CN1120334A - 用作血小板凝聚抑制剂的杂环衍生物 - Google Patents

用作血小板凝聚抑制剂的杂环衍生物 Download PDF

Info

Publication number
CN1120334A
CN1120334A CN94191664A CN94191664A CN1120334A CN 1120334 A CN1120334 A CN 1120334A CN 94191664 A CN94191664 A CN 94191664A CN 94191664 A CN94191664 A CN 94191664A CN 1120334 A CN1120334 A CN 1120334A
Authority
CN
China
Prior art keywords
group
compound
piperazine
pyridyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94191664A
Other languages
English (en)
Chinese (zh)
Inventor
M·G·韦恩
M·J·施密瑟斯
J·W·雷纳
A·W·法尔
R·J·皮尔斯
A·J·布卢斯特
R·E·舒特
S·D·米尔斯
P·W·R·考尔凯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of CN1120334A publication Critical patent/CN1120334A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN94191664A 1993-03-29 1994-03-28 用作血小板凝聚抑制剂的杂环衍生物 Pending CN1120334A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9306453.3 1993-03-29
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB9325605.5 1993-12-15
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
CN1120334A true CN1120334A (zh) 1996-04-10

Family

ID=26302668

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94191664A Pending CN1120334A (zh) 1993-03-29 1994-03-28 用作血小板凝聚抑制剂的杂环衍生物

Country Status (26)

Country Link
US (1) US5556977A (https=)
EP (2) EP0825184B1 (https=)
JP (1) JPH08508291A (https=)
KR (1) KR100231089B1 (https=)
CN (1) CN1120334A (https=)
AT (2) ATE202345T1 (https=)
AU (1) AU692438B2 (https=)
BR (1) BR9406613A (https=)
CA (1) CA2156070A1 (https=)
CZ (1) CZ250995A3 (https=)
DE (2) DE69411900T2 (https=)
DK (2) DK0825184T3 (https=)
ES (2) ES2119184T3 (https=)
FI (1) FI954616A0 (https=)
GB (1) GB9406143D0 (https=)
GR (2) GR3027751T3 (https=)
HU (2) HUT72088A (https=)
IL (1) IL109144A (https=)
NO (1) NO305244B1 (https=)
NZ (1) NZ262941A (https=)
PL (1) PL310889A1 (https=)
PT (1) PT825184E (https=)
SK (1) SK120895A3 (https=)
TW (1) TW276254B (https=)
WO (1) WO1994022834A1 (https=)
ZW (1) ZW4294A1 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
EP0799202A1 (de) * 1994-12-23 1997-10-08 Dr. Karl Thomae GmbH Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
US5700801A (en) * 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
FR2734818B1 (fr) * 1995-06-01 1998-07-10 Zeneca Ltd Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
AU710105B2 (en) * 1995-06-01 1999-09-16 Zeneca Limited (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
SK282833B6 (sk) * 1995-11-17 2002-12-03 Warner-Lambert Company Sulfónamidové inhibítory matricových metaloproteináz a farmaceutická kompozícia obsahujúca tieto inhibítory
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
US6313127B1 (en) * 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
JP2000505471A (ja) * 1996-02-28 2000-05-09 メルク エンド カンパニー インコーポレーテッド フィブリノーゲン受容体拮抗物質
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1997036887A1 (en) * 1996-03-29 1997-10-09 Meiji Seika Kaisha, Ltd. Novel heterocyclic compounds having platelet aggregation inhibitory effects
AU709631B2 (en) * 1996-06-28 1999-09-02 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5932582A (en) * 1996-06-28 1999-08-03 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5990107A (en) * 1996-06-28 1999-11-23 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
WO1998000134A1 (en) * 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonists
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US5945545A (en) * 1996-12-13 1999-08-31 Merck & Co., Inc. Fibrinogen receptor antagonists
JP2001511798A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ抑制剤として有用な複素環化合物
DE69815509T2 (de) 1997-02-13 2004-05-13 Astrazeneca Ab Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
US6221902B1 (en) 1998-05-12 2001-04-24 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
CA2331056A1 (en) 1998-05-12 1999-12-02 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en) 1998-05-12 2004-03-02 Wyeth Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
ES2221410T3 (es) * 1998-07-31 2004-12-16 Eli Lilly And Company Derivados heterociclil sulfamida.
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
DE60021368T2 (de) * 1999-04-19 2006-07-27 Lexicon Pharmaceuticals (New Jersey), Inc. Ppar-(gamma) agonisten zur behandlung von type ii diabetes
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
JP4564713B2 (ja) 2000-11-01 2010-10-20 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
AU2018352142B2 (en) 2017-10-18 2022-08-25 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
PT3704120T (pt) 2017-11-24 2024-07-03 Jubilant Episcribe Llc Compostos heterocíclicos como inibidores de prmt5
MX2020009517A (es) 2018-03-13 2021-01-20 Jubilant Prodel LLC Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1.

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875165A (en) * 1973-02-22 1975-04-01 Wyeth John & Brother Ltd (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
GB1474296A (en) * 1975-01-23 1977-05-18 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
JPS57183738A (en) * 1981-05-06 1982-11-12 Yamanouchi Pharmaceut Co Ltd Aromatic carboxylic acid derivative
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
CA1252788A (en) * 1985-03-12 1989-04-18 William J. Coates Pyridazinone derivatives
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
EP0264883A3 (en) * 1986-10-21 1990-04-04 Banyu Pharmaceutical Co., Ltd. Substituted pyridine derivatives
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
DE4134467A1 (de) * 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
DE69012570T2 (de) * 1989-07-25 1995-02-23 The Upjohn Co., Kalamazoo, Mich. Tertiäramin-alkenylphenylalkansulfonamide mit antiarrhythmischer wirkung.
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1992013552A1 (en) * 1991-02-05 1992-08-20 Smithkline Beecham Corporation Anti-aggregatory peptides containing an aromatic ester or amide
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
UA39849C2 (uk) * 1991-03-26 2001-07-16 Ф.Хоффманн-Ля Рош Аг ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
JPH08503920A (ja) * 1991-04-11 1996-04-30 ローヌ−プーラン ローラー インターナショナル（ホウルディングス） インコーポレイテッド 抗血栓ペプチドおよび偽ペプチド誘導体
WO1992019595A1 (en) * 1991-05-07 1992-11-12 Merck & Co., Inc. Fibrinogen receptor antagonists
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
ATE142641T1 (de) * 1991-05-13 1996-09-15 Fujisawa Pharmaceutical Co Neue peptid-verbindungen und verfahren zur herstellung davon
JPH05213884A (ja) * 1991-06-14 1993-08-24 Upjohn Co:The 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU646966B2 (en) * 1991-08-23 1994-03-10 Takeda Chemical Industries Ltd. 2-piperazinone compounds, their production and use
EP0630366B1 (en) * 1991-10-15 2003-01-02 G.D. Searle &amp; Co. Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
US5254573A (en) * 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
GB9122016D0 (en) * 1991-10-16 1991-11-27 Glaxo Group Ltd Chemical compounds
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
TW221996B (https=) * 1991-11-14 1994-04-01 Glaxo Group Ltd
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
AU3351293A (en) * 1992-01-21 1993-08-03 Glaxo Group Limited Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5264457A (en) * 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5726192A (en) * 1992-12-29 1998-03-10 Smithkline Beecham Corporation Platelet aggregation inhibiting compounds
TW301607B (https=) * 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
NO305244B1 (no) 1999-04-26
SK120895A3 (en) 1996-06-05
DE69427548T2 (de) 2002-04-18
DE69411900T2 (de) 1998-12-10
IL109144A0 (en) 1994-06-24
EP0691959B1 (en) 1998-07-22
ATE202345T1 (de) 2001-07-15
DK0825184T3 (da) 2001-09-10
GR3036640T3 (en) 2001-12-31
ES2119184T3 (es) 1998-10-01
HU211336A9 (en) 1995-11-28
ZW4294A1 (en) 1994-12-21
CZ250995A3 (en) 1996-01-17
GR3027751T3 (en) 1998-11-30
DE69427548D1 (de) 2001-07-26
HUT72088A (en) 1996-03-28
HU9502290D0 (en) 1995-10-30
WO1994022834A1 (en) 1994-10-13
JPH08508291A (ja) 1996-09-03
AU6288994A (en) 1994-10-24
AU692438B2 (en) 1998-06-11
EP0691959A1 (en) 1996-01-17
NO953837D0 (no) 1995-09-28
DK0691959T3 (da) 1999-04-26
NO953837L (no) 1995-09-28
US5556977A (en) 1996-09-17
EP0825184A1 (en) 1998-02-25
CA2156070A1 (en) 1994-10-13
EP0825184B1 (en) 2001-06-20
NZ262941A (en) 1997-07-27
FI954616A7 (fi) 1995-09-28
KR100231089B1 (ko) 1999-11-15
DE69411900D1 (de) 1998-08-27
ES2159798T3 (es) 2001-10-16
TW276254B (https=) 1996-05-21
PT825184E (pt) 2001-11-30
IL109144A (en) 2000-02-29
BR9406613A (pt) 1996-02-06
ATE168678T1 (de) 1998-08-15
FI954616L (fi) 1995-09-28
PL310889A1 (en) 1996-01-08
GB9406143D0 (en) 1994-05-18
FI954616A0 (fi) 1995-09-28

Similar Documents

Publication Publication Date Title
CN1120334A (zh) 用作血小板凝聚抑制剂的杂环衍生物
CN1049434C (zh) 芳族脒衍生物及其可药用盐的制备方法
CN1207289C (zh) 金属蛋白酶抑制剂,含有它们的药物组合物和其药物用途,其制备方法和中间体
CN1186322C (zh) 脯氨酸衍生物及其医药用途
CN1041923C (zh) 哌嗪衍生物及其制备方法及应用
CN100344632C (zh) 稠合的呋喃化合物
CN1070173C (zh) 用作药物的苯甲酰基胍衍生物
CN1248251A (zh) 二取代双环杂环,其制备法及作为药物的用途
CN1171394A (zh) 新的脲衍生物及其制法和医药用途
CN1193276A (zh) 氧化－角鲨烯环化酶抑制剂的降低血中胆甾醇的应用
CN1330637A (zh) 用于治疗炎性疾病的化合物
CN1253559A (zh) 芳族磺酰基α－羟基异羟肟酸化合物
CN1192729A (zh) 苯甲酰胺衍生物和它们作为后叶加压素拮抗剂的应用
CN1089947A (zh) 新的杂环化合物
CN1157617A (zh) 杂双环衍生物
CN1148503A (zh) 新的肽类化合物在制备药物中的应用
CN1328550A (zh) 作为前列腺素e2激动剂或拮抗剂的噁唑化合物
CN1290254A (zh) 氨磺酰衍生物及其制备和用途
CN1097753A (zh) 五员杂环、制备方法以及含有这些化合物的药物组合物
CN1278793A (zh) 磺酰基衍生物
CN1733725A (zh) 2－亚氨基吡咯烷衍生物
CN1069730A (zh) 2-哌嗪酮化合物及它们的制备和使用
CN1041919C (zh) 用作血小板激活因子拮抗物的N-(3-哌啶基碳酰)-β-氨基丙酸衍生物
CN1155599C (zh) 三环三唑并苯并氮杂�衍生物、用于制备该衍生物的方法和抗变态反应剂
CN1150162C (zh) 联苯基脒衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication