CN1273819A - Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold - Google Patents
Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold Download PDFInfo
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- CN1273819A CN1273819A CN 00107624 CN00107624A CN1273819A CN 1273819 A CN1273819 A CN 1273819A CN 00107624 CN00107624 CN 00107624 CN 00107624 A CN00107624 A CN 00107624A CN 1273819 A CN1273819 A CN 1273819A
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- release
- chinese medicine
- penetrating agent
- drug storage
- mentholum
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Abstract
A release-controlled Chinese-medicinal picking for lowering baby fever caused by cold is prepared through purifying Chinese medicine, concentrating to obtain extract, and coating on non-woven cloth by biomembrane technique for promoting osmosis and controlling release. Its advantages include quickly taking its effect, high durabiity, easy application and high curative effect.
Description
The invention belongs to medical supplies, is pure Chinese medicine reducing baby fever caused by cold external use plaster.
The subsides of Chinese medicine reducing baby fever caused by cold are the novel regeneration products with acupuncture point transdermal administration form children's antipyretic.Because a little less than the infant premunition, very easily upper respiratory tract infection, Common Cold, concurrent hyperpyrexia simultaneously.Add up according to children's hospital:, more general to autumn and winter season owing to affection due to external wind and heat, tracheitis, pneumonia etc. cause that hyperpyrexia accounts for 42% of case.Therefore cold, fever is children's's commonly encountered diseases, frequently-occurring disease.Hospital now adopts the method treatment of having an injection, take medicine, but medication is very difficult for infant, brings misery for the sick child and the head of a family.
The purpose of this invention is to provide a kind of pure Chinese medicine reducing baby fever caused by cold control release paster.Make clear paste after Chinese medicine purify concentrated, combine (penetrating agent, release-controlled film, porogen, pressure sensitive adhesive etc.) branch secondary and be coated on the non-woven fabrics base material with the short controlled-release technology that oozes of biomembrane again, make slim control release paster, be affixed on each subsides of DAZHUI acupoint and SHENQUE acupoint, reach the purpose of the treatment flu of bringing down a fever.The patch characteristics are simple and easy to do, inner disease outer treats, also control also anti-ly, and the hardship that saving has an injection takes medicine is easy to be accepted by the sick child and the head of a family.Do not see like product both at home and abroad.One. Chinese prescription of the present invention, form by ten flavor Chinese medicines:
Gypsum Fibrosum 16-20g Radix Bupleuri 7.75-9g Radix Isatidis 7.75-9g
Folium Isatidis 16-20g Flos Lonicerae 16-20g Herba Menthae 6-8g
Fructus Forsythiae 12-16g Radix Scutellariae 7.75-9g Herba Schizonepetae 7.75-9g
Radix Glycyrrhizae 3-5g two. the short controlled release transdermal drug-supplying system (TDDS) that oozes
TDDS is the new and high technology in the modern medicines preparation, the transdermal drug delivery system that this patch adopts concentrated traditional Chinese medicine to combine with framework film control diffusion control release type.Mainly form (figure one) by backing layer, Drug Storage (slow release layer), release-controlled film (EVA), pressure sensitive adhesive (release layer), lid lining (strippable paper) five layers.This drug-supplying system can make reducing baby fever caused by cold Chinese medicine continuously see through skin with zero order kinetics and directly enter blood circulation, and the blood drug level more stable than peroral dosage form is provided.
| Backing layer (medical adhesive-bonded fabric) |
| The Drug Storage slow release layer (polyisobutylene, Chinese medicine, liquid paraffin, Mentholum+Borneolum Syntheticum+Azone), thick 80 μ m |
| Release-controlled film (20%EVA), thick 45 μ m |
| Release layer (pressure sensitive adhesive, Chinese medicine, Mentholum), thick 60 μ m |
| Lid lining (silicone oil strippable paper) |
Figure one Chinese medicine reducing baby fever caused by cold control release paster is formed sketch map
1. Chinese medicine transdermal penetrating agent:
The transdermal penetrating agent comprises Mentholum, Borneolum Syntheticum and Azone (azone).Experiment finds that Chinese medicine menthol, Borneolum Syntheticum all can impel influenza defervesce Chinese medicine to increase the skin transmitance, but effect is weaker than Azone.Prove that simultaneously the two and Azone share, share in the 3%+3%+1% ratio has the effect of significantly short infiltration skin to Azone, and combination group increases 4-5 doubly than Azone group skin permeation rate when 4h, 9.97 times of matched group.Help the effect of oozing obviously to quicken, lag time (T
Lag) being kept to 2.4h by Azone group 7h, the purpose of curative effect is consolidated in help like this bringing down a fever cooling of Chinese medicine short time and the even release of Azone longer duration (more than the 10h).
2. controlled release transdermal administration:
(1) Drug Storage (slow release layer):
Polyisobutylene (middle dose 10%) soaked polyisobutylene after the abundant swelling of hermetic container with gasoline, add 6% liquid paraffin and 40% concentrated traditional Chinese medicine (clear paste, 60 ℃, proportion 1.08), transdermal penetrating agent (Mentholum: Borneolum Syntheticum: Azone=3: 3: 1) accounts for 1% in the total amount 56%.Stir, be coated on the medical adhesive-bonded fabric, 50 ℃ of dryings 10 minutes (being advisable), thick about 80 μ m with tack-free.
(2) release-controlled film preparation:
Be made into 20% chloroformic solution with ethylene-vinyl acetate copolymer (EVA) and make film on blow moulding machine, thickness 45 μ m, this thickness are the optimum speed that controlled release Drug Storage Chinese medicine discharges, more than the slow release 12h.
(3) release layer:
Polyacrylic acid metastasis pressuring maleate glue and concentrated traditional Chinese medicine are pressed 20%: 20% mix homogeneously, add 3% Mentholum (transdermal penetrating agent) that accounts in the total amount 40% again and stir evenly, be coated on the silicone oil strippable paper thick pact
60μm。
(4) control release paster preparation:
Drug Storage (1) with preparation directly is coated on the medical adhesive-bonded fabric earlier, and 50 ℃, 10 minutes, partial desiccation (tack-free being advisable), thick about 45 μ EVA films that will prepare again are affixed on the Drug Storage.Pressure-sensitive adhesive layer (release layer) is coated on the EVA film, and the lining that closes the lid is cut into 5 * 6cm paster.Preparation condition: room temperature 25-27 ℃.
3. using method:
To cover lining (silicone oil strippable paper) and throw off, the medicine laminating promptly pastes two subsides in DAZHUI acupoint and each subsides of SHENQUE acupoint.Three. effect of the present invention: 1995.12-1996.3 No.2 Hospital, Tianjin Medical Univ. Pediatrics Department uses [clinical experiment title " pediatrics febricide cream
(patch ", name is called " subsides of Chinese medicine reducing baby fever caused by cold controlled release " now] to 32 example flu
The heating sick child observes, and when using patch, does not use febrifuge, bring down a fever pin and hormone,
Child's effective percentage below five years old 92.6%, 12 years old is with interior effective percentage 87.5%.1997.12-1998.3 Tianjin Children's hospital's department of Chinese medicine is to the observation of curative effect of 61 routine infants, " children's
Bring down a fever cream (patch " to flu youngster curative effect effective percentage 85.7%, tracheitis effective percentage
83.3％。Characteristics are that onset is slower than Western medicine (antondin), but continual and steady cooling is not anti-
Bullet (after the Western medicine medication, body temperature can rise).
Embodiment:
The Xue Lei man went up sense in 4 years old, had a fever 1.5 days, and 38.7 ℃, paste and use 2h, 37.7 ℃, 4h, 37 ℃,
Body temperature is normal behind the 10h, no longer rises.King's zinc roc man went up sense in 1 years old, generated heat 39.3 ℃, and paste and use 1h, 38.5 ℃, 2h, 38 ℃, 3h,
37.5 ℃, 10h body temperature is normal, no longer rises.4 years old bronchitis of strange woman of Cao's winter coughed three days, and 38.5 ℃, paste and use 3h, 37.5 ℃, 8h is extensive
Multiple normal, body temperature no longer rises.
Claims (7)
1. Chinese medicine reducing baby fever caused by cold control release paster, characteristics are it by Chinese medicine clear paste, penetrating agent, Drug Storage skeleton, release-controlled film, pressure sensitive adhesive, non-woven fabrics, the methyl-silicone oil strippable paper is formed.The Chinese medicine of Chinese medicine clear paste is made up of Gypsum Fibrosum, Folium Isatidis, Fructus Forsythiae, Radix Bupleuri, Flos Lonicerae, Radix Scutellariae, Radix Isatidis, Herba Menthae, Radix Glycyrrhizae and Herba Schizonepetae; Penetrating agent is made up of Mentholum, Borneolum Syntheticum and azone; Release-controlled film is made of ethylene-vinyl acetate copolymer (EVA); Pressure sensitive adhesive selects for use polyacrylic acid metastasis pressuring maleate glue and Chinese medicine clear paste and penetrating agent Mentholum to constitute the paster release layer.
Above-mentioned material proportion is:
Drug Storage (slow release layer): Chinese medicine clear paste (decoction and alcohol sedimentation technique): 40%
Polyisobutylene 10%
Liquid paraffin 6%
Penetrating agent 1%
Release-controlled film: ethylene-vinyl acetate copolymer (EVA) 20%, thick 45 μ m
Release layer: Chinese medicine clear paste: 20%
Pressure sensitive adhesive 20%
Mentholum 3%
2. Chinese medicine composition and the weight according to claims 1. described control release pasters is
Gypsum Fibrosum 16-20g Radix Bupleuri 7.75-9g Radix Isatidis 7.75-9g
Folium Isatidis 16-20g Flos Lonicerae 16-20g Herba Menthae 6-8g
Fructus Forsythiae 12-16g Radix Scutellariae 7.75-9g Herba Schizonepetae 7.75-9g
Radix Glycyrrhizae 3-5g
3. the Drug Storage skeleton preparation procedure according to claims 1. described control release pasters is:
Content 10% polyisobutylene is soaked in the airtight glass container with gasoline, spends the night, make its abundant swelling after, add 6% liquid paraffin and 40% concentrated traditional Chinese medicine stirs, add 1% penetrating agent again, the penetrating agent ratio adds by 4., stirs evenly, and is stand-by.
4. form according to claims 1. described Drug Storages (slow release layer) and release layer transdermal penetrating agent and weight is:
Drug Storage penetrating agent: Mentholum: Borneolum Syntheticum: azone=3: 3: 1, accounting for this layer toatl proportion is 1%.
The release layer penetrating agent: Mentholum accounts for 3% of this layer toatl proportion, 25 ℃ of room temperatures.
5. according to claims 1. described release-controlled film preparation procedures be:
Be made into 20% chloroformic solution with vinyl acetate (EVA), be placed on and make film on the blow moulding machine, thickness 45 μ m, 25 ℃-27 ℃ of room temperatures.
6 according to claims 1. described release-controlled film preparation process are:
Drug Storage (1) with preparation directly is coated on the medical adhesive-bonded fabric earlier, and 50 ℃, 10 minutes, partial desiccation (tack-free being advisable), thick about 45 μ m EVA films that will prepare again are affixed on the Drug Storage.Pressure-sensitive adhesive layer (release layer) is coated on the EVA film, and the lining that closes the lid is cut into 5 * 6cm paster.Preparation condition: room temperature 25-27 ℃.
7. paster using method:
To cover the lining throw off after, the medicine laminating is on DAZHUI acupoint and SHENQUE acupoint, each pastes, and once pastes two subsides altogether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107624 CN1273819A (en) | 2000-05-16 | 2000-05-16 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107624 CN1273819A (en) | 2000-05-16 | 2000-05-16 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
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| Publication Number | Publication Date |
|---|---|
| CN1273819A true CN1273819A (en) | 2000-11-22 |
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|---|---|---|---|
| CN 00107624 Pending CN1273819A (en) | 2000-05-16 | 2000-05-16 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057229A1 (en) * | 2002-01-14 | 2003-07-17 | Wenhan Ma | Antiviral and antipyretic formulation and the preparation method thereof |
| CN100361699C (en) * | 2005-12-09 | 2008-01-16 | 成都诺迪康生物制药有限公司 | Medicine for treating common cold and its preparing method |
| CN100391480C (en) * | 2006-05-31 | 2008-06-04 | 武汉市海格尔科技有限公司 | Hydrophilic gel pleximetric paste and its preparation |
| CN102764251A (en) * | 2012-07-18 | 2012-11-07 | 黎秋萍 | Simple and effective method for externally treating internal diseases |
| CN103127365A (en) * | 2013-03-21 | 2013-06-05 | 南京中医药大学 | External use Chinese herbal medicine compound preparation for children fever and preparation method thereof |
| CN103751277A (en) * | 2013-12-30 | 2014-04-30 | 湖南中医药大学 | Infantile traditional Chinese medicine cooling patch |
| CN104013688A (en) * | 2014-06-30 | 2014-09-03 | 周冠旻 | Traditional Chinese medicine fever cooling patch |
| CN104189291A (en) * | 2014-09-19 | 2014-12-10 | 周玉娟 | Traditional Chinese medicine composition for treating upper respiratory infection |
| CN104825426A (en) * | 2015-05-26 | 2015-08-12 | 韩晓明 | Double-phase melatonin patch |
| CN104887384A (en) * | 2015-05-28 | 2015-09-09 | 京东方科技集团股份有限公司 | Intelligent fever-cooling patch |
| CN109432066A (en) * | 2018-12-27 | 2019-03-08 | 深圳津梁生活科技有限公司 | A kind of external drug application |
| CN112022839A (en) * | 2019-12-10 | 2020-12-04 | 江苏一全药业有限公司 | Pharmaceutical preparation containing cyclodextrin, transdermal patch containing cyclodextrin, and preparation method thereof |
| CN112057436A (en) * | 2019-12-10 | 2020-12-11 | 江苏一全药业有限公司 | Lipid-containing pharmaceutical preparation, transdermal drug delivery patch, and method for producing the same |
| CN112107561A (en) * | 2019-12-10 | 2020-12-22 | 江苏一全药业有限公司 | Medicinal preparation containing chitosan, medicinal transdermal patch and preparation method thereof |
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2000
- 2000-05-16 CN CN 00107624 patent/CN1273819A/en active Pending
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057229A1 (en) * | 2002-01-14 | 2003-07-17 | Wenhan Ma | Antiviral and antipyretic formulation and the preparation method thereof |
| CN100361699C (en) * | 2005-12-09 | 2008-01-16 | 成都诺迪康生物制药有限公司 | Medicine for treating common cold and its preparing method |
| CN100391480C (en) * | 2006-05-31 | 2008-06-04 | 武汉市海格尔科技有限公司 | Hydrophilic gel pleximetric paste and its preparation |
| CN102764251A (en) * | 2012-07-18 | 2012-11-07 | 黎秋萍 | Simple and effective method for externally treating internal diseases |
| CN102764251B (en) * | 2012-07-18 | 2013-08-07 | 黎秋萍 | Simple and effective medicine for externally treating internal diseases |
| CN103127365A (en) * | 2013-03-21 | 2013-06-05 | 南京中医药大学 | External use Chinese herbal medicine compound preparation for children fever and preparation method thereof |
| CN103751277A (en) * | 2013-12-30 | 2014-04-30 | 湖南中医药大学 | Infantile traditional Chinese medicine cooling patch |
| CN104013688A (en) * | 2014-06-30 | 2014-09-03 | 周冠旻 | Traditional Chinese medicine fever cooling patch |
| CN104189291A (en) * | 2014-09-19 | 2014-12-10 | 周玉娟 | Traditional Chinese medicine composition for treating upper respiratory infection |
| CN104825426A (en) * | 2015-05-26 | 2015-08-12 | 韩晓明 | Double-phase melatonin patch |
| CN104887384A (en) * | 2015-05-28 | 2015-09-09 | 京东方科技集团股份有限公司 | Intelligent fever-cooling patch |
| CN104887384B (en) * | 2015-05-28 | 2017-12-08 | 京东方科技集团股份有限公司 | A kind of intelligence is defervescence plaster used |
| US10406023B2 (en) | 2015-05-28 | 2019-09-10 | Boe Technology Group Co., Ltd. | Smart cooling paste |
| CN109432066A (en) * | 2018-12-27 | 2019-03-08 | 深圳津梁生活科技有限公司 | A kind of external drug application |
| CN112022839A (en) * | 2019-12-10 | 2020-12-04 | 江苏一全药业有限公司 | Pharmaceutical preparation containing cyclodextrin, transdermal patch containing cyclodextrin, and preparation method thereof |
| CN112057436A (en) * | 2019-12-10 | 2020-12-11 | 江苏一全药业有限公司 | Lipid-containing pharmaceutical preparation, transdermal drug delivery patch, and method for producing the same |
| CN112107561A (en) * | 2019-12-10 | 2020-12-22 | 江苏一全药业有限公司 | Medicinal preparation containing chitosan, medicinal transdermal patch and preparation method thereof |
| CN112107561B (en) * | 2019-12-10 | 2021-07-23 | 江苏一全药业有限公司 | Medicinal preparation containing chitosan, medicinal transdermal patch and preparation method thereof |
| CN113288884A (en) * | 2019-12-10 | 2021-08-24 | 江苏一全药业有限公司 | Medicinal preparation containing chitosan, medicinal transdermal patch and preparation method thereof |
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