CN104784351B - External used medicine of a kind of Hepatoma therapy and preparation method thereof - Google Patents
External used medicine of a kind of Hepatoma therapy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses external used medicine of a kind of Hepatoma therapy and preparation method thereof, this external used medicine comprises the composition of following parts by weight: Radix Astragali 5-10, Herba Hydrocotyles 2-5, Radix Angelicae Pubescentis 1-3, Indigo Naturalis 1-2, Folium Et Cacumen Murrayae 3-5, Radix Notoginseng 1-2, Grifola frondosa 2-5, Rhizoma Ligustici 1-3, Myrrha 5-8, Rhizoma Paridis 3-5, Thallus Laminariae (Thallus Eckloniae) 5-8, Fructus Corni 5-8, Folium et Ramulus Cephalotaxi 2-5, SONGGUOJU 2-5, tiger palm 2-5, Pericarpium Citri Reticulatae Viride 2-5, Concha Ostreae 8-12, Hirudo 5-8, Radix Platycodonis 2-5, Herba Sedi 5-10, green tea extract 2-5, this external used medicine of Herba Medicaginis extract 4-6 adopts micromolecule cutting technique, effective ingredient is absorbed rapidly by skin, targeting arrives desired area, anti-inflammatory analgesic adhesive, blood circulation promoting and blood stasis dispelling, softening the hard mass joints etc. reduce hepatoma Metastasis relapse rate, effective, instant effect.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to external used medicine of a kind of Hepatoma therapy and preparation method thereof.
Background technology
Hepatocarcinoma and liver malignancy, can be divided into constitutional and the large class of Secondary cases two.Characters of Primary Malignant Tumors of Liver originates from epithelium or the mesenchymal tissue of liver, and the former is called primary hepatocarcinoma, is that China is occurred frequently, very harmful malignant tumor; The latter is called sarcoma, comparatively rare compared with primary hepatocarcinoma.Secondary cases or title secondary liver cancer mean that the malignant tumor of the multiple organ origin of whole body is invaded to liver.The cause of disease of primary hepatocarcinoma and definite molecular mechanism still imperfectly understand, and think that its morbidity is complex process that is multifactor, multi-step at present, by environment and therefore double factor affect.
Chinese medicine composition that patent CN103285130A has disclosed Hepatoma therapy a kind of and preparation method thereof, belong to technical field of Chinese medicines, it comprises outer varnish and Orally-administered decoction; Outer varnish is made up of the raw material of following weight: Radix Astragali 12g, Radix Salviae Miltiorrhizae 5g, Rhizoma Chuanxiong 5g, Borneolum Syntheticum 6g, Herba Taraxaci 10g, Flos Lonicerae 12g, Indigo Naturalis 3g, Fructus Aurantii Immaturus 6g, Radix Glycyrrhizae 10g, Fructus Jujubae 20g, glycerol 30g; Described Orally-administered decoction is made up of the raw material of following weight: Herba Artemisiae Scopariae 10g, Rhizoma Chuanxiong 8g, Cortex Mori 10g, Semen Persicae 8g, Radix Aucklandiae 4g, Folium Ginkgo 11g, Resina Ferulae 8g, Herba Lobeliae Chinensis 10g, Folium Eriobotryae 12g, Pericarpium Citri Reticulatae 9g, Herba Pileae Scriptae 10g, Radix Angelicae Sinensis 10g, Radix Astragali 20g, Fructus Crataegi 18g, Rhizoma Zingiberis 8g, Herba Hedyotidis Diffusae 15g, Rhizoma Atractylodis Macrocephalae 10g, Massa Medicata Fermentata 10g, Fructus Jujubae 8g, Radix Glycyrrhizae 6g.The advantages such as this Chinese medicine composition is pure natural medical formula, has Hepatoma therapy determined curative effect, and toxic and side effects is few.CN104337955A discloses Chinese medicine formula of a kind of Hepatoma therapy and preparation method thereof.Be made up of oral medicine and medicine for external use; Wherein oral medicine is formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Acori Calami 3 ~ 5 parts, Herba Hedyotidis Diffusae 5 ~ 8 parts, Shell of Water Chestnut 10 ~ 15 parts, Resina Liquidambaris 3 ~ 5 parts, Radix Tripterygii Wilfordii 1 ~ 2 part, Radix Ginseng 3 ~ 5 parts, Radix Notoginseng powder 4 ~ 6 parts, Radix Angelicae Sinensis 5 ~ 8 parts, Radix Astragali 4 ~ 6 parts, Radix Arnebiae (Radix Lithospermi) 3 ~ 5 parts, 3 ~ 5 parts, Radix Glycyrrhizae; Wherein medicine for external use is formulated by the raw material of Chinese medicine of following parts by weight: 3 ~ 8 parts, Moschus, Olibanum 3 ~ 6 parts, Myrrha 3 ~ 5 parts, Borneolum Syntheticum 1 ~ 2 part, Semen Pharbitidis 3 ~ 5 parts, Radix Kansui 3 ~ 5 parts.Preparation method is that water decoction coordinates medicine for external use.CN104352590A discloses Chinese medicine formula of a kind of Hepatoma therapy and preparation method thereof.Be made up of oral medicine and medicine for external use; Wherein oral medicine is formulated by the raw material of Chinese medicine of following parts by weight: Herba Lysimachiae 3 ~ 8 parts, Radix Salviae Miltiorrhizae 3 ~ 8 parts, Cacumen Securinegae Suffruticosae 3 ~ 5 parts, Agkistrodon 2 ~ 3 parts, Herba Andrographis 2 ~ 3 parts, Hirudo 2 ~ 3 parts, Radix Ginseng 5 ~ 8 parts, Herba Agrimoniae 3 ~ 8 parts, Radix Angelicae Sinensis 3 ~ 5 parts, Radix Arnebiae (Radix Lithospermi) 3 ~ 5 parts, 3 ~ 5 parts, Radix Glycyrrhizae; Wherein medicine for external use is formulated by the raw material of Chinese medicine of following parts by weight: 3 ~ 8 parts, Moschus, Bufo siccus 2 ~ 3 parts, Olibanum 3 ~ 6 parts, Radix Astragali 3 ~ 5 parts, Semen Pharbitidis 3 ~ 5 parts, Radix Kansui 3 ~ 5 parts.Preparation method is that water decoction coordinates medicine for external use.The method coordinates the yin nourishing hepatoprotective of Chinese medicine for oral administration, the effect of strengthening vital QI to eliminate pathogenic factors by medicine for external use, can Tumor suppression breeding, harmonizing the liver and spleen metabolism, enhancing immunity, and can pain relieving dispersing tumor, saves patients ' lives.
The each tool advantage of medicine of the Hepatoma therapy disclosed in above-mentioned patent, but be difficult to reach good effect in drug absorption and curative effect.
Summary of the invention
The object of the present invention is to provide external used medicine of a kind of Hepatoma therapy and preparation method thereof, this medicine is used for the treatment of hepatocarcinoma, its good absorbing effect, good effect.
Technical scheme of the present invention is: a kind of external used medicine of Hepatoma therapy, comprises the composition of following parts by weight:
Radix Astragali 5-10, Herba Hydrocotyles 2-5, Radix Angelicae Pubescentis 1-3, Indigo Naturalis 1-2, Folium Et Cacumen Murrayae 3-5, Radix Notoginseng 1-2, Grifola frondosa 2-5, Rhizoma Ligustici 1-3, Myrrha 5-8, Rhizoma Paridis 3-5, Thallus Laminariae (Thallus Eckloniae) 5-8, Fructus Corni 5-8, Folium et Ramulus Cephalotaxi 2-5, SONGGUOJU 2-5, the tiger palm 2-5, Pericarpium Citri Reticulatae Viride 2-5, Concha Ostreae 8-12, Hirudo 5-8, Radix Platycodonis 2-5, Herba Sedi 5-10, green tea extract 2-5, Herba Medicaginis extract 4-6.
Preferably, the external used medicine of Hepatoma therapy, comprises the composition of following parts by weight:
The Radix Astragali 8, Herba Hydrocotyles 3, Radix Angelicae Pubescentis 2, Indigo Naturalis 1, Folium Et Cacumen Murrayae 4, Radix Notoginseng 1, Grifola frondosa 4, Rhizoma Ligustici 2, Myrrha 6, Rhizoma Paridis 4, Thallus Laminariae (Thallus Eckloniae) 6, Fructus Corni 6, Folium et Ramulus Cephalotaxi 3, SONGGUOJU 3, the tiger palm 4, Pericarpium Citri Reticulatae Viride 3, Concha Ostreae 10, Hirudo 6, Radix Platycodonis 4, Herba Sedi 8, green tea extract 3, Herba Medicaginis extract 5.
Preferably, the external used medicine of described Hepatoma therapy also comprises following auxiliary material:
Water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part.
A preparation method for the external used medicine of Hepatoma therapy, comprises the following steps:
(1) composition of following parts by weight is taken: Radix Astragali 5-10, Herba Hydrocotyles 2-5, Radix Angelicae Pubescentis 1-3, Indigo Naturalis 1-2, Folium Et Cacumen Murrayae 3-5, Radix Notoginseng 1-2, Grifola frondosa 2-5, Rhizoma Ligustici 1-3, Myrrha 5-8, Rhizoma Paridis 3-5, Thallus Laminariae (Thallus Eckloniae) 5-8, Fructus Corni 5-8, Folium et Ramulus Cephalotaxi 2-5, SONGGUOJU 2-5, the tiger palm 2-5, Pericarpium Citri Reticulatae Viride 2-5, Concha Ostreae 8-12, Hirudo 5-8, Radix Platycodonis 2-5, Herba Sedi 5-10; Add the 4-5 water doubly of above-mentioned Chinese medicine gross weight, decoct 100-150min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add 4-5 alcoholic solution doubly, decoct 120-160min, filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), add 4-5 acetic acid solution doubly, decoct 50-70min, filter to get filtrate;
(5) filtrate in combining step (1), step (3) and step (4), adds green tea extract 2-5 part and Herba Medicaginis extract 4-6 part, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
Preferably, the Chinese medicine in described step (1) first at room temperature soaks 20-25min, and then decoct 100-150min at 80-90 DEG C after adding 4-5 water doubly.
Preferably, the concentration adding alcoholic solution in described step (2) is 50-60%, and decoction temperature is 60-70 DEG C.
Preferably, in described step (4), the concentration of acetic acid solution is 15-18%, and decoction temperature is 40-50 DEG C.
Preferably, in described step (5), after first the filtrate obtained in step (1) and step (3) being down to 40-50 DEG C, then merge with the filtrate that obtains in step (4).
Preferably, adopt micromolecule cutting technique to process to the mixed solution obtained in described step (5), retain its active and effectiveness simultaneously.
The invention has the beneficial effects as follows: Chinese herbal medicine of drawing materials, toxic and side effects is little; Adopt multiple method effective component extracting, control the temperature and time in leaching process simultaneously, ensure the activity of each effective ingredient; Auxiliary material make medicine be convenient to smear on the one hand, can promote the performance of medicine on the other hand, strengthen curative effect; Prepared medicine can be smeared in skin surface directly outward, and adopt micromolecule cutting technique, effective ingredient is absorbed rapidly by skin, and targeting arrives desired area, anti-inflammatory analgesic adhesive, blood circulation promoting and blood stasis dispelling, and softening the hard mass joint etc. reduce hepatoma Metastasis relapse rate, effective, instant effect.
Detailed description of the invention
Embodiment 1
An external used medicine for Hepatoma therapy, comprises the composition of following parts by weight:
The Radix Astragali 5, Herba Hydrocotyles 2, Radix Angelicae Pubescentis 1, Indigo Naturalis 1, Folium Et Cacumen Murrayae 3, Radix Notoginseng 1, Grifola frondosa 2, Rhizoma Ligustici 1, Myrrha 5, Rhizoma Paridis 3, Thallus Laminariae (Thallus Eckloniae) 5, Fructus Corni 5, Folium et Ramulus Cephalotaxi 2, SONGGUOJU 2, the tiger palm 2, Pericarpium Citri Reticulatae Viride 2, Concha Ostreae 8, Hirudo 5, Radix Platycodonis 2, Herba Sedi 5, green tea extract 2, Herba Medicaginis extract 4;
Auxiliary material: water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part;
According to the proportioning of the external used medicine of above-mentioned Hepatoma therapy, prepare as follows, comprise the following steps:
(1) in the Radix Astragali, Herba Hydrocotyles, Radix Angelicae Pubescentis, Indigo Naturalis, Folium Et Cacumen Murrayae, Radix Notoginseng, Grifola frondosa, Rhizoma Ligustici, Myrrha, Rhizoma Paridis, Thallus Laminariae (Thallus Eckloniae), Fructus Corni, Folium et Ramulus Cephalotaxi, SONGGUOJU, the tiger palm, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Hirudo, Radix Platycodonis and Herba Sedi, add the 4-5 water doubly of its gross weight, 100-150min is decocted in 80-90 DEG C after soaking at room temperature 20-25min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add the alcoholic solution of 4-5 50%-60% doubly, and 60-70 DEG C decocts 120-160min, and filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), add the acetic acid solution of 4-5 15-18% doubly, and 40-50 DEG C decocts 50-70min, filter to get filtrate;
(5) after the filtrate obtained in step (1) and step (3) is down to 40-50 DEG C, filtrate in combining step (1), step (3) and step (4), add green tea extract and Herba Medicaginis extract, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly; Adopt micromolecule cutting technique to process solution, retain its active and effectiveness simultaneously;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
Embodiment 2
An external used medicine for Hepatoma therapy, comprises the composition of following parts by weight:
The Radix Astragali 8, Herba Hydrocotyles 3, Radix Angelicae Pubescentis 2, Indigo Naturalis 1, Folium Et Cacumen Murrayae 4, Radix Notoginseng 1, Grifola frondosa 4, Rhizoma Ligustici 2, Myrrha 6, Rhizoma Paridis 4, Thallus Laminariae (Thallus Eckloniae) 6, Fructus Corni 6, Folium et Ramulus Cephalotaxi 3, SONGGUOJU 3, the tiger palm 4, Pericarpium Citri Reticulatae Viride 3, Concha Ostreae 10, Hirudo 6, Radix Platycodonis 4, Herba Sedi 8, green tea extract 3, Herba Medicaginis extract 5;
Auxiliary material: water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part;
According to the proportioning of the external used medicine of above-mentioned Hepatoma therapy, prepare as follows, comprise the following steps:
(1) in the Radix Astragali, Herba Hydrocotyles, Radix Angelicae Pubescentis, Indigo Naturalis, Folium Et Cacumen Murrayae, Radix Notoginseng, Grifola frondosa, Rhizoma Ligustici, Myrrha, Rhizoma Paridis, Thallus Laminariae (Thallus Eckloniae), Fructus Corni, Folium et Ramulus Cephalotaxi, SONGGUOJU, the tiger palm, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Hirudo, Radix Platycodonis and Herba Sedi, add the 4-5 water doubly of its gross weight, 100-150min is decocted in 80-90 DEG C after soaking at room temperature 20-25min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add the alcoholic solution of 4-5 50%-60% doubly, and 60-70 DEG C decocts 120-160min, and filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), add the acetic acid solution of 4-5 15-18% doubly, and 40-50 DEG C decocts 50-70min, filter to get filtrate;
(5) after the filtrate obtained in step (1) and step (3) is down to 40-50 DEG C, filtrate in combining step (1), step (3) and step (4), add green tea extract and Herba Medicaginis extract, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly; Adopt micromolecule cutting technique to process solution, retain its active and effectiveness simultaneously;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
Embodiment 3
An external used medicine for Hepatoma therapy, comprises the composition of following parts by weight:
The Radix Astragali 10, Herba Hydrocotyles 5, Radix Angelicae Pubescentis 3, Indigo Naturalis 2, Folium Et Cacumen Murrayae 5, Radix Notoginseng 2, Grifola frondosa 5, Rhizoma Ligustici 3, Myrrha 8, Rhizoma Paridis 5, Thallus Laminariae (Thallus Eckloniae) 8, Fructus Corni 8, Folium et Ramulus Cephalotaxi 5, SONGGUOJU 5, the tiger palm 5, Pericarpium Citri Reticulatae Viride 5, Concha Ostreae 12, Hirudo 8, Radix Platycodonis 5, Herba Sedi 10, green tea extract 5, Herba Medicaginis extract 6;
Auxiliary material: water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part;
According to the proportioning of the external used medicine of above-mentioned Hepatoma therapy, prepare as follows, comprise the following steps:
(1) in the Radix Astragali, Herba Hydrocotyles, Radix Angelicae Pubescentis, Indigo Naturalis, Folium Et Cacumen Murrayae, Radix Notoginseng, Grifola frondosa, Rhizoma Ligustici, Myrrha, Rhizoma Paridis, Thallus Laminariae (Thallus Eckloniae), Fructus Corni, Folium et Ramulus Cephalotaxi, SONGGUOJU, the tiger palm, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Hirudo, Radix Platycodonis and Herba Sedi, add the 4-5 water doubly of its gross weight, 100-150min is decocted in 80-90 DEG C after soaking at room temperature 20-25min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add the alcoholic solution of 4-5 50%-60% doubly, and 60-70 DEG C decocts 120-160min, and filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), add the acetic acid solution of 4-5 15-18% doubly, and 40-50 DEG C decocts 50-70min, filter to get filtrate;
(5) after the filtrate obtained in step (1) and step (3) is down to 40-50 DEG C, filtrate in combining step (1), step (3) and step (4), add green tea extract and Herba Medicaginis extract, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly; Adopt micromolecule cutting technique to process solution, retain its active and effectiveness simultaneously;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
Embodiment 4
An external used medicine for Hepatoma therapy, comprises the composition of following parts by weight:
The Radix Astragali 8, Herba Hydrocotyles 3, Radix Angelicae Pubescentis 2, Indigo Naturalis 1, Folium Et Cacumen Murrayae 4, Radix Notoginseng 1, Grifola frondosa 4, Rhizoma Ligustici 2, Myrrha 6, Rhizoma Paridis 4, Thallus Laminariae (Thallus Eckloniae) 6, Fructus Corni 6, Folium et Ramulus Cephalotaxi 3, SONGGUOJU 3, the tiger palm 4, Pericarpium Citri Reticulatae Viride 3, Concha Ostreae 10, Hirudo 6, Radix Platycodonis 4, Herba Sedi 8, green tea extract 3, Herba Medicaginis extract 5;
Auxiliary material: water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part;
According to the proportioning of the external used medicine of above-mentioned Hepatoma therapy, prepare as follows, comprise the following steps:
(1) in the Radix Astragali, Herba Hydrocotyles, Radix Angelicae Pubescentis, Indigo Naturalis, Folium Et Cacumen Murrayae, Radix Notoginseng, Grifola frondosa, Rhizoma Ligustici, Myrrha, Rhizoma Paridis, Thallus Laminariae (Thallus Eckloniae), Fructus Corni, Folium et Ramulus Cephalotaxi, SONGGUOJU, the tiger palm, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Hirudo, Radix Platycodonis and Herba Sedi, add the 4-5 water doubly of its gross weight, decoct 100-150min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add 4-5 alcoholic solution doubly, decoct 120-160min, filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), add 4-5 acetic acid solution doubly, decoct 50-70min, filter to get filtrate;
(5) filtrate in combining step (1), step (3) and step (4), adds green tea extract 2-5 part and Herba Medicaginis extract 4-6 part, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly; Then, adopt micromolecule cutting technique to process solution, retain its active and effectiveness simultaneously;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
Embodiment 5
An external used medicine for Hepatoma therapy, comprises the composition of following parts by weight:
The Radix Astragali 8, Herba Hydrocotyles 3, Radix Angelicae Pubescentis 2, Indigo Naturalis 1, Folium Et Cacumen Murrayae 4, Radix Notoginseng 1, Grifola frondosa 4, Rhizoma Ligustici 2, Myrrha 6, Rhizoma Paridis 4, Thallus Laminariae (Thallus Eckloniae) 6, Fructus Corni 6, Folium et Ramulus Cephalotaxi 3, SONGGUOJU 3, the tiger palm 4, Pericarpium Citri Reticulatae Viride 3, Concha Ostreae 10, Hirudo 6, Radix Platycodonis 4, Herba Sedi 8, green tea extract 3, Herba Medicaginis extract 5;
Auxiliary material: water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part;
According to the proportioning of the external used medicine of above-mentioned Hepatoma therapy, prepare as follows, comprise the following steps:
(1) in the Radix Astragali, Herba Hydrocotyles, Radix Angelicae Pubescentis, Indigo Naturalis, Folium Et Cacumen Murrayae, Radix Notoginseng, Grifola frondosa, Rhizoma Ligustici, Myrrha, Rhizoma Paridis, Thallus Laminariae (Thallus Eckloniae), Fructus Corni, Folium et Ramulus Cephalotaxi, SONGGUOJU, the tiger palm, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Hirudo, Radix Platycodonis and Herba Sedi, add the 4-5 water doubly of its gross weight, 100-150min is decocted in 80-90 DEG C after soaking at room temperature 20-25min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add the alcoholic solution of 4-5 50%-60% doubly, and 60-70 DEG C decocts 120-160min, and filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), add the acetic acid solution of 4-5 15-18% doubly, and 40-50 DEG C decocts 50-70min, filter to get filtrate;
(5) after the filtrate obtained in step (1) and step (3) is down to 40-50 DEG C, filtrate in combining step (1), step (3) and step (4), add green tea extract and Herba Medicaginis extract, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
Adopt the external used medicine of Hepatoma therapy prepared by embodiment 1-3, after patient uses, pain effectively alleviates and even disappears, and have effect of good blood circulation promoting and blood stasis dispelling, hepatoma Metastasis relapse rate obviously reduces, and effectively improves the cure rate of hepatocarcinoma; Embodiment 4 is not owing to controlling the temperature in extract drugs process, and embodiment 5 processes medicine owing to not adopting micromolecule cutting technique, and it declines all to some extent to the cure rate of hepatocarcinoma.
Above to external used medicine of a kind of Hepatoma therapy that the embodiment of the present invention provides and preparation method thereof, be described in detail, apply specific case herein to set forth principle of the present invention and embodiment, the explanation of above embodiment just understands method of the present invention and core concept thereof for helping; Meanwhile, for one of ordinary skill in the art, according to thought of the present invention, all will change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.
Claims (3)
1. an external used medicine for Hepatoma therapy, is characterized in that, the external used medicine of Hepatoma therapy is made with the composition of following parts by weight:
The Radix Astragali 8, Herba Hydrocotyles 3, Radix Angelicae Pubescentis 2, Indigo Naturalis 1, Folium Et Cacumen Murrayae 4, Radix Notoginseng 1, Grifola frondosa 4, Rhizoma Ligustici 2, Myrrha 6, Rhizoma Paridis 4, Thallus Laminariae (Thallus Eckloniae) 6, Fructus Corni 6, Folium et Ramulus Cephalotaxi 3, SONGGUOJU 3, the tiger palm 4, Pericarpium Citri Reticulatae Viride 3, Concha Ostreae 10, Hirudo 6, Radix Platycodonis 4, Herba Sedi 8, green tea extract 3, Herba Medicaginis extract 5;
The external used medicine of described Hepatoma therapy also comprises following auxiliary material:
Water 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part, hydroxyacetic acid 0.1-0.5 part, vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part, xylitol 0.5-1 part and maltose 1-2 part;
The preparation method of the external used medicine of described Hepatoma therapy, comprises the following steps:
(1) composition of following parts by weight is taken: the Radix Astragali 8, Herba Hydrocotyles 3, Radix Angelicae Pubescentis 2, Indigo Naturalis 1, Folium Et Cacumen Murrayae 4, Radix Notoginseng 1, Grifola frondosa 4, Rhizoma Ligustici 2, Myrrha 6, Rhizoma Paridis 4, Thallus Laminariae (Thallus Eckloniae) 6, Fructus Corni 6, Folium et Ramulus Cephalotaxi 3, SONGGUOJU 3, the tiger palm 4, Pericarpium Citri Reticulatae Viride 3, Concha Ostreae 10, Hirudo 6, Radix Platycodonis 4 and Herba Sedi 8; Add the 4-5 water doubly of above-mentioned Chinese medicine gross weight, decoct 100-150min, filter, obtain filtrate, medicinal residues are for subsequent use;
(2) medicinal residues obtained in step (1), add 4-5 alcoholic solution doubly, decoct 120-160min, filter to get filtrate, medicinal residues are for subsequent use;
(3) filtrate obtained in step (2) is heated to 80-90 DEG C, reclaims ethanol and obtain filtrate;
(4) medicinal residues obtained in step (2), adding 4-5 concentration is doubly 15-18% acetic acid solution, decocts 50-70min, filter to get filtrate at 40-50 DEG C;
(5) after first the filtrate obtained in step (1) and step (3) being down to 40-50 DEG C, merge with the filtrate that obtains in step (4) again, add green tea extract 3 parts and Herba Medicaginis extract 5 parts, 40-50 DEG C of heated and stirred to the quality of mixed liquor be the 1.5-2 of all Chinese medicine gross masses doubly;
(6) water intaking 100-110 part, glycerol 4-5 part, xanthan gum 1-1.5 part and hydroxyacetic acid 0.1-0.5 part, after dissolving in advance, be mixed and heated to 80 DEG C, sterilizing;
(7) get vegetable oil 1-1.5 part, squalane 1-2 part, emulsifying agent 5-6 part, polydimethylsiloxane 0.5-1 part and xylitol 0.5-1 part, be mixed and heated to 80 DEG C;
(8) step (6) gained solution mixed with step (7) gained solution and stirs, being cooled to 40-50 DEG C, adding maltose 1-2 part, stir, insulation 20-25min;
(9) solution of step (5) and step (8) is mixed, continue to stir, be cooled to room temperature and stop stirring;
(10) by step (9) gained solution left standstill, inspection, fill, gets product.
2. the external used medicine of a kind of Hepatoma therapy according to claim 1, is characterized in that, the Chinese medicine in described step (1) first at room temperature soaks 20-25min, and then decocts 100-150min at 80-90 DEG C.
3. the external used medicine of a kind of Hepatoma therapy according to claim 1, is characterized in that, the concentration adding alcoholic solution in described step (2) is 50-60%, and decoction temperature is 60-70 DEG C.
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| 中晚期肝癌中医治法研究进展;张继东;《现代中西医结合杂志》;20080930;第17卷(第25期);4042-4043 * |
| 中药外敷治疗肝癌疼痛的近况;黄永康;《医学信息》;20110831;第24卷(第8期);5592-5593 * |
| 原发性肝癌的辨证论治进展;侯俐；等;《河南中医》;20071231;第27卷(第2期);78-81 * |
| 活血化瘀法治疗晚期肝癌一例;周正贤；等;《四川肿瘤防治》;19981231;第11卷(第1期);52 * |
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