CN113631584A - 硫酸软骨素多糖,其半合成制备方法和应用 - Google Patents

硫酸软骨素多糖,其半合成制备方法和应用 Download PDF

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CN113631584A
CN113631584A CN202080023949.7A CN202080023949A CN113631584A CN 113631584 A CN113631584 A CN 113631584A CN 202080023949 A CN202080023949 A CN 202080023949A CN 113631584 A CN113631584 A CN 113631584A
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chondroitin sulfate
polysaccharide
group
metal salt
sulfate polysaccharide
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CN113631584B (zh
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赵哲辉
雷平生
吴练秋
杨爽
王文杰
张海婧
李想
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Institute of Materia Medica of CAMS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

本发明涉及医药技术领域，具体涉及硫酸软骨素多糖，其半合成制备方法和应用。本发明提供的硫酸软骨素多糖金属盐具有抗炎效果，能够应用于制备抗炎症疾病药物。具体而言,本发明提供的硫酸软骨素多糖金属盐具有抗炎、骨保护功效，能够应用于制备抗类风湿性关节炎疾病药物和制备抗骨关节炎疾病药物。本发明提供了所述硫酸软骨素多糖金属盐的制备方法，本发明通过半合成的手段，能够获得不同硫酸化程度的硫酸软骨素多糖金属盐，方法操作简单、适宜规模化生产。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN202080023949.7A 2019-03-05 2020-03-05 硫酸软骨素多糖,其半合成制备方法和应用 Active CN113631584B (zh)

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CN201910163208.8A CN111662394B (zh) 2019-03-05 2019-03-05 硫酸软骨素多糖半合成制备方法和应用
CN2019101632088 2019-03-05
PCT/CN2020/078075 WO2020177749A1 (zh) 2019-03-05 2020-03-05 硫酸软骨素多糖，其半合成制备方法和应用

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EP (1) EP3936527A4 (zh)
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CN111662394B (zh) * 2019-03-05 2022-11-04 中国医学科学院药物研究所 硫酸软骨素多糖半合成制备方法和应用
WO2023250170A2 (en) * 2022-06-24 2023-12-28 The Board Of Regents Of The University Of Oklahoma Heparanase inhibitors and methods of use
CN115353574B (zh) * 2022-09-06 2023-06-13 福建省深蓝生物科技有限公司 高硫酸化度的硫酸软骨素cs-e及其提取方法

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CN1789287A (zh) * 2005-12-20 2006-06-21 山东大学 一种多硫酸化硫酸软骨素及其制备方法
CN103735572A (zh) * 2012-10-17 2014-04-23 山东明仁福瑞达制药股份有限公司 一种具有增加骨密度、抗炎镇痛作用的组合物及其制备方法
CN105399864A (zh) * 2015-12-23 2016-03-16 青岛九龙生物医药有限公司 高纯度低分子量硫酸软骨素钠的制备工艺
CN105924544A (zh) * 2016-05-16 2016-09-07 山东大学 一种高硫酸化硫酸软骨素及其制备方法与应用
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CN103735572A (zh) * 2012-10-17 2014-04-23 山东明仁福瑞达制药股份有限公司 一种具有增加骨密度、抗炎镇痛作用的组合物及其制备方法
CN105399864A (zh) * 2015-12-23 2016-03-16 青岛九龙生物医药有限公司 高纯度低分子量硫酸软骨素钠的制备工艺
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CN111662394A (zh) 2020-09-15
JP2024020460A (ja) 2024-02-14
EP3936527A1 (en) 2022-01-12
WO2020177749A1 (zh) 2020-09-10
KR20210151798A (ko) 2021-12-14
JP2022531825A (ja) 2022-07-12
CN111662394B (zh) 2022-11-04
CN113631584B (zh) 2023-09-29
EP3936527A4 (en) 2022-11-23

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