CN111954679A - Hpv特异性结合分子 - Google Patents
Hpv特异性结合分子 Download PDFInfo
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- CN111954679A CN111954679A CN201880076631.8A CN201880076631A CN111954679A CN 111954679 A CN111954679 A CN 111954679A CN 201880076631 A CN201880076631 A CN 201880076631A CN 111954679 A CN111954679 A CN 111954679A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/28—Expressing multiple CARs, TCRs or antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
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- Biomedical Technology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762567750P | 2017-10-03 | 2017-10-03 | |
| US62/567,750 | 2017-10-03 | ||
| US201762597411P | 2017-12-11 | 2017-12-11 | |
| US62/597,411 | 2017-12-11 | ||
| US201862653529P | 2018-04-05 | 2018-04-05 | |
| US62/653,529 | 2018-04-05 | ||
| PCT/US2018/053650 WO2019070541A1 (en) | 2017-10-03 | 2018-09-28 | HPV-SPECIFIC BINDING MOLECULES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111954679A true CN111954679A (zh) | 2020-11-17 |
Family
ID=63963486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880076631.8A Pending CN111954679A (zh) | 2017-10-03 | 2018-09-28 | Hpv特异性结合分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11952408B2 (enExample) |
| EP (2) | EP3692063A1 (enExample) |
| JP (2) | JP2020537515A (enExample) |
| KR (1) | KR20200104284A (enExample) |
| CN (1) | CN111954679A (enExample) |
| AU (1) | AU2018345539A1 (enExample) |
| BR (1) | BR112020006643A2 (enExample) |
| CA (1) | CA3080546A1 (enExample) |
| IL (1) | IL273631A (enExample) |
| MA (1) | MA50613A (enExample) |
| MX (1) | MX2020003536A (enExample) |
| SG (1) | SG11202002728VA (enExample) |
| WO (1) | WO2019070541A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113321726A (zh) * | 2020-02-28 | 2021-08-31 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv的t细胞受体 |
| CN113789304A (zh) * | 2021-10-14 | 2021-12-14 | 深圳大学总医院 | 高亲和力tcr及其应用 |
| WO2022111475A1 (zh) * | 2020-11-26 | 2022-06-02 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv抗原的tcr |
| WO2023005859A1 (zh) * | 2021-07-27 | 2023-02-02 | 香雪生命科学技术(广东)有限公司 | 针对抗原ssx2的高亲和力t细胞受体 |
| WO2023036169A1 (en) * | 2021-09-07 | 2023-03-16 | Corregene Biotechnology Co., Ltd. | Antigen binding proteins and uses thereof |
| WO2023040946A1 (zh) * | 2021-09-17 | 2023-03-23 | 香雪生命科学技术(广东)有限公司 | 一种识别ssx2的高亲和力tcr |
| WO2023050063A1 (zh) * | 2021-09-28 | 2023-04-06 | 溧阳瑅赛生物医药有限公司 | 一种识别hla-a*02:01/e629-38的tcr及其应用 |
| CN116589557A (zh) * | 2023-03-15 | 2023-08-15 | 北京大学人民医院 | 一种肿瘤新生抗原特异性tcr及其应用 |
| WO2023179768A1 (zh) * | 2022-03-24 | 2023-09-28 | 香雪生命科学技术(广东)有限公司 | 一种识别mage-a4抗原的高亲和力tcr及其序列和应用 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| EP4212547A1 (en) | 2015-12-03 | 2023-07-19 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| KR20190062505A (ko) | 2016-10-03 | 2019-06-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Hpv-특이적 결합 분자 |
| PT3558339T (pt) | 2016-12-22 | 2024-03-15 | Cue Biopharma Inc | Polipeptídeos multiméricos moduladores de células t e métodos de utilização dos mesmos |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| CA3054955A1 (en) | 2017-03-15 | 2018-09-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| EP3725092A4 (en) | 2017-12-14 | 2021-09-22 | FloDesign Sonics, Inc. | DRIVE AND CONTROL UNIT FOR ACOUSTIC CONVERTER |
| KR102764123B1 (ko) | 2018-04-05 | 2025-02-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Τ 세포 수용체 및 이를 발현하는 조작된 세포 |
| JP7589047B2 (ja) * | 2018-04-05 | 2024-11-25 | ジュノー セラピューティクス インコーポレイテッド | 組換え受容体を発現する細胞の作製方法および関連組成物 |
| KR20210091160A (ko) * | 2018-10-16 | 2021-07-21 | 인텔리아 테라퓨틱스, 인크. | 면역요법을 위한 조성물 및 방법 |
| CN114025788A (zh) * | 2019-05-01 | 2022-02-08 | 朱诺治疗学股份有限公司 | 从经修饰的tgfbr2基因座表达重组受体的细胞、相关多核苷酸和方法 |
| KR20220029584A (ko) | 2019-05-27 | 2022-03-08 | 이매틱스 유에스 인코포레이티드 | 바이러스 벡터 및 입양 세포 요법에서 그 사용 |
| CN113072635B (zh) * | 2020-01-06 | 2023-08-25 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv抗原的t细胞受体及其编码序列 |
| AU2021243742A1 (en) * | 2020-03-23 | 2022-11-10 | The Council Of The Queensland Institute Of Medical Research | Compositions and methods for targeting HPV-infected cells |
| KR20220160040A (ko) * | 2020-03-27 | 2022-12-05 | 2세븐티 바이오, 인코포레이티드 | T 세포 수용체 |
| US20240148869A1 (en) * | 2020-05-07 | 2024-05-09 | China Immunotech (Beijing) Biotechnology Co., Ltd | Improved T cell receptor-costimulatory molecule chimera |
| WO2021231376A2 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| WO2021254458A1 (zh) * | 2020-06-17 | 2021-12-23 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv抗原的高亲和力t细胞受体 |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ, インコーポレイテッド | 1型真性糖尿病(t1d)を治療するためのmhcクラスii t細胞調節多量体ポリペプチド及びその使用方法 |
| WO2022060904A1 (en) | 2020-09-16 | 2022-03-24 | Obsidian Therapeutics, Inc. | Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells |
| WO2022093694A1 (en) * | 2020-10-26 | 2022-05-05 | A2 Biotherapeutics, Inc. | Polypeptides targeting hpv peptide-mhc complexes and methods of use thereof |
| US20240009240A1 (en) * | 2020-11-05 | 2024-01-11 | Board Of Regents, The University Of Texas System | Engineered t cell receptors targeting egfr antigens and methods of use |
| WO2022099032A1 (en) * | 2020-11-06 | 2022-05-12 | Bioventures, Llc | T cells and bifunctional protein against human papillomavirus |
| CA3167637A1 (en) * | 2020-12-21 | 2022-06-30 | Eric Escobar-Cabrera | Stabilized tcr constructs and methods of use |
| WO2022187406A1 (en) | 2021-03-03 | 2022-09-09 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
| WO2022233956A1 (en) | 2021-05-05 | 2022-11-10 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| CN113912701B (zh) * | 2021-10-14 | 2024-07-19 | 深圳大学总医院 | Tcr及其在诊断/治疗中的应用 |
| WO2023081900A1 (en) | 2021-11-08 | 2023-05-11 | Juno Therapeutics, Inc. | Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods |
| CA3237646A1 (en) * | 2021-11-10 | 2023-05-19 | Tscan Therapeutics, Inc. | Binding proteins recognizing hpv16 e7 antigen and uses thereof |
| WO2023196884A1 (en) * | 2022-04-06 | 2023-10-12 | Juno Therapeutics, Inc. | Detection assay for human papillomavirus (hpv) type 16 (hpv-16) |
| AU2023259611A1 (en) * | 2022-04-28 | 2024-11-14 | Cue Biopharma, Inc. | Modified cytotoxic t cells and methods of use thereof |
| JP2025531850A (ja) | 2022-09-08 | 2025-09-25 | ジュノー セラピューティクス インコーポレイテッド | T細胞療法および継続的または間欠的dgk阻害剤投薬の組合せ |
| WO2025137646A1 (en) | 2023-12-22 | 2025-06-26 | Recode Therapeutics, Inc. | Gene editing methods and compositions for treating cystic fibrosis |
| WO2025226774A1 (en) * | 2024-04-24 | 2025-10-30 | Bluesphere Bio, Inc. | T cell receptors targeting minor histocompatibility antigen acc-1 |
| US20250345431A1 (en) | 2024-05-10 | 2025-11-13 | Juno Therapeutics, Inc. | Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015184228A1 (en) * | 2014-05-29 | 2015-12-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human papillomavirus 16 e7 t cell receptors |
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| CN113321726A (zh) * | 2020-02-28 | 2021-08-31 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv的t细胞受体 |
| CN113321726B (zh) * | 2020-02-28 | 2024-05-28 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv的t细胞受体 |
| WO2022111475A1 (zh) * | 2020-11-26 | 2022-06-02 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv抗原的tcr |
| WO2023005859A1 (zh) * | 2021-07-27 | 2023-02-02 | 香雪生命科学技术(广东)有限公司 | 针对抗原ssx2的高亲和力t细胞受体 |
| WO2023036169A1 (en) * | 2021-09-07 | 2023-03-16 | Corregene Biotechnology Co., Ltd. | Antigen binding proteins and uses thereof |
| WO2023040946A1 (zh) * | 2021-09-17 | 2023-03-23 | 香雪生命科学技术(广东)有限公司 | 一种识别ssx2的高亲和力tcr |
| WO2023050063A1 (zh) * | 2021-09-28 | 2023-04-06 | 溧阳瑅赛生物医药有限公司 | 一种识别hla-a*02:01/e629-38的tcr及其应用 |
| CN113789304A (zh) * | 2021-10-14 | 2021-12-14 | 深圳大学总医院 | 高亲和力tcr及其应用 |
| CN113789304B (zh) * | 2021-10-14 | 2023-03-31 | 深圳大学总医院 | 高亲和力tcr及其应用 |
| WO2023179768A1 (zh) * | 2022-03-24 | 2023-09-28 | 香雪生命科学技术(广东)有限公司 | 一种识别mage-a4抗原的高亲和力tcr及其序列和应用 |
| CN116589557A (zh) * | 2023-03-15 | 2023-08-15 | 北京大学人民医院 | 一种肿瘤新生抗原特异性tcr及其应用 |
| CN116589557B (zh) * | 2023-03-15 | 2024-04-02 | 北京大学人民医院 | 一种肿瘤新生抗原特异性tcr及其应用 |
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| AU2018345539A1 (en) | 2020-04-16 |
| IL273631A (en) | 2020-05-31 |
| MA50613A (fr) | 2020-08-12 |
| BR112020006643A2 (pt) | 2020-09-24 |
| RU2020115148A (ru) | 2021-11-09 |
| US20210284709A1 (en) | 2021-09-16 |
| WO2019070541A1 (en) | 2019-04-11 |
| EP4215543A2 (en) | 2023-07-26 |
| KR20200104284A (ko) | 2020-09-03 |
| JP2023099142A (ja) | 2023-07-11 |
| EP3692063A1 (en) | 2020-08-12 |
| JP2020537515A (ja) | 2020-12-24 |
| CA3080546A1 (en) | 2019-04-11 |
| EP4215543A3 (en) | 2023-10-11 |
| MX2020003536A (es) | 2020-09-14 |
| SG11202002728VA (en) | 2020-04-29 |
| US11952408B2 (en) | 2024-04-09 |
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