CN112437667B - 细胞保护方法和组合物 - Google Patents

细胞保护方法和组合物 Download PDF

Info

Publication number
CN112437667B
CN112437667B CN201980044697.3A CN201980044697A CN112437667B CN 112437667 B CN112437667 B CN 112437667B CN 201980044697 A CN201980044697 A CN 201980044697A CN 112437667 B CN112437667 B CN 112437667B
Authority
CN
China
Prior art keywords
mer
chondroitin sulfate
alkyl
subject
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980044697.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN112437667A (zh
Inventor
刘健
李金娥
苏国玮
拉法尔·波林斯基
埃里卡·斯帕克恩博
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of CN112437667A publication Critical patent/CN112437667A/zh
Application granted granted Critical
Publication of CN112437667B publication Critical patent/CN112437667B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980044697.3A 2018-06-20 2019-06-19 细胞保护方法和组合物 Active CN112437667B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687540P 2018-06-20 2018-06-20
US62/687,540 2018-06-20
PCT/US2019/037993 WO2019246264A1 (en) 2018-06-20 2019-06-19 Cell protective methods and compositions

Publications (2)

Publication Number Publication Date
CN112437667A CN112437667A (zh) 2021-03-02
CN112437667B true CN112437667B (zh) 2024-05-28

Family

ID=68984366

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980044697.3A Active CN112437667B (zh) 2018-06-20 2019-06-19 细胞保护方法和组合物

Country Status (5)

Country Link
US (2) US11633424B2 (https=)
EP (1) EP3810152A4 (https=)
JP (1) JP7538724B2 (https=)
CN (1) CN112437667B (https=)
WO (1) WO2019246264A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110446511B (zh) 2017-03-10 2024-04-02 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
WO2019010216A1 (en) * 2017-07-03 2019-01-10 The University Of North Carolina At Chapel Hill ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
WO2021097345A1 (en) 2019-11-13 2021-05-20 The University Of North Carolina At Chapel Hill Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury
CN116254296A (zh) * 2023-03-27 2023-06-13 中国科学院微生物研究所 利用昆虫细胞杆状病毒表达系统表达硫酸软骨素修饰酶的方法及应用
CN116254295A (zh) * 2023-03-27 2023-06-13 中国科学院微生物研究所 利用昆虫细胞杆状病毒表达系统表达软骨素6-o-硫酸转移酶的方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118609A2 (en) * 2004-05-26 2005-12-15 California Institute Of Technology Small molecule stimulators of neuronal growth
CN103402526A (zh) * 2010-12-01 2013-11-20 澳大利亚国立大学 组蛋白抑制

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
IT1232939B (it) 1987-11-06 1992-03-10 Opocrin Spa Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
US4865870A (en) 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
PT93847A (pt) 1989-04-24 1990-11-20 Harvard College Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
US5378829A (en) 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
AU2561792A (en) 1991-09-06 1993-04-05 Children's Medical Center Corporation Cell-type specific heparan sulfate proteoglycans and their uses
IT1260137B (it) 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
JP3818676B2 (ja) 1994-07-22 2006-09-06 生化学工業株式会社 ヘパラン硫酸６−ｏ−硫酸基転移酵素
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
JP3672359B2 (ja) 1995-07-24 2005-07-20 生化学工業株式会社 ヘパラン硫酸 ２−ｏ−硫酸基転移酵素
JP3713276B2 (ja) 1995-09-29 2005-11-09 バイオマリン ファーマシューティカル インコーポレイテッド 炎症反応の軽減のためのヘパリナーゼの使用
US5935824A (en) 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
US6861254B1 (en) 1997-10-24 2005-03-01 Massachusetts Institute Of Technology Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor
US7307159B2 (en) 2001-05-08 2007-12-11 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase from P. multocida and methods of making and using same
US8088604B2 (en) 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US6624141B1 (en) 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
US6255088B1 (en) 1999-05-11 2001-07-03 The Scripps Research Institute Enzymatic sulfation of biomolecules
US7101859B2 (en) * 2000-01-10 2006-09-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
WO2002004471A1 (fr) 2000-07-07 2002-01-17 Seikagaku Corporation Fractions oligosaccharidiques d'acide hyaluronique et medicament les contenant
US8067196B2 (en) 2001-03-28 2011-11-29 Massachusetts Institute Of Technology 6-O sulfated polysaccharides and methods of preparation thereof
US7300922B2 (en) 2001-05-25 2007-11-27 Duke University Modulators of pharmacological agents
WO2003018598A2 (en) 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
WO2004005475A2 (en) 2002-07-05 2004-01-15 University Of North Carolina At Chapel Hill Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
GB0216861D0 (en) 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
AU2003262794A1 (en) 2002-08-23 2004-03-11 Neose Technologies, Inc. Total synthesis of heparin
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
ATE502062T1 (de) 2003-10-24 2011-04-15 3M Innovative Properties Co Wässrige dispersionen von polytetrafluorethylenteilchen
US7655445B2 (en) 2003-11-12 2010-02-02 Massachusetts Institute Of Technology Methods for synthesis of sulfated saccharides
WO2006015171A2 (en) * 2004-07-28 2006-02-09 The Texas A & M University System Use of glycosoaminoglycans for the prevention and treatment of sepsis
WO2006124801A2 (en) 2005-05-12 2006-11-23 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides
CN101495517B (zh) 2006-05-25 2012-10-10 莫曼塔医药品有限公司 低分子量肝素及其用途
WO2009014715A2 (en) 2007-07-23 2009-01-29 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
ES2567079T3 (es) 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
EP2364165B1 (en) 2008-11-14 2018-01-03 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
CA2750188C (en) * 2009-02-02 2016-11-29 Otsuka Chemical Co., Ltd. Low-molecular polysulfated hyaluronic acid derivative and compositions containing same
BRPI1010516A2 (pt) 2009-04-09 2015-08-25 Univ North Carolina Métodos de tratamento de edema relacionados à isquemia-reperfusão
US20110054236A1 (en) 2009-08-25 2011-03-03 The Regents Of The University Of Michigan Compositions and methods for targeting tumors
EP2480237A1 (en) 2009-09-23 2012-08-01 Momenta Pharmaceuticals, Inc. Methods of treatment with a low molecular weight heparin composition
US11203772B2 (en) 2010-12-23 2021-12-21 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
TW201309305A (zh) 2011-02-22 2013-03-01 Rensselaer Polytech Inst 用於製造生物工程肝素之單一步驟肝素前體之ｎ－去乙醯化作用及解聚合作用
US8519189B2 (en) 2011-06-01 2013-08-27 University Of British Columbia Polymers for reversing heparin-based anticoagulation
CA2901225C (en) 2013-03-08 2023-09-19 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
ES2924830T3 (es) 2013-06-17 2022-10-11 Univ North Carolina Chapel Hill Moléculas de heparina reversibles
CN110446511B (zh) 2017-03-10 2024-04-02 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
WO2019010216A1 (en) 2017-07-03 2019-01-10 The University Of North Carolina At Chapel Hill ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
WO2021097345A1 (en) 2019-11-13 2021-05-20 The University Of North Carolina At Chapel Hill Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118609A2 (en) * 2004-05-26 2005-12-15 California Institute Of Technology Small molecule stimulators of neuronal growth
CN103402526A (zh) * 2010-12-01 2013-11-20 澳大利亚国立大学 组蛋白抑制

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones;Nagano等;European Journal of Pharmacology;第826卷;第48-55页 *
The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs;Freeman等;Biomaterials;第34卷(第22期);"摘要"、"前言"项下，第2.1、2.4、2.6、3.1、3.5、5小节，第5674页右边栏第2段，第5675页左边栏第3段，图5，表1 *

Also Published As

Publication number Publication date
WO2019246264A1 (en) 2019-12-26
CN112437667A (zh) 2021-03-02
JP7538724B2 (ja) 2024-08-22
EP3810152A4 (en) 2022-04-27
JP2021528421A (ja) 2021-10-21
EP3810152A1 (en) 2021-04-28
US20230277580A1 (en) 2023-09-07
US11633424B2 (en) 2023-04-25
US20210260098A1 (en) 2021-08-26

Similar Documents

Publication Publication Date Title
CN112437667B (zh) 细胞保护方法和组合物
JP4536918B2 (ja) 免疫調整機能を有するγ−グルタミルとβ−アスパルチル化合物および免疫調節剤
JP2806454B2 (ja) 脈管形成阻止剤
JP4861596B2 (ja) ヒアルロン酸オリゴ糖画分およびそれを含む医薬
US6943190B2 (en) Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions
US12539311B2 (en) Short-acting heparin-based anticoagulant compounds and methods
JP7801217B2 (ja) 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果
CN103402526B (zh) 组蛋白抑制
CA2190107A1 (en) Compositions for treatment of chronic inflammatory diseases
EP1082963A1 (en) Remedies for joint diseases bound to hyaluronic acid
US20120064044A1 (en) Methods of treating edema related to ischemia-reperfusion
BR112013027389B1 (pt) Processo para o preparo de sal sódico de sulfato de condroitina
BG65681B1 (bg) Средство за лечение на болести на ставите
JP2008501640A (ja) ミオシン軽鎖キナーゼ阻害剤及びその使用
JPH05503506A (ja) 芳香族ポリマーを含む薬学的組成物及びそれを用いる治療法
RU2622747C2 (ru) Способ и средство для лечения реактивного артрита хламидийной этиологии
JP2007126453A (ja) ヒアルロナン産生促進剤及びヒアルロナン分解抑制剤
EP1740176A2 (en) Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives
US20070191400A1 (en) Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives
EP3601312A1 (en) Heparan sulfate glycomimetic compounds and their pharmaceutical and cosmeceutical uses
US6313104B1 (en) Organoprotective solutions
Bannerman Mechanisms of endotoxin-induced endothelial monolayer disruption: Roles of tyrosine phosphorylation, caspase activation, and the actin-associated adherens junctions
JP2004051579A (ja) ヒアルロン酸合成促進剤
HK1034666A (en) Remedies for joint diseases bound to hyaluronic acid
HUP9903399A2 (hu) Készítmény leukocitainvázió gátlására szövetekben

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant