CN103638249B - A kind of pharmaceutical composition of external curing acne - Google Patents
A kind of pharmaceutical composition of external curing acne Download PDFInfo
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- CN103638249B CN103638249B CN201310699198.2A CN201310699198A CN103638249B CN 103638249 B CN103638249 B CN 103638249B CN 201310699198 A CN201310699198 A CN 201310699198A CN 103638249 B CN103638249 B CN 103638249B
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Abstract
The invention discloses the pharmaceutical composition of a kind of external curing acne, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Sophorae Flavescentis 30-35 part, Radix Linderae 30-35 part, Radix Et Rhizoma Rhei 30-35 part, Radix Angelicae Sinensis 30-35 part, Sanguis Draxonis 30-35 part, Flos Carthami 20-30 part, Radix Glycyrrhizae 20-30 part, Flos Lonicerae 20-30 part, Natrii Sulfas 35-45 part, Alumen 20-30 part. The externally-applied medicinal composition of the present invention can safely and effectively eliminate acne and the pigment left over, and makes skin become delicate glossy, plays treatment and cosmetic result.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to the pharmaceutical composition of a kind of external curing acne.
Background technology
Acne vulgaris is to be mainly in youth of both sexes, age in the chronic self limiting inflammation in 15-30 year, multiple in hair follicle, sebaceous gland, acne are significant Clinical symptoms, if being subject to unsuitable physicochemical irritation, have acne, pimple, pus born of the same parents, tuberosity, cyst even cicatrix to coexist. Clinical manifestation is the acne that weight does not wait, and skin lesion is often by non-inflammation with struvite cause. Acne the most often betides youth of both sexes skin surface, especially face, it is easy to causes the permanent skin infringements such as depression, hair follicle hole thick, pigmentation, cicatrix, causes serious psychological burden to patient, so the preventing and treating of acne is increasingly subject to pay attention to.
Summary of the invention
It is an object of the invention to provide the pharmaceutical composition of a kind of external curing acne.
The object of the present invention is achieved like this:
The pharmaceutical composition of a kind of external curing acne, described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Persicae 20-40 part, Radix Rehmanniae 20-40 part, Radix Scutellariae 20-30 part, Semen Arecae 20-30 part, Cortex Mori 20-30 part, Radix Angelicae Dahuricae 20-30 part, Herba Houttuyniae 20-30 part, Radix Gentianae 12-20 part, Radix Sanguisorbae 12-20 part, Radix Saposhnikoviae 12-20 part, Semen Plantaginis 12-20 part, Radix Glycyrrhizae 8-16 part.
Preferably, the pharmaceutical composition of external curing acne described above, wherein said pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Persicae 25-35 part, Radix Rehmanniae 28-32 part, Radix Scutellariae 23-27 part, Semen Arecae 23-27 part, Cortex Mori 23-27 part, Radix Angelicae Dahuricae 23-27 part, Herba Houttuyniae 23-27 part, Radix Gentianae 14-18 part, Radix Sanguisorbae 14-18 part, Radix Saposhnikoviae 14-18 part, Semen Plantaginis 14-18 part, Radix Glycyrrhizae 10-14 part.
Further preferably, the pharmaceutical composition of external curing acne described above, wherein said pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Persicae 30 parts, 30 parts of the Radix Rehmanniae, Radix Scutellariae 25 parts, Semen Arecae 25 parts, Cortex Mori 25 parts, the Radix Angelicae Dahuricae 25 parts, Herba Houttuyniae 25 parts, Radix Gentianae 16 parts, Radix Sanguisorbae 16 parts, Radix Saposhnikoviae 16 parts, Semen Plantaginis 16 parts, 12 parts of Radix Glycyrrhizae.
The pharmaceutical composition of external curing acne of the present invention, it is ointment, liniment, gel. Preferably described pharmaceutical composition is gel.
The preparation method of the external used medicine gel that the present invention relates to comprises the steps:
1) get the raw materials ready: weigh Radix Sophorae Flavescentis 30-35 part, Radix Linderae 30-35 part, Radix Et Rhizoma Rhei 30-35 part, Radix Angelicae Sinensis 30-35 part, Sanguis Draxonis 30-35 part, Flos Carthami 20-30 part, Radix Glycyrrhizae 20-30 part, Flos Lonicerae 20-30 part, Natrii Sulfas 35-45 part, Alumen 20-30 part, standby after mixing;
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 3 hours after ebuillition of heated, and extracting solution filters through 200 order filters and enters settling tanks; Second decocts the water heating extraction adding medical material amount 4 times, protects and boils 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: in settling tank, extracting solution precipitates 24��36 hours, extracts supernatant and filters to triple effect evaporator through 200 order filters, and precipitate presses offal treatment;
4) concentration: when supernatant be concentrated in triple effect evaporator relative density be 1.00��1.10 (40 DEG C of mensuration) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrate and mix and go out cream when being 1.30��1.32 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby;
5) dry: wherein vacuum :-0.1MPa, temperature: 78��82 DEG C, 20��24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder;
7) carbomer is slowly added in purified water, stirring while adding until forming transparent gel-type vehicle, clear paste powder is dissolved in suitable quantity of water, add in substrate, stir, add propylene glycol, glycerol, purified water to full dose, triethanolamine regulates pH value to neutral, obtains gel.
The source of the adopted Chinese crude drug of the present invention is as follows: Folium Persicae selects the dried leaves of rosaceous plant Fructus Persicae Prunuspersica (L.) Batsch. The Radix Rehmanniae is selected from the dried root of Scrophulariaceae herbaceos perennial Radix Rehmanniae RehmanniaglutinosaLibosch.. The dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi selected by Radix Scutellariae. The seed of babassu Semen Arecae ArecacatechuLinn. selected by Semen Arecae. Cortex Mori selects the root bark of moraceae plants Mulberry (MorusalbaL.). The Radix Angelicae Dahuricae selects the root of samphire angelica anomala. Herba Houttuyniae selects the dry above water of Saururaceae herbaceos perennial Herba Houttuyniae. Radix Gentianae selects root and the rhizome of gentianaceae plant Radix Gentianae (GentianascabraBge.). Radix Sanguisorbae selects the dry root of rosaceous plant Radix Sanguisorbae SanguisorbaofficinalisL.. Radix Saposhnikoviae selects the root of Umbelliferae herbaceos perennial Radix Saposhnikoviae. Semen Plantaginis selects seed and the herb of Plantaginaceae plant Herba Plantaginis Big Semen Plantaginis and Plantago depressa Willd. It is dicotyledon pulse family Leguminosae Radix Glycyrrhizae GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. G.inflataBat. that Radix Glycyrrhizae is selected, or the root and rhizome of Glycyrrhiza glabra L. G.glabraL..
The externally-applied medicinal composition of the present invention can safely and effectively eliminate acne and the pigment left over, and makes skin become delicate glossy, plays treatment and cosmetic result. It addition, the Chinese medicine gel prepared by the present invention also has safety feature big, non-stimulated, antianaphylactic, life-time service is determined curative effect not only, treats no pain, and clinical cure rate is high, and safety, patient is prone to accept.
Detailed description of the invention
The following is specific embodiments of the invention, technical scheme is done to be described further, but protection scope of the present invention is not limited to these embodiments. Every change without departing substantially from present inventive concept or equivalent replacement are included within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine gel
Crude drug prescription: Folium Persicae 30 parts, 30 parts of the Radix Rehmanniae, Radix Scutellariae 25 parts, Semen Arecae 25 parts, Cortex Mori 25 parts, the Radix Angelicae Dahuricae 25 parts, Herba Houttuyniae 25 parts, Radix Gentianae 16 parts, Radix Sanguisorbae 16 parts, Radix Saposhnikoviae 16 parts, Semen Plantaginis 16 parts, 12 parts of Radix Glycyrrhizae.
Preparation technology:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, standby;
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 3 hours after ebuillition of heated, and extracting solution filters through 200 order filters and enters settling tanks; Second decocts the water heating extraction adding medical material amount 4 times, protects and boils 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: in settling tank, extracting solution precipitates 30 hours, extracts supernatant and filters to triple effect evaporator through 200 order filters, and precipitate presses offal treatment;
4) concentration: when supernatant be concentrated in triple effect evaporator relative density be 1.05 (40 DEG C of mensuration) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrate and mix and go out cream when being 1.30��1.32 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby;
5) dry: wherein vacuum :-0.1MPa, temperature: 78��82 DEG C, 24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder;
7) 10g carbomer is slowly added in the purified water of about 500ml, stirring while adding until forming transparent gel-type vehicle, 2g clear paste powder is dissolved in suitable quantity of water, add in gel-type vehicle, stir, adding 60ml propylene glycol, 50ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, to obtain final product.
The preparation of embodiment 2 Chinese medicine gel
Crude drug prescription: Folium Persicae 38 parts, 40 parts of the Radix Rehmanniae, Radix Scutellariae 20 parts, Semen Arecae 27 parts, Cortex Mori 20 parts, the Radix Angelicae Dahuricae 28 parts, Herba Houttuyniae 29 parts, Radix Gentianae 12 parts, Radix Sanguisorbae 18 parts, Radix Saposhnikoviae 12 parts, Semen Plantaginis 16 parts, 10 parts of Radix Glycyrrhizae.
Preparation technology:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, standby;
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 3 hours after ebuillition of heated, and extracting solution filters through 200 order filters and enters settling tanks; Second decocts the water heating extraction adding medical material amount 4 times, protects and boils 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: in settling tank, extracting solution precipitates 36 hours, extracts supernatant and filters to triple effect evaporator through 200 order filters, and precipitate presses offal treatment;
4) concentration: when supernatant be concentrated in triple effect evaporator relative density be 1.10 (40 DEG C of mensuration) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrate and mix and go out cream when being 1.30��1.32 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby;
5) dry: wherein vacuum :-0.1MPa, temperature: 78��82 DEG C, 24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder;
7) 10g carbomer is slowly added in the purified water of about 500ml, stirring while adding until forming transparent gel-type vehicle, 2g clear paste powder is dissolved in suitable quantity of water, add in gel-type vehicle, stir, adding 60ml propylene glycol, 50ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, to obtain final product.
The preparation of embodiment 3 Chinese medicine gel
Crude drug prescription: Folium Persicae 20 parts, 20 parts of the Radix Rehmanniae, Radix Scutellariae 20 parts, Semen Arecae 22 parts, Cortex Mori 30 parts, the Radix Angelicae Dahuricae 20 parts, Herba Houttuyniae 25 parts, Radix Gentianae 20 parts, Radix Sanguisorbae 14 parts, Radix Saposhnikoviae 20 parts, Semen Plantaginis 12 parts, 16 parts of Radix Glycyrrhizae.
Preparation technology:
1) get the raw materials ready: weigh the above-mentioned Chinese crude drug cleaned up by recipe quantity, standby:
2) decocting: boiling, first decocts every tank adds water 8 times into medical material total amount, keeps 3 hours after ebuillition of heated, and extracting solution filters through 200 order filters and enters settling tanks;Second decocts the water heating extraction adding medical material amount 4 times, protects and boils 3 hours, and extracting solution filters through 200 order filters and enters settling tank:
3) precipitation: in settling tank, extracting solution precipitates 24 hours, extracts supernatant and filters to triple effect evaporator through 200 order filters, and precipitate presses offal treatment:
4) concentration: when supernatant be concentrated in triple effect evaporator relative density be 1.10 (40 DEG C of mensuration) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrate and mix and go out cream when being 1.30��1.32 (90 DEG C of mensuration) to relative density, to storage cream bucket, standby;
5) dry: wherein vacuum :-0.1MPa, temperature: 78��82 DEG C, 20 hours drying times;
6) beat powder: smashing fineness 80 mesh sieve, obtain clear paste powder;
7) 10g carbomer is slowly added in the purified water of about 500ml, stirring while adding until forming transparent gel-type vehicle, 2g clear paste powder is dissolved in suitable quantity of water, add in gel-type vehicle, stir, adding 60ml propylene glycol, 50ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, to obtain final product.
The embodiment 4 Chinese medicine gel of the present invention effectiveness study to homeliness type acne patient
48 example homeliness type acne patients, wherein male 17 examples, female 31 example; 18 years old-30 years old age, average 20.5 years old; Course of disease half a year to 3 years, average 1.6 years. All patients are randomly divided into two groups: Chinese drug-treated group (24 example), matched group (24 example). Two groups of Genders, age and the course of disease there was no significant difference (P > 0.05) through statistical procedures, have comparability.
Chinese drug-treated group patient's medicine for external application gel is treated, concrete grammar: first with warm water and be suitable to Combination, the cleansing milk of oily skin is washed one's face; Then taking the Chinese medicine gel prepared by the embodiment of the present invention 1 prescription and technique and be applied in affected part in right amount, every day each 1 time sooner or later, 4 weeks was 1 course for the treatment of. It is coated with adapalene gel (Hainan Quan Xing pharmaceutical Co. Ltd, specification: 15g, authentication code: traditional Chinese medicines quasi-word H20066621) outside matched group patient each 1 time sooner or later, within 4 weeks, was 1 course for the treatment of. Period diet aspect of taking medicine avoids irritable food, pungent such as alcohol prohibition etc. and raw and cold, greasy and carbohydrate food. The evaluation criterion of curative effect is as follows:
Curing: skin lesion disappears more than 95%, subjective symptoms disappears;
Take a turn for the better: skin lesion disappears 30%-95%, and subjective symptoms alleviates;
Invalid: though symptom is unchanged or skin lesion alleviates but to still have new skin lesion to occur, symptom is improved less than 30%.
Total effective rate=(recovery from illness+effective)/total case load �� 100%, when the efficacy determination time terminates for treatment on the 4th week. After treatment, two groups of concrete result of the tests of Clinical efficacy comparison are in Table 1.
The Clinical efficacy comparison (example) of table 1 Chinese drug-treated group and matched group
Be can be seen that by the clinical efficacy result of table 1, treatment by Chinese herbs group and matched group effective percentage respectively 91.7% and 58.3%, compare between two groups, have significant difference (P < 0.01), it was shown that the pharmaceutical composition of the present invention is better than adapalene gel in treatment homeliness type acne.
Claims (4)
1. the pharmaceutical composition of an external curing acne, it is characterised in that described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Persicae 25-35 part, Radix Rehmanniae 28-32 part, Radix Scutellariae 23-27 part, Semen Arecae 23-27 part, Cortex Mori 23-27 part, Radix Angelicae Dahuricae 23-27 part, Herba Houttuyniae 23-27 part, Radix Gentianae 14-18 part, Radix Sanguisorbae 14-18 part, Radix Saposhnikoviae 14-18 part, Semen Plantaginis 14-18 part, Radix Glycyrrhizae 10-14 part.
2. the pharmaceutical composition of external curing acne according to claim 1, it is characterised in that described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Persicae 30 parts, 30 parts of the Radix Rehmanniae, Radix Scutellariae 25 parts, Semen Arecae 25 parts, Cortex Mori 25 parts, the Radix Angelicae Dahuricae 25 parts, Herba Houttuyniae 25 parts, Radix Gentianae 16 parts, Radix Sanguisorbae 16 parts, Radix Saposhnikoviae 16 parts, Semen Plantaginis 16 parts, 12 parts of Radix Glycyrrhizae.
3. the pharmaceutical composition of external curing acne according to claim 1 or claim 2, it is characterised in that: described pharmaceutical composition is ointment, liniment, gel.
4. the pharmaceutical composition of external curing acne according to claim 3, it is characterised in that: described pharmaceutical composition is gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310699198.2A CN103638249B (en) | 2013-12-19 | 2013-12-19 | A kind of pharmaceutical composition of external curing acne |
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| CN201310699198.2A CN103638249B (en) | 2013-12-19 | 2013-12-19 | A kind of pharmaceutical composition of external curing acne |
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| CN103638249B true CN103638249B (en) | 2016-06-08 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224287A (en) * | 2007-12-27 | 2008-07-23 | 佟家勇 | Oral administration Chinese traditional medicine for treating acne and preparing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中医药治疗痤疮近况》;苏冠华 等;《中药材》;20041031;第27卷(第10期);791-794 * |
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Granted publication date: 20160608 Termination date: 20191219 |