CN111298119A - 用于通过使用肾相关抗原1(kaag1)的抑制剂来治疗三阴性乳癌和基底样乳癌的方法 - Google Patents
用于通过使用肾相关抗原1(kaag1)的抑制剂来治疗三阴性乳癌和基底样乳癌的方法 Download PDFInfo
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| EP2691421B1 (en) | 2011-03-31 | 2016-11-09 | Alethia Biotherapeutics Inc. | Antibodies against kidney associated antigen 1 and antigen binding fragments thereof |
| EA201992513A1 (ru) | 2012-01-09 | 2020-05-31 | Адс Терапьютикс Са | Способ лечения рака груди |
| US11384098B2 (en) | 2017-02-08 | 2022-07-12 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| GB201908128D0 (en) | 2019-06-07 | 2019-07-24 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CN114262718B (zh) * | 2021-12-28 | 2022-11-15 | 武汉爱博泰克生物科技有限公司 | 一种人源Ly6d重组蛋白细胞分泌表达方法及应用 |
| JPWO2024106394A1 (enExample) * | 2022-11-14 | 2024-05-23 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101663322A (zh) * | 2006-12-14 | 2010-03-03 | 株式会社未来创药研究所 | 抗紧密连接蛋白3单克隆抗体以及使用该抗体的癌症的治疗和诊断 |
| WO2010060186A1 (en) * | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| US20110150979A1 (en) * | 2009-08-06 | 2011-06-23 | Ray Partha S | Methods for diagnosis, prognosis and treatment of primary and metastatic basal-like breast cancer and other cancer types |
Family Cites Families (193)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075447A (en) | 1984-09-17 | 1991-12-24 | Hoffmann-La Roche Inc. | Ruthenium complexes useful as carriers for immunologically active materials |
| DK365785A (da) | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
| GB8601646D0 (en) | 1986-01-23 | 1986-02-26 | Davidson R S | Binding assay & reagent |
| US5585279A (en) | 1986-01-23 | 1996-12-17 | Davidson; Robert S. | Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium |
| US6018030A (en) | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| CA2071529C (en) | 1989-12-28 | 2001-03-20 | Donna Lee Romero | Diaromatic substituted anti-aids compounds |
| IL105325A (en) | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
| WO1996013510A1 (en) | 1994-10-28 | 1996-05-09 | Procept, Inc. | Ruthenium complexes and their use as immunosuppressive agents |
| US5708022A (en) | 1994-10-28 | 1998-01-13 | Procept, Inc. | Method for inhibiting immune response |
| US5712127A (en) | 1996-04-29 | 1998-01-27 | Genescape Inc. | Subtractive amplification |
| US5831003A (en) | 1996-06-28 | 1998-11-03 | Bayer Corporation | Peptides which bind to prothrombin and thrombin |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| AU755913B2 (en) | 1997-06-18 | 2003-01-02 | Masad Damha | Nucleic acid biosensor diagnostics |
| WO1999031513A1 (en) | 1997-12-15 | 1999-06-24 | Lakowicz Joseph R | Method and composition for characterizing a sample containing a sample lipid and an assay kit |
| US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| US6472367B1 (en) | 1998-05-05 | 2002-10-29 | Adherex Technologies, Inc. | Compounds and methods for modulating OB-cadherin mediated cell adhesion |
| JP2002514400A (ja) | 1998-05-13 | 2002-05-21 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 遍在的に発現される新規な遺伝子のリバースストランドによってコードされている腫瘍関連抗原 |
| JP4493846B2 (ja) | 1998-05-13 | 2010-06-30 | ドマンティス リミテッド | 選択系 |
| US7037667B1 (en) | 1998-06-01 | 2006-05-02 | Agensys, Inc. | Tumor antigen useful in diagnosis and therapy of prostate and colon cancer |
| US7521197B2 (en) | 1998-06-05 | 2009-04-21 | Alexis Biotech Limited | Method for producing cytotoxic T-cells |
| US20020106678A1 (en) | 1998-06-30 | 2002-08-08 | Robishaw Janet D. | cDNA clones encoding human G protein gamma subunits |
| US6562823B1 (en) | 1998-07-02 | 2003-05-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6288221B1 (en) | 1998-08-20 | 2001-09-11 | Duke University | Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction |
| WO2000014515A1 (en) | 1998-09-08 | 2000-03-16 | University Of Maryland At Baltimore | Low frequency modulation sensors using nanosecond fluorophores |
| US6806089B1 (en) | 1998-09-08 | 2004-10-19 | University Of Maryland, Baltimore | Low frequency modulation sensors using nanosecond fluorophores |
| EP1123294A1 (en) | 1998-10-22 | 2001-08-16 | Phillip B. B. Moheno | Novel pterin antineoplastic agents |
| AU762440B2 (en) | 1998-10-29 | 2003-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US20020049190A1 (en) | 1999-03-19 | 2002-04-25 | Bridger Gary J. | Pharmaceutical compositions comprising metal complexes |
| US6872519B1 (en) | 1999-04-27 | 2005-03-29 | Mirus Bio Corporation | In vitro process for selecting phage resistant to blood inactivation |
| US20090087878A9 (en) | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| IL148698A0 (en) | 1999-09-17 | 2002-09-12 | Cor Therapeutics Inc | INHIBITORS OF FACTOR Xa |
| WO2001046209A1 (en) | 1999-12-20 | 2001-06-28 | Fluorrx, Inc. | Fluorescent probes |
| US20030219806A1 (en) | 2000-02-22 | 2003-11-27 | Millennium Pharmaceuticals, Inc. | Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor |
| US7585839B2 (en) | 2000-02-23 | 2009-09-08 | Zealand Pharma A/S | Medical uses of intercellular communication facilitating compounds |
| US20030215860A1 (en) | 2000-02-29 | 2003-11-20 | Millennium Pharmaceuticals, Inc. | Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor |
| US20030165831A1 (en) | 2000-03-21 | 2003-09-04 | John Lee | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US7834146B2 (en) | 2000-05-08 | 2010-11-16 | Monsanto Technology Llc | Recombinant polypeptides associated with plants |
| WO2001098468A2 (en) | 2000-06-16 | 2001-12-27 | Incyte Genomics, Inc. | Proteases |
| AU2002214531A1 (en) | 2000-07-03 | 2002-01-30 | Curagen Corporation | Proteins and nucleic acids encoding same |
| US20050053930A1 (en) | 2000-07-18 | 2005-03-10 | David Anderson | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US6812339B1 (en) | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| GB0023008D0 (en) | 2000-09-20 | 2000-11-01 | Glaxo Group Ltd | Improvements in vaccination |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7320793B2 (en) | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US6783969B1 (en) | 2001-03-05 | 2004-08-31 | Nuvelo, Inc. | Cathepsin V-like polypeptides |
| US7030236B2 (en) | 2001-03-09 | 2006-04-18 | Mona Savitri Jhaveri | Antisense oligonucleotides tarageting folate receptor alpha, and the use thereof |
| US20030087250A1 (en) | 2001-03-14 | 2003-05-08 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
| US20030065157A1 (en) | 2001-04-04 | 2003-04-03 | Lasek Amy W. | Genes expressed in lung cancer |
| EP1573024A4 (en) | 2001-04-10 | 2007-08-29 | Agensys Inc | NUCLEIC ACIDS AND SUITABLE PROTEINS SUITABLE FOR THE TREATMENT AND EVIDENCE OF VARIOUS CANCER DISEASES |
| AU2002309583A1 (en) | 2001-04-18 | 2002-11-05 | Protein Desing Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| EP1390511B1 (en) | 2001-05-07 | 2008-03-12 | National Research Council Of Canada | Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| WO2002102235A2 (en) | 2001-06-18 | 2002-12-27 | Eos Biotechnology Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| US20040053824A1 (en) | 2001-06-29 | 2004-03-18 | Tang Y Tom | Extracellular matrix and cell adhesion molecules |
| US20030099974A1 (en) | 2001-07-18 | 2003-05-29 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits and methods for identification, assessment, prevention, and therapy of breast cancer |
| EP1421105B1 (en) | 2001-08-31 | 2010-10-06 | Btg International Limited | Anti-cancer cyclopenta¬g quinazoline compounds |
| PT1420809E (pt) | 2001-08-31 | 2012-01-03 | Btg Int Ltd | Utilização de derivados de ciclopenta[g]quinazolina para tratamento de cancro |
| US7622260B2 (en) | 2001-09-05 | 2009-11-24 | The Brigham And Women's Hospital, Inc. | Diagnostic and prognostic tests |
| US20030124579A1 (en) | 2001-09-05 | 2003-07-03 | Eos Biotechnology, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| RS54204A (sr) | 2001-11-19 | 2006-12-15 | Elan Pharmaceuticals Inc. | 3,4-disupstituisani, 3,5-disupstituisani i 3,4,5- supstituisani piperidini i piperazini |
| AU2002351194A1 (en) | 2001-11-30 | 2003-06-17 | Incyte Genomics, Inc. | Cell adhesion and extracellular matrix proteins |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| US7803749B2 (en) | 2002-01-09 | 2010-09-28 | Xigen Sa | Peptide inhibitors of MKK7 kinase binding to insulin binding proteins |
| ES2291613T3 (es) | 2002-01-16 | 2008-03-01 | Biocompatibles Uk Limited | Conjugados de polimeros. |
| EP1478328B1 (en) | 2002-01-28 | 2013-06-05 | Keraplast Technologies Ltd. | Bioactive keratin peptides |
| US6962910B2 (en) | 2002-02-01 | 2005-11-08 | Virginia Tech Intellectual Properties, Inc. | Supramolecular complexes as photoactivated DNA cleavage agents |
| US20050095592A1 (en) | 2002-02-13 | 2005-05-05 | Jazaeri Amir A. | Identification of ovarian cancer tumor markers and therapeutic targets |
| DE10206616A1 (de) | 2002-02-15 | 2003-09-04 | Qiagen Gmbh | Verfahren zur Reduktion der Background-Kontamination nach Markierungsreaktionen |
| US20040009939A1 (en) | 2002-03-05 | 2004-01-15 | Board Of Regent, The University Of Texas System | Methods of enhancing immune induction involving MDA-7 |
| EP1532175B1 (en) | 2002-03-22 | 2012-10-17 | Aprogen, Inc. | Humanized antibody and process for preparing the same |
| AU2003223520A1 (en) | 2002-04-12 | 2003-10-27 | Mitokor | Targets for therapeutic intervention identified in the mitochondrial proteome |
| WO2003099205A2 (en) | 2002-05-20 | 2003-12-04 | Abgenix, Inc. | Treatment of renal carcinoma using antibodies against the egfr |
| JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| EP1422242A1 (en) | 2002-11-22 | 2004-05-26 | Emory University | Plastic and elastic protein copolymers |
| CN1768139A (zh) | 2003-02-10 | 2006-05-03 | 独立行政法人产业技术总合研究所 | 通过dna干扰调控基因的表达 |
| WO2004087874A2 (en) | 2003-03-28 | 2004-10-14 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
| CA2526069A1 (en) | 2003-05-20 | 2004-12-02 | Cellpep Sa | Modified antiviral peptides with increased activity and cell membrane affinity |
| CA2526393A1 (en) | 2003-05-21 | 2004-12-02 | Genesense Technologies Inc. | Antisense oligonucleotides directed to ribonucleotide reductase r1 and uses thereof in the treatment of cancer |
| WO2005021710A2 (en) | 2003-06-02 | 2005-03-10 | University Of Miami | Chimeric molecules and methods of use |
| WO2005004795A2 (en) | 2003-06-09 | 2005-01-20 | University Of Cincinnati | Compositions and methods for targeted drug delivery |
| US20060078941A1 (en) | 2003-06-09 | 2006-04-13 | Santin Alessandro D | Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| GB0318096D0 (en) | 2003-08-01 | 2003-09-03 | Queen Mary & Westfield College | Vaccine |
| DE10335833A1 (de) | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
| US20070178458A1 (en) | 2003-09-05 | 2007-08-02 | O'brien Philippa | Methods of diagnosis and prognosis of ovarian cancer II |
| US20050147621A1 (en) | 2003-10-10 | 2005-07-07 | Higgins Darren E. | Use of bacterial 5' untranslated regions for nucleic acid expression |
| DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| JP2007514648A (ja) | 2003-10-24 | 2007-06-07 | エーザイ株式会社 | Toll−likereceptor2に関連する疾患及び状態を治療するための化合物及び方法 |
| US20050153333A1 (en) | 2003-12-02 | 2005-07-14 | Sooknanan Roy R. | Selective terminal tagging of nucleic acids |
| EP1547581A1 (en) | 2003-12-23 | 2005-06-29 | Vectron Therapeutics AG | Liposomal vaccine for the treatment of human hematological malignancies |
| EP1550458A1 (en) | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
| WO2005066337A2 (en) | 2004-01-09 | 2005-07-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds, pharmaceutical compositions and therapeutic methods of preventing and treating diseases and disorders associated with amyloid fibril formation |
| WO2005070456A2 (en) | 2004-01-09 | 2005-08-04 | Millennium Pharmaceuticals, Inc. | Diagnosing and treating female reproductive tract or chilhood cancer with pmsa antibodies |
| EP1747284A4 (en) | 2004-02-06 | 2009-03-11 | Wyeth Corp | DIAGNOSTICS AND THERAPEUTICS OF CANCER |
| JP4912894B2 (ja) | 2004-02-19 | 2012-04-11 | イェール ユニバーシティー | プロテオーム技術を使用した癌タンパク質バイオマーカーの同定 |
| BRPI0507822A (pt) | 2004-03-01 | 2007-07-10 | Peptera Pharmaceuticals Ltd | método e composição farmacêutica para a prevenção ou o tratamento de uma doença ou uma condição autoimune ou infecciosa, método e composição farmacêutica para a prevenção ou o tratamento de uma doença ou uma condição do sangue, método e composição farmacêutica para modular a formação de células do sangue, método e composição farmacêutica para intensificar a mobilização periférico da célula tronco, método e composição farmacêutica para a prevenção ou o tratamento de uma doença ou uma condição metabólica, método e composição farmacêutica para a prevenção ou o tratamento das condições associadas com doses mieloablativas de quimioradioterapia suportadas pelo transplante autólogo de medula óssea ou de células tronco do sangue periférico (asct) ou pelo transplante alogenéico de medula óssea (bmt), método e composição farmacêutica para aumentar o efeito de um fator estimulante de células do sangue, método e composição farmacêutica para intensificar a colonização de células tronco do sangue doadas em um receptor mieloablatado, método e composição farmacêutica para a prevenção ou o tratamento de uma doença ou uma condição bacteriana, composição farmacêutica para o tratamento ou a prevenção de uma indicação selecionada do grupo que consiste em doença ou condição autoimune, doença viral, infecção viral, doença hematológica, deficiências hematológicas, trombocitopenia, pancitopenia, granulopenia, hiperlipidemia, hipercolesterolemia, glucosuria, hiperglicemia, diabetes, aids, hiv-1, distúrbios de células t auxiliares, deficiências de células dendrìticas, deficiências de macrofagos, distúrbios de células tronco hematopoiéticas incluindo distúrbios com plaquetas, linfócitos, células do plasma e neutrófilos, condições pré-leucêmicas, condições leucêmicas, distúrbios do sistema imunológico resultantes da terapia de quimioterapia ou de radiação, distúrbios do sistema imunológico humano resultantes do tratamento das doenças de deficiência imunológica e infecções bacterianas, composição farmacêutica para o tratamento ou a prevenção de um indicação selecionada do grupo que consiste em doença hematológica, deficiências hematológicas, trombocitopenia, pancitopenia, granulopenia, deficiências de células dendrìticas, deficiências de macrofagos, distúrbios de células tronco hematopoiéticas incluindo distúrbios com plaquetas, linfócitos, células do plasma e neutrófilos, condições pré-leucêmicas, condições leucêmicas, sìndrome mielodisplástiacas, malignidades não mielóides, anemia plástica e insuficiência da medula óssea, peptìdeo purificado, peptìdeo quimérico purificado, peptìdeo quimérico, composição farmacêutica, composição farmacêutica para a prevenção ou o tratamento de uma condição associada com um agente infeccioso de sars, método de processamento a baixa temperatura de hidrolisato proteolìtico de caseìna e hidrolisato de proteìna de caseìna |
| EP1784430A1 (en) | 2004-07-06 | 2007-05-16 | Warwick Effect Polymers Limited | Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith , polypeptide conjugates and drugs obtained therefrom. |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| WO2007084413A2 (en) | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7553944B2 (en) | 2004-07-21 | 2009-06-30 | The University Of Hong Kong | Human virus causing respiratory tract infection and uses thereof |
| WO2006026569A2 (en) | 2004-08-27 | 2006-03-09 | Northeastern University | Comprehensive characterization of complex proteins at trace levels |
| DE102004042546A1 (de) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Kombinationstherapie zur Immunstimulation |
| WO2006027202A1 (en) | 2004-09-06 | 2006-03-16 | Unite De Recherche En Biotherapie Et Oncologie (Rubio) | Generation of multiparent cell hybrids |
| US7829708B2 (en) | 2004-09-08 | 2010-11-09 | Chelsea Therapeutics, Inc. | Metabolically inert antifolates for treating disorders of abnormal cellular proliferation and inflammation |
| US8247371B2 (en) | 2004-10-14 | 2012-08-21 | Yale University | Therapy with Clostridium perfringens enterotoxin to treat ovarian and uterine cancer |
| DK2586456T3 (en) | 2004-10-29 | 2016-03-21 | Ratiopharm Gmbh | Conversion and glycopegylation of fibroblast growth factor (FGF) |
| US7429567B2 (en) | 2005-01-04 | 2008-09-30 | The Brigham And Women's Hospital, Inc. | Sustained delivery of PDGF using self-assembling peptide nanofibers |
| US7531533B2 (en) | 2005-01-27 | 2009-05-12 | Asahi Kasei Pharma Corporation | 6-Membered heterocyclic compound and use thereof |
| CA2596003C (en) | 2005-01-27 | 2012-12-18 | Asahi Kasei Pharma Corporation | Six-membered heterocyclic compound and use thereof |
| CN101119744B (zh) | 2005-02-14 | 2013-03-13 | 埃皮托皮克斯有限责任公司 | 来自金黄色葡萄球菌的多肽和使用方法 |
| AU2006216683A1 (en) | 2005-02-24 | 2006-08-31 | Cemines, Inc. | Compositions and methods for classifying biological samples |
| US7902196B2 (en) | 2005-03-17 | 2011-03-08 | President And Fellows Of Harvard College | Synthesis of avrainvillamide, strephacidin B, and analogues thereof |
| CA2578908C (en) | 2005-03-17 | 2020-05-26 | Yves Durocher | Expression vectors for enhanced transient gene expression and mammalian cells expressing them |
| FR2885525B1 (fr) | 2005-05-13 | 2009-09-18 | Urodelia Sa | Medicament notamment anti-cancereux, destine a des traitements par immunotherapie, en particulier autologue |
| CA2612102C (en) | 2005-06-13 | 2016-02-09 | Cleveland Biolabs, Inc. | Methods of protecting against apoptosis using lipopeptides |
| JP5777846B2 (ja) | 2005-06-15 | 2015-09-09 | マサチューセッツ インスティテュート オブ テクノロジー | アミン含有脂質およびその使用 |
| NZ564916A (en) | 2005-06-27 | 2011-03-31 | Exelixis Inc | Imidazole based LXR modulators |
| WO2007005249A2 (en) | 2005-06-29 | 2007-01-11 | Hyperbranch Medical Technology, Inc. | Nanoparticles and dendritic-polymer-based hydrogels comprising them |
| US7494788B2 (en) | 2005-07-11 | 2009-02-24 | Molecular Kinetics, Inc. | Entropic bristle domain sequences and their use in recombinant protein production |
| US7820790B2 (en) | 2005-07-13 | 2010-10-26 | Amgen Mountain View Inc. | IL-6 binding proteins |
| US20090005268A1 (en) | 2005-07-18 | 2009-01-01 | Epigenomics Ag | Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers |
| GB0516058D0 (en) | 2005-08-04 | 2005-09-14 | Oxford Genome Sciences Uk Ltd | New protein isoforms and uses thereof |
| GB0517293D0 (en) | 2005-08-24 | 2005-10-05 | Cancer Rec Tech Ltd | Vectors and uses thereof |
| PL1931998T3 (pl) | 2005-09-15 | 2010-11-30 | Alk Abello As | Sposób ilościowego oznaczania alergenów |
| WO2007073432A2 (en) | 2005-10-11 | 2007-06-28 | Chemocentryx, Inc. | Piperidine derivatives and methods of use |
| CA2620248A1 (en) | 2005-10-21 | 2007-04-26 | Merz Pharma Gmbh & Co. Kgaa | Chromenones and their use as modulators of metabotropic glutamate receptors |
| UA96139C2 (uk) | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитіло до нейропіліну-1 (nrp1) |
| JP5175207B2 (ja) | 2005-11-10 | 2013-04-03 | ケモセントリックス インコーポレーティッド | 置換キノロンおよび使用法 |
| US20090203922A1 (en) | 2005-11-23 | 2009-08-13 | Kevin Michael Belyk | Process for Synthesizing 2-Phenyl-1H-Phenanthro[9,10-d]Imidazole Derivative |
| KR101049859B1 (ko) | 2007-11-28 | 2011-07-19 | 대한민국 | N-말단 pI 값 조절에 의한 수용성 재조합 단백질 생산방법 |
| KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| EP2002036A4 (en) | 2006-03-09 | 2010-01-27 | Univ Texas | COMPOSITIONS AND METHODS RELATING TO THE PROFILING OF MULTIPLE CELL LINES ON PEPTIDE BONDING BASIS |
| WO2007104948A2 (en) | 2006-03-10 | 2007-09-20 | Warwick Effect Polymers Ltd. | Polymers |
| WO2007110755A1 (en) | 2006-03-27 | 2007-10-04 | Medical Therapies Limited | Prophylaxis or treatment of cardiovascular inflammation |
| EP2014676B1 (en) | 2006-04-20 | 2012-03-07 | Kringle Pharma Inc. | Hgf precursor protein mutant and activated form thereof |
| US20090253156A1 (en) | 2006-05-05 | 2009-10-08 | Perkinelmer Las, Inc. | Mass spectrometry methods for multiplexed quantification of protein kinases and phosphatases |
| EP2348106B1 (en) | 2006-05-08 | 2014-07-02 | Adaerata, Limited Partnership | Chimeric proteins, cells comprising same, and assays using same |
| DK2032701T3 (da) | 2006-06-23 | 2014-02-10 | Alethia Biotherapeutics Inc | Polynukleotider og polypeptider, der er inddraget i cancer |
| US20120128661A1 (en) | 2006-06-23 | 2012-05-24 | Alethia Biotherapeutics Inc. | Polynucleotide and polypeptide sequences involved in cancer |
| WO2008002267A1 (en) | 2006-06-28 | 2008-01-03 | Rgb Technologies Ab | A sensor kit and a system for detecting an analyte in a test environment |
| US8198046B2 (en) | 2006-07-11 | 2012-06-12 | Danisco Us Inc. | KEX2 cleavage regions of recombinant fusion proteins |
| CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
| EP2121747A2 (en) | 2006-07-27 | 2009-11-25 | Oxford Genome Sciences (UK) Limited | New protein isoforms and uses thereof |
| WO2008016356A2 (en) | 2006-08-02 | 2008-02-07 | Genizon Biosciences | Genemap of the human genes associated with psoriasis |
| AU2007284651B2 (en) | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| EP2066806A2 (fr) | 2006-09-07 | 2009-06-10 | Laurence Faure | Test pharmaco diagnostique ciblant l'oncologie |
| WO2008033932A2 (en) | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Biarylthiazole carboxylic acid derivatives as protein tyrosine phosphatase-ib inhibitors |
| CA2668262A1 (en) | 2006-10-30 | 2008-05-08 | Sanrx Pharmaceuticals, Inc. | Dipterinyl calcium pentahydrate (dcp) and therapeutic methods based thereon |
| DE102006051516A1 (de) | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
| EP2097534A4 (en) | 2006-12-14 | 2010-05-12 | Medarex Inc | HUMAN ANTIBODIES BINDING TO CD70 AND USES THEREOF |
| WO2008082887A2 (en) | 2006-12-28 | 2008-07-10 | Abbott Laboratories | Inhibitors of poly(adp-ribose)polymerase |
| NZ578928A (en) | 2007-01-09 | 2013-03-28 | Cleveland Biolabs Inc | Methods to increase mobility of hematopoietic stem cells by use of a lipopeptide compound and treatment of associated diseases |
| DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
| WO2008104803A2 (en) | 2007-02-26 | 2008-09-04 | Oxford Genome Sciences (Uk) Limited | Proteins |
| WO2008124483A1 (en) | 2007-04-04 | 2008-10-16 | Specigen, Inc. | Protein cage immunotherapeutics |
| WO2009009186A2 (en) | 2007-04-13 | 2009-01-15 | The Regents Of The University Of California | Receptors useful for gas phase chemical sensing |
| EP2155177A2 (en) | 2007-04-30 | 2010-02-24 | Intezyne Technologies Incorporated | Modification of biological targeting groups for the treatment of cancer |
| US20080306007A1 (en) | 2007-04-30 | 2008-12-11 | Newcastle Innovation Limited | Agents for prophylaxis or treatment of neurological related diseases and conditions |
| US8143372B2 (en) | 2007-05-21 | 2012-03-27 | Children's Hospital & Research Center Oakland | Synthetic regulators of ferritin protein nanocage pores and methods of use thereof |
| US20100093554A1 (en) | 2007-06-01 | 2010-04-15 | Keting Chu | Methods for identifying biomarkers, autoantibody signatures, and stratifying subject groups using peptide arrays |
| US8618121B2 (en) | 2007-07-02 | 2013-12-31 | Cancer Research Technology Limited | 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors |
| US9018138B2 (en) | 2007-08-16 | 2015-04-28 | The Johns Hopkins University | Compositions and methods for generating and screening adenoviral libraries |
| KR20100087283A (ko) | 2007-09-07 | 2010-08-04 | 심포젠 에이/에스 | 항rsv 항체의 재조합 제조 방법 |
| US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| JP6039879B2 (ja) | 2007-11-05 | 2016-12-07 | ノルディック・ビオサイエンス・エー/エスNordic Bioscience A/S | Cvdリスク評価のための生化学マーカー |
| WO2009061681A2 (en) | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc | Antagonists of pgd2 receptors |
| EP2071334A1 (en) | 2007-12-14 | 2009-06-17 | Transmedi SA | Compositions and methods of detecting TIABS |
| US20110165223A1 (en) | 2008-01-02 | 2011-07-07 | The Johns Hopkins University | Antitumor Immunization by Liposomal Delivery of Vaccine to the Spleen |
| JP2011515666A (ja) | 2008-03-14 | 2011-05-19 | ドナー, インコーポレイテッド | トリプルネガティブ乳がんに関連するdna修復タンパク質およびその使用法 |
| US8568709B2 (en) | 2008-03-20 | 2013-10-29 | University Health Network | Thymidylate kinase fusions and uses thereof |
| US8445648B2 (en) | 2008-04-30 | 2013-05-21 | University Of Vermont And State Agricultural College | Methods and products relating to GSK3β regulation |
| EP2296629B1 (en) | 2008-05-09 | 2014-07-02 | Evonik Corporation | Biocompatible and biodegradable elastomeric polymers |
| WO2009144230A1 (en) | 2008-05-26 | 2009-12-03 | Universität Zürich | Protamine/rna nanoparticles for immunostimulation |
| WO2010003120A2 (en) | 2008-07-03 | 2010-01-07 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| US8148088B2 (en) | 2008-07-18 | 2012-04-03 | Abgent | Regulation of autophagy pathway phosphorylation and uses thereof |
| EP2309853A4 (en) | 2008-08-01 | 2012-04-25 | Lixte Biotechnology Inc | METHOD FOR CELL MITITULATING BY INHIBITION OF SERIN / THREONINE PHOSPHATASE |
| WO2010017479A1 (en) | 2008-08-08 | 2010-02-11 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| US20110171312A1 (en) | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Modified therapeutic peptides, methods of their preparation and use |
| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| EP2451844B1 (en) | 2009-07-10 | 2015-04-22 | Innate Pharma | Tlr3 binding agents |
| WO2011054112A1 (en) | 2009-11-03 | 2011-05-12 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of kidney associated antigen 1 |
| PL2544680T3 (pl) * | 2010-03-11 | 2015-08-31 | Merrimack Pharmaceuticals Inc | Zastosowanie inhibitorów ERBB1 w leczeniu potrójnie ujemnego raka gruczołu sutkowego |
| US20110233107A1 (en) | 2010-03-23 | 2011-09-29 | Emily Jainine Lockett | Personal Cosmetic Palette |
| EP2691421B1 (en) | 2011-03-31 | 2016-11-09 | Alethia Biotherapeutics Inc. | Antibodies against kidney associated antigen 1 and antigen binding fragments thereof |
| EA201992513A1 (ru) * | 2012-01-09 | 2020-05-31 | Адс Терапьютикс Са | Способ лечения рака груди |
| JP6554959B2 (ja) | 2015-07-14 | 2019-08-07 | 富士通株式会社 | 情報処理装置、コンパイル方法、およびコンパイルプログラム |
-
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- 2013-01-09 IN IN4690CHN2014 patent/IN2014CN04690A/en unknown
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- 2013-01-09 EP EP19156516.7A patent/EP3533468A1/en not_active Withdrawn
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101663322A (zh) * | 2006-12-14 | 2010-03-03 | 株式会社未来创药研究所 | 抗紧密连接蛋白3单克隆抗体以及使用该抗体的癌症的治疗和诊断 |
| WO2010060186A1 (en) * | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| US20110150979A1 (en) * | 2009-08-06 | 2011-06-23 | Ray Partha S | Methods for diagnosis, prognosis and treatment of primary and metastatic basal-like breast cancer and other cancer types |
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