CN1141292C - 细胞生长抑制剂 - Google Patents
细胞生长抑制剂 Download PDFInfo
- Publication number
- CN1141292C CN1141292C CNB988138476A CN98813847A CN1141292C CN 1141292 C CN1141292 C CN 1141292C CN B988138476 A CNB988138476 A CN B988138476A CN 98813847 A CN98813847 A CN 98813847A CN 1141292 C CN1141292 C CN 1141292C
- Authority
- CN
- China
- Prior art keywords
- methyl
- amino
- hydroxyl
- isobutyl
- formyl radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB1998/000754 WO1999046241A1 (en) | 1998-03-12 | 1998-03-12 | Cytostatic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1286681A CN1286681A (zh) | 2001-03-07 |
| CN1141292C true CN1141292C (zh) | 2004-03-10 |
Family
ID=10825272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB988138476A Expired - Lifetime CN1141292C (zh) | 1998-03-12 | 1998-03-12 | 细胞生长抑制剂 |
Country Status (17)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9901863D0 (en) | 1999-01-29 | 1999-03-17 | British Biotech Pharm | Antibacterial agents |
| WO2019039937A1 (en) | 2017-08-21 | 2019-02-28 | Stichting Vumc | POLYTHERAPY FOR THE TREATMENT OF CANCER |
| US10925851B2 (en) | 2018-03-15 | 2021-02-23 | Regents Of The University Of Minnesota | Use of Tosedostat and related compounds as analgesics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1002556A3 (en) * | 1992-05-01 | 2001-01-10 | British Biotech Pharmaceuticals Limited | Use of MMP inhibitors |
| GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| US5691381A (en) * | 1995-04-18 | 1997-11-25 | The Dupont Merck Pharmaceutical Company | Hydroxamic and carbocyclic acids as metalloprotease inhibitors |
| CZ298048B6 (cs) * | 1996-09-10 | 2007-06-06 | British Biotech Pharmaceuticals Limited | Farmaceutický prostredek a deriváty kyseliny hydroxamové |
-
1998
- 1998-03-12 GB GB0019414A patent/GB2349149A/en not_active Withdrawn
- 1998-03-12 BR BR9815717-5A patent/BR9815717A/pt unknown
- 1998-03-12 NZ NZ506293A patent/NZ506293A/en not_active IP Right Cessation
- 1998-03-12 AT AT98909620T patent/ATE231122T1/de not_active IP Right Cessation
- 1998-03-12 CN CNB988138476A patent/CN1141292C/zh not_active Expired - Lifetime
- 1998-03-12 AU AU64106/98A patent/AU747977B2/en not_active Expired
- 1998-03-12 HU HU0100999A patent/HUP0100999A2/hu unknown
- 1998-03-12 JP JP2000535622A patent/JP4324324B2/ja not_active Expired - Lifetime
- 1998-03-12 PL PL98342811A patent/PL190637B1/pl unknown
- 1998-03-12 CZ CZ20003317A patent/CZ299610B6/cs not_active IP Right Cessation
- 1998-03-12 DE DE69810817T patent/DE69810817T2/de not_active Expired - Lifetime
- 1998-03-12 KR KR1020007009865A patent/KR20010041661A/ko not_active Application Discontinuation
- 1998-03-12 EP EP98909620A patent/EP1062202B1/en not_active Expired - Lifetime
- 1998-03-12 WO PCT/GB1998/000754 patent/WO1999046241A1/en not_active Application Discontinuation
- 1998-03-12 CA CA002323414A patent/CA2323414C/en not_active Expired - Lifetime
- 1998-03-12 IL IL13777498A patent/IL137774A0/xx active IP Right Grant
-
2000
- 2000-08-09 IL IL137774A patent/IL137774A/en not_active IP Right Cessation
- 2000-09-11 NO NO20004528A patent/NO20004528L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6410698A (en) | 1999-09-27 |
| GB2349149A (en) | 2000-10-25 |
| WO1999046241A1 (en) | 1999-09-16 |
| CA2323414C (en) | 2008-05-13 |
| EP1062202A1 (en) | 2000-12-27 |
| NO20004528D0 (no) | 2000-09-11 |
| DE69810817T2 (de) | 2003-11-20 |
| CN1286681A (zh) | 2001-03-07 |
| CA2323414A1 (en) | 1999-09-16 |
| JP2002506057A (ja) | 2002-02-26 |
| ATE231122T1 (de) | 2003-02-15 |
| CZ299610B6 (cs) | 2008-09-17 |
| AU747977B2 (en) | 2002-05-30 |
| IL137774A0 (en) | 2001-10-31 |
| PL342811A1 (en) | 2001-07-02 |
| IL137774A (en) | 2006-07-05 |
| HUP0100999A2 (hu) | 2001-08-28 |
| NO20004528L (no) | 2000-09-11 |
| GB0019414D0 (en) | 2000-09-27 |
| BR9815717A (pt) | 2000-11-07 |
| NZ506293A (en) | 2003-05-30 |
| JP4324324B2 (ja) | 2009-09-02 |
| DE69810817D1 (de) | 2003-02-20 |
| EP1062202B1 (en) | 2003-01-15 |
| PL190637B1 (pl) | 2005-12-30 |
| KR20010041661A (ko) | 2001-05-25 |
| CZ20003317A3 (cs) | 2001-03-14 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20040310 |