℃ of aeration-dryings, packing promptly gets granule.

Through clinical verification:

With this side's treatment vertebro-basilar artery insufficiency person 82 examples, medication 10th was a course of treatment, medication cured person 70 examples on the 10th～30; Wherein, 1 the course of treatment healing person's 49 examples, 2 the course of treatment healing person's 28 examples, 3 the course of treatment healing person's 1 example; Produce effects 3 examples, nonresponder's 2 examples, total effective rate 97.5%.

1, Zhang, the woman, 48 years old, excuse was dizzy, headache, tinnitus, insomnia, dreaminess, brain is not limpid, forgetful and be admitted to hospital; Patient's cold hand and foot, the limbs weakness is liked lying up; MR is no abnormal for the cranium brain, and cranium brain Doppler shows color ultra: slow blood flow, prompting cerebral blood supply insufficiency.The promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule was taken 3 days, and dizzy, tinnitus obviously alleviates, and continues medication 7 days, and sleep improves, and requires to leave hospital.

2, Wang, the man, 56 years old, because of drowsiness, numb limbs and tense tendons, weak, dumb and be admitted to hospital, CT is no abnormal, and hemorheology is that blood viscosity increases.Be diagnosed as cerebral blood supply insufficiency, expand blood vessel, this medicine for oral administration, treat all symptom improvements and leave hospital.

3, Lee, the man, 62 years old excuse is dizzy, headache, numbness of hand and be admitted to hospital, and nuclear magnetic resonance, NMR shows cervical spondylosis, and the color ultra cerebral blood supply insufficiency that shows of brain is given and microcirculation improvement, cooperates this granule oral, and sx is in hospital and was left hospital in 10 days.

Claims

1. promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule that is used for vertebro-basilar artery insufficiency; It is characterized in that: the prescription of this Chinese medicinal granule is 15 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 12 parts of the Radixs Astragali, 12 parts of Rhizoma Dioscoreaes, 12 parts of Semen Ziziphi Spinosaes, 9 parts in Rhizoma Gastrodiae, 9 parts of Radix Salviae Miltiorrhizaes, 9 parts on Flos Carthami, 9 parts of Radix Rehmanniae Preparata, 9 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Lyciis, 6 parts of Radix Aconiti Lateralis Preparatas, 6 parts of Radix Glycyrrhizae Preparatas, Radix Cynanchi Paniculati 12 grams, the Radix Rehmanniae 12 grams, Cortex Moutan 9 grams and Radix Platycodonis 12 grams.

2. a kind of promoting blood circulation to remove obstruction in the collateral Chinese medicinal granule that is used for vertebro-basilar artery insufficiency according to claim 1 is characterized in that: (1) Radix Cynanchi Paniculati, Cortex Moutan extract with percolation with 75% soak with ethanol 24 hours, collect percolate, and pressurization is reclaimed behind the ethanol subsequent use; (2) Radix Codonopsis, Rhizoma Chuanxiong of getting recipe quantity be with 70% alcohol reflux alcohol dissolubility effective ingredient 3 times, and each 1.5 hours, merge alcohol extract, decompression recycling ethanol leaves standstill 24 hours depositions, and it is subsequent use to get supernatant; (3) get Radix Angelicae Sinensis and soaked 3 hours, extract volatile oil with volatile oil extractor, the reuse anhydrous sodium sulfate drying is obtained volatile oil, is weak yellow liquid, uses beta-cyclodextrin inclusion compound, and is subsequent use; (4) Radix Aconiti Lateralis Preparata is soaked; Be decocted first 2 hours; The Radix Astragali, Rhizoma Dioscoreae, Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Radix Platycodonis, the Radix Glycyrrhizae Preparata that adds Radix Cynanchi Paniculati, Cortex Moutan, Radix Codonopsis, Rhizoma Chuanxiong, Radix Angelicae Sinensis medicinal residues again and soaked 1 hour put into the multi-functional extractor heating extraction 2 times, and each 1 hour, merge extractive liquid; Leave standstill 24 hours depositions, it is subsequent use to get supernatant; (4) get the supernatant that extracts in (1) step and (3) step, be concentrated into thick paste adding prepared clathrate of (2) step and appropriate amount of starch and make absorbent, cross 14 mesh sieve system granules, 60 ℃ of aeration-dryings, packing promptly gets granule.