CN112437667B - 细胞保护方法和组合物 - Google Patents

细胞保护方法和组合物 Download PDF

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Publication number
CN112437667B
CN112437667B CN201980044697.3A CN201980044697A CN112437667B CN 112437667 B CN112437667 B CN 112437667B CN 201980044697 A CN201980044697 A CN 201980044697A CN 112437667 B CN112437667 B CN 112437667B
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chondroitin sulfate
alkyl
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aryl
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CN112437667A (zh
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刘健
李金娥
苏国玮
拉法尔·波林斯基
埃里卡·斯帕克恩博
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University of North Carolina at Chapel Hill
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980044697.3A 2018-06-20 2019-06-19 细胞保护方法和组合物 Active CN112437667B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687540P 2018-06-20 2018-06-20
US62/687,540 2018-06-20
PCT/US2019/037993 WO2019246264A1 (en) 2018-06-20 2019-06-19 Cell protective methods and compositions

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CN112437667A CN112437667A (zh) 2021-03-02
CN112437667B true CN112437667B (zh) 2024-05-28

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US (2) US11633424B2 (https=)
EP (1) EP3810152A4 (https=)
JP (1) JP7538724B2 (https=)
CN (1) CN112437667B (https=)
WO (1) WO2019246264A1 (https=)

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CN116622006B (zh) 2017-03-10 2025-05-30 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
US11993627B2 (en) * 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
JP7801217B2 (ja) 2019-11-13 2026-01-16 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果
CN116254296A (zh) * 2023-03-27 2023-06-13 中国科学院微生物研究所 利用昆虫细胞杆状病毒表达系统表达硫酸软骨素修饰酶的方法及应用
CN116254295A (zh) * 2023-03-27 2023-06-13 中国科学院微生物研究所 利用昆虫细胞杆状病毒表达系统表达软骨素6-o-硫酸转移酶的方法及应用

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CN116622006B (zh) 2017-03-10 2025-05-30 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
US11993627B2 (en) * 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
JP7801217B2 (ja) 2019-11-13 2026-01-16 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果

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Also Published As

Publication number Publication date
CN112437667A (zh) 2021-03-02
US20210260098A1 (en) 2021-08-26
US11633424B2 (en) 2023-04-25
EP3810152A4 (en) 2022-04-27
JP7538724B2 (ja) 2024-08-22
JP2021528421A (ja) 2021-10-21
EP3810152A1 (en) 2021-04-28
US20230277580A1 (en) 2023-09-07
WO2019246264A1 (en) 2019-12-26

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