JP2022509372A - 血液脳関門輸送の促進のためのヒト化され安定化されたｆｃ５バリアント - Google Patents

血液脳関門輸送の促進のためのヒト化され安定化されたｆｃ５バリアント Download PDF

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JP2022509372A
JP2022509372A JP2021547670A JP2021547670A JP2022509372A JP 2022509372 A JP2022509372 A JP 2022509372A JP 2021547670 A JP2021547670 A JP 2021547670A JP 2021547670 A JP2021547670 A JP 2021547670A JP 2022509372 A JP2022509372 A JP 2022509372A
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seq
amino acid
variable domain
antibody variable
position corresponding
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Inventor
ベンジャミン エー． スミス，
アンドレアス レーマン，
トーマス オー． キャメロン，
アール． ブレイク ペピンスキー，
ディンイー ウェン，
グラハム ケー． ファーリントン，
ゴパラン ラグナタン，
ネルス イー． ペダーソン，
ダニカ スタニミロヴィッチ，
トライアン スレア，
アルサラン エス． ハッカーニ，
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Biogen MA Inc
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Biogen MA Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • G—PHYSICS
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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JP2021547670A 2018-10-29 2019-10-28 血液脳関門輸送の促進のためのヒト化され安定化されたｆｃ５バリアント Pending JP2022509372A (ja)

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US201862751962P 2018-10-29 2018-10-29
US62/751,962 2018-10-29
PCT/US2019/058286 WO2020092202A2 (en) 2018-10-29 2019-10-28 Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport

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US (1) US20220089704A1 (https=)
EP (1) EP3873934A2 (https=)
JP (2) JP2022509372A (https=)
KR (1) KR20210111242A (https=)
CN (1) CN113508135A (https=)
AU (1) AU2019371814A1 (https=)
BR (1) BR112021008105A2 (https=)
CA (1) CA3117409A1 (https=)
EA (1) EA202191179A1 (https=)
IL (1) IL282677A (https=)
MA (1) MA54070A (https=)
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