CN114544785A - 一种氟比洛芬及其杂质的检测方法 - Google Patents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
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- G01N30/30—Control of physical parameters of the fluid carrier of temperature
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Abstract
Description
时间(分钟) | 流动相A的体积比 | 流动相B的体积比 |
0 | 50-100 | 0-50 |
15 | 50-100 | 0-50 |
35 | 30-70 | 30-70 |
50 | 30-70 | 30-70 |
时间(分钟) | 流动相A的体积比 | 流动相B的体积比 |
0 | 95 | 5 |
15 | 95 | 5 |
35 | 50 | 50 |
50 | 50 | 50 |
名称 | 浓度范围(μg/ml) | 回归方程 | 相关系数(r) |
杂质a | 0.01996~2.235 | y=2.8863x+0.5207 | 0.9991 |
杂质b | 0.01966~2.387 | y=19.7940x+0.6247 | 0.9992 |
杂质c | 0.02136~2.392 | y=11.2585x-0.9175 | 0.9999 |
杂质d | 0.1066~2.388 | y=35.6721x+1.0030 | 0.9998 |
时间(min) | 流动相A的体积比 | 流动相B的体积比 |
0 | 95 | 5 |
15 | 95 | 5 |
35 | 50 | 50 |
50 | 50 | 50 |
50.1 | 95 | 5 |
65 | 95 | 5 |
次数 | 保留时间(min) | 峰面积 | 理论塔板数 |
1 | 3.591 | 35.261 | 11884 |
2 | 3.592 | 35.239 | 11864 |
3 | 3.592 | 35.260 | 11875 |
4 | 3.592 | 35.269 | 11828 |
5 | 3.593 | 35.254 | 11847 |
6 | 3.592 | 35.265 | 11901 |
平均值 | 3.592 | 35.258 | 11866 |
RSD% | 0.02 | 0.20 | 0.2 |
次数 | 保留时间(min) | 峰面积 | 理论塔板数 |
1 | 6.021 | 34.361 | 11346 |
2 | 6.021 | 34.160 | 11349 |
3 | 6.021 | 34.351 | 11346 |
4 | 6.022 | 34.285 | 11336 |
5 | 6.022 | 34.286 | 11348 |
6 | 6.022 | 34.287 | 11366 |
平均值 | 6.022 | 34.288 | 11348 |
RSD% | 0.01 | 0.21 | 0.09 |
次数 | 保留时间(min) | 峰面积 | 理论塔板数 |
1 | 33.497 | 62.707 | 440147 |
2 | 33.494 | 61.794 | 442847 |
3 | 33.495 | 62.208 | 443411 |
4 | 33.494 | 61.730 | 442470 |
5 | 33.493 | 61.615 | 444762 |
6 | 33.480 | 61.507 | 448612 |
平均值 | 33.492 | 61.760 | 443708 |
RSD% | 0.02 | 0.72 | 0.64 |
名称 | 浓度范围(μg/ml) | 回归方程 | 相关系数(r) |
杂质a | 0.01996~2.235 | y=2.8863x+0.5207 | 0.9991 |
杂质b | 0.01966~2.387 | y=19.7940x+0.6247 | 0.9992 |
杂质c | 0.02136~2.392 | y=11.2585x-0.9175 | 0.9999 |
杂质d | 0.1066~2.388 | y=35.6721x+1.0030 | 0.9998 |
时间(min) | 流动相A的体积比 | 流动相B的体积比 |
0 | 60 | 40 |
15 | 60 | 40 |
35 | 30 | 70 |
50 | 30 | 70 |
50.1 | 60 | 40 |
65 | 60 | 40 |
检测物质 | 保留时间(min) | 分离度 | 含量(%) |
乙腈峰 | 2.107 | -- | -- |
杂质a | 3.589 | 3.107 | 0.03 |
杂质b | 5.935 | 2.896 | 0.03 |
杂质c | 8.980 | 49.322 | 0.05 |
氟比洛芬 | 22.200 | 57.108 | -- |
杂质d | 33.108 | 100.279 | 0.04 |
检测物质 | 保留时间(min) | 分离度 | 含量(%) |
乙腈峰 | 2.686 | -- | -- |
杂质a | 3.920 | 13.789 | 0.03 |
杂质b | 6.479 | 11.939 | 0.04 |
杂质c | 9.812 | 47.201 | 0.04 |
氟比洛芬 | 23.854 | 87.234 | -- |
杂质d | 34.231 | 101.960 | 0.05 |
时间(min) | 流动相A的体积比 | 流动相B的体积比 |
0 | 100 | 0 |
15 | 100 | 0 |
35 | 50 | 50 |
50 | 50 | 50 |
50.1 | 100 | 0 |
65 | 100 | 0 |
时间(min) | 流动相A的体积比 | 流动相B的体积比 |
0 | 90 | 10 |
15 | 90 | 10 |
35 | 30 | 70 |
50 | 30 | 70 |
50.1 | 90 | 10 |
65 | 90 | 10 |
检测物质 | 保留时间(min) | 分离度 |
乙腈峰 | 2.001 | -- |
杂质a | 2.015 | 0.213 |
杂质b | 5.897 | 11.347 |
杂质c | 8.993 | 50.281 |
氟比洛芬 | 22.700 | 58.104 |
杂质d | 32.791 | 103.878 |
Claims (10)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115728416A (zh) * | 2022-11-15 | 2023-03-03 | 辽宁味邦生物制药有限公司 | 1-溴乙基乙酸酯及其杂质的气相色谱检测方法 |
CN115728416B (zh) * | 2022-11-15 | 2024-07-12 | 远大生命科学(鞍山)有限公司 | 1-溴乙基乙酸酯及其杂质的气相色谱检测方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106770807A (zh) * | 2017-03-03 | 2017-05-31 | 北京蓝丹医药科技有限公司 | 一种氟比洛芬酯注射液中有关物质的检测方法 |
WO2019158044A1 (zh) * | 2018-02-13 | 2019-08-22 | 特丰制药有限公司 | 高效液相测定水合氯醛含量的方法 |
CN110988230A (zh) * | 2019-11-28 | 2020-04-10 | 纳谱分析技术(苏州)有限公司 | 氟比洛芬酯对映异构体及杂质a的液相色谱分离检测方法 |
CN111812228A (zh) * | 2020-06-19 | 2020-10-23 | 山东省药学科学院 | 一种超高效液相色谱测定酒石酸美托洛尔及片杂质的方法 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106770807A (zh) * | 2017-03-03 | 2017-05-31 | 北京蓝丹医药科技有限公司 | 一种氟比洛芬酯注射液中有关物质的检测方法 |
WO2019158044A1 (zh) * | 2018-02-13 | 2019-08-22 | 特丰制药有限公司 | 高效液相测定水合氯醛含量的方法 |
CN110988230A (zh) * | 2019-11-28 | 2020-04-10 | 纳谱分析技术(苏州)有限公司 | 氟比洛芬酯对映异构体及杂质a的液相色谱分离检测方法 |
CN111812228A (zh) * | 2020-06-19 | 2020-10-23 | 山东省药学科学院 | 一种超高效液相色谱测定酒石酸美托洛尔及片杂质的方法 |
Non-Patent Citations (1)
Title |
---|
付璀莹;孙煌;: "HPLC法测定酮洛芬原料药中10个特定杂质的含量", 中国药品标准, no. 02, 28 April 2017 (2017-04-28) * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115728416A (zh) * | 2022-11-15 | 2023-03-03 | 辽宁味邦生物制药有限公司 | 1-溴乙基乙酸酯及其杂质的气相色谱检测方法 |
CN115728416B (zh) * | 2022-11-15 | 2024-07-12 | 远大生命科学(鞍山)有限公司 | 1-溴乙基乙酸酯及其杂质的气相色谱检测方法 |
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