CN111670038A - 糖胺聚糖衍生物及其制备方法和用途 - Google Patents
糖胺聚糖衍生物及其制备方法和用途 Download PDFInfo
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- CN111670038A CN111670038A CN201980011282.6A CN201980011282A CN111670038A CN 111670038 A CN111670038 A CN 111670038A CN 201980011282 A CN201980011282 A CN 201980011282A CN 111670038 A CN111670038 A CN 111670038A
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
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Abstract
公开了一种糖胺聚糖羧基化衍生物、其制备方法，及其用于抑制肿瘤生长和/或转移的用途。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810105528 | 2018-02-02 | ||
| CN2018101055283 | 2018-02-02 | ||
| PCT/CN2019/073572 WO2019149179A1 (zh) | 2018-02-02 | 2019-01-29 | 糖胺聚糖衍生物及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111670038A true CN111670038A (zh) | 2020-09-15 |
| CN111670038B CN111670038B (zh) | 2024-01-26 |
Family
ID=67478627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980011282.6A Active CN111670038B (zh) | 2018-02-02 | 2019-01-29 | 糖胺聚糖衍生物及其制备方法和用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11225531B2 (zh) |
| CN (1) | CN111670038B (zh) |
| TW (1) | TWI798351B (zh) |
| WO (1) | WO2019149179A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022143853A1 (zh) | 2020-12-31 | 2022-07-07 | 深圳市海普瑞药业集团股份有限公司 | 一种用于检测样品中糖胺聚糖羧酸化衍生物含量的方法及其应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114901702B (zh) * | 2019-12-27 | 2024-01-09 | 深圳市海普瑞药业集团股份有限公司 | 一种糖胺聚糖衍生物及其应用 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001003A1 (en) * | 1990-07-10 | 1992-01-23 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion-ii |
| CN1396930A (zh) * | 2000-01-25 | 2003-02-12 | 希格马托制药工业公司 | 具有抗血管生成活性且没有抗凝作用的部分脱硫酸化糖胺聚糖的衍生物 |
| CN1422283A (zh) * | 2000-03-30 | 2003-06-04 | 伊纳尔科公司 | K5多糖衍生的具有高抗凝和抗血栓形成活性的葡糖胺聚糖及其制备方法 |
| CN1547477A (zh) * | 2001-09-12 | 2004-11-17 | ϣ��������ҩ��ҵ��˾ | 具有抗血管生成活性且没有抗凝作用的作为类肝素酶抑制剂的部分脱硫酸化糖胺聚糖衍生物 |
| CN101885787A (zh) * | 2009-05-11 | 2010-11-17 | 深圳市海普瑞药业股份有限公司 | 一种从肝素副产物纯化硫酸乙酰肝素的方法 |
| CN103288981A (zh) * | 2013-06-20 | 2013-09-11 | 深圳市海普瑞药业股份有限公司 | 一种抑制细胞增殖的硫酸酯化的硫酸乙酰肝素 |
| ITLO20130006A1 (it) * | 2013-11-06 | 2015-05-07 | He E Biochimiche G Ronzoni S R | Derivati carbossilati di glucosamminoglicani e loro uso come farmaci |
| CN105814086A (zh) * | 2013-10-31 | 2016-07-27 | ＂G.龙佐尼＂ S.R.生化高科技研究中心 | N-脱硫酸化葡糖胺聚糖的衍生物以及作为药物的用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105504097B (zh) * | 2015-12-30 | 2018-07-03 | 深圳市海普瑞药业集团股份有限公司 | 一种硫酸化肝素寡糖及其制备方法和应用 |
-
2019
- 2019-01-29 WO PCT/CN2019/073572 patent/WO2019149179A1/zh active Application Filing
- 2019-01-29 US US16/966,951 patent/US11225531B2/en active Active
- 2019-01-29 CN CN201980011282.6A patent/CN111670038B/zh active Active
- 2019-02-01 TW TW108104233A patent/TWI798351B/zh active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001003A1 (en) * | 1990-07-10 | 1992-01-23 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion-ii |
| CN1396930A (zh) * | 2000-01-25 | 2003-02-12 | 希格马托制药工业公司 | 具有抗血管生成活性且没有抗凝作用的部分脱硫酸化糖胺聚糖的衍生物 |
| CN1422283A (zh) * | 2000-03-30 | 2003-06-04 | 伊纳尔科公司 | K5多糖衍生的具有高抗凝和抗血栓形成活性的葡糖胺聚糖及其制备方法 |
| CN1547477A (zh) * | 2001-09-12 | 2004-11-17 | ϣ��������ҩ��ҵ��˾ | 具有抗血管生成活性且没有抗凝作用的作为类肝素酶抑制剂的部分脱硫酸化糖胺聚糖衍生物 |
| CN101885787A (zh) * | 2009-05-11 | 2010-11-17 | 深圳市海普瑞药业股份有限公司 | 一种从肝素副产物纯化硫酸乙酰肝素的方法 |
| CN103288981A (zh) * | 2013-06-20 | 2013-09-11 | 深圳市海普瑞药业股份有限公司 | 一种抑制细胞增殖的硫酸酯化的硫酸乙酰肝素 |
| CN105814086A (zh) * | 2013-10-31 | 2016-07-27 | ＂G.龙佐尼＂ S.R.生化高科技研究中心 | N-脱硫酸化葡糖胺聚糖的衍生物以及作为药物的用途 |
| ITLO20130006A1 (it) * | 2013-11-06 | 2015-05-07 | He E Biochimiche G Ronzoni S R | Derivati carbossilati di glucosamminoglicani e loro uso come farmaci |
| CN105744940A (zh) * | 2013-11-06 | 2016-07-06 | ＂G.龙佐尼＂ S.R.生化高科技研究中心 | 葡糖胺聚糖的羧基化衍生物以及作为药物的用途 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022143853A1 (zh) | 2020-12-31 | 2022-07-07 | 深圳市海普瑞药业集团股份有限公司 | 一种用于检测样品中糖胺聚糖羧酸化衍生物含量的方法及其应用 |
| CN116710772A (zh) * | 2020-12-31 | 2023-09-05 | 深圳市海普瑞药业集团股份有限公司 | 一种用于检测样品中糖胺聚糖羧酸化衍生物含量的方法及其应用 |
| CN116710772B (zh) * | 2020-12-31 | 2024-04-02 | 深圳市海普瑞药业集团股份有限公司 | 一种用于检测样品中糖胺聚糖羧酸化衍生物含量的方法及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201934584A (zh) | 2019-09-01 |
| US11225531B2 (en) | 2022-01-18 |
| US20210032376A1 (en) | 2021-02-04 |
| CN111670038B (zh) | 2024-01-26 |
| TWI798351B (zh) | 2023-04-11 |
| WO2019149179A1 (zh) | 2019-08-08 |
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