CN111051304B - 作为LRRK2抑制剂的咪唑并[4,5-c]喹啉衍生物 - Google Patents

作为LRRK2抑制剂的咪唑并[4,5-c]喹啉衍生物 Download PDF

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Publication number
CN111051304B
CN111051304B CN201880029989.5A CN201880029989A CN111051304B CN 111051304 B CN111051304 B CN 111051304B CN 201880029989 A CN201880029989 A CN 201880029989A CN 111051304 B CN111051304 B CN 111051304B
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methyl
imidazo
quinoline
chloro
pyran
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Chinese (zh)
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CN111051304A (zh
Inventor
M·A·布罗德尼
T·A·查皮
J·M·陈
J·W·科
K·J·科夫曼
P·加拉特西斯
M·R·加恩西
C·J·赫拉尔
J·L·亨德森
B·L·科莫斯
R·G·库鲁姆贝尔
L·A·马丁内斯-阿尔西纳
M·Y·彼得森
M·R·里斯
C·R·罗斯
A·F·斯特潘
P·R·费尔赫斯特
T·T·韦杰
J·S·沃马斯
Y·张
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Pfizer Corp SRL
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Pfizer Corp SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201880029989.5A 2017-03-10 2018-03-06 作为LRRK2抑制剂的咪唑并[4,5-c]喹啉衍生物 Active CN111051304B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762469756P 2017-03-10 2017-03-10
US62/469,756 2017-03-10
US201862629152P 2018-02-12 2018-02-12
US62/629,152 2018-02-12
PCT/IB2018/051439 WO2018163066A1 (en) 2017-03-10 2018-03-06 Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors

Publications (2)

Publication Number Publication Date
CN111051304A CN111051304A (zh) 2020-04-21
CN111051304B true CN111051304B (zh) 2022-12-27

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Country Link
US (1) US11312713B2 (enExample)
EP (1) EP3592741B1 (enExample)
JP (1) JP7219223B2 (enExample)
KR (1) KR102582626B1 (enExample)
CN (1) CN111051304B (enExample)
AU (1) AU2018230236B2 (enExample)
BR (1) BR112019018688A2 (enExample)
CA (1) CA3056030A1 (enExample)
IL (1) IL269214B (enExample)
MX (1) MX2019010756A (enExample)
SG (2) SG11201908322WA (enExample)
TW (1) TWI701246B (enExample)
WO (1) WO2018163066A1 (enExample)

Families Citing this family (7)

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KR20230006560A (ko) 2020-05-06 2023-01-10 르 라보레또레 쎄르비에르 새로운 거대고리 lrrk2 키나제 억제제
BR112023017834A2 (pt) 2021-03-18 2023-10-03 Servier Lab Inibidores de lrrk2 cinase macrocíclicos
CA3256816A1 (en) * 2022-05-12 2023-11-16 Interline Therapeutics, Inc. LRRK2 INHIBITORS
CN119546607A (zh) * 2022-05-12 2025-02-28 因特来治疗公司 Lrrk2抑制剂
CN115728413A (zh) * 2022-11-09 2023-03-03 内蒙古帕默康创医疗仪器有限公司 舍曲林血药浓度的定量分析方法
CN116879450A (zh) * 2023-07-25 2023-10-13 江苏汉邦科技股份有限公司 一种利用超临界流体色谱系统分离纯化芦可替尼前体的方法
CN118440041B (zh) * 2024-07-02 2024-09-27 苏州凯瑞医药科技有限公司 一种手性4-氨基-3-羟基四氢吡喃的制备方法

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US20210355117A1 (en) 2021-11-18
SG11201908322WA (en) 2019-10-30
EP3592741A1 (en) 2020-01-15
IL269214B (en) 2022-03-01
JP2020510046A (ja) 2020-04-02
EP3592741B1 (en) 2023-02-15
NZ757971A (en) 2024-12-20
WO2018163066A1 (en) 2018-09-13
AU2018230236B2 (en) 2022-05-19
KR102582626B1 (ko) 2023-09-22
RU2019131727A3 (enExample) 2021-04-26
CN111051304A (zh) 2020-04-21
IL269214A (en) 2019-11-28
US11312713B2 (en) 2022-04-26
AU2018230236A1 (en) 2019-10-31
JP7219223B2 (ja) 2023-02-07
CA3056030A1 (en) 2018-09-13
BR112019018688A2 (pt) 2020-04-07
KR20190138793A (ko) 2019-12-16
SG10202110112TA (en) 2021-10-28
TWI701246B (zh) 2020-08-11
RU2019131727A (ru) 2021-04-12
MX2019010756A (es) 2020-01-20
TW201900642A (zh) 2019-01-01

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