CN1120148C - 碘海醇的制备方法 - Google Patents

碘海醇的制备方法 Download PDF

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Publication number
CN1120148C
CN1120148C CN97197524A CN97197524A CN1120148C CN 1120148 C CN1120148 C CN 1120148C CN 97197524 A CN97197524 A CN 97197524A CN 97197524 A CN97197524 A CN 97197524A CN 1120148 C CN1120148 C CN 1120148C
Authority
CN
China
Prior art keywords
solvent
schering
methyl cellosolve
iohexol
virahol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN97197524A
Other languages
English (en)
Chinese (zh)
Other versions
CN1228763A (zh
Inventor
迪克·马尔思-索伦森
奥德·E·英格沃尔德斯泰德
埃斯彭·迈尔布拉滕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of CN1228763A publication Critical patent/CN1228763A/zh
Application granted granted Critical
Publication of CN1120148C publication Critical patent/CN1120148C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
CN97197524A 1996-08-29 1997-08-29 碘海醇的制备方法 Expired - Lifetime CN1120148C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9618056.7 1996-08-29
GBGB9618056.7A GB9618056D0 (en) 1996-08-29 1996-08-29 Process

Publications (2)

Publication Number Publication Date
CN1228763A CN1228763A (zh) 1999-09-15
CN1120148C true CN1120148C (zh) 2003-09-03

Family

ID=10799120

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97197524A Expired - Lifetime CN1120148C (zh) 1996-08-29 1997-08-29 碘海醇的制备方法

Country Status (25)

Country Link
US (2) US5948940A (cg-RX-API-DMAC7.html)
EP (1) EP0925275B1 (cg-RX-API-DMAC7.html)
JP (1) JP3780002B2 (cg-RX-API-DMAC7.html)
KR (1) KR100517588B1 (cg-RX-API-DMAC7.html)
CN (1) CN1120148C (cg-RX-API-DMAC7.html)
AT (1) ATE210631T1 (cg-RX-API-DMAC7.html)
AU (1) AU723184B2 (cg-RX-API-DMAC7.html)
BG (1) BG63663B1 (cg-RX-API-DMAC7.html)
BR (1) BR9711381A (cg-RX-API-DMAC7.html)
CA (1) CA2265047A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ295058B6 (cg-RX-API-DMAC7.html)
DE (1) DE69709127T2 (cg-RX-API-DMAC7.html)
EE (1) EE9900082A (cg-RX-API-DMAC7.html)
ES (1) ES2173476T3 (cg-RX-API-DMAC7.html)
GB (1) GB9618056D0 (cg-RX-API-DMAC7.html)
HU (1) HU229253B1 (cg-RX-API-DMAC7.html)
IL (1) IL128715A (cg-RX-API-DMAC7.html)
IN (1) IN186429B (cg-RX-API-DMAC7.html)
NO (1) NO322795B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ334817A (cg-RX-API-DMAC7.html)
PL (1) PL190151B1 (cg-RX-API-DMAC7.html)
PT (1) PT925275E (cg-RX-API-DMAC7.html)
SK (1) SK26499A3 (cg-RX-API-DMAC7.html)
TR (1) TR199900405T2 (cg-RX-API-DMAC7.html)
WO (1) WO1998008804A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US6262303B1 (en) * 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
NO20033058D0 (no) * 2003-07-03 2003-07-03 Amersham Health As Prosess
NO20053676D0 (no) 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
PT103391B (pt) 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
JP2011509943A (ja) 2008-01-14 2011-03-31 マリンクロッド・インコーポレイテッド イオシメノールを調製するためのプロセス
EP3113802A1 (en) * 2014-03-04 2017-01-11 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same
CN110054569B (zh) * 2019-05-17 2022-05-17 浙江海洲制药有限公司 一种制备碘海醇的方法
CN116178204A (zh) * 2022-04-21 2023-05-30 安徽普利药业有限公司 一种工业化生产碘海醇精制品的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1548594A (en) * 1922-05-27 1925-08-04 Helios Machine Company Motion-converting mechanism
CH608189A5 (cg-RX-API-DMAC7.html) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
ATE19622T1 (de) * 1982-10-01 1986-05-15 Nyegaard & Co As Roentgenkontrastmittel.
JPS59104352A (ja) * 1982-11-08 1984-06-16 ニユエガ−ド・アンド・コンパニ−・アクシエ・セルカペト Ｘ線造影剤
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5371278A (en) * 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process

Also Published As

Publication number Publication date
JP2000517312A (ja) 2000-12-26
IL128715A (en) 2002-08-14
AU723184B2 (en) 2000-08-17
US5948940A (en) 1999-09-07
CZ295058B6 (cs) 2005-05-18
IL128715A0 (en) 2000-01-31
JP3780002B2 (ja) 2006-05-31
CA2265047A1 (en) 1998-03-05
WO1998008804A1 (en) 1998-03-05
NZ334817A (en) 2000-09-29
NO990889D0 (no) 1999-02-25
DE69709127T2 (de) 2002-08-14
TR199900405T2 (xx) 1999-06-21
BR9711381A (pt) 1999-08-17
ES2173476T3 (es) 2002-10-16
PL331706A1 (en) 1999-08-02
EP0925275A1 (en) 1999-06-30
NO990889L (no) 1999-02-25
EE9900082A (et) 1999-10-15
GB9618056D0 (en) 1996-10-09
CN1228763A (zh) 1999-09-15
CZ66999A3 (cs) 1999-08-11
HUP9904325A3 (en) 2000-06-28
HU229253B1 (en) 2013-10-28
EP0925275B1 (en) 2001-12-12
ATE210631T1 (de) 2001-12-15
KR100517588B1 (ko) 2005-09-29
IN186429B (cg-RX-API-DMAC7.html) 2001-09-01
PT925275E (pt) 2002-05-31
KR20000035945A (ko) 2000-06-26
HK1020722A1 (en) 2000-05-19
NO322795B1 (no) 2006-12-11
AU4123697A (en) 1998-03-19
DE69709127D1 (de) 2002-01-24
PL190151B1 (pl) 2005-11-30
HUP9904325A2 (hu) 2000-04-28
SK26499A3 (en) 1999-08-06
BG103289A (en) 2000-01-31
BG63663B1 (bg) 2002-08-30
US6153796A (en) 2000-11-28

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: AERSHAME HEALTH CO.,LTD.

Free format text: FORMER NAME OR ADDRESS: IKEMADEKINMEIJIN CORP.

CP01 Change in the name or title of a patent holder

Patentee after: Amersham Health A/S

Patentee before: Nycomed Imaging A/S

C56 Change in the name or address of the patentee

Owner name: GE HEALTH CO.,LTD.

Free format text: FORMER NAME OR ADDRESS: AERSHAME HEALTH CO.,LTD.

CP01 Change in the name or title of a patent holder

Address after: Oslo, Norway

Patentee after: NYCOMED IMAGING A/S

Address before: Oslo, Norway

Patentee before: Amersham Health A/S

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20030903