CN112585143B - 作为毒蕈碱m1和/或m4受体的激动剂的桥接化合物 - Google Patents

作为毒蕈碱m1和/或m4受体的激动剂的桥接化合物 Download PDF

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Publication number
CN112585143B
CN112585143B CN201980054903.9A CN201980054903A CN112585143B CN 112585143 B CN112585143 B CN 112585143B CN 201980054903 A CN201980054903 A CN 201980054903A CN 112585143 B CN112585143 B CN 112585143B
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China
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oxa
azabicyclo
nonane
carboxylic acid
piperidin
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CN112585143A (zh
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盖尔斯·艾伯特·布朗
巴里·约翰·泰奥巴尔德
本杰明·杰拉尔德·特汉
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Nexla Pharmaceuticals Uk Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980054903.9A 2018-06-22 2019-06-24 作为毒蕈碱m1和/或m4受体的激动剂的桥接化合物 Active CN112585143B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1810239.2A GB201810239D0 (en) 2018-06-22 2018-06-22 Pharmaceutical compounds
GB1810239.2 2018-06-22
PCT/GB2019/051780 WO2019243851A1 (en) 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (2)

Publication Number Publication Date
CN112585143A CN112585143A (zh) 2021-03-30
CN112585143B true CN112585143B (zh) 2024-11-12

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US (2) US10787447B2 (https=)
EP (1) EP3810614B1 (https=)
JP (1) JP7317054B2 (https=)
CN (1) CN112585143B (https=)
AU (1) AU2019289217B2 (https=)
CA (1) CA3104222A1 (https=)
ES (1) ES2984420T3 (https=)
GB (1) GB201810239D0 (https=)
TW (1) TWI822803B (https=)
WO (1) WO2019243851A1 (https=)

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* Cited by examiner, † Cited by third party
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GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
CA3066200A1 (en) * 2017-06-09 2018-12-20 Adama Makhteshim Ltd. Formulation for seed treatment comprising fluensulfone
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

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WO2008117229A1 (en) * 2007-03-23 2008-10-02 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
CN104640851A (zh) * 2012-09-18 2015-05-20 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物
CN106659719A (zh) * 2014-03-19 2017-05-10 赫普泰雅治疗有限公司 毒蕈碱受体激动剂

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EP3810614B1 (en) 2024-03-27
CA3104222A1 (en) 2019-12-26
JP2021528446A (ja) 2021-10-21
TW202019922A (zh) 2020-06-01
JP7317054B2 (ja) 2023-07-28
US20210002271A1 (en) 2021-01-07
ES2984420T3 (es) 2024-10-29
US20200002328A1 (en) 2020-01-02
GB201810239D0 (en) 2018-08-08
WO2019243851A1 (en) 2019-12-26
US11773090B2 (en) 2023-10-03
EP3810614C0 (en) 2024-03-27
TWI822803B (zh) 2023-11-21
US10787447B2 (en) 2020-09-29
EP3810614A1 (en) 2021-04-28
AU2019289217A1 (en) 2021-01-14
AU2019289217B2 (en) 2023-08-17
CN112585143A (zh) 2021-03-30

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