CN1121381C - 制备酮亚胺的新方法 - Google Patents

制备酮亚胺的新方法 Download PDF

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Publication number
CN1121381C
CN1121381C CN98813087A CN98813087A CN1121381C CN 1121381 C CN1121381 C CN 1121381C CN 98813087 A CN98813087 A CN 98813087A CN 98813087 A CN98813087 A CN 98813087A CN 1121381 C CN1121381 C CN 1121381C
Authority
CN
China
Prior art keywords
sertraline
solvent
mixture
monomethylamine
optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN98813087A
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English (en)
Chinese (zh)
Other versions
CN1285819A (zh
Inventor
胡安·C·科尔伯格
戴维·M·菲斯特勒
杰拉尔丁·P·泰伯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22102365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1121381(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1285819A publication Critical patent/CN1285819A/zh
Application granted granted Critical
Publication of CN1121381C publication Critical patent/CN1121381C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
CN98813087A 1998-01-16 1998-10-15 制备酮亚胺的新方法 Expired - Fee Related CN1121381C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7160098P 1998-01-16 1998-01-16
US60/071,600 1998-01-16

Publications (2)

Publication Number Publication Date
CN1285819A CN1285819A (zh) 2001-02-28
CN1121381C true CN1121381C (zh) 2003-09-17

Family

ID=22102365

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98813087A Expired - Fee Related CN1121381C (zh) 1998-01-16 1998-10-15 制备酮亚胺的新方法

Country Status (47)

Country Link
US (1) US6232500B1 (enExample)
EP (1) EP1047666B1 (enExample)
JP (1) JP3533179B2 (enExample)
KR (1) KR100362788B1 (enExample)
CN (1) CN1121381C (enExample)
AP (1) AP956A (enExample)
AR (1) AR016168A1 (enExample)
AT (1) ATE231121T1 (enExample)
AU (1) AU747861B2 (enExample)
BG (2) BG64647B1 (enExample)
BR (1) BR9814248A (enExample)
CA (1) CA2315761C (enExample)
CO (1) CO5040154A1 (enExample)
CZ (1) CZ20002594A3 (enExample)
DE (1) DE69810815T2 (enExample)
DK (1) DK1047666T3 (enExample)
DZ (1) DZ2705A1 (enExample)
EA (1) EA004952B1 (enExample)
EG (1) EG21515A (enExample)
ES (1) ES2186226T3 (enExample)
GT (1) GT199800176A (enExample)
HN (1) HN1998000167A (enExample)
HR (1) HRP20000473A2 (enExample)
HU (1) HUP0101253A3 (enExample)
ID (1) ID24971A (enExample)
IL (2) IL136888A0 (enExample)
IN (1) IN191358B (enExample)
IS (1) IS5538A (enExample)
MA (1) MA24744A1 (enExample)
MY (1) MY132956A (enExample)
NO (1) NO20003625L (enExample)
NZ (1) NZ505027A (enExample)
OA (1) OA11439A (enExample)
PA (1) PA8461901A1 (enExample)
PE (1) PE20000171A1 (enExample)
PL (1) PL192489B1 (enExample)
PT (1) PT1047666E (enExample)
RS (1) RS49773B (enExample)
SI (1) SI1047666T1 (enExample)
SK (1) SK10182000A3 (enExample)
TN (1) TNSN99004A1 (enExample)
TR (1) TR200002065T2 (enExample)
TW (1) TW505624B (enExample)
UA (1) UA55504C2 (enExample)
UY (1) UY25348A1 (enExample)
WO (1) WO1999036394A1 (enExample)
ZA (1) ZA99278B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226423B1 (en) * 1998-05-05 2008-12-29 Egis Gyogyszergyar Nyrt Process for producing a 1(2h)-naphtalene-1-ylidene derivative
HUP0104323A3 (en) * 1998-10-30 2002-11-28 Ciba Sc Holding Ag Method of producing ketimines
EP1632475A1 (en) * 1998-11-27 2006-03-08 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
IN185109B (enExample) * 1999-09-01 2000-11-18 Torrent Pharmaceuticals Ltd
WO2001036377A1 (en) * 1999-11-16 2001-05-25 Ciba Specialty Chemicals Holding Inc. Process for the preparation of ketimines
CN1246298C (zh) * 1999-11-16 2006-03-22 西巴特殊化学品控股有限公司 制备酮亚胺的方法
IN187170B (enExample) 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
JP2003527359A (ja) * 2000-03-14 2003-09-16 テバ ファーマシューティカル インダストリーズ リミティド （＋）−シス−セルトラリンの製造のための新規方法
EP1397342A1 (en) * 2001-05-31 2004-03-17 Orion Corporation Fermion Process for preparing sertraline intermediates
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
KR20030061474A (ko) * 2002-01-14 2003-07-22 한미약품 주식회사 서트랄린 제조용 중간체로서 사용되는 시스-라세메이트화합물의 개선된 제조방법
WO2006129324A2 (en) 2005-06-03 2006-12-07 Hetero Drugs Limited A highly stereoselective synthesis of sertraline

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4855500A (en) * 1988-05-04 1989-08-08 Pfizer Inc. Process for preparing a ketimine
HU226424B1 (en) 1998-05-05 2008-12-29 Egis Gyogyszergyar Nyrt Process for producing enantiomer mixture for preparation of sertraline

Also Published As

Publication number Publication date
DE69810815D1 (de) 2003-02-20
EA004952B1 (ru) 2004-10-28
EP1047666A1 (en) 2000-11-02
ZA99278B (en) 2000-07-17
EG21515A (en) 2001-11-28
DZ2705A1 (fr) 2003-09-01
SI1047666T1 (en) 2003-04-30
HUP0101253A2 (hu) 2002-05-29
ES2186226T3 (es) 2003-05-01
HN1998000167A (es) 1999-02-09
AU747861B2 (en) 2002-05-23
PE20000171A1 (es) 2000-03-09
KR100362788B1 (ko) 2002-11-29
DK1047666T3 (da) 2003-02-24
UA55504C2 (uk) 2003-04-15
KR20010034117A (ko) 2001-04-25
BR9814248A (pt) 2000-10-10
PT1047666E (pt) 2003-03-31
MA24744A1 (fr) 1999-10-01
CA2315761C (en) 2004-08-31
BG64647B1 (bg) 2005-10-31
IL136888A (en) 2006-12-10
EA200000661A1 (ru) 2000-12-25
CZ20002594A3 (cs) 2001-12-12
JP3533179B2 (ja) 2004-05-31
NO20003625D0 (no) 2000-07-14
CN1285819A (zh) 2001-02-28
RS49773B (sr) 2008-06-05
BG104669A (en) 2001-04-30
CA2315761A1 (en) 1999-07-22
JP2002509132A (ja) 2002-03-26
HK1032039A1 (en) 2001-07-06
IL136888A0 (en) 2001-06-14
IN191358B (enExample) 2003-11-29
AU9278698A (en) 1999-08-02
NO20003625L (no) 2000-09-13
TNSN99004A1 (fr) 2005-11-10
PL192489B1 (pl) 2006-10-31
PL341648A1 (en) 2001-04-23
TR200002065T2 (tr) 2000-11-21
EP1047666B1 (en) 2003-01-15
YU44300A (sh) 2002-09-19
MY132956A (en) 2007-10-31
HUP0101253A3 (en) 2002-06-28
NZ505027A (en) 2002-08-28
PA8461901A1 (es) 2000-05-24
ATE231121T1 (de) 2003-02-15
ID24971A (id) 2000-08-31
BG64621B1 (bg) 2005-09-30
WO1999036394A1 (en) 1999-07-22
DE69810815T2 (de) 2003-08-07
TW505624B (en) 2002-10-11
AP956A (en) 2001-04-06
IS5538A (is) 2000-06-16
SK10182000A3 (sk) 2002-06-04
US6232500B1 (en) 2001-05-15
OA11439A (en) 2004-04-26
GT199800176A (es) 1998-11-09
UY25348A1 (es) 1999-09-27
HRP20000473A2 (en) 2001-04-30
AR016168A1 (es) 2001-06-20
AP9901441A0 (en) 1999-03-31
CO5040154A1 (es) 2001-05-29

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