CA3104222A1 - Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor - Google Patents

Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor Download PDF

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Publication number
CA3104222A1
CA3104222A1 CA3104222A CA3104222A CA3104222A1 CA 3104222 A1 CA3104222 A1 CA 3104222A1 CA 3104222 A CA3104222 A CA 3104222A CA 3104222 A CA3104222 A CA 3104222A CA 3104222 A1 CA3104222 A1 CA 3104222A1
Authority
CA
Canada
Prior art keywords
oxa
carboxylate
azabicyclo
nonane
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3104222A
Other languages
English (en)
French (fr)
Inventor
Giles Albert Brown
Barry John Teobald
Benjamin Gerald TEHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nxera Pharma UK Ltd
Original Assignee
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heptares Therapeutics Ltd filed Critical Heptares Therapeutics Ltd
Publication of CA3104222A1 publication Critical patent/CA3104222A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3104222A 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor Pending CA3104222A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1810239.2A GB201810239D0 (en) 2018-06-22 2018-06-22 Pharmaceutical compounds
GB1810239.2 2018-06-22
PCT/GB2019/051780 WO2019243851A1 (en) 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (1)

Publication Number Publication Date
CA3104222A1 true CA3104222A1 (en) 2019-12-26

Family

ID=63042513

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3104222A Pending CA3104222A1 (en) 2018-06-22 2019-06-24 Bridged compounds as agonists of the muscarinic m1 and/or m4 receptor

Country Status (10)

Country Link
US (2) US10787447B2 (https=)
EP (1) EP3810614B1 (https=)
JP (1) JP7317054B2 (https=)
CN (1) CN112585143B (https=)
AU (1) AU2019289217B2 (https=)
CA (1) CA3104222A1 (https=)
ES (1) ES2984420T3 (https=)
GB (1) GB201810239D0 (https=)
TW (1) TWI822803B (https=)
WO (1) WO2019243851A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
CA3066200A1 (en) * 2017-06-09 2018-12-20 Adama Makhteshim Ltd. Formulation for seed treatment comprising fluensulfone
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

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Also Published As

Publication number Publication date
EP3810614B1 (en) 2024-03-27
JP2021528446A (ja) 2021-10-21
TW202019922A (zh) 2020-06-01
JP7317054B2 (ja) 2023-07-28
US20210002271A1 (en) 2021-01-07
ES2984420T3 (es) 2024-10-29
US20200002328A1 (en) 2020-01-02
GB201810239D0 (en) 2018-08-08
CN112585143B (zh) 2024-11-12
WO2019243851A1 (en) 2019-12-26
US11773090B2 (en) 2023-10-03
EP3810614C0 (en) 2024-03-27
TWI822803B (zh) 2023-11-21
US10787447B2 (en) 2020-09-29
EP3810614A1 (en) 2021-04-28
AU2019289217A1 (en) 2021-01-14
AU2019289217B2 (en) 2023-08-17
CN112585143A (zh) 2021-03-30

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