GB2349149A - Cytostatic agents - Google Patents

Cytostatic agents

Info

Publication number
GB2349149A
GB2349149A GB0019414A GB0019414A GB2349149A GB 2349149 A GB2349149 A GB 2349149A GB 0019414 A GB0019414 A GB 0019414A GB 0019414 A GB0019414 A GB 0019414A GB 2349149 A GB2349149 A GB 2349149A
Authority
GB
United Kingdom
Prior art keywords
hydroxycarbamoyl
enoylamino
hex
isobutyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0019414A
Other versions
GB0019414D0 (en
Inventor
Lindsey Ann Pearson
Andrew Paul Ayscough
Philip Huxley
Alan Hastings Drummond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of GB0019414D0 publication Critical patent/GB0019414D0/en
Publication of GB2349149A publication Critical patent/GB2349149A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

2(R or S)-[2R-(S-Hydroxy-hydroxycarbamoyl-methyl)-4-methyl-pentanoylaminel]-2-phenyl-ethanoic acid cyclopenty ester' 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-phenylethanoic acid isopropyl ester; 2(R or S)-[2R-(S-Hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3-phenylethanoic acid cyclopentyl ester; 2(R or S-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(4-methoxyphenyl)ethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(thien-2-yl)ethanoic acid cyclopentyl ester; and 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(thien-3-yl)ethanoic acid cyclopentyl ester are cytostatic agents.
GB0019414A 1998-03-12 1998-03-12 Cytostatic agents Withdrawn GB2349149A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB1998/000754 WO1999046241A1 (en) 1998-03-12 1998-03-12 Cytostatic agents

Publications (2)

Publication Number Publication Date
GB0019414D0 GB0019414D0 (en) 2000-09-27
GB2349149A true GB2349149A (en) 2000-10-25

Family

ID=10825272

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0019414A Withdrawn GB2349149A (en) 1998-03-12 1998-03-12 Cytostatic agents

Country Status (17)

Country Link
EP (1) EP1062202B1 (en)
JP (1) JP4324324B2 (en)
KR (1) KR20010041661A (en)
CN (1) CN1141292C (en)
AT (1) ATE231122T1 (en)
AU (1) AU747977B2 (en)
BR (1) BR9815717A (en)
CA (1) CA2323414C (en)
CZ (1) CZ299610B6 (en)
DE (1) DE69810817T2 (en)
GB (1) GB2349149A (en)
HU (1) HUP0100999A2 (en)
IL (2) IL137774A0 (en)
NO (1) NO20004528L (en)
NZ (1) NZ506293A (en)
PL (1) PL190637B1 (en)
WO (1) WO1999046241A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9901863D0 (en) * 1999-01-29 1999-03-17 British Biotech Pharm Antibacterial agents
WO2019039937A1 (en) 2017-08-21 2019-02-28 Stichting Vumc Therapeutic combination for cancer treatment
US10925851B2 (en) 2018-03-15 2021-02-23 Regents Of The University Of Minnesota Use of Tosedostat and related compounds as analgesics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2268934A (en) * 1992-07-23 1994-01-26 British Bio Technology Hydroxamic acid derivatives
WO1996033166A1 (en) * 1995-04-18 1996-10-24 The Du Pont Merck Pharmaceutical Company Hydroxamic and carboxylic acids as metalloprotease inhibitors
WO1998011063A1 (en) * 1996-09-10 1998-03-19 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4267293A (en) * 1992-05-01 1993-11-29 British Biotech Pharmaceuticals Limited Use of MMP inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2268934A (en) * 1992-07-23 1994-01-26 British Bio Technology Hydroxamic acid derivatives
WO1996033166A1 (en) * 1995-04-18 1996-10-24 The Du Pont Merck Pharmaceutical Company Hydroxamic and carboxylic acids as metalloprotease inhibitors
WO1998011063A1 (en) * 1996-09-10 1998-03-19 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives

Also Published As

Publication number Publication date
WO1999046241A1 (en) 1999-09-16
EP1062202B1 (en) 2003-01-15
EP1062202A1 (en) 2000-12-27
IL137774A (en) 2006-07-05
GB0019414D0 (en) 2000-09-27
DE69810817T2 (en) 2003-11-20
DE69810817D1 (en) 2003-02-20
CN1141292C (en) 2004-03-10
NO20004528D0 (en) 2000-09-11
JP4324324B2 (en) 2009-09-02
JP2002506057A (en) 2002-02-26
CZ20003317A3 (en) 2001-03-14
CN1286681A (en) 2001-03-07
CA2323414C (en) 2008-05-13
ATE231122T1 (en) 2003-02-15
HUP0100999A2 (en) 2001-08-28
BR9815717A (en) 2000-11-07
PL190637B1 (en) 2005-12-30
IL137774A0 (en) 2001-10-31
CZ299610B6 (en) 2008-09-17
KR20010041661A (en) 2001-05-25
NO20004528L (en) 2000-09-11
AU6410698A (en) 1999-09-27
AU747977B2 (en) 2002-05-30
NZ506293A (en) 2003-05-30
CA2323414A1 (en) 1999-09-16
PL342811A1 (en) 2001-07-02

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)