CN100361699C - Medicine for treating common cold and its preparing method - Google Patents
Medicine for treating common cold and its preparing method Download PDFInfo
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Abstract
The present invention provides a medicament for treating common cold, which is basically prepared from the raw materials of 4.6 to 7.0 portions of honeysuckle flower, 3.5 to 5.2 portions of weeping forsythia capsule, 3.5 to 5.2 portions of bupleurum root, 3.5 to 5.2 portions of kudzu root, 3.5 to 5.2 portions of gypsum, 3.5 to 5.2 portions of dyers woad leaf, 3.8 to 5.8 portions of isatis root, 1.8 to 2.9 portions of schizonepeta spike and 1.5 to 2.3 portions of mint. The medicament has the functions of expelling exterior evil energy, clearing heat and toxins and eliminating dampness. The medicament mainly treats patients with common cold, heat generation, slight evil wind cold, sweeting absence or inhibited sweating, headaches, limb pain or tussis, sore pharynx, stuffiness, tumefaction and discomfort of chest and gastric cavity, no thought of food and drink and rapid floating pulse caused by externally contracted wind-heat or transformed heat from wind cold or combined dampness and evil energy, and has excellent curative effect. The present invention also provides a preparation method for the medicament for treating common cold.
Description
Technical field:
The present invention is relevant with medicine for the treatment of flu and preparation method thereof.
Background technology:
The acute upper respiratory tract infection that flu system virus causes is clinical common exogenous diseases, and the four seasons all have, especially with season in spring and autumn for seeing more, local symptoms such as watery nasal discharge, spray, nasal obstruction can appear in the lighter, and General Symptomies such as general malaise, heating, aversion to cold, headache appear in weight person, influence work and life.At present, the medicine of treatment flu is more, can reach tens of kinds more than, and Western medicine has GANMAOTONG, contac, capsule for cold etc., Chinese and Western in conjunction with the patent medicine thoughts emit clearly, three nine-day periods after the winter solstice cold drug, V
CYINQIAO sheet etc.; Have YINQIAO JIEDU PIAN, KANGBINGDU CHONGJI, strange power that Chinese patent medicine is commonly used are coughed GANKANG, YINHUANG KOUFUYE etc.Make a general survey of present flu with in composition, mostly only patients whose symptoms were less severe are had certain curative effect, and real General Symptoms is heavier, then curative effect is not unsatisfactory following time for hyperpyrexia.
Summary of the invention:
The objective of the invention is to evacuate pathogenic factor in the exterior in order to provide a kind of, heat-clearing and toxic substances removing, hold concurrently with dehumidifying, cure mainly affection due to external wind and heat or wind and cold heat-transformation or cold, fever, the micro evil wind of the folder damp of holding concurrently are cold, lossless or have that antiperspirant is smooth, headache limb Chu or cough, pharyngalgia, breast gastral cavity vexed expand easypro, anorexia, floating and rapid pulse, the medicine of the treatment flu that therapeutic effect is good.Another object of the present invention is for a kind of preparation method for the treatment of the medicine of flu is provided.
Purpose of the present invention realizes like this:
The present invention treats the medicine of flu, makes the raw materials of effective components medicine and mainly consists of by weight:
Flos Lonicerae 4.6～7.0, Fructus Forsythiae 3.5～5.2, Radix Bupleuri 3.5～5.2,
Radix Puerariae 3.5～5.2, Gypsum Fibrosum 3.5～5.2, Folium Isatidis 3.5～5.2,
Radix Isatidis 3.8～5.8, Herba Schizonepetae 1.8～2.9, Herba Menthae 1.5～2.3.
Make the Herba Pogostemonis that the raw materials of effective components medicine also has 1.5～2.3 weight portions in the above-mentioned medicine.
Make the raw materials of effective components medicine in the above-mentioned medicine and also have the Herba Artemisiae Scopariae of 4.6～7.0 weight portions.
Make the Rhizoma Phragmitis that the raw materials of effective components medicine also has 1.8～2.9 weight portions in the above-mentioned medicine.
Make the raw materials of effective components medicine in the said medicine and also have the Radix Glycyrrhizae of 1.0～1.8 weight portions.
Making the raw materials of effective components medicine in the above-mentioned medicine consists of by weight:
Flos Lonicerae 5.76, Fructus Forsythiae 4.32, Radix Bupleuri 4.32,
Radix Puerariae 4.32, Gypsum Fibrosum 4.32, Folium Isatidis 4.32,
Radix Isatidis 4.8, Herba Schizonepetae 2.4, Herba Menthae 1.92,
Herba Pogostemonis 1.92, Herba Artemisiae Scopariae 5.76, Rhizoma Phragmitis 2.4, Radix Glycyrrhizae 1.44.
The preparation method that the present invention treats the medicine of flu is each raw material mixed powder to be broken into coarse powder or with remix behind each raw material pulverize separately, cross the aperture and be 0.701～0.991 millimeter sieve, contain water quantities below 9% being dried to below 60 ℃, sterilized at least 3 hours.
Above-mentioned method is each raw material to be mixed pulverize the back after sieve, pulverizes simultaneously and mixes, and each medicine is uniformly dispersed, and particularly Herba Artemisiae Scopariae is also poly-not agglomerating, the flour extraction height.
Be to adopt cobalt 60 irradiation sterilizations 3 hours in the above-mentioned method, the sterilizing efficiency height, the time is short, and atomic to medicine destruction, through test, uses cobalt 60 irradiation sterilizations 3 hours, can make the every gram of bacterial population and fungi count below 100.
Be with the sterilization prepared medicine packing in back in the above-mentioned method, the packing bagged steeping drug type medicine, bagged steeping drug adopts boiling water bubble medicine, promptly kept the absorption of decoction fast, the speed of proving effective, it is big to have overcome the decoction volume again, the waste medical material, and the active ingredient dissolution rate is low, shortcoming such as inconvenience is carried and is used in storage, in addition, from leaching process, bagged steeping drug is to be suspended in the boiling water to soak, around the medicated bag, concentration ratio is bigger, leaches material and sunk by gravity, and new molten coal constantly replenishes, make it to exist all the time concentration difference, utilize and leach, can keep volatile ingredient when bagged steeping drug leaches morely, exceed several times than muddy property of decoction component content.
Theory of Chinese medical science and experience are thought, affection due to external wind and heat or wind and cold heat-transformation, and have the flu patient of damp concurrently, and defending branch from the beginning of heresy, defend gas by strongly fragrant, so see heating, micro evil wind is cold, and wind heat is a YANG pathogen, invades human body, easily cause " prepoderance of YANG ", show as the pathology situation of " excess of YANG bringing about heat syndrome ", aversion to cold is light so see heating to weigh.Wind and cold heat-transformation, aversion to cold are gradually light, and fever of the body increases Sheng, also between heating and aversion to cold is light, heresy of wind heat visitor is in the flesh table, it is entire that influence is opened, it is cold that space between skin and muscles closes, thus see lossless, so wind catharsis, hot liter is diffusing, mutability has antiperspirant, because of its space between skin and muscles obturation, though there is the antiperspirant also can not be smooth.Lung associating with skin and hair again with to defend gas phase logical, is defended gas by strongly fragrant lung qi thereby unsuitable, so see cough, throat is the door of lung, and the heresy of wind heat is attacked lung, so see and have sore throat.Hold together to empty and flesh natural fibre line of meat obturation on the sun heat, so see headache body Chu.Hinder in damp, the fortuneization of damage spleen is not relaxed so see vexed the expanding of breast gastral cavity, and desire is not thought food.But because of the event of prepoderance of YANG, damp is easily from transconversion into heat, and dehumidifying should be fragrant clear sharp, and should not use the product of warm-dryness syndrome.Pathogenic heat are at table, so see floating and rapid pulse.
Use the Flos Lonicerae heat-clearing and toxic substances removing in the medicine of the present invention, gently should evacuate, with the heat clearing away expelling pathogenic factors from the exterior; Radix Bupleuri is dredged heresy and is induced sweat, and lets out flesh heat clearly, and with the heat radiation of inducing sweat, between two medicines are assisted mutually, evacuate with removing summer-heat and lay equal stress on, be monarch drug altogether, Fructus Forsythiae, Gypsum Fibrosum, Folium Isatidis, Radix Isatidis help honeysuckle flower for reducing fever, detoxicating; Radix Puerariae, Herba Schizonepetae, the auxilliary Radix Bupleuri relieving the exterior syndrome with drugs of pungent in flavor and cool in nature of Herba Menthae are ministerial drug altogether, and all the other Herba Pogostemonis virtues are gone and loose, and removing dampness is held concurrently and can be delivered, and the flu folder is wet causes heating, the aversion to cold headache, and the breast gastral cavity is vexed to expand, and the inappetence person is very suitable; Herba Artemisiae Scopariae can clearing away heat-damp and promoting diuresis, can draw damp and hotly to go out from urine; Rhizoma Phragmitis can help Gypsum Fibrosum etc. to let out the heat of lung stomach clearly, controlling cough, pharyngalgia, and can work in coordination with the Herba Artemisiae Scopariae clearing away heat and promoting diuresis.Above three is adjuvant drug altogether, but both heat-clearing and toxic substances removing of Radix Glycyrrhizae, again can coordinating the actions of various ingredients in a prescription, and be messenger drug.
Medicine of the present invention is compatible with diffusing pathogenic factor in the exterior medicine of suffering and heat and toxic materials clearing away medicine, and is aided with the product of the clear agent of virtueization, is total to the diffusing pathogenic factor in the exterior of long memorial, heat-clearing and toxic substances removing, and hold concurrently with the merit of dehumidifying.
Medicine of the present invention has carried out Pharmacodynamic test of active extract and toxicology test:
(1) Pharmacodynamic test of active extract:
Medicine of the present invention is to RSV, the AdV3 type all has obvious deactivation, wherein deactivation is better than virazole to the AdV3 type, to staphylococcus aureus, staphylococcus epidermidis, diphtheria corynebacterium, escherichia coli, shigella flexneri, bacillus enteritidis, Salmonella anatis, enterocolitis yersinia enterocolitica etc. have preferable bacteriostasis; Fever in rabbit is had remarkable refrigeration function, with KANGBINGDU CHONGJI relatively, medicine of the present invention has the refrigeration function peak and occurs early, advantage such as acts on and acting duration is longer stronger; It is the effect of sole of the foot portion sweat secretion that the normal rat of promotion is arranged; Can significantly suppress rat paw edema due to the Ovum Gallus domesticus album, suppress mice caused by dimethylbenzene xylene auricle inflammation, suppress the mouse peritoneal capillary permeability, demonstrate good antiinflammatory action, and be better than KANGBINGDU CHONGJI; Can significantly promote the phagocytic activity of leukocytes of mice whole blood, promote mice whole blood T, bone-marrow-derived lymphocyte to transform, have the effect of enhancing human body immunity function preferably; Dichlorodiphenyl Acetate induced mice pain also shows good analgesic activity.Above many-sided pharmacodynamics test shows that medicine of the present invention is better than KANGBINGDU CHONGJI.
(2) acute toxicity test
Acute toxicity test in mice shows that the maximum tolerated dose of mouse stomach administration is 120g/kg, is equivalent to 150 times of 60kg body weight adult's oral dose (48g crude drug in whole), shows that this product is nontoxic substantially, safer when usual amounts.
(3) long term toxicity test
Around the continuous gastric infusion of rat, the result shows, medicinal bag infusion 4.0g/kg of the present invention, (5 times of people's consumptions), 32g/kg (40 times of people's consumptions) and three dosage groups of 64g/kg (80 times of people's consumptions) do not have obvious influence to the rat hemogram, liver function and renal function are not had the overt toxicity damage, animal growth and body weight are not also had obvious influence, the heart, liver, spleen, lung, kidney, adrenal gland, stomach, small intestinal, large intestine are not all found pathological lesion, it is lower, safer to show that this medicine is taken toxicity for a long time.
(4) clinical trial
Ratify through Sichuan Province Department of Public Health, in * * * * year August～December, in Chengdu Wu Jia hospital bagged steeping drug type medicine of the present invention has been carried out formal clinical trial, treat fever caused by exogenous pathogens altogether and demonstrate,prove 401 examples, bagged steeping drug type medication therapy groups 301 examples wherein of the present invention, total effective rate 90.7%, the obvious effective rate rate 41.78% of bringing down a fever in 89.44%, 24 hour, the rate 67.12% of bringing down a fever in 48 hours, KANGBINGDU CHONGJI matched group 100 examples, total effective rate 72%, obvious effective rate 45%.Two groups relatively, and treatment group total effective rate and obvious effective rate all obviously are better than matched group (P＜0.001) (seeing Table 1～table 5).
Table 1 liang group total effects contrast
| Group | N (example) | Recovery from illness (example) | Produce effects (example) | Effectively (example) | Invalid (example) | Total effective rate (%) | Total obvious effective rate (%) |
| Treatment group matched group | 301 100 | 130 19 | 79 26 | 64 27 | 28 28 | 90.70 72.00 | 69.44 45.00 |
Table 2 liang group therapeutic effect of syndrome contrast
| Symptom | The treatment group | Matched group | ||||||||
| Total example (n) | Example (296) disappears | 1 day (296) | 2 days (296) | 3 days (296) | Total example (n) | Example (296) disappears | 1 day (296) | 2 days (296) | 3 days (296) | |
| Fear of cold fever and headache nasal obstruction watery nasal discharge sneeze cough dry pharynx, bitterly, the tongue BOHUANG of itching floating and tense pulse floating and rapid pulse pharyngeal hyperemia edema | 124 292 102 218 232 163 193 216 181 54 247 240 | 115(92.74) 239(81.85) 84(82.35) 194(88.99) 213(91.82) 153(93.87) 172(89.12) 145(87.13) 162(89.50) 47(87.04) 228(92.31) 173(72.08) | 43(34.68) 45(15.41) 21(20.59) 50(22.94) 54(23.28) 52(31.90) 35(18.13) 18(8.00) 32(17.68) 9(16.67) 45(18.22) 10(4.17) | 40(32.26) 101(35.62) 35(34.31) 86(39.45) 108(45.69) 81(49.69) 45(23.32) 53(24.54) 40(22.10) 12(22.22) 54(21.86) 54(22.50) | 32(25.81) 90(30.82) 28(27.45) 58(26.61) 53(22.84) 20(12.27) 92(47.67) 74(34.26) 90(49.72) 26(48.15) 129(52.23) 109(45.42) | 37 98 32 81 78 62 74 71 60 21 79 81 | 34(91.89) 70(71.43) 23(71.88) 87(82.72) 89(88.48) 58(93.55) 65(87.84) 42(59.15) 48(80) 15(71.43) 80(75.95) 45(55.58) | 5(13.51) 13(13.27) 5(15.63) 9(11.11) 8(10.28) 11(17.74) 6(8.11) 7(9.86) 7(11.87) 3(14.29) 9(11.39) 3(3.70) | 21(56.76) 28(28.57) 14(43.75) 29(35.80) 41(52.58) 28(45.18) 25(33.78) 15(21.13) 12(20.00) 4(19.05) 18(20.25) 13(18.05) | 8(21.26) 29(29.59) 5(15.83) 29(35.80) 20(25.84) 19(30.65) 14(18.92) 20(28.17) 29(48.33) 8(38.10) 35(44.30) 29(35.80) |
It is fast that watch 2 shows that every clinical syndrome treatment group better disappears according to group
The table 3 liang normal time ratio of group temperature recovery
| Group | The total example of heating (n) | Recover normal routine number in each time | |||||||
| 2h | 4h | 6h | 8h | 12h | 24h | 48h | 72h | ||
| Treatment group matched group | 292 98 | 4 1 | 15 4 | 29 9 | 52 13 | 76 15 | 122(41.78) 20(20.41) | 98(67.12) 42(42.86) | 239(81.15) 70(71.43) |
Table 3 shows that two groups of effects of bringing down a fever were through X in 72 hours
2Check, X
2=4.84, there is significant difference P＜0.05,24 hours, 48 hours two groups of effect X that bring down a fever
2Value is respectively 11.01 and 14.82, and there is significant differences P＜0.001, and the prompting treatment group effect of bringing down a fever obviously is better than matched group, and the time of performance antipyretic effect also than matched group early.
Table 4 a liang group hemogram changes contrast
| Total white blood cells (＞10 * 10 9/ L) or neutrophilic granulocyte (＞70%) | Normal or the reduction lymphocyte (＞40%) of total white blood cells | ||
| Treatment group (n=93) | After controlling before controlling | 70 12 | 23 4 |
| Matched group (n=32) | After controlling before controlling | 21 13 | 11 6 |
Table 4 shows, treats the distribution of preceding two groups of hemogram and learns processing there was no significant difference (P＞0.05) by statistics; After the treatment, the total white blood cells that the treatment group increases, neutrophilic granulocyte, lymphocyte all has obvious decline, compared significant differences (P＜0.01) with matched group, compare utmost point significant difference (P＞0.001) before and after the treatment group self, pointed out medicinal bag infusion of the present invention that bacterial infection and viral infection are all had obvious curative effects.
Table 5 pattern of syndrome Comparison of therapeutic
| Pattern of syndrome | n | Recovery from illness (n) | Produce effects (n) | Effectively (n) | Invalid (n) | Total effective rate (n) | Total obvious effective rate (n) |
| The wind-heat syndrome syndrome of heat transformed from wind-cold | 247 54 | 110 20 | 67 12 | 53 11 | 17 11 | 93.12 79.63 | 71.66 59.26 |
Above data shows that medicinal bag infusion of the present invention is all effective to each pattern of syndrome, is remarkable especially with the wind-heat syndrome.
Organize in 301 examples in treatment, double damp syndrome 36 examples of holding under the arm, 13 examples of wherein fully recovering, produce effects 7 examples, effective 8 examples, invalid 8 examples, total effective rate 77.78%, total obvious effective rate 55.56%, this product is also effective to holding wet disease under the arm.
Medicine of the present invention is evacuated with removing summer-heat and is laid equal stress on, hold concurrently with dehumidifying, cure mainly affection due to external wind and heat or wind and cold heat-transformation or the cold, fever of the folder damp of holding concurrently, micro evil wind cold, lossless or have that antiperspirant is smooth, headache limb Chu, or cough, pharyngalgia, breast gastral cavity vexed expand do not relax, the patient of anorexia, floating and rapid pulse.Therapeutic effect is good.Preparation method of the present invention is simple, and particularly bagged steeping drug type effect is better.
The specific embodiment:
Medicine embodiment of the present invention sees Table 6:
Table 6:
The preparation method of the various embodiments described above medicine is with Flos Lonicerae, Herba Artemisiae Scopariae, Fructus Forsythiae, Radix Bupleuri, Herba Schizonepetae, Herba Menthae, Herba Pogostemonis, the selected lime-ash of removing; Radix Isatidis, Radix Puerariae, Gypsum Fibrosum, Radix Glycyrrhizae are removed impurity such as earth through drip washing, dry (these a few flavor medicines all do not contain volatile ingredient, all can dry or dry), each raw material back mixed powder of preparing burden in proportion is broken into coarse powder, cross aperture and be 0.833 millimeter sieve; Mix once more, each medicated powder is uniformly dispersed, being dried to water content under 60 ℃ is below 9%; Adopt cobalt 60 sterilizations 3 hours; Packing, with pharmaceutical plastics package the medicine of bagged steeping drug type treatment flu.
Medicine of the present invention also can adopt conventional method to make tablet or other dosage form.
The various embodiments described above are that foregoing of the present invention is further described, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to the foregoing description.All technology that realizes based on foregoing all belong to scope of the present invention.
Claims (10)
1. the medicine of treatment flu, make the raw materials of effective components medicine and mainly consist of by weight:
Flos Lonicerae 4.6～7.0, Fructus Forsythiae 3.5～5.2, Radix Bupleuri 3.5～5.2,
Radix Puerariae 3.5～5.2, Gypsum Fibrosum 3.5～5.2, Folium Isatidis 3.5～5.2,
Radix Isatidis 3.8～5.8, Herba Schizonepetae 1.8～2.9, Herba Menthae 1.5～2.3.
2. the medicine of treatment flu as claimed in claim 1 is characterized in that making in the described medicine Herba Pogostemonis that the raw materials of effective components medicine also has 1.5～2.3 weight portions.
3. the medicine of treatment flu as claimed in claim 2 is characterized in that making in the described medicine Herba Artemisiae Scopariae that the raw materials of effective components medicine also has 4.6～7.0 weight portions.
4. the medicine of treatment flu as claimed in claim 3 is characterized in that making in the described medicine Rhizoma Phragmitis that the raw materials of effective components medicine also has 1.8～2.9 weight portions.
5. the medicine of treatment flu as claimed in claim 4 is characterized in that making in the described medicine Radix Glycyrrhizae that the raw materials of effective components medicine also has 1.0～1.8 weight portions.
6. the medicine of treatment flu as claimed in claim 5 is characterized in that making the raw materials of effective components medicine and consists of by weight:
Flos Lonicerae 5.76, Fructus Forsythiae 4.32, Radix Bupleuri 4.32,
Radix Puerariae 4.32, Gypsum Fibrosum 4.32, Folium Isatidis 4.32,
Radix Isatidis 4.8, Herba Schizonepetae 2.4, Herba Menthae 1.92,
Herba Pogostemonis 1.92, Herba Artemisiae Scopariae 5.76, Rhizoma Phragmitis 2.4, Radix Glycyrrhizae 1.44.
7. as the preparation method of the medicine of the described treatment of one of claim 1～6 flu, it is characterized in that described method is each raw material mixed powder to be broken into coarse powder or with remix behind each raw material pulverize separately, cross the aperture and be 0.701～0.991 millimeter sieve, contain water quantities below 9% being dried to below 60 ℃, sterilized at least 3 hours.
8. the preparation method of the medicine of treatment flu as claimed in claim 7 is characterized in that described method is each raw material to be mixed pulverize the back after sieve.
9. the process for preparing medicine of treatment flu as claimed in claim 7 is characterized in that adopting cobalt 60 irradiation sterilizations 3 hours.
10. the process for preparing medicine of treatment as claimed in claim 7 flu, it is characterized in that with the sterilization prepared medicine packing in back, pack bagged steeping drug type medicine.
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| CN101322776B (en) * | 2008-07-24 | 2010-11-17 | 栾艳霞 | Chinese medicinal composition for treating exogenous fever and preparation thereof |
| CN101653507A (en) * | 2009-08-10 | 2010-02-24 | 黄山 | Particle for relieving heat and cough |
| CN101711795B (en) * | 2009-11-25 | 2013-06-26 | 北京大北农动物保健科技有限责任公司 | Veterinary antipyretic and antiviral medicine composite |
| CN103083428A (en) * | 2011-10-28 | 2013-05-08 | 天津威隆动物药品有限公司 | Lian hua chai huang detoxication powder |
| CN102526517B (en) * | 2011-12-21 | 2014-06-04 | 南方医科大学珠江医院 | Traditional Chinese medicinal composition for treating influenzas and preparation method thereof |
| CN102526319A (en) * | 2011-12-31 | 2012-07-04 | 大连大学 | Traditional Chinese medicine prescription for treating epidemic febrile disease and preparation method thereof |
| CN102743779B (en) * | 2012-07-18 | 2014-05-21 | 无锡市灵山香烛工艺制品有限公司 | Incense for preventing common cold |
| CN103142989B (en) * | 2013-04-09 | 2014-07-30 | 杜京辉 | Traditional Chinese medicine composition for treating infantile cough and preparation method thereof |
| CN104435409A (en) * | 2014-12-26 | 2015-03-25 | 马思东 | Traditional Chinese medicine agent for treating exogenous fever and preparation method |
| CN104983837A (en) * | 2015-06-05 | 2015-10-21 | 李跃 | Foot bath health care traditional Chinese medicine for treating influenza |
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| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN1273819A (en) * | 2000-05-16 | 2000-11-22 | 刘安西 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN1273819A (en) * | 2000-05-16 | 2000-11-22 | 刘安西 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
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