NO953877L - Fosfonometyldipeptider - Google Patents
FosfonometyldipeptiderInfo
- Publication number
- NO953877L NO953877L NO953877A NO953877A NO953877L NO 953877 L NO953877 L NO 953877L NO 953877 A NO953877 A NO 953877A NO 953877 A NO953877 A NO 953877A NO 953877 L NO953877 L NO 953877L
- Authority
- NO
- Norway
- Prior art keywords
- fosfonometyldipeptider
- dipeptides
- analogs
- useful
- converting enzyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Dipeptider og analoger derav med en fosfonometylgruppe bundet dertil som inhiberer endotelinomdannende enzym og således er anvendbare ved behandling av tilstander som er mottakelige for dette. Forbindelse av formelen: O l RlO ¿P - CH2 ¿ l R20 R« formel I stereoisonerer, hydrater, indre salter eller farmaseytisk ak- septable salter derav, hvori R, eller R, hver uavhengig er hydrogen, C,.,-alkyl, (CH,).-aryl, R4-C(0)0-CH(R,)- eller ingenting når det indre salt dannes, forutsatt at når en av R, eller R, er hydro- gen, C,.,-alkyl, eller (CH,).-eryl, er den andre hydro- gen eller ingenting når det Indre salt dannes; R, er hydrogen, C,.,-alkyl, (CH,).-sykloalkyl eller (CH,).-aryl; "4 er C,.10-alkyl, (CH,).-sykloalkyl eller (CH,).-aryl; R, er C,.,-alkyl, (CH,).-sykloalkyl eller hydrogen; "¿ er "¿ eller H, når en av R, eller R, er ingenting og således danner det indre salt; R, er CH, eller H; "¿ er H- Br. CH, eller OCH,, forutsatt at en av R, eller R, er H; Z er (CH,).-aryl eller Cj.n-alkyl; X er hydrogen eller C,.,-alkyl; hver ra er uavhengig O, l, 2 eller 3; og n er l, 2 'eller 3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93400824A EP0618224A1 (en) | 1993-03-30 | 1993-03-30 | Phosphonomethyldipeptides |
| PCT/US1994/001716 WO1994022908A1 (en) | 1993-03-30 | 1994-02-22 | Phosphonomethyldipeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO953877D0 NO953877D0 (no) | 1995-09-29 |
| NO953877L true NO953877L (no) | 1995-11-30 |
Family
ID=8214693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953877A NO953877L (no) | 1993-03-30 | 1995-09-29 | Fosfonometyldipeptider |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP0618224A1 (no) |
| JP (1) | JP3541230B2 (no) |
| KR (1) | KR100311852B1 (no) |
| CN (1) | CN1120844A (no) |
| AT (1) | ATE192456T1 (no) |
| AU (1) | AU670866B2 (no) |
| CA (1) | CA2156742C (no) |
| DE (1) | DE69424281T2 (no) |
| DK (1) | DK0691985T3 (no) |
| ES (1) | ES2148322T3 (no) |
| FI (1) | FI954656A (no) |
| GR (1) | GR3034015T3 (no) |
| HU (1) | HU217836B (no) |
| IL (1) | IL109128A (no) |
| NO (1) | NO953877L (no) |
| NZ (1) | NZ262996A (no) |
| PT (1) | PT691985E (no) |
| TW (1) | TW290550B (no) |
| WO (1) | WO1994022908A1 (no) |
| ZA (1) | ZA942091B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583123A (en) * | 1994-12-22 | 1996-12-10 | Ciba-Geigy Corporation | Certain tetrazole derivatives |
| US5550119A (en) * | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8726714D0 (en) * | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| JP2811608B2 (ja) * | 1991-04-26 | 1998-10-15 | 日本ケミファ株式会社 | ホスホン酸アミド誘導体およびエンドセリン変換酵素阻害剤 |
| JPH05105698A (ja) * | 1991-06-13 | 1993-04-27 | Takeda Chem Ind Ltd | ホスホン酸誘導体、その製造法および用途 |
-
1993
- 1993-03-30 EP EP93400824A patent/EP0618224A1/en not_active Withdrawn
-
1994
- 1994-02-22 NZ NZ262996A patent/NZ262996A/en unknown
- 1994-02-22 DK DK94910701T patent/DK0691985T3/da active
- 1994-02-22 EP EP94910701A patent/EP0691985B1/en not_active Expired - Lifetime
- 1994-02-22 DE DE69424281T patent/DE69424281T2/de not_active Expired - Fee Related
- 1994-02-22 HU HU9502852A patent/HU217836B/hu not_active IP Right Cessation
- 1994-02-22 PT PT94910701T patent/PT691985E/pt unknown
- 1994-02-22 JP JP52205194A patent/JP3541230B2/ja not_active Expired - Fee Related
- 1994-02-22 ES ES94910701T patent/ES2148322T3/es not_active Expired - Lifetime
- 1994-02-22 CN CN94191635A patent/CN1120844A/zh active Pending
- 1994-02-22 AU AU62989/94A patent/AU670866B2/en not_active Ceased
- 1994-02-22 AT AT94910701T patent/ATE192456T1/de not_active IP Right Cessation
- 1994-02-22 KR KR1019950704199A patent/KR100311852B1/ko not_active IP Right Cessation
- 1994-02-22 CA CA002156742A patent/CA2156742C/en not_active Expired - Fee Related
- 1994-02-22 WO PCT/US1994/001716 patent/WO1994022908A1/en active IP Right Grant
- 1994-03-24 ZA ZA942091A patent/ZA942091B/xx unknown
- 1994-03-25 TW TW083102628A patent/TW290550B/zh active
- 1994-03-25 IL IL10912894A patent/IL109128A/en not_active IP Right Cessation
-
1995
- 1995-09-29 NO NO953877A patent/NO953877L/no unknown
- 1995-09-29 FI FI954656A patent/FI954656A/fi not_active IP Right Cessation
-
2000
- 2000-07-26 GR GR20000401701T patent/GR3034015T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ262996A (en) | 1996-06-25 |
| PT691985E (pt) | 2000-08-31 |
| DE69424281T2 (de) | 2000-09-21 |
| KR100311852B1 (ko) | 2002-02-28 |
| DK0691985T3 (da) | 2000-08-07 |
| TW290550B (no) | 1996-11-11 |
| JP3541230B2 (ja) | 2004-07-07 |
| HU217836B (hu) | 2000-04-28 |
| CA2156742A1 (en) | 1994-10-13 |
| AU670866B2 (en) | 1996-08-01 |
| IL109128A0 (en) | 1994-06-24 |
| AU6298994A (en) | 1994-10-24 |
| FI954656A0 (fi) | 1995-09-29 |
| WO1994022908A1 (en) | 1994-10-13 |
| ATE192456T1 (de) | 2000-05-15 |
| DE69424281D1 (en) | 2000-06-08 |
| IL109128A (en) | 1999-09-22 |
| CN1120844A (zh) | 1996-04-17 |
| EP0691985B1 (en) | 2000-05-03 |
| EP0618224A1 (en) | 1994-10-05 |
| NO953877D0 (no) | 1995-09-29 |
| ZA942091B (en) | 1994-10-24 |
| GR3034015T3 (en) | 2000-11-30 |
| CA2156742C (en) | 2001-04-17 |
| EP0691985A1 (en) | 1996-01-17 |
| HUT72465A (en) | 1996-04-29 |
| JPH08508480A (ja) | 1996-09-10 |
| ES2148322T3 (es) | 2000-10-16 |
| KR960701088A (ko) | 1996-02-24 |
| HU9502852D0 (en) | 1995-11-28 |
| FI954656A (fi) | 1995-09-29 |
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