CN113508135A - 增强血脑屏障转运的人源化和稳定化的fc5变体 - Google Patents

增强血脑屏障转运的人源化和稳定化的fc5变体 Download PDF

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CN113508135A
CN113508135A CN201980081497.5A CN201980081497A CN113508135A CN 113508135 A CN113508135 A CN 113508135A CN 201980081497 A CN201980081497 A CN 201980081497A CN 113508135 A CN113508135 A CN 113508135A
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seq
amino acid
acid sequence
variable domain
sequence
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B.A.史密斯
A.莱曼
T.O.卡梅隆
R.B.佩平斯基
D.温
G.K.法林顿
G.拉古纳坦
N.E.佩德森
D.斯塔尼米罗维奇
T.苏莱亚
A.S.哈卡尼
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National Research Council of Canada
Biogan Ma Co
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National Research Council of Canada
Biogan Ma Co
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C07K2317/00—Immunoglobulins specific features
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CN201980081497.5A 2018-10-29 2019-10-28 增强血脑屏障转运的人源化和稳定化的fc5变体 Pending CN113508135A (zh)

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US201862751962P 2018-10-29 2018-10-29
US62/751,962 2018-10-29
PCT/US2019/058286 WO2020092202A2 (en) 2018-10-29 2019-10-28 Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport

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CN113508135A true CN113508135A (zh) 2021-10-15

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US (1) US20220089704A1 (https=)
EP (1) EP3873934A2 (https=)
JP (2) JP2022509372A (https=)
KR (1) KR20210111242A (https=)
CN (1) CN113508135A (https=)
AU (1) AU2019371814A1 (https=)
BR (1) BR112021008105A2 (https=)
CA (1) CA3117409A1 (https=)
EA (1) EA202191179A1 (https=)
IL (1) IL282677A (https=)
MA (1) MA54070A (https=)
MX (1) MX2021004772A (https=)
WO (1) WO2020092202A2 (https=)

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CN116650660A (zh) * 2023-07-27 2023-08-29 上海偌妥生物科技有限公司 制备抗体偶联小分子药物的方法及其应用
CN116650660B (zh) * 2023-07-27 2023-11-03 上海偌妥生物科技有限公司 制备抗体偶联小分子药物的方法及其应用
WO2025020982A1 (zh) * 2023-07-27 2025-01-30 上海偌妥生物科技有限公司 制备抗体偶联小分子药物的方法及其应用

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