CN1120844A - 膦酰甲基二肽 - Google Patents

膦酰甲基二肽 Download PDF

Info

Publication number
CN1120844A
CN1120844A CN94191635A CN94191635A CN1120844A CN 1120844 A CN1120844 A CN 1120844A CN 94191635 A CN94191635 A CN 94191635A CN 94191635 A CN94191635 A CN 94191635A CN 1120844 A CN1120844 A CN 1120844A
Authority
CN
China
Prior art keywords
compound
leucyl
alkyl
acid
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94191635A
Other languages
English (en)
Chinese (zh)
Inventor
H·奥切蒙特
M·比格奥特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Ltd filed Critical Merrell Dow Pharmaceuticals Ltd
Publication of CN1120844A publication Critical patent/CN1120844A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
CN94191635A 1993-03-30 1994-02-22 膦酰甲基二肽 Pending CN1120844A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93400824A EP0618224A1 (en) 1993-03-30 1993-03-30 Phosphonomethyldipeptides
EP93400824.4 1993-03-30

Publications (1)

Publication Number Publication Date
CN1120844A true CN1120844A (zh) 1996-04-17

Family

ID=8214693

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94191635A Pending CN1120844A (zh) 1993-03-30 1994-02-22 膦酰甲基二肽

Country Status (20)

Country Link
EP (2) EP0618224A1 (el)
JP (1) JP3541230B2 (el)
KR (1) KR100311852B1 (el)
CN (1) CN1120844A (el)
AT (1) ATE192456T1 (el)
AU (1) AU670866B2 (el)
CA (1) CA2156742C (el)
DE (1) DE69424281T2 (el)
DK (1) DK0691985T3 (el)
ES (1) ES2148322T3 (el)
FI (1) FI954656A (el)
GR (1) GR3034015T3 (el)
HU (1) HU217836B (el)
IL (1) IL109128A (el)
NO (1) NO953877L (el)
NZ (1) NZ262996A (el)
PT (1) PT691985E (el)
TW (1) TW290550B (el)
WO (1) WO1994022908A1 (el)
ZA (1) ZA942091B (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583123A (en) * 1994-12-22 1996-12-10 Ciba-Geigy Corporation Certain tetrazole derivatives
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
JP2811608B2 (ja) * 1991-04-26 1998-10-15 日本ケミファ株式会社 ホスホン酸アミド誘導体およびエンドセリン変換酵素阻害剤
JPH05105698A (ja) * 1991-06-13 1993-04-27 Takeda Chem Ind Ltd ホスホン酸誘導体、その製造法および用途

Also Published As

Publication number Publication date
NZ262996A (en) 1996-06-25
PT691985E (pt) 2000-08-31
DE69424281T2 (de) 2000-09-21
KR100311852B1 (ko) 2002-02-28
DK0691985T3 (da) 2000-08-07
TW290550B (el) 1996-11-11
JP3541230B2 (ja) 2004-07-07
HU217836B (hu) 2000-04-28
CA2156742A1 (en) 1994-10-13
AU670866B2 (en) 1996-08-01
IL109128A0 (en) 1994-06-24
AU6298994A (en) 1994-10-24
NO953877L (no) 1995-11-30
FI954656A0 (fi) 1995-09-29
WO1994022908A1 (en) 1994-10-13
ATE192456T1 (de) 2000-05-15
DE69424281D1 (en) 2000-06-08
IL109128A (en) 1999-09-22
EP0691985B1 (en) 2000-05-03
EP0618224A1 (en) 1994-10-05
NO953877D0 (no) 1995-09-29
ZA942091B (en) 1994-10-24
GR3034015T3 (en) 2000-11-30
CA2156742C (en) 2001-04-17
EP0691985A1 (en) 1996-01-17
HUT72465A (en) 1996-04-29
JPH08508480A (ja) 1996-09-10
ES2148322T3 (es) 2000-10-16
KR960701088A (ko) 1996-02-24
HU9502852D0 (en) 1995-11-28
FI954656A (fi) 1995-09-29

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication