NO953877L - Fosfonometyldipeptider - Google Patents

Fosfonometyldipeptider

Info

Publication number
NO953877L
NO953877L NO953877A NO953877A NO953877L NO 953877 L NO953877 L NO 953877L NO 953877 A NO953877 A NO 953877A NO 953877 A NO953877 A NO 953877A NO 953877 L NO953877 L NO 953877L
Authority
NO
Norway
Prior art keywords
fosfonometyldipeptider
dipeptides
analogs
useful
converting enzyme
Prior art date
Application number
NO953877A
Other languages
English (en)
Other versions
NO953877D0 (no
Inventor
Orchymont Hugues D
Marc Bigaud
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO953877D0 publication Critical patent/NO953877D0/no
Publication of NO953877L publication Critical patent/NO953877L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Dipeptider og analoger derav med en fosfonometylgruppe bundet dertil som inhiberer endotelinomdannende enzym og således er anvendbare ved behandling av tilstander som er mottakelige for dette. Forbindelse av formelen: O l RlO ¿P - CH2 ¿ l R20 R« formel I stereoisonerer, hydrater, indre salter eller farmaseytisk ak- septable salter derav, hvori R, eller R, hver uavhengig er hydrogen, C,.,-alkyl, (CH,).-aryl, R4-C(0)0-CH(R,)- eller ingenting når det indre salt dannes, forutsatt at når en av R, eller R, er hydro- gen, C,.,-alkyl, eller (CH,).-eryl, er den andre hydro- gen eller ingenting når det Indre salt dannes; R, er hydrogen, C,.,-alkyl, (CH,).-sykloalkyl eller (CH,).-aryl; "4 er C,.10-alkyl, (CH,).-sykloalkyl eller (CH,).-aryl; R, er C,.,-alkyl, (CH,).-sykloalkyl eller hydrogen; "¿ er "¿ eller H, når en av R, eller R, er ingenting og således danner det indre salt; R, er CH, eller H; "¿ er H- Br. CH, eller OCH,, forutsatt at en av R, eller R, er H; Z er (CH,).-aryl eller Cj.n-alkyl; X er hydrogen eller C,.,-alkyl; hver ra er uavhengig O, l, 2 eller 3; og n er l, 2 'eller 3.
NO953877A 1993-03-30 1995-09-29 Fosfonometyldipeptider NO953877L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93400824A EP0618224A1 (en) 1993-03-30 1993-03-30 Phosphonomethyldipeptides
PCT/US1994/001716 WO1994022908A1 (en) 1993-03-30 1994-02-22 Phosphonomethyldipeptides

Publications (2)

Publication Number Publication Date
NO953877D0 NO953877D0 (no) 1995-09-29
NO953877L true NO953877L (no) 1995-11-30

Family

ID=8214693

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953877A NO953877L (no) 1993-03-30 1995-09-29 Fosfonometyldipeptider

Country Status (20)

Country Link
EP (2) EP0618224A1 (no)
JP (1) JP3541230B2 (no)
KR (1) KR100311852B1 (no)
CN (1) CN1120844A (no)
AT (1) ATE192456T1 (no)
AU (1) AU670866B2 (no)
CA (1) CA2156742C (no)
DE (1) DE69424281T2 (no)
DK (1) DK0691985T3 (no)
ES (1) ES2148322T3 (no)
FI (1) FI954656A (no)
GR (1) GR3034015T3 (no)
HU (1) HU217836B (no)
IL (1) IL109128A (no)
NO (1) NO953877L (no)
NZ (1) NZ262996A (no)
PT (1) PT691985E (no)
TW (1) TW290550B (no)
WO (1) WO1994022908A1 (no)
ZA (1) ZA942091B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583123A (en) * 1994-12-22 1996-12-10 Ciba-Geigy Corporation Certain tetrazole derivatives
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
JP2811608B2 (ja) * 1991-04-26 1998-10-15 日本ケミファ株式会社 ホスホン酸アミド誘導体およびエンドセリン変換酵素阻害剤
JPH05105698A (ja) * 1991-06-13 1993-04-27 Takeda Chem Ind Ltd ホスホン酸誘導体、その製造法および用途

Also Published As

Publication number Publication date
NZ262996A (en) 1996-06-25
PT691985E (pt) 2000-08-31
DE69424281T2 (de) 2000-09-21
KR100311852B1 (ko) 2002-02-28
DK0691985T3 (da) 2000-08-07
TW290550B (no) 1996-11-11
JP3541230B2 (ja) 2004-07-07
HU217836B (hu) 2000-04-28
CA2156742A1 (en) 1994-10-13
AU670866B2 (en) 1996-08-01
IL109128A0 (en) 1994-06-24
AU6298994A (en) 1994-10-24
FI954656A0 (fi) 1995-09-29
WO1994022908A1 (en) 1994-10-13
ATE192456T1 (de) 2000-05-15
DE69424281D1 (en) 2000-06-08
IL109128A (en) 1999-09-22
CN1120844A (zh) 1996-04-17
EP0691985B1 (en) 2000-05-03
EP0618224A1 (en) 1994-10-05
NO953877D0 (no) 1995-09-29
ZA942091B (en) 1994-10-24
GR3034015T3 (en) 2000-11-30
CA2156742C (en) 2001-04-17
EP0691985A1 (en) 1996-01-17
HUT72465A (en) 1996-04-29
JPH08508480A (ja) 1996-09-10
ES2148322T3 (es) 2000-10-16
KR960701088A (ko) 1996-02-24
HU9502852D0 (en) 1995-11-28
FI954656A (fi) 1995-09-29

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