CN113896645B - 一种左旋对羟基苯甘氨酸的清洁生产方法 - Google Patents
一种左旋对羟基苯甘氨酸的清洁生产方法 Download PDFInfo
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- CN113896645B CN113896645B CN202111498673.0A CN202111498673A CN113896645B CN 113896645 B CN113896645 B CN 113896645B CN 202111498673 A CN202111498673 A CN 202111498673A CN 113896645 B CN113896645 B CN 113896645B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/082—Compounds containing nitrogen and non-metals and optionally metals
- C01B21/087—Compounds containing nitrogen and non-metals and optionally metals containing one or more hydrogen atoms
- C01B21/093—Compounds containing nitrogen and non-metals and optionally metals containing one or more hydrogen atoms containing also one or more sulfur atoms
- C01B21/096—Amidosulfonic acid; Salts thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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CN202111498673.0A CN113896645B (zh) | 2021-12-09 | 2021-12-09 | 一种左旋对羟基苯甘氨酸的清洁生产方法 |
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CN202111498673.0A CN113896645B (zh) | 2021-12-09 | 2021-12-09 | 一种左旋对羟基苯甘氨酸的清洁生产方法 |
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CN113896645A CN113896645A (zh) | 2022-01-07 |
CN113896645B true CN113896645B (zh) | 2022-03-15 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN116354838A (zh) * | 2023-03-20 | 2023-06-30 | 安徽普洛生物科技有限公司 | 一种回收对羟基苯甘氨酸和邻羟基苯甘氨酸的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101362703B (zh) * | 2007-08-09 | 2011-11-16 | 谢建中 | 对羟基苯甘氨酸合成技术 |
CN101759582A (zh) * | 2008-12-08 | 2010-06-30 | 河南新天地药业有限公司 | Dl-对羟基苯甘氨酸生产新工艺 |
CN102757356B (zh) * | 2012-07-20 | 2015-05-13 | 浙江云涛生物技术股份有限公司 | 一种混旋对羟基苯甘氨酸的拆分工艺 |
CN103524366B (zh) * | 2013-09-18 | 2015-04-15 | 山东汉兴医药科技有限公司 | 一种(r)-对羟基苯甘氨酸的合成工艺 |
CN110467537B (zh) * | 2019-08-08 | 2022-10-04 | 河南新天地药业股份有限公司 | 一种左旋对羟基苯甘氨酸的制备工艺 |
CN113636948B (zh) * | 2021-08-20 | 2024-04-09 | 湖北省宏源药业科技股份有限公司 | 一种dl-对羟基苯甘氨酸不对称转化拆分废液处理方法 |
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Effective date of registration: 20221206 Address after: 400021 Mahe Chemical Village, Jiangbei District, Chongqing Patentee after: Chongqing Chemical Research Institute Co.,Ltd. Address before: 230031 401, Building 2, Phase I, Jinggang Road E-commerce Park, Shushan Economic Development Zone, Hefei, Anhui Patentee before: HEFEI LONGZHIYUN PHARMACEUTICAL TECHNOLOGY Co.,Ltd. Effective date of registration: 20221206 Address after: 230031 401, Building 2, Phase I, Jinggang Road E-commerce Park, Shushan Economic Development Zone, Hefei, Anhui Patentee after: HEFEI LONGZHIYUN PHARMACEUTICAL TECHNOLOGY Co.,Ltd. Address before: 300410 2 Luohe Road, Beichen District, Tianjin Patentee before: TIANJIN VOCATIONAL INSTITUTE |
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