CN113633851A - 伸缩式注射器止动部驱动器驱动组件的线性旋转稳定器 - Google Patents

伸缩式注射器止动部驱动器驱动组件的线性旋转稳定器 Download PDF

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CN113633851A
CN113633851A CN202110839418.1A CN202110839418A CN113633851A CN 113633851 A CN113633851 A CN 113633851A CN 202110839418 A CN202110839418 A CN 202110839418A CN 113633851 A CN113633851 A CN 113633851A
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约西·巴-厄尔
吉尔·伊格尔
鲁文·Y·费尔曼
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Medimop Medical Projects Ltd
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Abstract

本发明提供一种盒式接口组件，其驱动药物贮存器或者药物输送装置中的止动部。防旋转引导部可选地沿着贮存器的腔体的轴线移动。防旋转引导部可选地可滑动且防旋转地联接到药物输送装置的壳体。伸缩柱塞驱动器可以包括通过相对旋转伸缩的近端轴和远端轴。远端轴可选地可滑动且防旋转地联接到防旋转引导部。轴可选地沿所述轴线定位。在一些实施例中，近端轴相对于防旋转引导部的旋转使引导部沿着轴线相对于壳体移动并且使远端轴沿着轴线相对于防旋转引导部移动。

Description

伸缩式注射器止动部驱动器驱动组件的线性旋转稳定器
本申请是申请日为2016年5月30日、申请号为201610371499.6、发明名称为“伸缩式注射器止动部驱动器驱动组件的线性旋转稳定器”的发明专利申请的分案申请。
技术领域
本发明的一些实施例涉及一种用于药物输送装置的止动部驱动器，更特别地但不是专门地涉及一种药物盒(cartridge)的伸缩式止动部驱动器。
背景技术
美国专利第6,800,071号公开了“一种用于控制的流体的输送的改进的泵、贮存器和贮存器活塞”。马达被可操作地联接到传动构件，诸如传动螺杆，其用于响应于马达的操作来推进柱塞滑动部。柱塞滑动部被可移除地联接到活塞。活塞包含第一构件和第二构件。第一构件具有外部近端侧和外部远端侧。外部近端侧用于接触流体并且由具有第一刚度的材料组成。第二构件具有第一侧和第二侧并且至少部分设置在第一构件内。第二构件的第一侧邻近第一构件的外部近端侧并且由具有大于第一刚度的刚度的材料组成。
当前申请人(卡比利亚(Cabiri))的国际专利申请公开第W0/2011/090956号和/或格罗斯(Gross)的美国专利申请公开第2009/0093792号。
附加的背景技术包括美国专利申请公开20130304021、美国专利申请公开20130296799、美国专利申请公开20130245596、美国专利第8,465,455号、国际专利申请公开第WO/2011/090956号和美国专利申请公开第2009/0093792号。
发明内容
根据本发明的一些实施例的方面，提供了一种用于驱动药物输送装置的药物贮存器中的止动部的组件，其包含：伸缩组件，其通过沿着贮存器的轴线定位的至少近端轴和远端轴之间的相对旋转而伸缩；远端轴配置成接合药物贮存器的止动部；防旋转引导部，其具有沿着贮存器的轴线移动的尺寸；防旋转引导部可滑动地且防旋转地联接到药物输送装置的壳体；联接部，其可滑动地且防旋转地将防旋转引导部链接到远端轴；滑动和防旋转相对于贮存器的轴线使得近端轴相对于防旋转引导部的旋转使远端轴沿着轴线移动并且相对于防旋转引导部移动远端轴，防旋转引导部也沿着轴线移动。
根据本发明的一些实施例，远端轴相对于贮存器的最大轴向移动大于引导部相对于贮存器的最大轴向移动。
根据本发明的一些实施例，组件进一步包含：中间轴，其可螺纹地接合到近端轴和远端轴，使得伸缩组件也通过近端轴相对于中间轴旋转而伸缩。
根据本发明的一些实施例，远端轴相对于贮存器的最大轴向移动大于中间轴相对于贮存器的最大轴向移动。
根据本发明的一些实施例，组件进一步包含：线性稳定器，其联接到近端轴，防止近端轴在近端方向上相对于线性稳定器轴向移动，线性稳定器联接到贮存器防止线性稳定器在近端方向上相对于贮存器轴向移动，使得近端轴的旋转导致远端轴在药物贮存器内向远端推进。
根据本发明的一些实施例，线性稳定器包括形成为附接到贮存器的近端部分的连接部。
根据本发明的一些实施例，连接部形成为附接到贮存器的凸缘。
根据本发明的一些实施例，线性稳定器包括防旋转连接器，其适配到用于防止线性稳定器相对于壳体旋转的壳体并且其中防旋转引导部借助于线性稳定器可滑动地接合到壳体。
根据本发明的一些实施例，贮存器和组件形成盒，并且其中壳体包括适配盒的开口，并且其中防旋转连接器形成为连接到壳体以当盒插入开口时限制防旋转连接器相对于壳体的旋转。
根据本发明的一些实施例，组件进一步包含：轴承，其防止近端轴相对于壳体的近端移动并且允许近端轴相对于壳体旋转。
根据本发明的一些实施例，组件进一步包括用于驱动止动部的止动部接口；接口可选地连接到远端轴。
根据本发明的一些实施例，联接部包括可滑动地插入到轨道中的突起。
根据本发明的一些实施例的方面，提供一种将药物供给输送装置的方法，其包含：提供包含药物并且用止动部和伸缩组件密封的贮存器，其中伸缩组件通过相对于远端轴旋转近端轴伸缩；远端轴配置成接合止动部；可滑动且防旋转地将防旋转引导部接合到输送装置的壳体；通过可滑动地引导远端轴沿着防旋转引导部，防止远端轴相对于壳体旋转，并且通过旋转近端轴在贮存器的腔体内朝着贮存器的远端线性延伸远端轴和防旋转引导部，其中远端轴的延伸的距离大于防旋转引导部的延伸的距离。
根据本发明的一些实施例，方法进一步包括：利用药物输送装置的马达驱动近端轴的旋转。
根据本发明的一些实施例，远端轴与止动部最初最近地间隔一定距离并且朝着止动部延伸。
根据本发明的一些实施例，远端轴抵靠止动部，并且进一步包含：通过远端轴的延伸朝着贮存器的远端在腔体内驱动止动部。
根据本发明的一些实施例，方法进一步包含：将线性稳定器附接到贮存器，并且防止近端轴相对于线性稳定器近端移动。
根据本发明的一些实施例，方法进一步包括：形成盒，盒包括贮存器、止动部、远端轴、防旋转引导部和线性稳定器，并且将盒作为单个单元插入药物输送装置中。
根据本发明的一些实施例，方法进一步包含：将壳体联接到近端轴，并且防止近端轴相对于壳体近端移动。
根据本发明的一些实施例，防止包括将突起插入轨道中。
根据本发明的一些实施例，插入包括使远端轴和防旋转引导部中的至少一个弹性变形。
除非另有定义，否则在这里使用的所有技术和/或科学术语与本发明所属技术领域的普通技术人员普遍理解的意思相同。尽管类似于或相当于在这里说明的那些的方法和材料能够被用于实践或者测试发明的实施例，但是下面描述示例性的方法和/或材料。在冲突的情况下，包括定义的专利说明书将控制。另外，材料、方法和实例仅仅是例证性的而不是想要进行必要的限制。
附图说明
参照附图，仅通过实例的方式，在此描述发明的一些实施例。现在具体参照附图，指出通过实例的方式显示详细部件并且是为了例证性描述发明的实施例。就这一点而言，对附图的说明使得如何实践本发明的实施例对于本领域的技术人员来说是显而易见的。
在图中：
图1A是根据本发明的实施例的止动部驱动器的方框图；
图1B是根据本发明的实施例的插入药物输送装置的盒的方框图；
图2是图解根据本发明的实施例驱动止动部的方法的流程图；
图3是图解根据本发明的实施例装配止动部驱动器的方法的流程图；
图4A是根据本发明的实施例的包括滑动套筒防旋转引导部的贮存器和止动部驱动器的分解图；
图4B是根据本发明的实施例的包括呈延伸构造的滑动套筒的止动部驱动器的截面图；
图4C是根据本发明的实施例的包括呈缩回构造的滑动套筒的贮存器和止动部驱动器的透视图；
图4D是根据本发明的实施例的包括止动部驱动器和贮存器的盒插入药物输送装置的透视图；
图4E是根据本发明的实施例的盒与药物输送装置的马达之间的链接的透视图；
图5A是根据本发明的实施例的包括呈缩回构造的滑动柱防旋转引导部的止动部驱动器的透视图；
图5B是根据本发明的实施例的包括呈延伸构造的滑动柱防旋转引导部的止动部驱动器的截面图；
图6A是根据本发明的实施例的通过呈缩回构造的装置壳体稳定的止动部驱动器的近距离截面图；
图6B是根据本发明的实施例的贮存器和通过呈缩回构造的装置壳体稳定的止动部驱动器的截面图；和
图6C是根据本发明的实施例的贮存器和通过呈缩回构造的装置壳体稳定的止动部驱动器的截面图。
具体实施方式
本发明的一些实施例涉及一种用于药物输送装置的止动部驱动器，并且更特别地但不是专门地涉及一种药物盒的伸缩式止动部驱动器。
概述
本发明的一些实施例的方面涉及一种用于药物输送装置的止动部传动组件的防旋转引导部。可选地，驱动器组件的远端轴通过引导部被旋转地保持静止，同时通过旋转近端元件的相对旋转被向远端驱动到贮存器中。由于远端元件向远端前进到贮存器中，因此轴可以相对于引导部向远端滑动。另外或可选地，引导部和轴可以一起向远端滑动到贮存器中。在一些实施例中，近端元件和远端轴当彼此之间旋转时可以伸缩。近端元件可以相对于贮存器轴向保持固定，从而近端和远端元件的伸缩使得远端轴进入贮存器中。
一些实施例可以包括线性和/或旋转稳定器。例如，旋转稳定器可以由药物输送装置的壳体和/或马达架支撑，从而伸缩组件上的扭矩与防旋转引导部和/或马达和/或输送装置的壳体保持平衡。可选地，扭矩将不被施加于与药物接触的药物贮存器和/或止动部和/或任何部分。
在一些实施例中，止动部和驱动器组件之间的线性力与贮存器保持平衡。可选地，推动组件和止动部之间的线性应力与药物输送装置上和/或贮存器和药物输送装置之间的微不足道的或者没有的外部线性应力平衡。
在一些实施例中，驱动器组件可以附接到药物贮存器以形成盒。整个盒作为一个单元被可选地插入药物输送装置中。在一些实施例中，盒可以量出(meter out)药物，同时在药物输送装置上产生微不足道的或者没有的外部轴向力。例如，盒组件可以包括将TSA连接到药物贮存器的线性稳定器。例如，线性稳定器可以连接到接近贮存器的近端开口和/或在贮存器的近端凸缘上的贮存器。可选地，止动部和TSA之间的线性力可以通过线性稳定器和贮存器之间的力平衡。可选地，整个盒组件插入药物输送装置中的近端开口中。可选地，当盒插入药物输送装置的近端开口中时，套管穿透在贮存器和药物输送装置之间创建流体路径的隔板。例如，隔板可以位于盒的远端上和/或接近盒的远端。可选地或者另外的实例，隔板可以位于药物输送装置的远端部上和/或接近药物输送装置的远端部。
在一些实施例中，盒推动组件可以附接到贮存器的近端开口，而不用考虑止动部在贮存器中的精确纵向位置。可选地，在将止动部推动组件连接到贮存器之后，TSA可以延伸直到推动组件接触止动部。例如，TSA可以在将盒组件插入药物装置之前延伸。可选地或者另外，TSA可以在将盒组件插入药物输送装置之后延伸。
在一些实施例中，TSA的行程长度可以大于TSA的最小长度。例如，TSA可以具有三个伸缩轴和/或三个伸缩引导部。例如，伸缩轴可以包括延伸杆。可选地或者另外，TSA可以具有四个伸缩轴和/或四个伸缩引导部。可选地或者另外，TSA可以具有五个伸缩轴和/或五个伸缩引导部。例如，TSA可以具有长度范围在0.8和1.6cm之间的缩回构造和/或长度范围在2.0至4.0cm之间的延伸构造。可选地，TSA的延伸长度可以介于缩回长度的2.0至3.0倍之间和/或介于缩回长度的3.0至5.0倍之间。
在详细说明发明的至少一个实施例之前，可以理解，发明不是将它的应用必需限制到下文的说明中所阐述的和/或附图和/或实例中图解的部件和/或方法的详细构造和布置。发明能够用多种方式实践或者进行其它实施例。
盒组件
现在参照附图，图1A是根据本发明的实施例的止动部传动组件150的方框图。传动组件150可选地包括线性稳定器106，该线性稳定器106支撑驱动器组件150和/或平衡驱动器组件150和止动部(例如图1B的止动部140)之间的线性力。驱动器组件150可选地包括防旋转引导部，例如引导部104。防旋转引导部104可选地支撑驱动器组件和/或平衡驱动器组件和马达(例如图1B的马达108)之间的扭矩。
在一些实施例中，止动部驱动器组件150可以包括伸缩组件(例如TSA 152)。可选地，TSA 152包括近端轴和/或远端轴，近端轴例如为螺纹传动轴110和/或螺纹中间轴112，远端轴例如为螺纹推动轴114。轴110、112和/或114可以被联接成使得传动轴110相对于推动轴114的旋转使得TSA 152伸长和/或缩短。可选地，通过线性稳定器106限制传动轴110的轴向移动，从而传动轴110相对于推动轴114的旋转使得推动轴114相对于线性稳定器106线性移动。可选地，联接部(coupling)将推动轴114链接到防旋转引导部104。例如，推动轴114的旋转可以受防旋转引导部104限制，从而传动轴110相对于防旋转引导部104的旋转使得TSA 152伸长和/或缩短。可选地或者另外，传动轴110和/或推动轴114可以被螺母和/或螺纹圆盘和/或环替代。
图1B是根据本发明的实施例的插入药物输送装置122中的盒153的方框图。可选地，盒153包括传动组件150、药物贮存器120和/或止动部140。可选地，药物输送装置122包括马达108。可选地或者另外，马达108可以包括直流电动机、化学发动机、无刷马达和交流马达、致动器等等。
在一些实施例中，线性稳定器106可以附接到药物贮存器120和/或推动轴114可以抵靠止动部140，从而延伸TSA 152使得止动部140相对于贮存器120轴向移动。止动部140相对于贮存器120的轴线反向力(例如，由于止动部和贮存器之间的摩擦和/或由于流动阻力产生的)通过线性稳定器106和贮存器120之间的线性力在盒153内可选地平衡。
在一些实施例中，马达108可以将扭矩施加于传动轴110。可选地，防旋转引导部104可以附接到药物贮存器120，从而启动马达108以使推动轴114相对于传动轴110轴向移动。传动轴110和推动轴114之间的摩擦通过马达108和防旋转引导部104之间的反向扭矩可选地平衡，从而TSA 152用作线性致动器，其将净线性力(和/或微不足道的扭矩)施加到与药物接触的装置的部分(例如止动部140和/或贮存器120)上。
在一些实施例中，线性稳定器106、传动轴110、中间轴112、推动轴114和/或防旋转引导部104的任何一个或者全部可以被部分和/或全部定位在贮存器120的内部。可选地或者另外，线性稳定器106、传动轴110、中间轴112、推动轴114和/或防旋转引导部104的任何一个或者全部当TSA 152收缩时可以被全部或部分定位在贮存器120的外部，和/或当TSA152延伸时可以全部或部分移动到贮存器120中。
在一些实施例中，中间轴112和/或防旋转引导部104可以轴向移动。例如，中间轴112和/或防旋转引导部104可以移动到贮存器120中和/或从贮存器120移出。可选地，中间轴112可以浮动。在当前公开中，在一些构造中(例如当TSA 152部分延伸时)，浮动部件的位置可以是不确定的。例如，该部件可以移动而无需改变TSA 152的长度。例如，TSA 152的部件的移动的次序可以是不固定的。可选地，传动轴110可以是内轴并且推动轴114可以是外轴。可选地或者另外，传动轴110可以是外轴并且推动轴114可以是内轴。本发明的任意部件或者全部部件可以由塑料和/或金属和/或另一种材料制成。
驱动止动部
图2是图解根据本发明的实施例的驱动止动部的方法的流程图。在一些实施例中，TSA可以通过旋转单个轴210和/或通过防止单个轴的旋转来延伸或者缩回大于它的最小长度的100％。例如，TSA可以通过旋转210传动轴打开。可选地，近端传动轴可以位于最接近远端推动轴。例如，传动轴可以通过安装在装置上的马达相对于药物输送装置旋转210。例如，传动轴的旋转210可以相对于药物输送装置的壳体和/或相对于马达的架。可选地，在传动轴旋转的同时，推动轴可以被防止旋转202。例如，防旋转引导部可以防止推动轴相对于药物输送装置壳体和/或相对于马达和/或相对于马达架旋转。传动轴相对于推动轴的旋转210使TSA和/或推动轴和/或止动部可选地延伸。
在一些实施例中，中间轴可以轴向浮动。例如，当TSA延伸时，中间轴可以或者随着推动轴线性延伸212和/或随着传动轴旋转213。可选地，对于TSA的一些长度，中间轴的位置可以是不确定的。例如，旋转210传动轴可以例如将中间轴延伸212到贮存器中(例如，当传动轴旋转得比中间轴快时和/或借助于传动轴到中间轴的螺纹联接)。可选地，将中间轴延伸212到贮存器中同时将推动轴延伸214到贮存器中。可选地或者另外，旋转210传动轴可以使中间轴旋转213。可选地，旋转213中间轴使推动轴延伸214到贮存器中(例如借助于传动轴到中间层的螺纹联接)。中间轴的旋转和/或延伸可以同时和/或连续发生。
在一些实施例中，防旋转引导部可以轴向浮动。例如，当TSA延伸时，防旋转引导部可以或者与推动轴一起延伸204(例如相对于贮存器轴向移动和/或轴向移动到贮存器中)，和/或防旋转引导部可以相对于贮存器保持固定，和/或推动轴可以相对于防旋转引导部轴向延伸214。可选地，对于TSA的一些长度，防旋转引导部的位置可以是不确定的。在一些实施例中，推动轴可以旋转，同时TSA的另一元件被防旋转地稳定(防止例如相对于药物输送装置壳体和/或马达旋转)。
止动部驱动器的装配和/或安装
图3是图解根据本发明的实施例的装配止动部驱动器的方法的流程图。例如，止动部驱动器可以适配用标准制药设备可填充的贮存器(例如，在具有为标准注射器和/或盒制成的填充设备的现有净化室中)。可选地，止动部驱动器接合位于贮存器内的任意位置处的止动部。在一些实施例中，止动部驱动器可以与部件咬合在一起而装配。部件可选地由诸如塑料的铸模材料制成，例如聚氧化亚甲基(POM)树脂。
在一些实施例中，供给320药物贮存器。可选地，贮存器可以被预填充。例如，贮存器可以利用标准填充设备填充。例如，贮存器可以具有任意截面的圆柱形和/或管状本体。例如，本体可以为直圆柱体的形式。贮存器可选地包括内部腔体。可选地，内部腔体可以是任意形状。例如，内部腔体可以具有超过它的至少一半长度和/或超过它的至少90％的长度的平滑壁。例如，贮存器的腔体可以大体上为超过它的至少一半长度和/或超过它的至少90％的长度的直圆柱体。例如，内部腔体可以在超过它的至少一半长度和/或超过它的至少90％的长度上与贮存器的外壁同轴。例如，腔体的截面可以在超过它的至少一半长度和/或超过它的至少90％的长度上是均匀的。可选地，贮存器可以包括远端开口。例如，贮存器的远端可以包括套管，例如皮下注射针和/或用于这种情况的架。可选地或者另外，贮存器的远端和/或远端开口可以包括例如隔板的密封部，和/或例如针头盖的无菌盖。贮存器的近端可以包括近端开口。可选地，近端开口可以大于远端开口。例如，近端开口的截面面积可以介于远端开口的截面面积的5至50倍之间，和/或远端开口的截面面积的50至500倍之间。可选地，截面开口可以是倾斜的和/或可以平稳连接到贮存器的内部腔体。可选地，止动部可以插入近端开口中。可选地，止动部可以密封和/或保持贮存器的内容物的无菌。可选地，止动部的位置可以依赖于贮存器的内容物的体积而改变。可选地，贮存器的近端可以包括凸缘。例如，凸缘可以从贮存器的外周伸出20％至100％之间。例如，凸缘可以从近端开口的内壁延伸1mm和2cm之间。可选地，贮存器作为单个完整单元可以例如由模压玻璃或者塑料和/或切割和/或处理的管材制成。
在一些实施例中，用简单的方式装配TSA。可选地，装配可以是单向的。单向装配可以包括例如，从TSA的相同端部插入全部或者最多的轴。单向装配可以包括例如在相同方向上螺纹拧入一些大多数和/或全部轴。可选地，在装配期间无需部件倒转方位就可以完成装配，和/或无需其它复杂工作，例如焊接、铆接、塑性变形等等而添加。
在一些实施例中，一系列轴可以一起螺纹拧入。例如，内部轴的前端可以通过较外部轴的后端(远端)插入。例如，内部轴的前端可以螺纹拧入较外部轴和/或较外部轴的远端中。如这里所使用的，术语/短语前端意思是在延伸状态下内轴从其突出的TSA的端部。如这里所使用的，术语/短语后端意思是在延伸状态下外轴从其突出的TSA的端部。如这里所使用的，术语/短语螺纹拧入意思是朝着引导方向螺纹连接较内部轴(在一些实施例中，螺纹拧入用于装配和/或延伸TSA)。如这里所使用的，术语/短语脱螺纹意思是朝着外轴的后面螺纹连接较内部轴(在一些实施例中，脱螺纹用于收缩TSA)。可选地或者另外，在一些实施例中，脱螺纹可以用于装配和/或延伸TSA，和/或螺纹拧入可以用于收缩TSA。可选地，最内轴的前端可以包括紧固件和/或最外部轴的后端可以包括紧固件。
在本发明的一些实施例中，基于延伸TSA阻止轴的脱离和/或分离。例如，TSA的内部轴在它的后端可以包括凸缘和/或阶梯。凸缘可以防止与较外轴脱离。可选地或者另外，凸缘可以由不同的几何形状的突起替代。
在一些实施例中，TSA可以从倒转的延伸位置简单单向装配。装配的TSA可以通过延伸任意阻止拆卸。
在一些实施例中，TSA由模制部件装配。在一些实施例中，模制提供高度精确的部件几何形状。模制部件在装配期间可与最小的变型任意装配。例如，TSA的组件可以包括最小粘着力或者无粘着力的部件，和/或通过热和/或超声波工具和/或通过力(例如通过卷曲)改变部件几何形状。模制部件可以可选地包括便于适当定位的特征。模制部件可以可选地包括嵌入的连接器和/或紧固件(例如锁扣、锁闩、抓钩、钩、扣等等)。在一些实施例中，部件可以由塑料模制。例如，塑料可以包括低摩擦材料。这种材料的实例包括聚对苯二甲酸丁二酯(PBT)树脂(例如可从泰科纳(TICONA)获得的
Figure BDA0003178401660000121
树脂)和/或POM树脂(例如杜邦(DuPontTM)的迭尔林(Delrin)
Figure BDA0003178401660000122
树脂)。
在一些实施例中，内部轴可以利用后凸缘和/或突起模制在单个件中。凸缘和/或突起可以可选地阻止轴的无意分离。在一些实施例中，部件可以利用紧固件模制在单个件中。在一些实施例中，部件可以利用螺纹止动部和/或干涉元件模制在单个件中。
在一些实施例中，组件的轴的一些或者全部可以可选地从端盖拆卸而供给。例如，一些或者全部轴和/或端盖可以包括紧固件。轴可以可选地装配有凸缘，该凸缘防止由于过度延伸而导致的拆卸。例如，内部轴可以在后端上具有凸缘。可选地，凸缘和/或紧固件可以是固有的。例如，轴和/或盖可以利用紧固件和/或凸缘模制在单个件中。
在一些实施例中，一些或者全部轴可以通过反向延伸而装配在一起。例如，内部轴的前端可以插入较外部轴的后端。例如，内部轴可以从拆卸(反向延伸)位置通过它的收缩位置离开配合轴的前端螺纹拧出到延伸位置。在一些实施例中，防止轴在延伸状态下分离的凸缘也可以防止轴在延伸状态下附接并且将轴螺纹拧入到收缩状态。
在一些实施例中，在内轴的前端上可以供给紧固件。一旦内轴的前端延伸超过配合轴，端盖(例如驱动器和/或致动器)可以固定到紧固件。可选地，可以供给干涉元件。例如，干涉元件可以包括凸缘和/或可以包括一个或多个突起，该凸缘阻碍脱螺纹回到反向的延伸位置，该突起防止轴和端盖之间的碰撞产生的螺纹锁止。
现在参照图3，该图图解用于装配TSA的示例性方法。在一些实施例中，内轴(例如，图4A所示的传动轴410)的前端可以螺纹拧入310中间轴(例如，图4A的中间轴412)的后端。可选地，内轴的前端可以通过中间轴始终被螺纹拧入直到内轴的前端从中间轴的前端突出。
在一些实施例中，中间轴的前端与内轴一起可以螺纹拧入312远端外轴(例如，图4A的推动轴414)的后端。螺纹拧入312可以继续直到内轴的前端从外轴的前端突出。可选地，组件可以仅包括两个轴和/或三个轴和/或多于三个轴(例如四个、五个、六个或更多轴)。在一些实施例中，不管轴的数量，轴的组件可以具有从前端突出的内轴的紧固件和从后端突出的外轴的紧固件。
在一些实施例中，致动器盖(例如，图4A的远端盖424)可以附接324到外轴的紧固件。例如，致动器盖可以包括注射器止动部和/或附接到注射器止动部的适配部。通过伸缩组件致动的注射器止动部的实例可以例如在卡比利亚(Cabiri)的国际专利申请公开第WO/2011/090956号和/或格罗斯(Gross)的美国专利申请公开第2009/0093792号中找到，它们的全部内容通过引用而结合在本文中。
在一些实施例中，外轴可以连接304到第一防旋转引导部(例如图4A的防旋转引导部404)。例如，第一引导部和外轴可以相对于彼此轴向移动，但是可以防止绕轴线相对于彼此的旋转。可选地，第一引导部可以连接302到第二引导部(例如，图4A的稳定器402)。例如，第二引导部和第一引导部可以相对于彼此轴向移动，但是可以防止绕轴线相对于彼此的旋转。在一些实施例中，线性稳定器也是防旋转稳定器。在一些实施例中，第一防旋转引导部和第二防旋转引导部可以收缩，从而传动轴的近端突出超过引导部的近端。传动轴的近端可以连接到传动装置。例如，传动轴410的近端可以插入326通过齿轮中的狭缝(例如，传动轴410的连接器432a可以插入图4A的盒齿轮426的狭缝432b中)。可选地，组件的近端将通过近端盖结合在一起327(例如，在图4A中，端盖438可以咬合保持器437，该保持器437可以保持到在传动轴410的近端上的紧固件430)。
在一些实施例中，在装配之后，TSA可以收缩和/或重绕328到停止位置(例如通过脱螺纹)。可选地，TSA可以包括一个或多个螺纹止动部。例如，螺纹止动部可以包括在旋转轴(例如中间轴412和/或传动轴410)上和/或在端盖(例如致动器盖424)上的干涉元件和/或突起。一个或多个干涉元件可以在TSA收缩时在预定点处相遇并且防止进一步的相对旋转。例如，干涉元件可以防止在内轴的脱螺纹方向上相对于外轴的旋转，从而防止进一步收缩和/或螺纹锁止(例如，参见图4A的干涉元件436和434)。
在一些实施例中，止动部驱动器附接到药物贮存器以形成盒。例如，线性稳定器(例如稳定器402)可以附接到贮存器(例如，连接器421a可以附接到凸缘421b，如图4A和图4C所示)。防止线性稳定器的线性移动的连接器可以称为线性连接器。例如，线性连接器421a防止稳定器402相对于盒420的线性移动。可选地或者另外，止动部驱动器和/或线性稳定器可以附接到药物输送装置的壳体(例如，如图6A-6C中所示)。
在一些实施例中，在将盒插入药物输送装置之前，TSA可以延伸314以接触贮存器中的止动部。在TSA接合到输送装置之前止动部与TSA的接触可以使得易于确定注入的药物的体积(基于与马达和/或传动轴的转数成比例的止动部已经移动的距离[例如可以调整在全部轴上的螺纹的螺距以便转数与排出的体积的比是常数])。可选地或者另外，在一些实施例中，贮存器和/或止动部驱动器和/或完整的盒可以在TSA已经接触止动部之前插入药物输送装置中。例如，药物输送装置的马达可以首先驱动传动轴以延伸314TSA直到它接触止动部然后继续驱动传动轴以排出药物。允许TSA不接触止动部直到插入药物输送装置中之后，可选地使得盒的生产和/或装运简单化。在一些实施例中，药物输送装置可以输送盒的整个内容物而无需跟踪输送的数量。例如，在有些情况下，盒可以精确地包括一次剂量。在一些实施例中，药物输送装置可以包括传感器(例如负载传感器)，该传感器传感到何时TSA朝着止动部延伸314和/或何时TSA接合止动部和/或何时TSA逆着阻力推动止动部(例如排出药物)。可选地或者另外，止动部可以放置到贮存器中的精确位置上，从而正在安装时TSA接触止动部。例如，没有必要在安装之后延伸314TSA以接触止动部。
在一些实施例中，防旋转引导部附接322到药物输送装置的壳体。例如，在图4D中，当盒插入装置中时，连接器421a适配到狭缝421c中从而防止稳定器402相对于药物输送装置422的壳体和/或附接到其的马达408(例如参见图4E)的旋转。在一些实施例中，当盒453插入输送装置422中时，壳体422可以接合盒。例如，干涉元件439可以咬合到盒453和/或将453保持在输送装置中。可选地或者另外，防旋转引导部可以附接到贮存器和/或贮存器可以附接到输送装置的壳体和/或马达。防止防旋转稳定器的旋转移动的连接器可以称为防旋转连接器。例如，防旋转连接器421a防止稳定器402相对于壳体输送装置422的旋转移动。
具有滑动套筒防旋转引导部的止动部驱动器
现在参照图4A，附图是图解包括在反向延伸状态下的滑动套筒的贮存器和止动部驱动器的实施例的分解图。在一些实施例中，贮存器420用止动部440供给密封。可选地，利用标准填充设备，贮存器420被预填充和/或止动部440被密封在适当的位置。在一些实施例中，止动部驱动器450可以由简单的部件装配和/或与部件咬合在一起。
在一些实施例中，贮存器420可以包括近端开口454，和/或远端开口456。止动部440可选地密封贮存器420的腔体。可选地，取决于例如药物远端到止动部440的体积和/或收缩的止动部驱动器近端到止动部440所需要的空间，止动部可以放置在任意纵向位置上。
在一些实施例中，贮存器420可以包括远端开口456和/或近端开口454。例如，近端开口454可以足够大以插入止动部440。可选地，远端开口可以配置有用于针和/或隔板的颈部和/或架。
在一些实施例中，止动部驱动器450包括TSA 452。TSA 452从反向延伸状态(例如，如图4A中所示)任意装配。例如，传动轴410的近端插入中间轴412中，直到传动轴410的外螺纹411a接合在中间轴412的近端附近的内螺纹411b。可选地，传动轴410螺纹穿过中间轴412直到传动轴410的近端突出中间轴412的近端。可选地，组合装配的中间轴412和/或传动轴410的近端插入推动轴414中，直到中间轴412的外螺纹413a接合在推动轴414的近端附近的内螺纹413b。可选地，中间轴412螺纹通过推动轴414直到传动轴410的近端突出推动轴414的近端。可选地，锁止和/或咬合元件防止TSA 452被拆卸。例如，远端盖424可以包括干涉元件，该干涉元件锁止(例如咬合适配)约束元件，例如推动轴中的孔。可选地或者另外，远端盖424可以防止TSA 452的脱螺纹。例如，一旦远端盖424在适当的位置，当传动轴410从中间轴412脱螺纹时，远端盖424上的接收器通过防止进一步脱螺纹的推动轴414上的配合的干涉元件螺纹锁止保护器阻止进一步移动。例如，一旦远端盖424在适当的位置，当中间轴412从推动轴414脱螺纹时，中间轴412的远端上的干涉元件螺纹锁止保护器干涉元件436通过防止进一步脱螺纹的远端盖424上的配合的干涉元件被阻止。可选地，TSA可以包括多于三个轴。例如，可以有多于1个中间轴。在一些实施例中，传动轴410可以是内轴并且推动轴414可以是外轴。可选地或者另外，传动轴可以是外轴并且推动轴可以是内轴。在一些实施例中，装配的TSA 452被装配到止动部驱动器450中。
在一些实施例中，TSA 452接合到防旋转引导部和/或传动元件。例如，包括接合到轨道415b的突起415a的联接部可以将推动轴414链接到防旋转引导部404。防旋转引导部任意接合到稳定器402。例如，防旋转引导部404的突起405a在稳定器402中可以接合到轨道405b(例如参见图4B)。可选地，推动轴414、防旋转引导部404和/或稳定器402可滑动接合。例如，推动轴414、防旋转引导部404和/或稳定器402可以相对于彼此轴向滑动，但是防止一个相对于另一个绕轴线旋转。在一些实施例中，引导元件可以咬合在一起。例如，轨道415b和/或轨道405b可以包括干涉元件(例如在其远端和/或在其近端)。通过在插入突起415a时使得防旋转引导部404弹性变形，突起415a越过远端干涉元件任意插入轨道415b中。一旦突起415a在轨道415b内，防旋转引导部404任意返回到它的原来形状，和/或通过干涉元件防止突起415a退出轨道415b。可选地或者另外，推动轴414可以被弹性挤压以在它们适配到轨道415b中处缩回突起415a。通过在插入突起405a时使得防稳定器402弹性变形，突起405a越过远端干涉元件任意插入轨道405b中。一旦突起405a在轨道405b内，稳定器402任意返回到它的原来形状，和/或通过干涉元件防止突起405a退出轨道405b。可选地或者另外，旋转引导部404可以被弹性挤压以在它们适配到轨道405b中处缩回突起405a。
在一些实施例中，一旦TSA 452连接它的防旋转引导部(例如防旋转引导部404和/或稳定器402)，引导部一起滑动和/或压缩，从而传动轴410的近端突出稳定器402中的近端开口403和/或直到传动轴410的联接部(例如肩部轴承406)相对于稳定器402静止。可选地，传动轴410在开口403内自由旋转。可选地，传动元件包括例如盒齿轮426。传动元件任意接合到传动轴410的突出近端部分。例如，非旋转配合部432a可以插入通过盒齿轮426的狭缝和/或接收器432b，从而传动轴410固定接合和/或对准到齿轮426和/或随着齿轮426旋转。可选地，紧固件和/或咬合元件防止拆卸止动部驱动器450。例如，端盖438可以咬合保持器437，在图4A中，该保持器437可以保持到传动轴410的近端上的紧固件430。在一些实施例中，装配的止动部驱动器450例如通过齿轮426相对于稳定器402的旋转再绕和/或传动轴410相对于推动轴414旋转。可选地，旋转在使TSA 452脱螺纹的方向上，直到它已经收缩和/或直到通过螺纹停止元件停止脱螺纹。收缩的止动部驱动器450任意附接到贮存器420以形成盒453(例如参见图4C)。
现在参照图4B，附图是图解在延伸状态下的止动部驱动器450的实施例的截面图。例如，在装配止动部驱动器450之后，盒齿轮426相对于稳定器402旋转和/或传动轴410相对于推动轴414旋转。可选地，例如如图4B所示，旋转在传动轴410和/或中间轴412近端通过推动轴414的近端螺纹拧入从而延伸TSA 452到延伸构造的方向上。
在一些实施例中，轴可以包括防止在螺纹拧入和/或延伸TSA期间轴的脱离的构件。例如，传动轴410包括后凸缘482并且中间轴412包括后凸缘484。当轴410达到全部延伸时，凸缘482任意接触中间轴412的内部螺纹411b从而防止进一步延伸。当轴412达到全部延伸时，凸缘484任意接触推动轴414的内部螺纹413b从而防止进一步延伸。可选地或者另外，元件防止由于超过延伸而导致的轴的脱离(例如凸缘482和/或484)。可选地，防止超过延伸的元件可以包括干涉元件和/或突起和/或任何几何形状的另一元件，例如环形元件。
在一些实施例中，线性稳定器将阻止传动轴在近端方向上移动。例如，肩部轴承406支撑稳定器402。可选地，传动轴410可以绕止动部驱动器450的纵轴相对于稳定器402旋转，但是防止传动轴410在近端方向上相对于稳定器402轴向移动。
图4C是根据本发明的实施例的包括贮存器420、止动部440和/或止动部驱动器450的盒453的透视图。在一些实施例中，装配的止动部驱动器450可以附接到贮存器420。例如，连接器421a可以将稳定器402夹紧到贮存器420的后凸缘421b上。可选地，稳定器402是线性稳定器，将TSA 452线性稳定和/或保持在贮存器420的腔体内和/或防止驱动器410的近端移动(例如借助于肩部轴承406，如图4B所示)。当TSA 452延伸时，推动轴414相对于稳定器402和/或贮存器420向远端移动，直到推动轴414接触止动部440。TSA 452的进一步延伸向远端推动止动部440和/或排出药物。
在一些实施例中，盒453作为单个元件插入药物输送装置中。可选地，当止动部驱动器450安装到收缩状态下的盒453时，驱动器450的大部分(例如，介于50％至75％之间和/或介于75％至90％之间和/或介于90至100％之间)定位在贮存器420内。可选地或者另外，当驱动器处于收缩状态和/或当驱动器附接到贮存器时，止动部驱动器的大部分或者全部可以在贮存器的外侧。
图4D是根据本发明的实施例的盒453插入药物输送装置422中的透视图。在一些实施例中，盒插入药物输送装置422中将打开贮存器420与装置422之间的流体流动路径，和/或将盒453的传动元件接合到装置422的马达，和/或旋转地稳定盒。例如，盒453线性插入装置422中的引导路径中。在插入盒453时，装置422内部的套管穿透盒453的远端上的隔板从而创建装置422和贮存器420之间的流体路径。可选地或者另外，盒453的远端上的套管可以穿透装置422的隔板形成流体路径。可选地或者另外，盒453的远端上的皮下注射针直接插入受试者。
在一些实施例中，线性稳定器402(如上所述)也是防旋转稳定器402。可选地，稳定器402直接连接至装置422以补偿马达408施加给盒齿轮426的扭矩而无需将重要的扭矩施加给贮存器420。例如，稳定器402的连接器421a适配到药物输送装置422中的狭槽421c中。狭槽421c防止稳定器402相对于装置422旋转。狭槽421c成一定角度以引导连接器421a和/或旋转地对准盒453。例如，盒453可以插入装置422中，而无需要求操作者进行角度对准。可选地或者另外，盒可以具有具体的插入对准。在一些实施例中，线性稳定器可以与防旋转稳定器分离。
图4E是根据本发明的实施例的止动部驱动器和药物输送装置的马达之间的链接的透视图。在盒453插入药物输送装置422中时，齿轮426任意滑动成接合传动部474(例如包括传动齿轮473)和/或与传动部474啮合。传动部474和/或传动齿轮473可选地由马达408驱动。在一些实施例中，马达架472可以将马达408连接至药物输送装置422的壳体。例如，在马达将扭矩施加到传动部474时，马达408的本体通过马达架472防旋转地相对于装置422的壳体稳定。可选地，防旋转扭矩通过装置422的壳体和/或连接器421a传送至防旋转稳定器402和/或防旋转引导部404和/或推动轴414(例如，如上所述)。
具有滑动柱防旋转引导部的止动部驱动器
图5A是根据本发明的实施例的包括缩回构造的滑动柱防旋转引导部的止动部驱动器550的透视图。可选地，防旋转稳定器502通过包括中空导轨505b和/或滑动柱515a的引导组件连接到止动部适配器542。在一些实施例中，盒齿轮526驱动TSA 552。可选地，连接器521将防旋转稳定器502连接到药物输送装置。例如，驱动器可以纵向滑动到药物输送装置中。可选地，盒齿轮526啮合到装置的传动部，和/或连接器521滑动到装置中的狭槽中。可选地，扭矩提供给齿轮426例如以延伸TSA 552和/或推动止动部。在一些实施例中，防旋转稳定提供给连接器521和/或引导元件(例如，稳定器502、轨道505b和/或柱515a)。
图5B是根据本发明的实施例的呈延伸构造的止动部驱动器550的截面图。可选地，TSA 552包括近端传动轴410、中间轴412和/或远端止动部推动轴514。例如，止动部适配器542和/或柱515a将推动轴514链接到滑动引导柱505a和/或固定导轨505b和/或稳定器502。可选地，装配的TSA 552可以通过远端盖524结合在一起。可选地，驱动器550的防旋转引导部包括伸缩柱，例如内柱515a可以滑动到中空中间柱505a中，中空中间柱505a可以滑动到中空轨道505b中。可选地，传动轴410通过联接部例如肩部轴承506线性地稳定。可选地，轴承506停留在稳定器502上。
具有通过装置壳体稳定的防旋转引导部的止动部驱动器
图6A是根据本发明的实施例的通过呈缩回构造的装置壳体稳定的止动部驱动器的近距离截面图。在一些实施例中，通过药物输送装置622的壳体稳定TSA 452。例如，防旋转引导部404的突起405a连接到导轨605，该导轨605附接到和/或固定到装置622的壳体。可选地，传动轴410相对于装置422的壳体线性稳定。例如，线性稳定可以经由联接部(例如轴承606)进行。为简单起见，图6A-6C中未显示传动部和马达组件。
图6B是根据本发明的实施例的贮存器和止动部驱动器的透视图，其中止动部驱动器通过呈缩回构造的装置壳体稳定并且与止动部440和贮存器620接合。例如，贮存器620可以比贮存器420短。在收缩状态下，TSA 452保留在贮存器420的远端的外侧。可选地，在图6A-6C的实施例中，贮存器620和TSA 452构建在药物输送装置622中，而不是作为盒由用户插入装置中。装置622的壳体可选地包括线性稳定贮存器620(例如相对于壳体将它锁止在轴向位置上)的肩部621。为简单起见，图6A-6C未显示连接远端开口456至装置622的流体路径。
图6C是根据本发明的实施例的贮存器和通过呈缩回构造的装置壳体稳定的止动部驱动器的透视图。可选地，旋转传动轴410以延伸TSA 452。例如，TSA 452延伸到贮存器620中和/或推动止动部440到贮存器620中和/或将药物从贮存器620排出。可选地，在TSA452延伸时，防旋转引导部移动到贮存器620中。例如，由于防旋转引导部404可以滑动到贮存器620中，因此突起405a可以沿着轨道605向下滑动，和/或由于推动轴414相对于防旋转引导部404滑动，因此突起415a可以沿着轨道415b向下滑动。
药物输送装置的示例性尺寸
在一些实施例中，贮存器(例如注射器)的有效负载可以包括，例如0.5与3ml之间和/或3与6ml之间和/或6与10ml之间和/或10与15ml之间的药物和/或更多。在一些实施例中，注射器可以作为单剂排出整个有效负载。例如，药物输送装置可以包括笔型注射器和/或转接注射器(patch injector)，和/或内部供电的驱动器以驱动止动部和/或排出有效负载。注射器的贮存器可以被定位成平行于受试者的皮肤和/或垂直于皮肤和/或在平行和垂直之间成一定角度，例如60至90度之间和/或30至60度之间和/或0至30度之间。为了该应用起见，内部供电的注射器驱动器可以定义为通过至少暂时存储在注射器内的能量驱动的驱动机构。电力可以存储在电源中，例如化学势(例如产生膨胀气体的化学品和/或电池)和/或机械势(例如存储在弹性构件和/或弹簧和/或压缩气体中)。例如，可以将驱动器设计成在介于20和120秒之间和/或120和600秒之间和/或600和7200秒之间和/或更长的时间周期上排出有效负载。在一些实施例中，通过驱动器驱动排出。内部供电的驱动器可以由包括例如马达(包括例如DC马达、致动器、无刷马达)的各种机构和/或传动部驱动，其中传动部包括例如伸缩组件和/或螺纹元件和/或齿轮和/或联接部和/或弹性机构(例如弹簧和/或橡皮圈)和/或膨胀气体和/或液压致动器。
根据当前发明的一些实施例的药物输送装置可以包括贮存器。例如，贮存器可以包括药物容器和/或标准型注射器。可选地，标准型注射器可以利用标准设备和/或在无菌室中用药物预加载。可选地，预加载标准型注射器可以包括近端开口。可选地，止动部可以密封近端开口和/或保护注射器的内容物的无菌。可选地，无菌针(例如中空针)可以连接到注射器筒。例如，中空的针可以与筒的内部流体连通。可选地，针可以严密地附接到筒的远端。针的全部和/或部分的无菌性可以例如通过无菌盖保护。当注射器供给和/或安装到注射器中时，无菌盖可以保留在针上。例如，可选地，药物容器可以包括严密附接到针的圆柱形筒。可选地，注射器的针和筒的长轴可以是平行和/或同轴的。可选地，针可以安装到筒的远端上。可选地，针尖可以指向远端方向。在一些实施例中，止动部可以沿着筒的内部轴向滑动以排出药物有效负载。例如，药物可以通过中空针排出。
在一些实施例中，TSA可以产生例如介于0.02至0.2N之间和/或0.2至0.5N之间和/或0.5至5N之间和/或5至60N之间和/或60至90N之间的力。例如，注射药物所需的力可以取决于注射速率和/或药物的粘度和/或注射器几何形状和/或针尺寸。
在一些实施例中，注射药物的应力可以包括扭矩。例如，药物的注射可以由止动部驱动。可选地，止动部可以由螺纹组件驱动，例如螺纹螺钉和/或齿和/或伸缩组件。可选地，齿和/或关联的螺钉的螺距可以例如介于0.5和2mm之间。螺钉的直径可以例如介于3和15mm之间。推动注射的扭矩可以例如介于0.2和1.0N*cm之间。
在注射期间，止动部的线性移动可以例如介于5至40mm之间和/或40至50mm之间。止动部的移动的长度可以例如随着要被注射的药物的体积而改变，例如体积介于0.5至3ml之间和/或3至10ml之间。
可以期望，在从该申请许多相关的技术成熟的专利的寿命将得到发展并且术语的范围意图是包括所有这种新技术。
如这里所使用的术语“大约”指的是±5％。
术语“包含”、“含在内”、“包括”、“含有”、“具有”和它们的变形词意思是“包括但不限于”。
术语“组成”意思是“包括但不限于”。
术语“基本组成”意思是合成物、方法或者结构可以包括附加的成分、步骤和/或部分，但是只要附加的成分、步骤和/或部分没有显著改变权利要求所述的合成物、方法或者结构的基本和新颖的特征。
如这里所使用的，单数形式“一”、“一个”、“所述”包括多数形式，除非文中另有明确规定。例如，术语“化合物”或者“至少一个化合物”可以包括多种化合物，包括它们的混合物。
遍及本申请，本发明的各种实施例可以用范围形式表示。应当理解用范围形式的说明仅仅是为了方便和简短起见并且不应该理解为对发明的范围进行硬性限制。因此，范围的说明应该被认为具有具体公开的所有可能的子范围以及在该范围内的独立数值。例如，比如从1至6的范围的说明应该被认为具有具体公开的子范围，比如从1至3、从1至4、从1至5、从2至4、从2至6、从3至6等等，以及在该范围内的单独数值，例如1、2、3、4、5和6。这适用而不管范围的幅度。
无论何时在这里指示数值范围时，意思是包括指示范围内的任何引用的数(分数或者整数)。短语“介于第一指示数和第二指示数之间”和“范围从第一指示数至第二指示数”可以在这里交替地使用并且意思是包括第一和第二指示数以及这两者之间所有分数和整数。
应该理解，在个别实施例的内容中明确描述的发明的某些特征，也可以组合地提供给单个实施例。相反，在单个实施例的内容中简单描述发明的各种特征，也可以单独或者以任何适当的子组合或者适当地提供给发明的任何其它描述的实施例。各种实施例的内容中描述的某些特征不认为是那些实施例的基本特征，除非没有那些元件实施例就起不到作用。
在本说明书中提到的所有公开、专利和专利申请的全部内容通过引用结合在本说明书中，至与每个单独公开、专利或者专利申请具体且单独指示以通过引用而结合到本文中相同的程度。另外，本申请的任何参考的引用或者识别将不会理解为这种参考能够像现有技术从本发明得到。在使用部分标题的程度上，应该不会理解为是必须的限制。

Claims (10)

1.一种用于驱动药物输送装置的药物贮存器中的止动部的组件，其包含：
伸缩组件，其通过沿着所述贮存器的轴线定位的至少近端轴和远端轴之间的相对旋转而伸缩；所述远端轴配置成接合所述药物贮存器的止动部；
防旋转引导部，其具有沿着所述贮存器的所述轴线移动的尺寸；所述防旋转引导部可滑动地且防旋转地联接到所述药物输送装置的壳体；
联接部，其可滑动地且防旋转地将所述防旋转引导部链接到所述远端轴；所述滑动和防旋转相对于所述贮存器的所述轴线使得所述近端轴相对于所述防旋转引导部的旋转使所述远端轴沿着所述轴线移动并且相对于所述防旋转引导部移动所述远端轴，所述防旋转引导部也沿着所述轴线移动；
线性稳定器，其联接到所述近端轴，防止所述近端轴在近端方向上相对于所述线性稳定器轴向移动，所述线性稳定器联接到所述贮存器防止所述线性稳定器在近端方向上相对于所述贮存器轴向移动，使得所述近端轴的所述旋转导致所述远端轴在所述药物贮存器内向远端推进，
其中所述线性稳定器包括防旋转连接器，其适配到用于防止所述线性稳定器相对于所述壳体旋转的所述壳体，并且其中所述防旋转引导部借助于所述线性稳定器可滑动地接合到所述壳体。
2.根据权利要求1所述的组件，其中所述防旋转连接器还形成为附接到所述贮存器的近端部分。
3.根据权利要求2所述的组件，其中所述防旋转连接器形成为附接到所述贮存器的凸缘。
4.根据权利要求1所述的组件，其中所述贮存器和所述组件形成盒，并且其中所述壳体包括适配所述盒的开口，并且其中所述防旋转连接器形成为连接到所述壳体以当所述盒插入所述开口中时限制所述防旋转连接器相对于所述壳体的旋转。
5.根据权利要求1所述的组件，其进一步包含：
轴承，其防止所述近端轴相对于所述壳体的近端移动并且允许所述近端轴相对于所述壳体旋转。
6.一种稳定药物输送装置中的贮存器的方法，其包含：
将贮存器插入所述药物输送装置的壳体中，所述贮存器容纳药物并用止动部密封；
将止动部适配器与所述贮存器的所述止动部接合；并且
将防旋转稳定器防旋转地联接到所述药物输送装置的所述壳体，
其中：
防旋转引导部和伸缩组件在所述防旋转稳定器和所述止动部适配器之间延伸，所述防旋转引导部包括在所述防旋转稳定器和所述止动部适配器之间防旋转地延伸的伸缩柱，并且所述伸缩组件通过沿着所述贮存器的轴线定位的至少近端轴和远端轴之间的相对旋转而伸缩；所述近端轴通过所述防旋转稳定器的肩部轴承线性地稳定，所述肩部轴承防止所述近端轴在近端方向上相对于所述防旋转稳定器移动，同时允许所述近端轴相对于所述防旋转稳定器旋转，并且所述远端轴与所述止动部适配器接合，由此所述近端轴相对于所述防旋转稳定器的旋转被配置成沿着所述轴线移动所述远端轴和所述止动部适配器，从而可滑动地延伸防旋转伸缩柱。
7.根据权利要求6所述的方法，其进一步包含：
利用所述药物输送装置的马达旋转所述近端轴。
8.根据权利要求6所述的方法，其进一步包含：
接合所述贮存器、所述止动部适配器、所述防旋转稳定器、所述防旋转引导部和所述伸缩组件以形成盒，并且
将所述盒作为单个单元插入所述药物输送装置中。
9.一种将药物供给输送装置的方法，其包含：
提供一种用于驱动药物输送装置的药物贮存器中的止动部的组件，该组件包含：
防旋转稳定器，其防旋转地联接到所述药物输送装置的壳体，
止动部适配器，其被配置成接合所述药物贮存器的所述止动部，
伸缩组件，其通过沿着所述贮存器的轴线定位的至少近端轴和远端轴之间的相对旋转而伸缩，所述近端轴通过所述防旋转稳定器的肩部轴承线性地稳定，所述肩部轴承防止所述近端轴在近端方向上相对于所述防旋转稳定器移动，同时允许所述近端轴相对于所述防旋转稳定器旋转，并且所述远端轴与所述止动部适配器接合，以及
防旋转引导部，其包括在所述防旋转稳定器和所述止动部适配器之间防旋转地延伸的伸缩柱；并且
相对于所述防旋转稳定器旋转所述近端轴以沿着所述轴线移动所述远端轴和所述止动部适配器，从而可滑动地延伸防旋转伸缩柱。
10.一种将药物供给输送装置的方法，其包含：
提供一种用于驱动药物输送装置的药物贮存器中的止动部的组件，该组件包含：
伸缩组件，其通过沿着所述贮存器的轴线定位的至少近端轴和远端轴之间的相对旋转而伸缩；所述远端轴配置成接合所述药物贮存器的止动部，
防旋转引导部，其具有沿着所述贮存器的所述轴线移动的尺寸；所述防旋转引导部可滑动地且防旋转地联接到所述药物输送装置的壳体，
联接部，其可滑动地且防旋转地将所述防旋转引导部链接到所述远端轴；所述滑动和防旋转相对于所述贮存器的所述轴线使得所述近端轴相对于所述防旋转引导部的旋转使所述远端轴沿着所述轴线移动并且相对于所述防旋转引导部移动所述远端轴，所述防旋转引导部也沿着所述轴线移动，以及
线性稳定器，其联接到所述近端轴，防止所述近端轴在近端方向上相对于所述线性稳定器轴向移动，所述线性稳定器联接到所述贮存器防止所述线性稳定器在近端方向上相对于所述贮存器轴向移动，使得所述近端轴的所述旋转导致所述远端轴在所述药物贮存器内向远端推进，
其中所述线性稳定器包括防旋转连接器，其适配到用于防止所述线性稳定器相对于所述壳体旋转的所述壳体；并且
借助于所述线性稳定器将所述防旋转引导部可滑动地接合到所述壳体。
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EP3108916A2 (en) 2016-12-28
CN106178196A (zh) 2016-12-07
CN117582586A (zh) 2024-02-23
CN106178196B (zh) 2021-08-10
EP3108916A3 (en) 2017-03-15
US20160346478A1 (en) 2016-12-01
CN113633851B (zh) 2023-11-17
US20190105445A1 (en) 2019-04-11
EP3108916B1 (en) 2024-04-24
US10758679B2 (en) 2020-09-01

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